Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models

Oncotarget

Volumn 6, Issue 11, 2015, Pages 8900-8913

  Li, Encheng ^a   Xu, Zhiyun ^a   Zhao, Hui ^a   Sun, Zhao ^a   Wang, Lei ^b   Guo, Zhe ^a   Zhao, Yang ^a   Gao, Zhancheng ^c   Wang, Qi ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^c PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Macrophages; Malignant transformation; Microfluidic chip; NF B; STAT3

Indexed keywords

BENZO[A]PYRENE; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; SMALL INTERFERING RNA; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; CCND1 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; PASSIVE SMOKING; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, RAT; TUMOR NECROSIS FACTOR; TUMOR PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL PROLIFERATION; CHRONIC INFLAMMATION; COLONY FORMATION; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG CARCINOGENESIS; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; RAT; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; ADENOCARCINOMA; ADVERSE EFFECTS; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BRONCHUS; CELL COUNT; CELL TRANSFORMATION; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; LAB ON A CHIP; LUNG TUMOR; MIDDLE AGED; NUDE MOUSE; PASSIVE SMOKING; PATHOLOGY; PHYSIOLOGY; SQUAMOUS CELL CARCINOMA; WISTAR RAT;

ADENOCARCINOMA; AGED; ANIMALS; BENZO(A)PYRENE; BRONCHI; CARCINOMA, SQUAMOUS CELL; CELL COUNT; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; EPITHELIAL CELLS; FEMALE; HUMANS; INTERLEUKIN-6; LAB-ON-A-CHIP DEVICES; LUNG NEOPLASMS; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM PROTEINS; NF-KAPPA B; RATS; RATS, WISTAR; STAT3 TRANSCRIPTION FACTOR; TOBACCO SMOKE POLLUTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84928753300     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3561     Document Type: Article

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