Cerebrovascular autoregulation after rewarming from hypothermia in a neonatal swine model of asphyxic brain injury

Journal of Applied Physiology

Volumn 115, Issue 10, 2013, Pages 1433-1442

  Larson, Abby C ^a   Jamrogowicz, Jessica L ^a   Kulikowicz, Ewa ^a   Wang, Bing ^a   Yang, Zeng Jin ^a   Shaffner, Donald H ^a   Koehler, Raymond C ^a   Lee, Jennifer K ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac arrest; Cerebral blood flow; Near infrared spectroscopy; Neonatal hypoxic ischemic encephalopathy; Pig

Indexed keywords

ANIMAL; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; DISEASE MODEL; HEART ARREST; HOMEOSTASIS; HYPERTENSION; HYPOTENSION; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; LASER DOPPLER FLOWMETRY; NEAR INFRARED SPECTROSCOPY; NEAR-INFRARED SPECTROSCOPY; NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY; NEWBORN; NEWBORN HYPOXIA; PATHOPHYSIOLOGY; SWINE; TIME; WARMING;

CARDIAC ARREST; CEREBRAL BLOOD FLOW; NEAR-INFRARED SPECTROSCOPY; NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY; PIG;

ANIMALS; ANIMALS, NEWBORN; ASPHYXIA NEONATORUM; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; HOMEOSTASIS; HYPERTENSION; HYPOTENSION; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; LASER-DOPPLER FLOWMETRY; REWARMING; SPECTROSCOPY, NEAR-INFRARED; SWINE; TIME FACTORS;

EID: 84888336754     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00238.2013     Document Type: Article

References (33)

1. Agnew DM, Koehler RC, Guerguerian AM, Shaffner DH, Traystman RJ, Martin LJ, Ichord RN. Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming. Pediatr Res 54: 253-262, 2003.
2. Armstead WM, Kiessling JW, Kofke WA, Vavilala MS. Impaired cerebral blood flow autoregulation during posttraumatic arterial hypotension after fluid percussion brain injury is prevented by phenylephrine in female but exacerbated in male piglets by extracellular signal-related kinase mitogen-activated protein kinase upregulation. Crit Care Med 38: 1868-1874, 2010.
3. Bisschops LL, Hoedemaekers CW, Mollnes TE, van der Hoeven JG. Rewarming after hypothermia after cardiac arrest shifts the inflammatory balance. Crit Care Med 40: 1136-1142, 2012.
4. Brady KM, Lee JK, Kibler KK, Easley RB, Koehler RC, Czosnyka M, Smielewski P, Shaffner DH. The lower limit of cerebral blood flow autoregulation is increased with elevated intracranial pressure. Anesth Analg 108: 1278-1283, 2009.
5. Brady KM, Lee JK, Kibler KK, Easley RB, Koehler RC, Shaffner DH. Continuous measurement of autoregulation by spontaneous fluctuations in cerebral perfusion pressure: comparison of 3 methods. Stroke 39: 2531- 2537, 2008.
6. Brady KM, Lee JK, Kibler KK, Smielewski P, Czosnyka M, Easley RB, Koehler RC, Shaffner DH. Continuous time-domain analysis of cerebrovascular autoregulation using near-infrared spectroscopy. Stroke 38: 2818-2825, 2007.
7. Brady KM, Mytar JO, Lee JK, Cameron DE, Vricella LA, Thompson WR, Hogue CW, Easley RB. Monitoring cerebral blood flow pressure autoregulation in pediatric patients during cardiac surgery. Stroke 41: 1957-1962, 2010.
8. Celotto AC, Restini CB, Capellini VK, Bendhack LM, Evora PR. Acidosis induces relaxation mediated by nitric oxide and potassium channels in rat thoracic aorta. Eur J Pharmacol 656: 88-93, 2011.
9. Chemtob S, Beharry K, Rex J, Varma DR, Aranda JV. Changes in cerebrovascular prostaglandins and thromboxane as a function of systemic blood pressure. Cerebral blood flow autoregulation of the newborn. Circ Res 67: 674-682, 1990.
10. Fujita M, Wei EP, Povlishock JT. Effects of hypothermia on cerebral autoregulatory vascular responses in two rodent models of traumatic brain injury. J Neurotrauma 29: 1491-1498, 2012.
11. Graham EM, Ruis KA, Hartman AL, Northington FJ, Fox HE. A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 199: 587-595, 2008.
12. Hahn GH, Heiring C, Pryds O, Greisen G. Cerebral vascular effects of hypovolemia and dopamine infusions: A study in newborn piglets. Acta Paediatr 101: 736-742, 2012.
13. Jones SC, Radinsky CR, Furlan AJ, Chyatte D, Qu Y, Easley KA, Perez-Trepichio AD. Variability in the magnitude of the cerebral blood flow response and the shape of the cerebral blood flow-pressure autoregulation curve during hypotension in normal rats [corrected]. Anesthesiology 97: 488-496, 2002.
14. Joshi B, Brady K, Lee J, Easley B, Panigrahi R, Smielewski P, Czosnyka M, Hogue CW Jr. Impaired autoregulation of cerebral blood flow during rewarming from hypothermic cardiopulmonary bypass and its potential association with stroke. Anesth Analg 110: 321-328, 2010.
15. Joshi B, Ono M, Brown C, Brady K, Easley RB, Yenokyan G, Gottesman RF, Hogue CW. Predicting the limits of cerebral autoregulation during cardiopulmonary bypass. Anesth Analg 114: 503-510, 2012.
16. Lee JK, Brady KM, Mytar JO, Kibler KK, Carter EL, Hirsch KG, Hogue CW, Easley RB, Jordan LC, Smielewski P, Czosnyka M, Shaffner DH, Koehler RC. Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia. Crit Care Med 39: 2337-2345, 2011.
17. Lee JK, Kibler KK, Benni PB, Easley RB, Czosnyka M, Smielewski P, Koehler RC, Shaffner DH, Brady KM. Cerebrovascular reactivity measured by near-infrared spectroscopy. Stroke 40: 1820-1826, 2009.
18. Lee JK, Yang ZJ, Wang B, Larson AC, Jamrogowicz JL, Kulikowicz E, Kibler KK, Mytar JO, Carter EL, Burman HT, Brady KM, Smielewski P, Czosnyka M, Koehler RC, Shaffner DH. Noninvasive autoregulation monitoring in a swine model of pediatric cardiac arrest. Anesth Analg 114: 825-836, 2012.
19. Lucas SJ, Tzeng YC, Galvin SD, Thomas KN, Ogoh S, Ainslie PN. Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55: 698-705, 2010.
20. Martin LJ, Brambrink A, Koehler RC, Traystman RJ. Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia. J Comp Neurol 377: 262-285, 1997.
21. Miller SP, Ramaswamy V, Michelson D, Barkovich AJ, Holshouser B, Wycliffe N, Glidden DV, Deming D, Partridge JC, Wu YW, Ashwal S, Ferriero DM. Patterns of brain injury in term neonatal encephalopathy. J Pediatr 146: 453-460, 2005.
22. Mueller-Burke D, Koehler RC, Martin LJ. Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia. Int J Dev Neurosci 26: 67-76, 2008.
23. Ogoh S, Brothers RM, Eubank WL, Raven PB. Autonomic neural control of the cerebral vasculature: Acute hypotension. Stroke 39: 1979- 1987, 2008.
24. Pietrini D, Piastra M, Luca E, Mancino A, Conti G, Cavaliere F, De Luca D. Neuroprotection and hypothermia in infants and children. Curr Drug Targets 13: 925-935, 2012.
25. Pryds O, Greisen G, Lou H, Friis-Hansen B. Vasoparalysis associated with brain damage in asphyxiated term infants. J Pediatr 117: 119-125, 1990.
26. Shah PS. Hypothermia: A systematic review and meta-analysis of clinical trials. Semin Fetal Neonatal Med 15: 238-246, 2010.
27. Shankaran S, Laptook AR, McDonald SA, Higgins RD, Tyson JE, Ehrenkranz RA, Das A, Sant'Anna G, Goldberg RN, Bara R, Walsh MC, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatr Crit Care Med 13: 53- 59, 2012.
28. Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, Yolton K, Gustafson KE, Leach TM, Green C, Bara R, Petrie Huitema CM, Ehrenkranz RA, Tyson JE, Das A, Hammond J, Peralta-Carcelen M, Evans PW, Heyne RJ, Wilson-Costello DE, Vaucher YE, Bauer CR, Dusick AM, Adams-Chapman I, Goldstein RF, Guillet R, Papile LA, Higgins RD, Eunice Kennedy Shriver NICHD Neonatal Research Network. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 366: 2085-2092, 2012.
29. Smielewski P, Czosnyka M, Steiner L, Belestri M, Piechnik S, Pickard JD. ICM-: software for on-line analysis of bedside monitoring data after severe head trauma. Acta Neurochir Suppl 95: 43-49, 2005.
30. Tress EE, Kochanek PM, Saladino RA, Manole MD. Cardiac arrest in children. J Emerg Trauma Shock 3: 267-272, 2010.
31. van Erkel AR, Pattynama PM. Receiver operating characteristic (ROC) analysis: basic principles and applications in radiology. Eur J Radiol 27: 88-94, 1998.
32. Walter B, Aisenpreis K, Fritz HG, Soukup J, Eiselt M, Bauer R. Age-dependent effects of gradual decreases in cerebral perfusion pressure on the neurochemical response in swine. Intensive Care Med 36: 1067- 1075, 2010.
33. Zanelli S, Buck M, Fairchild K. Physiologic and pharmacologic considerations for hypothermia therapy in neonates. J Perinatol 31: 377-386, 2011.