Design of protein switches based on an ensemble model of allostery

Nature Communications

Volumn 6, Issue , 2015, Pages

  Choi, Jay H ^a   Laurent, Abigail H ^a   Hilser, Vincent J ^b   Ostermeier, Marc ^a  

^a Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; BETA LACTAMASE; BETA-LACTAMASE TEM-1; ENZYME; MALTOSE BINDING PROTEIN;

ENZYME ACTIVITY; PROTEIN; THERMODYNAMICS;

ALLOSTERISM; ARTICLE; ENTROPY; IN VITRO STUDY; IN VIVO STUDY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SWITCH; TEMPERATURE; TEMPERATURE DEPENDENCE; THERMODYNAMICS; BINDING SITE; CHEMISTRY; MOLECULAR MODEL; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; BETA-LACTAMASES; ENTROPY; ENZYMES; IN VITRO TECHNIQUES; MALTOSE-BINDING PROTEINS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY;

EID: 84928799061     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7968     Document Type: Article

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