Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model

Pediatric Research

Volumn 71, Issue 5, 2012, Pages 559-565

  Liu, Yiqing ^a   Shangguan, Yu ^a   Barks, John D E ^a   Silverstein, Faye S ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUMETANIDE; PHENOBARBITAL; PROTEIN P14; PROTEIN P35;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; FEMALE; FOREFOOT; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; MALE; NEUROPROTECTION; NEWBORN HYPOXIA; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SURVIVAL; TEMPERATURE;

ANIMALS; ANIMALS, NEWBORN; BUMETANIDE; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; NEUROPROTECTIVE AGENTS; PHENOBARBITAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84859903461     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2012.7     Document Type: Article

References (20)

1. Edwards AD, Brocklehurst P, Gunn AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ 2010;340:c363.
2. Cilio MR, Ferriero DM. Synergistic neuroprotective therapies with hypothermia. Semin Fetal Neonatal Med 2010;15:293-8.
3. Barks JD, Liu YQ, Shangguan Y, Silverstein FS. Phenobarbital augments hypothermic neuroprotection. Pediatr Res 2010;67:532-7.
4. Silverstein FS, Jensen FE. Neonatal seizures. Ann Neurol 2007;62:112-20. (Pubitemid 47546496)
5. Dzhala VI, Talos DM, Sdrulla DA, et al. NKCC1 transporter facilitates seizures in the developing brain. Nat Med 2005;11:1205-13. (Pubitemid 43093668)
6. Dzhala VI, Brumback AC, Staley KJ. Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. Ann Neurol 2008;63:222-35. (Pubitemid 351355301)
7. Dzhala VI, Kuchibhotla KV, Glykys JC, et al. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci 2010;30:11745-61.
8. Dai Y, Tang J, Zhang JH. Role of Cl-in cerebral vascular tone and expression of Na+-K+-2Cl-co-transporter after neonatal hypoxia-ischemia. Can J Physiol Pharmacol 2005;83:767-73. (Pubitemid 41784015)
9. Silverstein FS. Do seizures contribute to neonatal hypoxic-ischemic brain injury? J Pediatr 2009;155:305-6.
10. Wirrell EC, Armstrong EA, Osman LD, Yager JY. Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage. Pediatr Res 2001;50:445-54. (Pubitemid 32911333)
11. Yager JY, Armstrong EA, Jaharus C, Saucier DM, Wirrell EC. Preventing hyperthermia decreases brain damage following neonatal hypoxic-ischemic seizures. Brain Res 2004;1011:48-57. (Pubitemid 38609455)
12. Gunn AJ, Bennet L, Gunning MI, Gluckman PD, Gunn TR. Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr Res 1999;46:274-80. (Pubitemid 29400570)
13. Yan Y, Dempsey RJ, Flemmer A, Forbush B, Sun D. Inhibition of NaKCl cotransporter during focal cerebral ischemia decreases edema and neuronal damage. Brain Res 2003;961:22-31. (Pubitemid 36084465)
14. Pond BB, Berglund K, Kuner T, Feng G, Augustine GJ, Schwartz-Bloom RD. The chloride transporter Na-K-Cl cotransporter isoform-1 contributes to intracellular chloride increases after in vitro ischemia. J Neurosci 2006;26:1396-406. (Pubitemid 43237010)
15. Bittigau P, Sifringer M, Ikonomidou C. Antiepileptic drugs and apoptosis in the developing brain. Ann N Y Acad Sci 2003;993:103-14; discussion 123-4. (Pubitemid 36808438)
16. Creeley CE, Olney JW. The young: neuroapoptosis induced by anesthetics and what to do about it. Anesth Analg 2010;110:442-8.
17. Wang DD, Kriegstein AR. Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits. Cereb Cortex 2011;21:574-87.
18. Liu Y, Barks JD, Xu G, Silverstein FS. Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke 2004;35:1460-5. (Pubitemid 38697476)
19. Yager J, Towfighi J, Vannucci RC. Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat. Pediatr Res 1993;34:525-9. (Pubitemid 23297185)
20. Brandt C, Nozadze M, Heuchert N, Rattka M, Löcher W. Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy. J Neurosci 2010;30:8602-12.