Rewarming from therapeutic hypothermia induces cortical neuron apoptosis in a swine model of neonatal hypoxic-ischemic encephalopathy

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 5, 2015, Pages 781-793

  Wang, Bing ^a   Armstrong, Jillian S ^a   Lee, Jeong Hoo ^a   Bhalala, Utpal ^a   Kulikowicz, Ewa ^a   Zhang, Hui ^a,b   Reyes, Michael ^a   Moy, Nicole ^a   Spicer, Dawn ^a   Zhu, Junchao ^a   Yang, Zeng Jin ^a   Koehler, Raymond C ^a   Martin, Lee J ^c   Lee, Jennifer K ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b FUDAN UNIVERSITY   (China)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

asphyxia; heart arrest; hypothermia; neuronal cell death; newborn; rewarming

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; EOSIN; HEMATOXYLIN; PHENYLEPHRINE; CASPASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BODY TEMPERATURE; BRAIN CELL; BRAIN CORTEX; CONTROLLED STUDY; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOBLOTTING; INDUCED HYPOTHERMIA; MOTOR CORTEX; NERVE DEGENERATION; NEWBORN; NONHUMAN; OUTCOME ASSESSMENT; PORCINE MODEL; PRIORITY JOURNAL; PYRIFORM CORTEX; RANDOMIZED CONTROLLED TRIAL; SUBDURAL CATHETER; TUNEL ASSAY; WARMING; ANIMAL; DISEASE MODEL; HUMAN; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN, DISEASES; METABOLISM; NERVE CELL; PATHOLOGY; PIG;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CASPASES; DISEASE MODELS, ANIMAL; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; MOTOR CORTEX; NEURONS; SWINE;

EID: 84928827605     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.245     Document Type: Article

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