Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia

Critical Care Medicine

Volumn 39, Issue 10, 2011, Pages 2337-2345

  Lee, Jennifer K ^a   Brady, Ken M ^a   Mytar, Jennifer O ^a   Kibler, Kathleen K ^a   Carter, Erin L ^a   Hirsch, Karen G ^a   Hogue, Charles W ^a   Easley, Ronald B ^a   Jordan, Lori C ^a   Smielewski, Peter ^a   Czosnyka, Marek ^b   Shaffner, Donald H ^a   Koehler, Raymond C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

blood pressure; cerebrovascular circulation; heart arrest; hypothermia; ischemia; pediatrics

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; BALLOON CATHETER; BRAIN BLOOD FLOW; BRAIN PERFUSION; CEREBROVASCULAR AUTOREGULATION; CONTROLLED STUDY; HEART ARREST; HYPERTENSION; HYPOTENSION; HYPOTHERMIA; INFERIOR CAVA VEIN; LASER DOPPLER FLOWMETRY; MALE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PERFUSION PRESSURE; PIGLET; PRIORITY JOURNAL; PROSPECTIVE STUDY; SHAM PROCEDURE;

EID: 80052961407     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318223b910     Document Type: Article

References (30)

1. Topjian AA, Berg RA, Nadkarni VM: Pediatric cardiopulmonary resuscitation: Advances in science, techniques, and outcomes. Pediatrics 2008; 122:1086-1098
2. Nishizawa H, Kudoh I: Cerebral autoregulation is impaired in patients resuscitated after cardiac arrest. Acta Anaesthesiol Scand 1996; 40:1149-1153 (Pubitemid 26363279)
3. Sundgreen C, Larsen FS, Herzog TM, et al: Autoregulation of cerebral blood flow in patients resuscitated from cardiac arrest. Stroke 2001; 32:128-132 (Pubitemid 32063836)
4. Manole MD, Foley LM, Hitchens TK, et al: Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats. J Cereb Blood Flow Metab 2009; 29:197-205
5. International Liaison Committee on Resuscitation: The International Liaison Committee on Resuscitation (ILCOR) consensus on science with treatment recommendations for pediatric and neonatal patients: Pediatric basic and advanced life support. Pediatrics 2006; 117:e955-e977
6. Brady KM, Lee JK, Kibler KK, et al: Continuous measurement of autoregulation by spontaneous fluctuations in cerebral perfusion pressure: Comparison of 3 methods. Stroke 2008; 39:2531-2537
7. Brady KM, Lee JK, Kibler KK, et al: Continuous time-domain analysis of cerebrovascular autoregulation using near-infrared spectroscopy. Stroke 2007; 38:2818-2825 (Pubitemid 47494023)
8. Brady KM, Mytar JO, Kibler KK, et al: Noninvasive autoregulation monitoring with and without intracranial pressure in the naive piglet brain. Anesth Analg 2010; 111: 191-195
9. Lee JK, Kibler KK, Benni PB, et al: Cerebrovascular reactivity measured by near-infrared spectroscopy. Stroke 2009; 40:1820-1826
10. Papile LA, Rudolph AM, Heymann MA: Autoregulation of cerebral blood flow in the preterm fetal lamb. Pediatr Res 1985; 19: 159-161 (Pubitemid 15155336)
11. Ramaekers VT, Casaer P, Daniels H, et al: Upper limits of brain blood flow autoregulation in stable infants of various conceptional age. Early Hum Dev 1990; 24:249-258
12. Tuor UI, Grewal D: Autoregulation of cerebral blood flow: Influence of local brain development and postnatal age. Am J Physiol 1994; 267:H2220-H2228
13. Helou S, Koehler RC, Gleason CA, et al: Cerebrovascular autoregulation during fetal development in sheep. Am J Physiol 1994; 266: H1069-H1074
14. Chemtob S, Beharry K, Rex J, et al: Changes in cerebrovascular prostaglandins and thromboxane as a function of systemic blood pressure. Cerebral blood flow autoregulation of the newborn. Circ Res 1990; 67:674-682 (Pubitemid 20314994)
15. Laptook AR, Stonestreet BS, Oh W: Brain blood flow and O2 delivery during hemorrhagic hypotension in the piglet. Pediatr Res 1983; 17:77-80 (Pubitemid 13223459)
16. Brady KM, Lee JK, Kibler KK, et al: The lower limit of cerebral blood flow autoregulation is increased with elevated intracranial pressure. Anesth Analg 2009; 108:1278-1283
17. Agnew DM, Koehler RC, Guerguerian AM, et al: Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming. Pediatr Res 2003; 54:253-262 (Pubitemid 36918161)
18. Strebel S, Lam AM, Matta B, et al: Dynamic and static cerebral autoregulation during isoflurane, desflurane, and propofol anesthesia. Anesthesiology 1995; 83:66-76
19. Vavilala MS, Tontisirin N, Udomphorn Y, et al: Hemispheric differences in cerebral autoregulation in children with moderate and severe traumatic brain injury. Neurocrit Care 2008; 9:45-54
20. Moler FW, Meert K, Donaldson AE, et al: In-hospital versus out-of-hospital pediatric cardiac arrest: A multicenter cohort study. Crit Care Med 2009; 37:2259-2267
21. Martin LJ, Brambrink A, Koehler RC, et al: Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia. J Comp Neurol 1997; 377:262-285 (Pubitemid 27009833)
22. Brambrink AM, Martin LJ, Hanley DF, et al: Effects of the AMPA receptor antagonist NBQX on outcome of newborn pigs after asphyxic cardiac arrest. J Cereb Blood Flow Metab 1999; 19:927-938 (Pubitemid 30173394)
23. Miller SP, Ramaswamy V, Michelson D, et al: Patterns of brain injury in term neonatal encephalopathy. J Pediatr 2005; 146: 453-460 (Pubitemid 40469706)
24. Dirnagl U, Kaplan B, Jacewicz M, et al: Continuous measurement of cerebral cortical blood flow by laser-Doppler flowmetry in a rat stroke model. J Cereb Blood Flow Metab 1989; 9:589-596 (Pubitemid 19239477)
25. Bishai JM, Blood AB, Hunter CJ, et al: Fetal lamb cerebral blood flow (CBF) and oxygen tensions during hypoxia: A comparison of laser Doppler and microsphere measurements of CBF. J Physiol 2003; 546:869-878 (Pubitemid 36204520)
26. Jones SC, Radinsky CR, Furlan AJ, et al: Variability in the magnitude of the cerebral blood flow response and the shape of the cerebral blood flow-pressure autoregulation curve during hypotension in normal rats [corrected]. Anesthesiology 2002; 97: 488-496 (Pubitemid 34847764)
27. Carp SA, Dai GP, Boas DA, et al: Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoring. Biomed Opt Express 2010; 1:553-565
28. Elliott JT, Diop M, Tichauer KM, et al: Quantitative measurement of cerebral blood flow in a juvenile porcine model by depthresolved near-infrared spectroscopy. J Biomed Opt 2010; 15:037014
29. Busija DW, Leffler CW: Hypothermia reduces cerebral metabolic rate and cerebral blood flow in newborn pigs. Am J Physiol 1987; 253:H869-H873
30. Cheng G, Sun J, Wang L, et al: Effects of selective head cooling on cerebral blood flow and metabolism in newborn piglets after hypoxia-ischemia. Early Hum Dev 2011; 87: 109-114