Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia

Pediatric Research

Volumn 64, Issue 1, 2008, Pages 74-80

  Karlsson, Mathias ^a,b   Tooley, James R ^a   Satas, Saulius ^a   Hobbs, Catherine E ^a   Chakkarapani, Ela ^a   Stone, Janet ^a   Porter, Helen ^a,c   Thoresen, Marianne ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b STOCKHOLM SÖDER HOSPITAL   (Sweden)

^c LEICESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; MAGNESIUM; POTASSIUM; ANTICONVULSIVE AGENT; CARDIOTONIC AGENT; LACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN INJURY; BRAIN ISCHEMIA; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEMALE; HISTOPATHOLOGY; HYPOTHERMIA; HYPOXIA; INDUCED HYPOTHERMIA; LEUKOCYTE; MAGNESIUM BLOOD LEVEL; MALE; NEUROLOGY; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SELECTIVE HEAD COOLING; SEX DIFFERENCE; SWINE; ANIMAL; ANOXIA; BLOOD; COMPARATIVE STUDY; CRYOANESTHESIA; DISEASE MODEL; HEAD; ISCHEMIA; METABOLISM; METHODOLOGY; MULTIPLE ORGAN FAILURE; PATHOLOGY; PH; TIME;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; ANTICONVULSANTS; CALCIUM; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; FEMALE; HEAD; HYDROGEN-ION CONCENTRATION; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; ISCHEMIA; LACTIC ACID; MAGNESIUM; MALE; MULTIPLE ORGAN FAILURE; POTASSIUM; SEX FACTORS; SWINE; TIME FACTORS;

EID: 49849087547     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e318174efdd     Document Type: Article

References (31)

1. Thoresen M, Penrice J, Lorek A, Cady EB, Wylezinska M, Kirkbride V, Cooper CE, Brown GC, Edwards AD, Wyatt JS, Reynolds EO 1995 Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet. Pediatr Res 37:667-670
2. Tooley JR, Satas S, Porter H, Silver IA, Thoresen M 2003 Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective. Ann Neurol 53:65-72
3. Gunn AJ, Gunn TR, de Haan HH, Williams CE, Gluckman PD 1997 Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest 99:248-256
4. Bona E, Hagberg H, Loberg EM, Bagenholm R, Thoresen M 1998 Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: short- and long-term outcome. Pediatr Res 43:738-745
5. Hobbs C, Thoresen M, Tucker A, Aquilina K, Chakkarapani E, Dingley J 2008 Xenon and hypothermia combine additively, offering long-term functional and histopathological neuroprotection after neonatal hypoxia/ischemia. Stroke 39:1307-1313
6. Gunn AJ 2000 Cerebral hypothermia for prevention of brain injury following perinatal asphyxia. Curr Opin Pediatr 12:111-115
7. Taylor DL, Mehmet H, Cady EB, Edwards AD 2002 Improved neuroprotection with hypothermia delayed by 6 hours following cerebral hypoxia-ischemia in the 14-day-old rat. Pediatr Res 51:13-19
8. Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, Polin RA, Robertson CM, Thoresen M, Whitelaw A, Gunn AJ 2005 Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 365:663-670
9. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH 2005 Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 353:1574-1584
10. Eicher DJ, Wagner CL, Katikaneni LP, Hulsey TC, Bass WT, Kaufman DA, Horgan MJ, Languani S, Bhatia JJ, Givelichian LM, Sankaran K, Yager JY 2005 Moderate hypothermia in neonatal encephalopathy: safety outcomes. Pediatr Neurol 32:18-24
11. Schulzke SM, Rao S, Patole SK 2007 A systematic review of cooling for neuro- protection in neonates with hypoxic ischemic encephalopathy-are we there yet? BMC Pediatr 7:30
12. Lorek A, Takei Y, Cady EB, Wyatt JS, Penrice J, Edwards AD, Peebles D, Wylezinska M, Owen-Reece H, Kirkbride V, Cooper RF, Alldridge RF, Roth SC, Brown G, Delpy DT, Reynolds EO 1994 Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res 36:699706
13. Thoresen M, Haaland K, Loberg EM, Whitelaw A, Apricena F, Hanko E, Steen PA 1996 A piglet survival model of posthypoxic encephalopathy. Pediatr Res 40:738748
14. Haaland K, Loberg EM, Steen PA, Thoresen M 1997 Posthypoxic hypothermia in newborn piglets. Pediatr Res 41:505-512
15. SatasS, LobergEM, PorterH, WhitelawA, Steen PA, ThoresenM2003Effectofglobal hypoxia-ischaemia followed by 24 h of mild hypothermia on organ pathology and biochemistry in a newborn pig survival model. Biol Neonate 83:146-156
16. Gressens P, Dingley J, Plaisant F, Porter H, Schwendimann L, Verney C, Tooley J, Thoresen M 2008 Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brain. Brain Pathol 18:10-20
17. Thoresen M, Haaland K, Steen PA, Thoresen M, Haaland K, Steen PA 1994 Cerebral doppler and misrepresentation of flow changes. Arch Dis Child 71:F103-F106
18. Schubert A, Schubert A 1995 Side effects of mild hypothermia. J Neurosurg Anesthesiol 7:139-147
19. Amess PN, Penrice J, Howard S, Thoresen M, Edwards AD, Cady EB, Wyatt JS, Sams V 1998 Organ pathology following mild hypothermia used as neural rescue therapy in newborn piglets. Biol Neonate 73:40-46
20. Bernhard WF, Mc MJ, Curtis GW 1955 Feasibility ofpartial hepatic resection under hypothermia. N Engl J Med 253:159-164
21. Qing M, Nimmesgern A, Heinrich PC, Schumacher K, Vazquez-Jimenez JF, Hess J, von Bernuth G, Seghaye MC 2003 Intrahepatic synthesis of tumor necrosis factor- alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway. Crit Care Med 31:2769-2775
22. deSa DJ 1995 Pulmonary complications of assisted ventilation. In: deSa DJ (ed) Pathology of Neonatal Intensive Care. Chapman & Hall, London, pp 28-47
23. Cohen IT, Nelson SD, Moxley RA, Hirsh MP, Counihan TC, Martin RF 1991 ecrotizing enterocolitis in a neonatal piglet model. J Pediatr Surg 26:598-601
24. Haaland K, Loberg EM, Steen PA, Satas S, Thoresen M 1997 The effect of mild ost-hypoxic hypothermia on organ pathology in a piglet survival model of global hypoxia. Prenat Neonatal Med 2:329-337
25. Frink M, Pape HC, van Griensven M, Krettek C, Chaudry IH, Hildebrand F 2007 nfluence of sex and age on mods and cytokines after multiple injuries. Shock 27:151-156
26. Jensen A, Garnier Y, Berger R 1999 Dynamics of fetal circulatory responses to hypoxia and asphyxia. Eur J Obstet Gynecol Reprod Biol 84:155-172
27. Johnston MV, Hagberg H 2007 Sex and the pathogenesis of cerebral palsy. Dev Med Child Neurol 49:74-78
28. Yoneda S, Ibara S, Kobayashi K, Kato E, Maruyama Y, Maruyama H, Sumida Y, Sunami R, Sakai M, Ikenoue T, Saito S 2005 Low adjusted serum ionized calcium concentration shortly after birth predicts poor outcome in neonatal hypoxic-ischemic encephalopathy. J Obstet Gynaecol Res 31:57-64
29. Bickler PE, Hansen BM 1994 Causes of calcium accumulation in rat cortical brain slices during hypoxia and ischemia: role of ion channels and membrane damage. Brain Res 665:269-276
30. Johnston MV 1993 Cellular alterations associated with perinatal asphyxia. Clin Invest Med 16:122-132
31. Ilves P, Blennow M, Kutt E, Magi ML, Kudrjavtseva G, Lagercrantz H, Talvik T 1996 Concentrations of magnesium and ionized calcium in umbilical cord blood in distressed term newborn infants with hypoxic-ischemic encephalopathy. Acta Paediatr 85:1348-1350