메뉴 건너뛰기




Volumn 252, Issue 11, 2014, Pages 1737-1745

Hyperthermia-induced upregulation of vascular endothelial growth factor in retinal pigment epithelial cells is regulated by mitogen-activated protein kinases

Author keywords

Hyperthermia; MAPK; RPE; TRPV; VEGF

Indexed keywords

ENZYME INHIBITOR; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84928762155     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-014-2750-z     Document Type: Article
Times cited : (16)

References (69)
  • 1
    • 21244451958 scopus 로고    scopus 로고
    • The retinal pigment epithelium in visual function
    • COI: 1:CAS:528:DC%2BD2MXmsFymu7Y%3D, PID: 15987797
    • Strauss O (2005) The retinal pigment epithelium in visual function. Physiol Rev 85:845–881
    • (2005) Physiol Rev , vol.85 , pp. 845-881
    • Strauss, O.1
  • 2
    • 84863845318 scopus 로고    scopus 로고
    • Mechanisms of age-related macular degeneration
    • COI: 1:CAS:528:DC%2BC38XhtVektbbP, PID: 22794258
    • Ambati J, Fowler BJ (2012) Mechanisms of age-related macular degeneration. Neuron 75:26–39
    • (2012) Neuron , vol.75 , pp. 26-39
    • Ambati, J.1    Fowler, B.J.2
  • 3
    • 48649088785 scopus 로고    scopus 로고
    • The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration
    • PID: 18523633
    • Chen H, Liu B, Lukas TJ, Neufeld AH (2008) The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration. PLoS ONE 3:e2339
    • (2008) PLoS ONE , vol.3 , pp. e2339
    • Chen, H.1    Liu, B.2    Lukas, T.J.3    Neufeld, A.H.4
  • 5
    • 84863727273 scopus 로고    scopus 로고
    • Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex
    • COI: 1:CAS:528:DC%2BC38XhtVShurnF
    • Bhutto I, Lutty G (2012) Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. Mol Asp Med 33:295–317
    • (2012) Mol Asp Med , vol.33 , pp. 295-317
    • Bhutto, I.1    Lutty, G.2
  • 7
    • 84868613782 scopus 로고    scopus 로고
    • Targeted deletion of Vegfa in adult mice induces vision loss
    • COI: 1:CAS:528:DC%2BC38Xhs1CisLzO, PID: 23093773
    • Kurihara T, Westenskow PD, Bravo S, Aguilar E, Friedlander M (2012) Targeted deletion of Vegfa in adult mice induces vision loss. J Clin Invest 122:4213–4217
    • (2012) J Clin Invest , vol.122 , pp. 4213-4217
    • Kurihara, T.1    Westenskow, P.D.2    Bravo, S.3    Aguilar, E.4    Friedlander, M.5
  • 8
    • 84891634699 scopus 로고    scopus 로고
    • Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials
    • Grunwald JE, Daniel E, Huang J, Ying GS, Maguire MG, Toth CA, Jaffe GJ, Fine SL, Blodi B6, Klein ML, Martin AA, Hagstrom SA, Martin DF; CATT Research Group (2014) Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials. Ophthalmology 121:150–156
    • (2014) Ophthalmology , vol.121 , pp. 150-156
  • 9
    • 0037277741 scopus 로고    scopus 로고
    • Schlingemann RO (2003) Vascular endothelial growth factors and angiogenesis in eye disease
    • COI: 1:CAS:528:DC%2BD3sXht1Cqsb0%3D, PID: 12597922
    • Witmer AN, Vrensen GF, Van Noorden CJ (2003) Schlingemann RO (2003) Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res 22:1–29
    • (2003) Prog Retin Eye Res , vol.22 , pp. 1-29
    • Witmer, A.N.1    Vrensen, G.F.2    Van Noorden, C.J.3
  • 10
    • 0032807809 scopus 로고    scopus 로고
    • Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris evidence for a trophic paracrine relation
    • Blaauwegeers HGT, Holtkamp GM, Rutten H, Witmer AN, Koolwijk P, Partanen TA, Alitalo K, Kroon ME, Kijlstra A, van Hinsbergh VW, Schlingemann RO (1999) Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris evidence for a trophic paracrine relation. Am J Pathol 155:421–428
    • (1999) Am J Pathol , vol.155 , pp. 421-428
    • Blaauwegeers, H.G.T.1    Holtkamp, G.M.2    Rutten, H.3    Witmer, A.N.4    Koolwijk, P.5    Partanen, T.A.6    Alitalo, K.7    Kroon, M.E.8    Kijlstra, A.9    van Hinsbergh, V.W.10    Schlingemann, R.O.11
  • 12
    • 84876413038 scopus 로고    scopus 로고
    • Toll-like receptor 3 activation in retinal pigment epithelium cells- Mitogen-activated protein kinase pathways of cell death and vascular endothelial growth factor secretion
    • COI: 1:CAS:528:DC%2BC3sXptlGjsLg%3D, PID: 23387336
    • Klettner A, Koinzer S, Meyer T, Roider J (2013) Toll-like receptor 3 activation in retinal pigment epithelium cells- Mitogen-activated protein kinase pathways of cell death and vascular endothelial growth factor secretion. Acta Ophthalmol 91:e211–e218
    • (2013) Acta Ophthalmol , vol.91 , pp. e211-e218
    • Klettner, A.1    Koinzer, S.2    Meyer, T.3    Roider, J.4
  • 13
    • 33845983659 scopus 로고    scopus 로고
    • Stimulation of apical and basolateral vascular endothelial growth factor-A and vascular endothelial growth factor-C secretion by oxidative stress in polarized retinal pigment epithelial cells
    • COI: 1:CAS:528:DC%2BD2sXjsVentQ%3D%3D, PID: 17200665
    • Kannan R, Zhang N, Sreekumar P, Spee C, Rodriguez A, Barron E, Hinton DR (2006) Stimulation of apical and basolateral vascular endothelial growth factor-A and vascular endothelial growth factor-C secretion by oxidative stress in polarized retinal pigment epithelial cells. Mol Vis 12:1649–1659
    • (2006) Mol Vis , vol.12 , pp. 1649-1659
    • Kannan, R.1    Zhang, N.2    Sreekumar, P.3    Spee, C.4    Rodriguez, A.5    Barron, E.6    Hinton, D.R.7
  • 14
    • 78649824873 scopus 로고    scopus 로고
    • Hypothermia reduces secretion of vascular endothelial growth factor by cultured retinal pigment epithelial cells
    • PID: 20805126
    • Coassin M, Duncan KG, Bailey KR, Singh A, Schwartz DM (2010) Hypothermia reduces secretion of vascular endothelial growth factor by cultured retinal pigment epithelial cells. Br J Ophthalmol 94:1678–1683
    • (2010) Br J Ophthalmol , vol.94 , pp. 1678-1683
    • Coassin, M.1    Duncan, K.G.2    Bailey, K.R.3    Singh, A.4    Schwartz, D.M.5
  • 15
    • 79956020106 scopus 로고    scopus 로고
    • Heat-sensitive TRPV channels in retinal pigment epithelial cells: regulation of VEGF-A secretion
    • PID: 20539001
    • Cordeiro S, Seyler S, Stindl J, Milenkovic VM, Strauss O (2010) Heat-sensitive TRPV channels in retinal pigment epithelial cells: regulation of VEGF-A secretion. Invest Ophthalmol Vis Sci 51:6001–6008
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 6001-6008
    • Cordeiro, S.1    Seyler, S.2    Stindl, J.3    Milenkovic, V.M.4    Strauss, O.5
  • 16
    • 0018817452 scopus 로고
    • Choroidal blood flow as a heat dissipating mechanism in the macula
    • COI: 1:STN:280:DyaL3c7psFOqug%3D%3D, PID: 6769334
    • Parver LM, Auker C, Carpenter DO (1980) Choroidal blood flow as a heat dissipating mechanism in the macula. Am J Ophthalmol 89:641–646
    • (1980) Am J Ophthalmol , vol.89 , pp. 641-646
    • Parver, L.M.1    Auker, C.2    Carpenter, D.O.3
  • 17
    • 77249168118 scopus 로고    scopus 로고
    • The multifunctional choroid
    • PID: 20044062
    • Nickla DL, Wallman J (2010) The multifunctional choroid. Prog Retin Eye Res 29:144–168
    • (2010) Prog Retin Eye Res , vol.29 , pp. 144-168
    • Nickla, D.L.1    Wallman, J.2
  • 20
    • 0026335526 scopus 로고
    • Xenon arch photocoagulator used for transpupillary hyperthermia
    • COI: 1:STN:280:DyaK387msVersQ%3D%3D, PID: 1790739
    • Journee-de Korver JG, Oosterhuis JA, van Best JA, Fakkel J (1991) Xenon arch photocoagulator used for transpupillary hyperthermia. Doc Ophthalmol 78:183–187
    • (1991) Doc Ophthalmol , vol.78 , pp. 183-187
    • Journee-de Korver, J.G.1    Oosterhuis, J.A.2    van Best, J.A.3    Fakkel, J.4
  • 22
    • 84863548218 scopus 로고    scopus 로고
    • A prospective study on different methods for the treatment of choroidal neovascularization. The efficacy of verteporfin photodynamic therapy, intravitreal bevacizumab and transpupillary thermotherapy in patients with neovascular age-related macular degeneration
    • COI: 1:CAS:528:DC%2BC38XhsVWntrfE, PID: 22648253
    • Nowak MS, Jurowski P, Grzybowski A, Gos R, Pastuszka M, Kapica A, Smigielski J (2012) A prospective study on different methods for the treatment of choroidal neovascularization. The efficacy of verteporfin photodynamic therapy, intravitreal bevacizumab and transpupillary thermotherapy in patients with neovascular age-related macular degeneration. Med Sci Monit 18:CR374–CR380
    • (2012) Med Sci Monit , vol.18 , pp. CR374-CR380
    • Nowak, M.S.1    Jurowski, P.2    Grzybowski, A.3    Gos, R.4    Pastuszka, M.5    Kapica, A.6    Smigielski, J.7
  • 23
    • 84860224470 scopus 로고    scopus 로고
    • Combination therapy with low-dose transpupillary thermotherapy and intravitreal ranibizumab for neovascular age-related macular degeneration: a 24-month prospective randomised clinical study
    • PID: 22241923
    • Söderberg AC, Algvere PV, Hengstler JC, Söderberg P, Seregard S, Kvanta A (2012) Combination therapy with low-dose transpupillary thermotherapy and intravitreal ranibizumab for neovascular age-related macular degeneration: a 24-month prospective randomised clinical study. Br J Ophthalmol 96:714–718
    • (2012) Br J Ophthalmol , vol.96 , pp. 714-718
    • Söderberg, A.C.1    Algvere, P.V.2    Hengstler, J.C.3    Söderberg, P.4    Seregard, S.5    Kvanta, A.6
  • 24
    • 84872927533 scopus 로고    scopus 로고
    • Indocyanine green enhanced transpupillary thermotherapy in combination with ophthalmic artery chemosurgery for retinoblastoma
    • PID: 23143908
    • Francis JH, Abramson DH, Brodie SE, Marr BP (2013) Indocyanine green enhanced transpupillary thermotherapy in combination with ophthalmic artery chemosurgery for retinoblastoma. Br J Ophthalmol 97:164–168
    • (2013) Br J Ophthalmol , vol.97 , pp. 164-168
    • Francis, J.H.1    Abramson, D.H.2    Brodie, S.E.3    Marr, B.P.4
  • 25
    • 84872060647 scopus 로고    scopus 로고
    • Subthreshold transpupillary thermotherapy in management of foveal subretinal fluid in small pigmented choroidal lesions
    • PID: 22990320
    • Caminal JM, Mejia-Castillo KA, Arias L, Catala J, Rubio M, Garcia P, Pujol O, Arruga J (2013) Subthreshold transpupillary thermotherapy in management of foveal subretinal fluid in small pigmented choroidal lesions. Retina 33:194–199
    • (2013) Retina , vol.33 , pp. 194-199
    • Caminal, J.M.1    Mejia-Castillo, K.A.2    Arias, L.3    Catala, J.4    Rubio, M.5    Garcia, P.6    Pujol, O.7    Arruga, J.8
  • 26
    • 80053192977 scopus 로고    scopus 로고
    • Transpupillary thermotherapy for circumscribed choroidal hemangioma: clinical profile and treatment outcome
    • PID: 21751767
    • Sharma T, Krishnan T, Gopal L, Nagpal A, Khetan V, Rishi P (2011) Transpupillary thermotherapy for circumscribed choroidal hemangioma: clinical profile and treatment outcome. Ophthalmic Surg Lasers Imaging 42:360–368
    • (2011) Ophthalmic Surg Lasers Imaging , vol.42 , pp. 360-368
    • Sharma, T.1    Krishnan, T.2    Gopal, L.3    Nagpal, A.4    Khetan, V.5    Rishi, P.6
  • 27
    • 24344482437 scopus 로고    scopus 로고
    • Complications and lack of benefit after transpupillary thermotherapy for occult choroidal neovascularization: 1-year results
    • PID: 16141869
    • Rougier MB, Francois L, Fourmaux E, Isber R, Colin J, Korobelnik JF (2005) Complications and lack of benefit after transpupillary thermotherapy for occult choroidal neovascularization: 1-year results. Retina 25:784–788
    • (2005) Retina , vol.25 , pp. 784-788
    • Rougier, M.B.1    Francois, L.2    Fourmaux, E.3    Isber, R.4    Colin, J.5    Korobelnik, J.F.6
  • 28
    • 76649136947 scopus 로고    scopus 로고
    • Which choroidal melanoma should be treated with primary transpupillary thermotherapy? Our experience from 78 patients
    • PID: 19882517
    • Yarovoy AA, Magaramov DA, Bulgakova ES (2010) Which choroidal melanoma should be treated with primary transpupillary thermotherapy? Our experience from 78 patients. Eur J Ophthalmol 20:186–193
    • (2010) Eur J Ophthalmol , vol.20 , pp. 186-193
    • Yarovoy, A.A.1    Magaramov, D.A.2    Bulgakova, E.S.3
  • 29
    • 72349085976 scopus 로고    scopus 로고
    • Long term outcome of transpupillary thermotherapy as primary treatment of selected choroidal melanoma
    • PID: 18778335
    • Parrozzani R, Boccassini B, De Belvis V, Radin PR, Midena E (2009) Long term outcome of transpupillary thermotherapy as primary treatment of selected choroidal melanoma. Acta Ophthalmol 87:789–792
    • (2009) Acta Ophthalmol , vol.87 , pp. 789-792
    • Parrozzani, R.1    Boccassini, B.2    De Belvis, V.3    Radin, P.R.4    Midena, E.5
  • 30
    • 0033825280 scopus 로고    scopus 로고
    • Failure of transpupillary thermotherapy (TTT) for choroidal melanoma: two cases with histopathological correlation
    • COI: 1:STN:280:DC%2BD3cvotVKntQ%3D%3D, PID: 11032441
    • Finger PT, Lipka AC, Lipkowitz J, Jofe M, McCormick SA (2000) Failure of transpupillary thermotherapy (TTT) for choroidal melanoma: two cases with histopathological correlation. Br J Ophthalmol 84:1075–1082
    • (2000) Br J Ophthalmol , vol.84 , pp. 1075-1082
    • Finger, P.T.1    Lipka, A.C.2    Lipkowitz, J.3    Jofe, M.4    McCormick, S.A.5
  • 31
    • 84873563991 scopus 로고    scopus 로고
    • Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor kappaB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway
    • Klettner A, Westhues D, Lassen J, Bartsch S, Roider J (2013) Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor kappaB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway. Mol Vis 19:281–291
    • (2013) Mol Vis , vol.19 , pp. 281-291
    • Klettner, A.1    Westhues, D.2    Lassen, J.3    Bartsch, S.4    Roider, J.5
  • 32
    • 0034531952 scopus 로고    scopus 로고
    • MAP kinases and hypoxia in the control of VEGF expression
    • COI: 1:CAS:528:DC%2BD3MXktlSmsA%3D%3D, PID: 11191053
    • Berra E, Pagès G, Pouysségur J (2000) MAP kinases and hypoxia in the control of VEGF expression. Cancer Metastasis Rev 19:139–145
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 139-145
    • Berra, E.1    Pagès, G.2    Pouysségur, J.3
  • 33
    • 0037036451 scopus 로고    scopus 로고
    • Identification of two p42/p44 mitogen activated kinases phosphorylation sites on Sp1: Their implication on vascular endothelial growth factor gene transcription
    • PID: 11904305
    • Milanini-Mongiat J, Pouysségur J (2002) Identification of two p42/p44 mitogen activated kinases phosphorylation sites on Sp1: Their implication on vascular endothelial growth factor gene transcription. J Biol Chem. doi:10.1074/jbc.M201753200
    • (2002) J Biol Chem
    • Milanini-Mongiat, J.1    Pouysségur, J.2
  • 34
    • 0034714265 scopus 로고    scopus 로고
    • Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability
    • PID: 10849421
    • Pagès G, Berra E, Milanini J, Levy AP, Pouysségur J (2000) Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability. J Biol Chem 275:26484–26491
    • (2000) J Biol Chem , vol.275 , pp. 26484-26491
    • Pagès, G.1    Berra, E.2    Milanini, J.3    Levy, A.P.4    Pouysségur, J.5
  • 35
    • 84871738418 scopus 로고    scopus 로고
    • The production of VEGF involving MAP kinase activation by low level laser therapy in human granulosa cells
    • PID: 24511196
    • Kawano Y, Utsunomiya-Kai Y, Kai K, Miyakawa I, Ohshiro T, Narahara H (2012) The production of VEGF involving MAP kinase activation by low level laser therapy in human granulosa cells. Laser Ther 21:269–274
    • (2012) Laser Ther , vol.21 , pp. 269-274
    • Kawano, Y.1    Utsunomiya-Kai, Y.2    Kai, K.3    Miyakawa, I.4    Ohshiro, T.5    Narahara, H.6
  • 36
    • 35348927430 scopus 로고    scopus 로고
    • Impaired TNFalpha-induced VEGF expression in human airway smooth muscle cells from smokers with COPD: role of MAPkinases and histone acetylation–effect of dexamethasone
    • COI: 1:CAS:528:DC%2BD2sXhtFKntbbE, PID: 17906365
    • Raidl M, Sibbing B, Strauch J, Müller K, Nemat A, Schneider PM, Hag H, Erdmann E, Koch A (2007) Impaired TNFalpha-induced VEGF expression in human airway smooth muscle cells from smokers with COPD: role of MAPkinases and histone acetylation–effect of dexamethasone. Cell Biochem Biophys 49:98–110
    • (2007) Cell Biochem Biophys , vol.49 , pp. 98-110
    • Raidl, M.1    Sibbing, B.2    Strauch, J.3    Müller, K.4    Nemat, A.5    Schneider, P.M.6    Hag, H.7    Erdmann, E.8    Koch, A.9
  • 37
    • 0033739097 scopus 로고    scopus 로고
    • Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes
    • COI: 1:CAS:528:DC%2BD3cXntl2ntrk%3D, PID: 11040101
    • Tanaka T, Kanai H, Sekiguchi K, Aihara Y, Yokoyama T, Arai M, Kanda T, Nagai R, Kurabayashi M (2000) Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes. J Mol Cell Cardiol 32:1955–1967
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1955-1967
    • Tanaka, T.1    Kanai, H.2    Sekiguchi, K.3    Aihara, Y.4    Yokoyama, T.5    Arai, M.6    Kanda, T.7    Nagai, R.8    Kurabayashi, M.9
  • 38
    • 34347259574 scopus 로고    scopus 로고
    • Thrombin-induced VEGF expression in human retinal pigment epithelial cells
    • PID: 17525207
    • Bian ZM, Elner SG, Elner VM (2007) Thrombin-induced VEGF expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 48:2738–2746
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 2738-2746
    • Bian, Z.M.1    Elner, S.G.2    Elner, V.M.3
  • 39
    • 70449509897 scopus 로고    scopus 로고
    • MAP kinase pathway is involved in IGF-1-stimulated proliferation of human retinal pigment epithelial cells (hRPE)
    • COI: 1:CAS:528:DC%2BD1MXhsFChtrvM, PID: 19895315
    • Weng CY, Kothary PC, Verkade AJ, Reed DM, Del Monte MA (2009) MAP kinase pathway is involved in IGF-1-stimulated proliferation of human retinal pigment epithelial cells (hRPE). Curr Eye Res 34:867–876
    • (2009) Curr Eye Res , vol.34 , pp. 867-876
    • Weng, C.Y.1    Kothary, P.C.2    Verkade, A.J.3    Reed, D.M.4    Del Monte, M.A.5
  • 40
    • 70349884317 scopus 로고    scopus 로고
    • Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases
    • PID: 19603178
    • Klettner A, Roider J (2009) Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases. Graefes Arch Clin Exp Ophthalmol 247:1487–1492
    • (2009) Graefes Arch Clin Exp Ophthalmol , vol.247 , pp. 1487-1492
    • Klettner, A.1    Roider, J.2
  • 41
    • 79959899039 scopus 로고    scopus 로고
    • Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers
    • COI: 1:CAS:528:DC%2BC3MXot1GlsrY%3D, PID: 21566137
    • Kunchithapautham K, Rohrer B (2011) Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers. J Biol Chem 286:23717–23724
    • (2011) J Biol Chem , vol.286 , pp. 23717-23724
    • Kunchithapautham, K.1    Rohrer, B.2
  • 42
    • 77952219361 scopus 로고    scopus 로고
    • Deferoxamine mesylate is toxic for retinal pigment epithelium cells, and its toxicity is mediated by p38
    • COI: 1:CAS:528:DC%2BC3cXls1Wjs7k%3D, PID: 20380623
    • Klettner A, Koinzer S, Waetzig V, Herdegen T, Roider J (2010) Deferoxamine mesylate is toxic for retinal pigment epithelium cells, and its toxicity is mediated by p38. Cutan Ocul Toxicol 29:122–129
    • (2010) Cutan Ocul Toxicol , vol.29 , pp. 122-129
    • Klettner, A.1    Koinzer, S.2    Waetzig, V.3    Herdegen, T.4    Roider, J.5
  • 43
    • 0029872876 scopus 로고    scopus 로고
    • ARPE-19, a human retinal pigment epithelial cell line with differentiated properties
    • COI: 1:CAS:528:DyaK28XhsVersbY%3D, PID: 8698076
    • Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM (1996) ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res 62:155–169
    • (1996) Exp Eye Res , vol.62 , pp. 155-169
    • Dunn, K.C.1    Aotaki-Keen, A.E.2    Putkey, F.R.3    Hjelmeland, L.M.4
  • 44
    • 84887153666 scopus 로고    scopus 로고
    • ARMS2 interference leads to decrease of proinflammatory mediators
    • COI: 1:CAS:528:DC%2BC3sXhtlWgurjE, PID: 23959158
    • Zeng F, Zhang M, Xu Y, Xu H (2013) ARMS2 interference leads to decrease of proinflammatory mediators. Graefes Arch Clin Exp Ophthalmol 251:2539–2544
    • (2013) Graefes Arch Clin Exp Ophthalmol , vol.251 , pp. 2539-2544
    • Zeng, F.1    Zhang, M.2    Xu, Y.3    Xu, H.4
  • 45
    • 84857373600 scopus 로고    scopus 로고
    • The PI3K/Akt pathway mediates the expression of type I collagen induced by TGF-β2 in human retinal pigment epithelial cells
    • COI: 1:CAS:528:DC%2BC38XhtFKgu7c%3D, PID: 21858467
    • Yokoyama K, Kimoto K, Itoh Y, Nakatsuka K, Matsuo N, Yoshioka H, Kubota T (2012) The PI3K/Akt pathway mediates the expression of type I collagen induced by TGF-β2 in human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol 250:15–23
    • (2012) Graefes Arch Clin Exp Ophthalmol , vol.250 , pp. 15-23
    • Yokoyama, K.1    Kimoto, K.2    Itoh, Y.3    Nakatsuka, K.4    Matsuo, N.5    Yoshioka, H.6    Kubota, T.7
  • 47
    • 33645769466 scopus 로고    scopus 로고
    • Differential protein profiling of primary versus immortalized human RPE cells identifies expression patterns associated with cytoskeletal remodeling and cell survival
    • COI: 1:CAS:528:DC%2BD28XhsFOrtL8%3D, PID: 16602694
    • Alge CS, Hauck SM, Priglinger SG, Kampik A, Ueffing M (2006) Differential protein profiling of primary versus immortalized human RPE cells identifies expression patterns associated with cytoskeletal remodeling and cell survival. J Proteome Res 5:862–878
    • (2006) J Proteome Res , vol.5 , pp. 862-878
    • Alge, C.S.1    Hauck, S.M.2    Priglinger, S.G.3    Kampik, A.4    Ueffing, M.5
  • 48
    • 30044432338 scopus 로고    scopus 로고
    • Gene expression profile of cultured adult compared to immortalized human RPE
    • COI: 1:CAS:528:DC%2BD28XitFeksL4%3D, PID: 16446697
    • Cai H, Del Priore LV (2006) Gene expression profile of cultured adult compared to immortalized human RPE. Mol Vis 12:1–14
    • (2006) Mol Vis , vol.12 , pp. 1-14
    • Cai, H.1    Del Priore, L.V.2
  • 49
    • 27344455035 scopus 로고    scopus 로고
    • The expression of native and cultured human retinal pigment epithelial cells grown in different culture conditions
    • COI: 1:STN:280:DC%2BD2MrlsF2itw%3D%3D, PID: 16234463
    • Tian J, Ishibashi K, Honda S, Boylan SA, Hjelmeland LM, Handa JT (2005) The expression of native and cultured human retinal pigment epithelial cells grown in different culture conditions. Br J Ophthalmol 89:1510–1517
    • (2005) Br J Ophthalmol , vol.89 , pp. 1510-1517
    • Tian, J.1    Ishibashi, K.2    Honda, S.3    Boylan, S.A.4    Hjelmeland, L.M.5    Handa, J.T.6
  • 50
    • 84856335642 scopus 로고    scopus 로고
    • Expression and role of VEGF in the adult retinal pigment epithelium
    • COI: 1:CAS:528:DC%2BC38XjtVKrs7w%3D, PID: 22058334
    • Ford KM, Saint-Geniez M, Walshe T, Zahr A, D'Amore PA (2011) Expression and role of VEGF in the adult retinal pigment epithelium. Invest Ophthalmol Vis Sci 52:9478–9487
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 9478-9487
    • Ford, K.M.1    Saint-Geniez, M.2    Walshe, T.3    Zahr, A.4    D'Amore, P.A.5
  • 51
    • 85027926194 scopus 로고    scopus 로고
    • Lysosomal stress and lipid peroxidation products induce VEGF-121 and VEGF-165 expression in ARPE-19 cells
    • COI: 1:CAS:528:DC%2BC3MXht1Wqtb%2FP, PID: 21509530
    • Bergmann M, Holz F, Kopitz J (2011) Lysosomal stress and lipid peroxidation products induce VEGF-121 and VEGF-165 expression in ARPE-19 cells. Graefes Arch Clin Exp Ophthalmol 249:1477–1483
    • (2011) Graefes Arch Clin Exp Ophthalmol , vol.249 , pp. 1477-1483
    • Bergmann, M.1    Holz, F.2    Kopitz, J.3
  • 52
    • 84879202514 scopus 로고    scopus 로고
    • The p38 MAPK NF-κB pathway, not the ERK pathway, is involved in exogenous HIV-1 Tat-induced apoptotic cell death in retinal pigment epithelial cells
    • COI: 1:CAS:528:DC%2BC3sXhtFaktLvK, PID: 23732112
    • Bai L, Zhu X, Ma T, Wang J, Wang F, Zhang S (2013) The p38 MAPK NF-κB pathway, not the ERK pathway, is involved in exogenous HIV-1 Tat-induced apoptotic cell death in retinal pigment epithelial cells. Int J Biochem Cell Biol 45:1794–1801
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 1794-1801
    • Bai, L.1    Zhu, X.2    Ma, T.3    Wang, J.4    Wang, F.5    Zhang, S.6
  • 53
    • 57949091193 scopus 로고    scopus 로고
    • The effect of clonidine on VEGF expression in human retinal pigment epithelial cells (ARPE-19)
    • COI: 1:CAS:528:DC%2BD1cXhsV2lur7N, PID: 19011889
    • Watanabe K, Zhang XY, Kitagawa K, Yunoki T, Hayashi A (2009) The effect of clonidine on VEGF expression in human retinal pigment epithelial cells (ARPE-19). Graefes Arch Clin Exp Ophthalmol 247:207–213
    • (2009) Graefes Arch Clin Exp Ophthalmol , vol.247 , pp. 207-213
    • Watanabe, K.1    Zhang, X.Y.2    Kitagawa, K.3    Yunoki, T.4    Hayashi, A.5
  • 54
    • 83055173953 scopus 로고    scopus 로고
    • IL-17A stimulates the production of inflammatory mediators via Erk1/2, p38 MAPK, PI3K/Akt, and NF-κB pathways in ARPE-19 cells
    • COI: 1:CAS:528:DC%2BC38XhsFWnsw%3D%3D, PID: 22162626
    • Chen Y, Kijlstra A, Chen Y, Yang P (2011) IL-17A stimulates the production of inflammatory mediators via Erk1/2, p38 MAPK, PI3K/Akt, and NF-κB pathways in ARPE-19 cells. Mol Vis 17:3072–3077
    • (2011) Mol Vis , vol.17 , pp. 3072-3077
    • Chen, Y.1    Kijlstra, A.2    Chen, Y.3    Yang, P.4
  • 56
    • 79952740871 scopus 로고    scopus 로고
    • OX-LDL up-regulates the vascular endothelial growth factor-to-pigment epithelium-derived factor ratio in human retinal pigment epithelial cells
    • COI: 1:CAS:528:DC%2BC3MXjt1SlsLc%3D, PID: 21348596
    • Yin L, Wu X, Gong Y, Shi Y, Qiu Y, Zhang H, Liu X, Gu Q (2011) OX-LDL up-regulates the vascular endothelial growth factor-to-pigment epithelium-derived factor ratio in human retinal pigment epithelial cells. Curr Eye Res 36:379–385
    • (2011) Curr Eye Res , vol.36 , pp. 379-385
    • Yin, L.1    Wu, X.2    Gong, Y.3    Shi, Y.4    Qiu, Y.5    Zhang, H.6    Liu, X.7    Gu, Q.8
  • 57
    • 84856269228 scopus 로고    scopus 로고
    • The thermo-TRP ion channel family: properties and therapeutic implications
    • COI: 1:CAS:528:DC%2BC38XhvFGqsLw%3D, PID: 21797839
    • Vay L, Gu C, McNaughton PA (2012) The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol 165:787–801
    • (2012) Br J Pharmacol , vol.165 , pp. 787-801
    • Vay, L.1    Gu, C.2    McNaughton, P.A.3
  • 59
    • 73249132759 scopus 로고    scopus 로고
    • An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris
    • COI: 1:CAS:528:DC%2BD1MXhsVKmtL7N, PID: 19841260
    • Saint-Geniez M, Kurihara T, Sekiyama E, Maldonado A, D'Amore P (2009) An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci U S A 106:18751–18756
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 18751-18756
    • Saint-Geniez, M.1    Kurihara, T.2    Sekiyama, E.3    Maldonado, A.4    D'Amore, P.5
  • 60
    • 77449104200 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGFR-2/PI3K/Akt pathway
    • Byeon SH, Lee SC, Choi SH, Lee HK, Lee JH, Chu YK, Kwon OW (2010) Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGFR-2/PI3K/Akt pathway. Invest Ophthalmol Vis Sci 51:1190–1197
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 1190-1197
    • Byeon, S.H.1    Lee, S.C.2    Choi, S.H.3    Lee, H.K.4    Lee, J.H.5    Chu, Y.K.6    Kwon, O.W.7
  • 61
    • 14044265526 scopus 로고    scopus 로고
    • Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration
    • COI: 1:CAS:528:DC%2BD2MXhsVCru78%3D, PID: 15615788
    • El-Remessy AB, Bartoli M, Platt DH, Fulton D, Caldwell RB (2005) Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration. J Cell Sci 118:243–252
    • (2005) J Cell Sci , vol.118 , pp. 243-252
    • El-Remessy, A.B.1    Bartoli, M.2    Platt, D.H.3    Fulton, D.4    Caldwell, R.B.5
  • 62
    • 33845242529 scopus 로고    scopus 로고
    • Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK1/2 and Akt pathways
    • COI: 1:CAS:528:DC%2BD28XhtlWqsL3M, PID: 17135405
    • Kilic Ü, Kilic E, Järve A, Guo Z, Spudich A, Bieber K, Barzena U, Bassetti CL, Marti HH, Hermann DM (2006) Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK1/2 and Akt pathways. J Neurosci 26:12439–12446
    • (2006) J Neurosci , vol.26 , pp. 12439-12446
    • Kilic, Ü.1    Kilic, E.2    Järve, A.3    Guo, Z.4    Spudich, A.5    Bieber, K.6    Barzena, U.7    Bassetti, C.L.8    Marti, H.H.9    Hermann, D.M.10
  • 63
    • 0037610290 scopus 로고    scopus 로고
    • Die molekularen Mechanismen der neovaskulären AMD
    • COI: 1:STN:280:DC%2BD3s%2FnvVCnuw%3D%3D, PID: 12589451
    • Miller DW, Joussen AM, Holz FG (2003) Die molekularen Mechanismen der neovaskulären AMD. Ophthalmologe 100:92–96
    • (2003) Ophthalmologe , vol.100 , pp. 92-96
    • Miller, D.W.1    Joussen, A.M.2    Holz, F.G.3
  • 64
    • 77955781894 scopus 로고    scopus 로고
    • Pathophysiology of macular edema
    • COI: 1:CAS:528:DC%2BC3cXhtVaqtL3K, PID: 20714176
    • Scholl S, Kirchhof J, Augustin AJ (2010) Pathophysiology of macular edema. Ophthalmologica 224:8–15
    • (2010) Ophthalmologica , vol.224 , pp. 8-15
    • Scholl, S.1    Kirchhof, J.2    Augustin, A.J.3
  • 65
    • 70350704800 scopus 로고    scopus 로고
    • Current molecular understanding and future treatment strategies for pathological ocular neovascularization
    • COI: 1:CAS:528:DC%2BD1MXhsFGqtLzN, PID: 19925410
    • Tolentino MJ (2009) Current molecular understanding and future treatment strategies for pathological ocular neovascularization. Curr Mol Med 9:973–981
    • (2009) Curr Mol Med , vol.9 , pp. 973-981
    • Tolentino, M.J.1
  • 66
    • 77953259280 scopus 로고    scopus 로고
    • Bevacizumab suppression of establishment of micrometastases in experimental ocular melanoma
    • PID: 20089875
    • Yang H, Jager MJ, Grossniklaus HE (2010) Bevacizumab suppression of establishment of micrometastases in experimental ocular melanoma. Invest Ophthalmol Vis Sci 51:2835–2842
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 2835-2842
    • Yang, H.1    Jager, M.J.2    Grossniklaus, H.E.3
  • 67
    • 0036253481 scopus 로고    scopus 로고
    • Transpupillary thermotherapy (TTT) for malignant choroidal melanoma
    • COI: 1:STN:280:DC%2BD387nsVamsg%3D%3D
    • Stoffelns BM (2002) Transpupillary thermotherapy (TTT) for malignant choroidal melanoma. Acta Ophthalmol 80:25–31
    • (2002) Acta Ophthalmol , vol.80 , pp. 25-31
    • Stoffelns, B.M.1
  • 68
    • 31544450522 scopus 로고    scopus 로고
    • Morphologische und funktionelle Ergebnisse nach transpupillarer Thermotherapie (TTT) maligner Aderhautmelanome
    • COI: 1:STN:280:DC%2BD28%2FnslGqsQ%3D%3D, PID: 16418939
    • Stoffelns BM (2006) Morphologische und funktionelle Ergebnisse nach transpupillarer Thermotherapie (TTT) maligner Aderhautmelanome. Klin Monatsbl Augenheilkd 223:74–80
    • (2006) Klin Monatsbl Augenheilkd , vol.223 , pp. 74-80
    • Stoffelns, B.M.1
  • 69
    • 78149476012 scopus 로고    scopus 로고
    • Development of choroidal neovascularisation following transpupillary thermotherapy (TTT) for a small malignant melanoma of the choroid at the posterior pole – a case report
    • Schöpfer K, Stoffelns B (2010) Development of choroidal neovascularisation following transpupillary thermotherapy (TTT) for a small malignant melanoma of the choroid at the posterior pole – a case report. Med Laser Appl 25:223–228
    • (2010) Med Laser Appl , vol.25 , pp. 223-228
    • Schöpfer, K.1    Stoffelns, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.