Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl

FEBS Letters

Volumn 585, Issue 12, 2011, Pages 1741-1747

  Takahashi, Yuga ^a,b   Shimokawa, Noriaki ^a   Esmaeili Mahani, Saeed ^a,c   Morita, Akihito ^a   Masuda, Hiroko ^a   Iwasaki, Toshiharu ^a   Tamura, Jun'Ichi ^b   Haglund, Kaisa ^d   Koibuchi, Noriyuki ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY HOSPITAL   (Japan)

^c SHAHID BAHONAR UNIVERSITY OF KERMAN   (Iran)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

c Cbl; Nedd4 2; TrkA degradation; Ubiquitination

Indexed keywords

CASPASE 2; CBL PROTEIN; NERVE GROWTH FACTOR; PROTEIN TYROSINE KINASE A; UBIQUITIN PROTEIN LIGASE NEDD4;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHOSPHORYLATION; BIOTINYLATION; COMPLEX FORMATION; DIMERIZATION; DOWN REGULATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; INTERNALIZATION; LIGAND BINDING; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; UBIQUITINATION;

ANIMALS; CELL LINE; DOWN-REGULATION; HUMANS; LIGANDS; LYSOSOMES; MICE; NERVE GROWTH FACTOR; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-CBL; RATS; RECEPTOR, TRKA; UBIQUITINATION;

EID: 79958128563     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.04.056     Document Type: Article

References (29)

1. J. Schlessinger Cell signaling by receptor tyrosine kinases Cell 103 2000 211 255
2. T. Hunter Oncoprotein networks Cell 88 1997 333 346 (Pubitemid 27131375)
3. M.A. Lemmon, and J. Schlessinger Cell signaling by receptor tyrosine kinases Cell 141 2010 1117 1134
4. A. Sorkin, and C.M. Waters Endocytosis of growth factor receptors BioEssays 15 1993 375 382
5. C.R. Hopkins, A. Gibson, M. Shipman, and K. Miller Movement of internalized ligand-receptor complexes along a continuous endosomal reticulum Nature 346 1990 335 339
6. H. Waterman, and Y. Yarden Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases FEBS Lett. 490 2001 142 152 (Pubitemid 32171933)
7. C.B. Thien, and W.Y. Langdon Cbl: many adaptations to regulate protein tyrosine kinases Nat. Rev. Mol. Cell Biol. 2 2001 294 307
8. A. Petrelli, G.F. Gilestro, S. Lanzardo, P.M. Comoglio, N. Migone, and S. Giordano The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met Nature 416 2002 187 190 (Pubitemid 34246477)
9. P. Soubeyran, K. Kowanetz, I. Szymkiewicz, W.Y. Langdon, and I. Dikic Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors Nature 416 2002 183 187 (Pubitemid 34246476)
10. S. Miyake, M.L. Lupher Jr., B. Druker, and H. Band The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α Proc. Natl. Acad. Sci 95 1998 7927 7932 (Pubitemid 28326043)
11. K. Haglund, N. Shimokawa, I. Szymkiewicz, and I. Dikic Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors Proc. Natl. Acad. Sci. USA 99 2002 12191 12196
12. K. Haglund, S. Sigismund, S. Polo, I. Szymkiewicz, P.P. Di Fiore, and I. Dikic Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation Nat. Cell Biol. 5 2003 461 466 (Pubitemid 36592270)
13. M.A. Pierotti, and A. Greco Oncogenic rearrangements of the NTRK1/NGF receptor Cancer Lett. 232 2006 90 98 (Pubitemid 43053936)
14. T. Geetha, and M.W. Wooten TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent Traffic 9 2008 1146 1156 (Pubitemid 351916889)
15. J.C. Arévalo, J. Waite, R. Rajagopal, M. Beyna, Z.Y. Chen, F.S. Lee, and M.V. Chao Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination Neuron 50 2006 549 559
16. + channel FASEB J. 15 2001 204 214 (Pubitemid 32061671)
17. (+) channel cell surface expression EMBO J. 20 2001 7052 7059 (Pubitemid 34062297)
18. A. Caporali, G.B. Sala-Newby, M. Meloni, G. Graiani, E. Pani, B. Cristofaro, A.C. Newby, P. Madeddu, and C. Emanueli Identification of the prosurvival activity of nerve growth factor on cardiac myocytes Cell Death Differ. 15 2008 299 311
19. N. Shimokawa, K. Haglund, S.M. Hölter, C. Grabbe, V. Kirkin, N. Koibuchi, C. Schultz, J. Rozman, D. Hoeller, C.H. Qiu, M.B. Londono, J. Ikezawa, P. Jedlicka, B. Stein, S.W. Schwarzacher, D.P. Wolfer, N. Ehrhardt, R. Heuchel, I. Nezis, A. Brech, M.H. Schmidt, H. Fuchs, V. Gailus-Durner, M. Klingenspor, O. Bogler, W. Wurst, T. Deller, M.H. de Angelis, and I. Dikic CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice EMBO J. 29 2010 2421 2432
20. S. Jing, P. Tapley, and M. Barbacid Nerve growth factor mediates signal transduction through Trk homodimer receptors Neuron 9 1992 1067 1079 (Pubitemid 23007178)
21. N. Inagaki, H. Thoenen, and D. Lindholm TrkA tyrosine residues involved in NGF-induced neurite outgrowth of PC12 cells Eur. J. Neurosci. 7 1995 1125 1133
22. A. Zapf-Colby, and J.M. Olefsky Nerve growth factor processing and trafficking events following TrkA-mediated endocytosis Endocrinology 139 1998 3232 3240 (Pubitemid 28512354)
23. P. van Kerkhof, Alves, C.M. dos Santos, M. Sachse, J. Klumperman, G. Bu, and G.J. Strous Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins Mol. Biol. Cell 12 2001 2556 2566 (Pubitemid 33051975)
24. D.P. Bonita, S. Miyake, M.L. Lupher Jr., W.Y. Langdon, and H. Band Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity Mol. Cell. Biol. 17 1997 4597 4610 (Pubitemid 27318136)
25. F. Huang, L.K. Goh, and A. Sorkin EGF receptor ubiquitination is not necessary for its internalization Proc. Natl. Acad. Sci. USA 104 2007 16904 16909 (Pubitemid 350210963)
26. S. Pennock, and Z. Wang A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation Mol. Cell. Biol. 28 2008 3020 3037 (Pubitemid 351556533)
27. J.P. Makkerh, C. Ceni, D.S. Auld, F. Vaillancourt, G. Dorval, and P.A. Barker p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation EMBO Rep. 6 2005 936 941 (Pubitemid 41521948)
28. Y. Takayama, P. May, R.G. Anderson, and J. Herz Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta) J. Biol. Chem. 280 2005 18504 18510 (Pubitemid 41389100)
29. T. Ohrt, A. Mancini, T. Tamura, and R. Niedenthal c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination Cell. Signal. 16 2004 1291 1298 (Pubitemid 39165457)