메뉴 건너뛰기




Volumn 35, Issue 5, 2015, Pages 759-765

Assessment of metabolic fluxes in the mouse brain in vivo using 1 H-[13 C] NMR spectroscopy at 14.1 Tesla

Author keywords

energy metabolism; glucose; glutamate; lactate; MR spectroscopy

Indexed keywords

2 OXOGLUTARIC ACID; 4 AMINOBUTYRIC ACID; ALANINE; ASPARTIC ACID; CARBON 13; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; LACTIC ACID; PYRUVIC ACID; AMINO ACID; CARBON; RADIOPHARMACEUTICAL AGENT; SWEETENING AGENT;

EID: 84928824083     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.251     Document Type: Article
Times cited : (22)

References (40)
  • 1
    • 84901022727 scopus 로고    scopus 로고
    • Metabolic flux and compartmentation analysis in the brain
    • Lanz B, Gruetter R, Duarte JM. Metabolic flux and compartmentation analysis in the brain. Front Endocrinol 2013; 4: 156
    • (2013) Front Endocrinol , vol.4 , pp. 156
    • Lanz, B.1    Gruetter, R.2    Duarte, J.M.3
  • 2
    • 33646164169 scopus 로고    scopus 로고
    • In vivo 13c nmr spectroscopy and metabolic modeling in the brain: A practical perspective
    • Henry PG, Adriany G, Deelchand D, Gruetter R, Marjanska M, Oz G, et al. In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective. Magn Reson Imaging 2006; 24: 527-539
    • (2006) Magn Reson Imaging , vol.24 , pp. 527-539
    • Henry, P.G.1    Adriany, G.2    Deelchand, D.3    Gruetter, R.4    Marjanska, M.5    Oz, G.6
  • 4
    • 0036345741 scopus 로고    scopus 로고
    • Impaired glutamate transport and glutamate-glutamine cycling: Downstream effects of the huntington mutation
    • Behrens PF, Franz P, Woodman B, Lindenberg KS, Landwehrmeyer GB. Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. Brain 2002; 125: 1908-1922
    • (2002) Brain , vol.125 , pp. 1908-1922
    • Behrens, P.F.1    Franz, P.2    Woodman, B.3    Lindenberg, K.S.4    Landwehrmeyer, G.B.5
  • 5
    • 0028170043 scopus 로고
    • Localized 13c nmr spectroscopy in the human brain of amino acid labeling from d-[1-13c]glucose
    • Gruetter R, Novotny EJ, Boulware SD, Mason GF, Rothman DL, Shulman GI, et al. Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose. J Neurochem 1994; 63: 1377-1385
    • (1994) J Neurochem , vol.63 , pp. 1377-1385
    • Gruetter, R.1    Novotny, E.J.2    Boulware, S.D.3    Mason, G.F.4    Rothman, D.L.5    Shulman, G.I.6
  • 7
    • 84885023305 scopus 로고    scopus 로고
    • Glutamatergic and gabaergic tca cycle and neurotransmitter cycling fluxes in different regions of mouse brain
    • Tiwari V, Ambadipudi S, Patel AB. Glutamatergic and GABAergic TCA cycle and neurotransmitter cycling fluxes in different regions of mouse brain. J Cereb Blood Flow Metab 2013; 33: 1523-1531
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1523-1531
    • Tiwari, V.1    Ambadipudi, S.2    Patel, A.B.3
  • 8
    • 36249017389 scopus 로고    scopus 로고
    • Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: Evidence for glial dysfunction and reduced glutamate/glutamine cycling
    • Chowdhury GM, Gupta M, Gibson KM, Patel AB, Behar KL. Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling. J Neurochem 2007; 103: 2077-2091
    • (2007) J Neurochem , vol.103 , pp. 2077-2091
    • Chowdhury, G.M.1    Gupta, M.2    Gibson, K.M.3    Patel, A.B.4    Behar, K.L.5
  • 9
    • 40449088883 scopus 로고    scopus 로고
    • Localized sensitivity enhanced in vivo 13c mrs to detect glucose metabolism in the mouse brain
    • Nabuurs CI, Klomp DW, Veltien A, Kan HE, Heerschap A. Localized sensitivity enhanced in vivo 13C MRS to detect glucose metabolism in the mouse brain. Magn Reson Med 2008; 59: 626-630
    • (2008) Magn Reson Med , vol.59 , pp. 626-630
    • Nabuurs, C.I.1    Klomp, D.W.2    Veltien, A.3    Kan, H.E.4    Heerschap, A.5
  • 10
    • 0032588201 scopus 로고    scopus 로고
    • Localized in vivo 1h nmr detection of neurotransmitter labeling in rat brain during infusion of [1-13c] d-glucose
    • Pfeuffer J, Tkac I, Choi IY, Merkle H, Ugurbil K, Garwood M, et al. Localized in vivo 1H NMR detection of neurotransmitter labeling in rat brain during infusion of [1-13C] D-glucose. Magn Reson Med 1999; 41: 1077-1083
    • (1999) Magn Reson Med , vol.41 , pp. 1077-1083
    • Pfeuffer, J.1    Tkac, I.2    Choi, I.Y.3    Merkle, H.4    Ugurbil, K.5    Garwood, M.6
  • 11
    • 77955116310 scopus 로고    scopus 로고
    • 1h-[13c] nmr spectroscopy of the rat brain during infusion of [2-13c] acetate at 14.1 t
    • Xin L, Mlynarik V, Lanz B, Frenkel H, Gruetter R. 1H-[13C] NMR spectroscopy of the rat brain during infusion of [2-13C] acetate at 14.1 T. Magn Reson Med 2010; 64: 334-340
    • (2010) Magn Reson Med , vol.64 , pp. 334-340
    • Xin, L.1    Mlynarik, V.2    Lanz, B.3    Frenkel, H.4    Gruetter, R.5
  • 12
    • 0036677949 scopus 로고    scopus 로고
    • Decreased tca cycle rate in the rat brain after acute 3-np treatment measured by in vivo 1h-[13c] nmr spectroscopy
    • Henry PG, Lebon V, Vaufrey F, Brouillet E, Hantraye P, Bloch G. Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo 1H-[13C] NMR spectroscopy. J Neurochem 2002; 82: 857-866
    • (2002) J Neurochem , vol.82 , pp. 857-866
    • Henry, P.G.1    Lebon, V.2    Vaufrey, F.3    Brouillet, E.4    Hantraye, P.5    Bloch, G.6
  • 13
    • 84855862624 scopus 로고    scopus 로고
    • Compartmentalized cerebral metabolism of [1, 6-(13)c]glucose determined by in vivo (13)c nmr spectroscopy at 14.1 t
    • Duarte JM, Lanz B, Gruetter R. Compartmentalized cerebral metabolism of [1, 6-(13)C]glucose determined by in vivo (13)C NMR spectroscopy at 14.1 T. Front Neuroenerg 2011; 3: 3
    • (2011) Front Neuroenerg , vol.3 , pp. 3
    • Duarte, J.M.1    Lanz, B.2    Gruetter, R.3
  • 15
    • 84864593295 scopus 로고    scopus 로고
    • Continuous arterial spin labeling of mouse cerebral blood flow using an actively-detuned two-coil system at 9.4t
    • Lei H, Pilloud Y, Magill AW, Gruetter R. Continuous arterial spin labeling of mouse cerebral blood flow using an actively-detuned two-coil system at 9.4T. Conf Proc IEEE Eng Med Biol Soc 2011; 2011: 6993-6996
    • (2011) Conf Proc IEEE Eng Med Biol Soc , vol.2011 , pp. 6993-6996
    • Lei, H.1    Pilloud, Y.2    Magill, A.W.3    Gruetter, R.4
  • 16
    • 33750632039 scopus 로고    scopus 로고
    • Localized short-echo-Time proton mr spectroscopy with full signal-intensity acquisition
    • Mlynarik V, Gambarota G, Frenkel H, Gruetter R. Localized short-echo-Time proton MR spectroscopy with full signal-intensity acquisition. Magn Reson Med 2006; 56: 965-970
    • (2006) Magn Reson Med , vol.56 , pp. 965-970
    • Mlynarik, V.1    Gambarota, G.2    Frenkel, H.3    Gruetter, R.4
  • 17
    • 0010812427 scopus 로고
    • Heteronuclear spectral editing with adiabatic pulses
    • Garwood M, Merkle H. Heteronuclear spectral editing with adiabatic pulses. J Magn Reson 1991; 94: 180-185
    • (1991) J Magn Reson , vol.94 , pp. 180-185
    • Garwood, M.1    Merkle, H.2
  • 18
    • 0032588957 scopus 로고    scopus 로고
    • In vivo 1h nmr spectroscopy of rat brain at 1 ms echo time
    • Tkac I, Starcuk Z, Choi IY, Gruetter R. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 1999; 41: 649-656
    • (1999) Magn Reson Med , vol.41 , pp. 649-656
    • Tkac, I.1    Starcuk, Z.2    Choi, I.Y.3    Gruetter, R.4
  • 19
    • 0342948677 scopus 로고    scopus 로고
    • Field mapping without reference scan using asymmetric echoplanar techniques
    • Gruetter R, Tkac I. Field mapping without reference scan using asymmetric echoplanar techniques. Magn Reson Med 2000; 43: 319-323
    • (2000) Magn Reson Med , vol.43 , pp. 319-323
    • Gruetter, R.1    Tkac, I.2
  • 20
    • 0027200329 scopus 로고
    • Automatic, localized in vivo adjustment of all first-And second-order shim coils
    • Gruetter R. Automatic, localized in vivo adjustment of all first-And second-order shim coils. Magn Reson Med 1993; 29: 804-811
    • (1993) Magn Reson Med , vol.29 , pp. 804-811
    • Gruetter, R.1
  • 21
    • 0027375098 scopus 로고
    • Estimation of metabolite concentrations from localized in vivo proton nmr spectra
    • Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993; 30: 672-679
    • (1993) Magn Reson Med , vol.30 , pp. 672-679
    • Provencher, S.W.1
  • 22
    • 77957318351 scopus 로고    scopus 로고
    • Diffusionweighted spectroscopy: A novel approach to determine macromolecule resonances in short-echo time 1h-mrs
    • Kunz N, Cudalbu C, Mlynarik V, Huppi PS, Sizonenko SV, Gruetter R. Diffusionweighted spectroscopy: a novel approach to determine macromolecule resonances in short-echo time 1H-MRS. Magn Reson Med 2010; 64: 939-946
    • (2010) Magn Reson Med , vol.64 , pp. 939-946
    • Kunz, N.1    Cudalbu, C.2    Mlynarik, V.3    Huppi, P.S.4    Sizonenko, S.V.5    Gruetter, R.6
  • 23
    • 44649118663 scopus 로고    scopus 로고
    • Proton t2 relaxation time of j-coupled cerebral metabolites in rat brain at 9.4 t
    • Xin L, Gambarota G, Mlynarik V, Gruetter R. Proton T2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4 T. NMR Biomed 2008; 21: 396-401
    • (2008) NMR Biomed , vol.21 , pp. 396-401
    • Xin, L.1    Gambarota, G.2    Mlynarik, V.3    Gruetter, R.4
  • 25
    • 0019731594 scopus 로고
    • Energy-metabolizing enzymes in brain regions of adult and aging rats
    • Leong SF, Lai JC, Lim L, Clark JB. Energy-metabolizing enzymes in brain regions of adult and aging rats. J Neurochem 1981; 37: 1548-1556
    • (1981) J Neurochem , vol.37 , pp. 1548-1556
    • Leong, S.F.1    Lai, J.C.2    Lim, L.3    Clark, J.B.4
  • 26
    • 33846827313 scopus 로고    scopus 로고
    • In vivo 13c saturation transfer effect of the lactate dehydrogenase reaction
    • Xu S, Yang J, Shen J. In vivo 13C saturation transfer effect of the lactate dehydrogenase reaction. Magn Reson Med 2007; 57: 258-264
    • (2007) Magn Reson Med , vol.57 , pp. 258-264
    • Xu, S.1    Yang, J.2    Shen, J.3
  • 27
    • 35848970073 scopus 로고    scopus 로고
    • Mathematical modeling of (13)c label incorporation of the tca cycle: The concept of composite precursor function
    • Uffmann K, Gruetter R. Mathematical modeling of (13)C label incorporation of the TCA cycle: the concept of composite precursor function. J Neurosci Res 2007; 85: 3304-3317
    • (2007) J Neurosci Res , vol.85 , pp. 3304-3317
    • Uffmann, K.1    Gruetter, R.2
  • 29
    • 77957942042 scopus 로고    scopus 로고
    • In vivo 13c spectroscopy in the rat brain using hyperpolarized [1-(13 c]pyruvate and [2-(13)c]pyruvate
    • Marjanska M, Iltis I, Shestov AA, Deelchand DK, Nelson C, Ugurbil K, et al. In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-(13)C]pyruvate and [2-(13)C]pyruvate. J Magn Reson 2010; 206: 210-218
    • (2010) J Magn Reson , vol.206 , pp. 210-218
    • Marjanska, M.1    Iltis, I.2    Shestov, A.A.3    Deelchand, D.K.4    Nelson, C.5    Ugurbil, K.6
  • 30
    • 80052848694 scopus 로고    scopus 로고
    • State of the art direct 13c and indirect 1h-[13c] nmr spectroscopy in vivo a practical guide
    • de Graaf RA, Rothman DL, Behar KL. State of the art direct 13C and indirect 1H-[13C] NMR spectroscopy in vivo. A practical guide. NMR Biomed 2011; 24: 958-972
    • (2011) NMR Biomed , vol.24 , pp. 958-972
    • De Graaf, R.A.1    Rothman, D.L.2    Behar, K.L.3
  • 31
    • 80055013088 scopus 로고    scopus 로고
    • Determination of oxidative glucose metabolism in vivo in the young rat brain using localized direct-detected (1) (3)c nmr spectroscopy
    • Ennis K, Deelchand DK, Tkac I, Henry PG, Rao R. Determination of oxidative glucose metabolism in vivo in the young rat brain using localized direct-detected (1) (3)C NMR spectroscopy. Neurochem Res 2011; 36: 1962-1968
    • (2011) Neurochem Res , vol.36 , pp. 1962-1968
    • Ennis, K.1    Deelchand, D.K.2    Tkac, I.3    Henry, P.G.4    Rao, R.5
  • 32
    • 52949130629 scopus 로고    scopus 로고
    • 1h nmr spectroscopy of rat brain in vivo at 14.1tesla: Improvements in quantification of the neurochemical profile
    • Mlynarik V, Cudalbu C, Xin L, Gruetter R. 1H NMR spectroscopy of rat brain in vivo at 14.1Tesla: improvements in quantification of the neurochemical profile. J Magn Reson 2008; 194: 163-168
    • (2008) J Magn Reson , vol.194 , pp. 163-168
    • Mlynarik, V.1    Cudalbu, C.2    Xin, L.3    Gruetter, R.4
  • 33
    • 63949087557 scopus 로고    scopus 로고
    • Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain
    • Lei H, Berthet C, Hirt L, Gruetter R. Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain. J Cereb Blood Flow Metab 2009; 29: 811-819
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 811-819
    • Lei, H.1    Berthet, C.2    Hirt, L.3    Gruetter, R.4
  • 34
    • 0038601579 scopus 로고    scopus 로고
    • Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo h-1 nmr spectroscopy
    • Tkac I, Rao R, Georgieff MK, Gruetter R. Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo H-1 NMR spectroscopy. Magn Reson Med 2003; 50: 24-32
    • (2003) Magn Reson Med , vol.50 , pp. 24-32
    • Tkac, I.1    Rao, R.2    Georgieff, M.K.3    Gruetter, R.4
  • 35
    • 84855874072 scopus 로고    scopus 로고
    • Regional neurochemical profiles in the human brain measured by (1) h mrs at 7 t using local b(1) shimming
    • Emir UE, Auerbach EJ, Moortele PF, Marjanska M, Ugurbil K, Terpstra M, et al. Regional neurochemical profiles in the human brain measured by (1) H MRS at 7 T using local B(1) shimming. NMR Biomed 2011; 25: 152-160
    • (2011) NMR Biomed , vol.25 , pp. 152-160
    • Emir, U.E.1    Auerbach, E.J.2    Moortele, P.F.3    Marjanska, M.4    Ugurbil, K.5    Terpstra, M.6
  • 36
    • 77958528666 scopus 로고    scopus 로고
    • The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13c nuclear magnetic resonance spectroscopy
    • Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI, et al. The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. J Neurosci 2010; 30: 13983-13991
    • (2010) J Neurosci , vol.30 , pp. 13983-13991
    • Boumezbeur, F.1    Petersen, K.F.2    Cline, G.W.3    Mason, G.F.4    Behar, K.L.5    Shulman, G.I.6
  • 37
    • 84890788731 scopus 로고    scopus 로고
    • In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1h-[13c] mrs at 14.1t
    • Lanz B, Xin L, Millet P, Gruetter R. In vivo quantification of neuro-glial metabolism and glial glutamate concentration using 1H-[13C] MRS at 14.1T. J Neurochem 2014; 128: 125-139
    • (2014) J Neurochem , vol.128 , pp. 125-139
    • Lanz, B.1    Xin, L.2    Millet, P.3    Gruetter, R.4
  • 38
    • 0034814676 scopus 로고    scopus 로고
    • A mathematical model of compartmentalized neurotransmitter metabolism in the human brain
    • Gruetter R, Seaquist ER, Ugurbil K. A mathematical model of compartmentalized neurotransmitter metabolism in the human brain. Am J Physiol Endocrinol Metab 2001; 281: E100-E112
    • (2001) Am J Physiol Endocrinol Metab , vol.281 , pp. E100-E112
    • Gruetter, R.1    Seaquist, E.R.2    Ugurbil, K.3
  • 39
    • 0033505439 scopus 로고    scopus 로고
    • Measurement of the tricarboxylic acid cycle rate in human grey and white matter in vivo by 1h-[13c] magnetic resonance spectroscopy at 4.1t
    • Mason GF, Pan JW, Chu WJ, Newcomer BR, Zhang Y, Orr R, et al. Measurement of the tricarboxylic acid cycle rate in human grey and white matter in vivo by 1H-[13C] magnetic resonance spectroscopy at 4.1T. J Cereb Blood Flow Metab 1999; 19: 1179-1188
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 1179-1188
    • Mason, G.F.1    Pan, J.W.2    Chu, W.J.3    Newcomer, B.R.4    Zhang, Y.5    Orr, R.6
  • 40
    • 0028798036 scopus 로고
    • Simultaneous determination of the rates of the tca cycle, glucose utilization, alphaketoglutarate/glutamate exchange, and glutamine synthesis in human brain by nmr
    • Mason GF, Gruetter R, Rothman DL, Behar KL, Shulman RG, Novotny EJ. Simultaneous determination of the rates of the TCA cycle, glucose utilization, alphaketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab 1995; 15: 12-25
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 12-25
    • Mason, G.F.1    Gruetter, R.2    Rothman, D.L.3    Behar, K.L.4    Shulman, R.G.5    Novotny, E.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.