Diffusion-weighted spectroscopy: A novel approach to determine macromolecule resonances in short-echo time 1H-MRS

Magnetic Resonance in Medicine

Volumn 64, Issue 4, 2010, Pages 939-946

  Kunz, N ^a,b   Cudalbu, C ^a   Mlynarik, V ^a   Huppi P S ^b   Sizonenko, S V ^b   Gruetter, R ^a,b,c  

^a EPFL   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

LCModel; Macromolecules; Proton magnetic resonance spectroscopy; Quantification accuracy; Ultra high field of 14.1 T

Indexed keywords

AMINO ACIDS; BIOMOLECULES; DIFFUSION; MACROMOLECULES; MAGNETIC FIELD EFFECTS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTONS;

DIFFUSION WEIGHTING; HIGH MAGNETIC FIELDS; INVERSION RECOVERY; LCMODEL; METABOLITE CONCENTRATIONS; QUANTIFICATION ACCURACY; SIGNAL CONTRIBUTION; ULTRA-HIGH FIELDS;

METABOLITES;

CHOLINE; CREATININE; GLUTAMIC ACID; GLUTAMINE; INOSITOL; N ACETYLASPARTIC ACID; TAURINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; DIFFUSION WEIGHTED IMAGING; MACROMOLECULE; MAGNETIC FIELD; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 77957318351     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22490     Document Type: Article

References (32)

1. Pfeuffer J, Tkac I, Provencher SW, Gruetter R. Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain. J Magn Reson 1999;141:104-120.
2. Cudalbu C, Beuf O, Cavassila S. In vivo short echo time localized 1H MRS of the rat brain at 7 T: influence of two strategies of background-accommodation on the metabolite concentration estimation using QUEST. J Sign Process Syst 2008;55:25-34.
3. Hakumaki JM, Grohn OH, Pirttila TR, Kauppinen RA. Increased macromolecular resonances in the rat cerebral cortex during severe energy failure as detected by 1H nuclear magnetic resonance spectroscopy. Neurosci Lett 1996;212:151-154.
4. Ratiney H, Srinivasan R, Henry RG, Okuda D, Nelson S, Pelletier D. Early and progressive disease marker in MS: results from a large cross-sectional spectroscopic imaging study at 3T. In: American academy of neurology 59th annual meeting. Boston, MA; May 2007. p 02.041.
5. Lemmerling P, Vanhamme L, in't Zandt H, van Huffel S, van Hecke P. Time-domain quantification of short-echo-time in-vivo proton MRS. MAGMA 2002;15:178-179.
6. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679.
7. Provencher SW. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 2001;14:260-264.
8. Schubert F, Seifert F, Elster C, Link A, Walzel M, Mientus S, Haas J, Rinneberg H. Serial 1H-MRS in relapsing-remitting multiple sclerosis: effects of interferon-beta therapy on absolute metabolite concentrations. MAGMA 2002;14:213-222.
9. Soher BJ, Young K, Maudsley AA. Representation of strong baseline contributions in 1H MR spectra. Magn Reson Med 2001;45:966-972.
10. Weiland E, Roell S, Leibfritz D, Krueger G. Time-domain fitting of 1H-MR spectra of the human brain: a model-free integration of the macromolecular baseline. In: International Society for Magnetic Resonance in Medicine, Toronto, Canada; May, 2003. p 1160.
11. Young K, Soher BJ, Maudsley AA. Automated spectral analysis. II. Application of wavelet shrinkage for characterization of non-parameterized signals. Magn Reson Med 1998;40:816-821.
12. Cudalbu C, Mlynarik V, Xin L, Gruetter R. Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 Tesla using two different approaches of modelling the macromolecule spectrum. Meas Sci Technol 2009;20:104034.
13. Hwang JH, Graham GD, Behar KL, Alger JR, Prichard JW, Rothman DL. Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain. Magn Reson Med 1996;35:633-639.
14. Mlynarik V, Cudalbu C, Xin L, Gruetter R. 1H NMR spectroscopy of rat brain in vivo at 14.1Tesla: improvements in quantification of the neurochemical profile. J Magn Reson 2008;194:163-168.
15. Cavassila S, van Ormondt D, Graveron-Demilly D. Cramér-Rao bound analysis of spectroscopic signal processing methods. In: Yan H, editor. Signal processing for magnetic resonance imaging and spectroscopy, Vol. 22. New York: Marcel Dekker; 2002.
16. Coenradie Y, de Beer R, van Ormondt D, Cavassila S, Ratiney H, Graveron-Demilly D. Background-signal parametrization in in vivo MR spectroscopy. In Proceedings of ProRISC 2002;248-259.
17. Gottschalk M, Lamalle L, Segebarth C. Short-TE localised 1H MRS of the human brain at 3 T: quantification of the metabolite signals using two approaches to account for macromolecular signal contributions. NMR Biomed 2008;21:507-517.
18. Hofmann L, Slotboom J, Boesch C, Kreis R. Characterization of the macromolecule baseline in localized (1)H-MR spectra of human brain. Magn Reson Med 2001;46:855-863.
19. Stanley JA, Pettegrew JW. Postprocessing method to segregate and quantify the broad components underlying the phosphodiester spectral region of in vivo (31)P brain spectra. Magn Reson Med 2001;45:390-396.
20. Hofmann L, Slotboom J, Jung B, Maloca P, Boesch C, Kreis R. Quantitative 1H-magnetic resonance spectroscopy of human brain: influence of composition and parameterization of the basis set in linear combination model-fitting. Magn Reson Med 2002;48:440-453.
21. Seeger U, Mader I, Nagele T, Grodd W, Lutz O, Klose U. Reliable detection of macromolecules in single-volume 1H NMR spectra of the human brain. Magn Reson Med 2001;45:948-954.
22. Pfeuffer J, Tkac I, Gruetter R. Extracellular-intracellular distribution of glucose and lactate in the rat brain assessed noninvasively by diffusion-weighted 1H nuclear magnetic resonance spectroscopy in vivo. J Cereb Blood Flow Metab 2000;20:736-746.
23. Mlynarik V, Gambarota G, Frenkel H, Gruetter R. Localized short-echo-time proton MR spectroscopy with full signal-intensity acquisition. Magn Reson Med 2006;56:965-970.
24. Mulkern R, Bowers J. Density matrix calculations of AB spectra from multipulse sequences: quantum mechanics meets in vivo specroscopy. Concepts Magn Reson 1994;6:1-23.
25. Govindaraju V, Young K, Maudsley AA. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 2000;13:129-153.
26. Lei H, Zhang Y, Zhu XH, Chen W. Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T. Magn Reson Med 2003;49:979-984.
27. Xin L, Gambarota G, Mlynarik V, Gruetter R. Proton T2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4 T. NMR Biomed 2008;21:396-401.
28. Ellegood J, Hanstock CC, Beaulieu C. Diffusion tensor spectroscopy (DTS) of human brain. Magn Reson Med 2006;55:1-8.
29. de Graaf RA. In vivo NMR spectroscopy: principles and techniques. University of Virginia: Wiley; 1998; 269-277 p.
30. Cudalbu C, Mlynarik V, Xin L, Gruetter R. Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4T and 14.1T. Magn Reson Med 2009;62:862-867.
31. de Graaf RA, Brown PB, McIntyre S, Nixon TW, Behar KL, Rothman DL. High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo. Magn Reson Med 2006;56:386-394.
32. Pijnappel WWF, van den Boogaart A, de Beer R, van Ormondt D. SVD-based quantification of magnetic resonance signals. J Magn Reson 1992;97:122-134.