In vitro recombination of non-homologous genes can result in gene fusions that confer a switching phenotype to cells

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Heins, Richard A ^a,b   Choi, Jay H ^a   Sohka, Takayuki ^a,c   Ostermeier, Marc ^a  

^a Johns Hopkins University   (United States)

^b SANDIA NATIONAL LABORATORIES   (United States)

^c ASAHI KASEI CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; BETA LACTAMASE TEM 1; HYBRID PROTEIN; MALTOSE BINDING PROTEIN; BETA LACTAMASE; MALTOSE;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENE EXPRESSION REGULATION; GENE FUSION; GENE IDENTIFICATION; GENE INTERACTION; GENE SEQUENCE; GENE SWITCHING; GENETIC CODE; GENETIC REGULATION; GENETIC SELECTION; GENOME ANALYSIS; HYDROLYSIS KINETICS; IN VITRO STUDY; MALTOSE BINDING PROTEIN GENE; MELTING POINT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PHENOTYPIC VARIATION; PROTEIN FUNCTION; STEADY STATE; TEM1 BETA LACTAMASE GENE; DRUG EFFECT; ENZYME ACTIVATION; ESCHERICHIA COLI; GENETIC RECOMBINATION; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN ENGINEERING;

ALLOSTERIC REGULATION; BETA-LACTAMASES; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE FUSION; MALTOSE; MALTOSE-BINDING PROTEINS; PROTEIN ENGINEERING; RECOMBINATION, GENETIC;

EID: 80855139801     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027302     Document Type: Article

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