Prolonged therapeutic hypothermia is more effective in attenuating brain apoptosis in a swine cardiac arrest model

Critical Care Medicine

Volumn 42, Issue 2, 2014, Pages

  Suh, Gil Joon ^a   Kwon, Woon Yong ^a   Kim, Kyung Su ^a   Lee, Hui Jai ^b   Jeong, Ki Young ^c   Jung, Yoon Sun ^a   Lee, Jae Hyuk ^d  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University Boramae Hospital   (South Korea)

^c National Medical Center   (South Korea)

^d Seoul National University Bundang Hospital   (South Korea)

Author keywords

Apoptosis; Brain; Heart Arrest; Hypothermia; Induced; Protein Kinase C

Indexed keywords

ANIMAL; APOPTOSIS; BRAIN; HEART ARREST; INDUCED HYPOTHERMIA; MALE; PATHOLOGY; PROCEDURES; SWINE; TIME;

ANIMALS; APOPTOSIS; BRAIN; HEART ARREST; HYPOTHERMIA, INDUCED; MALE; SWINE; TIME FACTORS;

EID: 84893334956     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3182a668e4     Document Type: Article

References (34)

1. Peberdy MA, Callaway CW, Neumar RW, et al; American Heart Association: Part 9: Post-cardiac arrest care: 2010 American Heart Association Guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010; 122:S768-S786
2. Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346:549-556
3. Bernard SA, Smith K, Cameron P, et al; Rapid Infusion of Cold Hartmanns (RICH) Investigators: Induction of therapeutic hypothermia by paramedics after resuscitation from out-of-hospital ventricular fibrillation cardiac arrest: A randomized controlled trial. Circulation 2010; 122:737-742
4. Castrén M, Nordberg P, Svensson L, et al: Intra-arrest transnasal evaporative cooling: A randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness). Circulation 2010; 122:729-736
5. Tang M, Alexander H, Clark RS, et al: Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest. J Cereb Blood Flow Metab 2010; 30:119-129
6. Clark DL, Penner M, Orellana-Jordan IM, et al: Comparison of 12, 24 and 48 h of systemic hypothermia on outcome after permanent focal ischemia in rat. Exp Neurol 2008; 212:386-392
7. Fingas M, Penner M, Silasi G, et al: Treatment of intracerebral hemorrhage in rats with 12 h, 3 days and 6 days of selective brain hypothermia. Exp Neurol 2009; 219:156-162
8. McIntyre LA, Fergusson DA, Hébert PC, et al: Prolonged therapeutic hypothermia after traumatic brain injury in adults: A systematic review. JAMA 2003; 289:2992-2999
9. Shankaran S, Pappas A, McDonald SA, et al; Eunice Kennedy Shriver NICHD Neonatal Research Network: Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 2012; 366:2085-2092
10. Bisschops LL, Van Der Hoeven JG, Hoedemaekers CW: Effects of prolonged mild hypothermia on cerebral blood flow after cardiac arrest. Crit Care Med 2012; 40:2362-2367
11. Choi DW: Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 1996; 6:667-672
12. Raval AP, Dave KR, Prado R, et al: Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation. J Cereb Blood Flow Metab 2005; 25:730-741
13. Bright R, Raval AP, Dembner JM, et al: Protein kinase C delta mediates cerebral reperfusion injury in vivo. J Neurosci 2004; 24:6880-6888
14. Chou WH, Messing RO: Protein kinase C isozymes in stroke. Trends Cardiovasc Med 2005; 15:47-51
15. Shimohata T, Zhao H, Sung JH, et al: Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia. J Cereb Blood Flow Metab 2007; 27:1463-1475
16. Hwang SO, Lee KH, Cho JH, et al: Simultaneous sternothoracic cardiopulmonary resuscitation: A new method of cardiopulmonary resuscitation. Resuscitation 2001; 48:293-299
17. Gong P, Li CS, Hua R, et al: Mild hypothermia attenuates mitochondrial oxidative stress by protecting respiratory enzymes and upregulating MnSOD in a pig model of cardiac arrest. PLoS One 2012; 7:e35313
18. Yannopoulos D, Zviman M, Castro V, et al: Intra-cardiopulmonary resuscitation hypothermia with and without volume loading in an ischemic model of cardiac arrest. Circulation 2009; 120:1426-1435
19. Sunde K, Pytte M, Jacobsen D, et al: Implementation of a standardised treatment protocol for post resuscitation care after out-ofhospital cardiac arrest. Resuscitation 2007; 73:29-39
20. Gaieski DF, Band RA, Abella BS, et al: Early goal-directed hemodynamic optimization combined with therapeutic hypothermia in comatose survivors of out-of-hospital cardiac arrest. Resuscitation 2009; 80:418-424
21. Ravindran J, Gupta N, Agrawal M, et al: Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism. Apoptosis 2011; 16:145-161
22. Derugin N, Wendland M, Muramatsu K, et al: Evolution of brain injury after transient middle cerebral artery occlusion in neonatal rats. Stroke 2000; 31:1752-1761
23. Vogel P, Putten Hv, Popp E, et al: Improved resuscitation after cardiac arrest in rats expressing the baculovirus caspase inhibitor protein p35 in central neurons. Anesthesiology 2003; 99:112-121
24. Jia X, Koenig MA, Shin HC, et al: Quantitative EEG and neurological recovery with therapeutic hypothermia after asphyxial cardiac arrest in rats. Brain Res 2006; 1111:166-175
25. Buitrago MM, Luft AR, Thakor NV, et al: Effects of somatosensory electrical stimulation on neuronal injury after global hypoxia-ischemia. Exp Brain Res 2004; 158:336-344
26. Eke A, Conger KA, Anderson M, et al: Histologic assessment of neurons in rat models of cerebral ischemia. Stroke 1990; 21:299-304
27. Noguchi K, Gel YR, Brunner E, et al: NparLD: An R software package for the nonparametric analysis of longitudinal data in factorial experiments. J Stat Softw 2012; 50:1-23
28. Che D, Li L, Kopil CM, et al: Impact of therapeutic hypothermia onset and duration on survival, neurologic function, and neurodegeneration after cardiac arrest. Crit Care Med 2011; 39:1423-1430
29. Post H, Schmitto JD, Steendijk P, et al: Cardiac function during mild hypothermia in pigs: Increased inotropy at the expense of diastolic dysfunction. Acta Physiol (Oxf) 2010; 199:43-52
30. Gong P, Hua R, Zhang Y, et al: Hypothermia-induced neuroprotection is associated with reduced mitochondrial membrane permeability in a swine model of cardiac arrest. Available at: Http://www.jcbfm.com. Accessed May 13, 2013
31. Schratter A, Holzer M, Sterz F, et al: New conventional long-term survival normovolemic cardiac arrest pig model. Resuscitation 2011; 82:90-96
32. Böttiger BW, Schmitz B, Wiessner C, et al: Neuronal stress response and neuronal cell damage after cardiocirculatory arrest in rats. J Cereb Blood Flow Metab 1998; 18:1077-1087
33. Kirsch JR, Traystman RJ, Hurn PD: Anesthetics and cerebroprotection: Experimental aspects. Int Anesthesiol Clin 1996; 34:73-93
34. Fee JP, Thompson GH: Comparative tolerability profiles of the inhaled anaesthetics. Drug Saf 1997; 16:157-170