Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4'-chlorophenyl)thiazol-2-yl] thiosemicarbazide

European Journal of Pharmaceutical Sciences

Volumn 9, Issue 1, 1999, Pages 25-31

  Pandeya, S N ^a   Sriram, D ^a   Nath, G ^b   Declercq, E ^c  

^a BANARAS HINDU UNIVERSITY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antimicrobial; Isatin; Mannich bases; Schiff bases; Thiazole; Thiosemicarbazone

Indexed keywords

ISATIN; ISATIN DERIVATIVE; MANNICH BASE; SCHIFF BASE; THIAZOLE; THIOSEMICARBAZIDE;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; METHODOLOGY; MICROSPORUM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

EID: 0032822045     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(99)00038-X     Document Type: Article

References (11)

1. Agarwal N., Kumar S., Srivastava A.K., Sarkar P.C. Synthesis and biological evaluation of 2-amino-4-aryl thiazole and their N-aroyl derivatives. Ind. J. Het. Chem. 6:1997;291-294.
2. Barry A. Procedures and theoretical considerations for testing antimicrobial agents in agar media. Corian M.D. Antibiotics in Laboratory Medicine. 5th ed. 1991;1-16 William and Wilkins, Baltimore.
3. Dimmock J.R., Kandepu N.M., Hetherington M., Quail J.W., Pugazhenthi U., Sudom A.M., Chamankhah M., Rose P., Pass B., Allen T.M., Halleran S., Szydlowski J., Mutus B., Tannous M., Manavathu B.K., Myers T.G., Declercq E., Balzarini J. Cytotoxic activities of Mannich bases of Chalcones and related compounds. J. Med. Chem. 41:1998;1014-1026.
4. Dimmock J.R., Kumar P. Anticancer and cytotoxic properties of Mannich bases. Curr. Med. Chem. 4:1997;1-22.
5. Daisley R.W., Shah V.K. Synthesis and antibacterial activity of some 5-nitro-3-phenyl imino indole-2 (3H)-ones and their N-Mannich bases. J. Pharm. Sci. 73:1984;407-409.
6. Liu M.C., Lin T.S., Sartorelli A.C. Synthesis and antitumor activity of pyridine-2-carboxaldehyde thiosemicarbazone. J. Med. Chem. 35:1992;3672-3677.
7. Maass G., Immendoerfer U., Koenig B., Leser U., Mueller B., Goody R., Pfatt B. Viral resistance to the thiazolo isoindolinones, a new class NNRTI of HIV-1 reverse transcriptase. Antimicrob. Agents Chemother. 37:1993;2612-2617.
8. Pandeya S.N., Sriram D., DeClercq E., Pannecouque C., Witvrouw M. Anti-HIV activity of some Mannich bases of isatin derivatives. Indian J. Pharm. Sci. 60:1998;207-212.
9. Piscopo B., Diumo M.V., Godliardi R., Cucciniello M., Veneruso G. Studies on heterocyclic compounds Indole-2,3-dione derivatives variously substituted hydrazones with antimicrobial activity. Bol. Soc. Ital. Biol. Sper. 63:1987;827-830.
10. Sup R.C., Sup R.Y., Bang C.W. Synthesis and fungicidal activity of novel 2-amino thiazol carboxamide derivatives. Korean J. Med. Chem. 5:1995;72-75.
11. Teitz Y., Ronen P., Vasover A., Stematsky T., Riggs J.L. Inhibition of human immunodeficiancy virus by N-methylisatin-beta-4′,4′-diethyl thiosemicarbazone and N-allylisatin-beta-4′,4′-diallyl thiosemicarbazone. Antiviral Res. 24:1994;305-314.