-
2
-
-
22044440425
-
Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma
-
P.L. Bergsagel, W.M. Kuehl, F. Zhan, J. Sawyer, B. Barlogie, and J. Shaughnessy Jr. Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma Blood 106 2005 296 303
-
(2005)
Blood
, vol.106
, pp. 296-303
-
-
Bergsagel, P.L.1
Kuehl, W.M.2
Zhan, F.3
Sawyer, J.4
Barlogie, B.5
Shaughnessy, J.6
-
3
-
-
0026786675
-
Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation
-
M.H. Bakkus, C. Heirman, I. Van Riet, B. Van Camp, and K. Thielemans Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation Blood 80 1992 2326 2335
-
(1992)
Blood
, vol.80
, pp. 2326-2335
-
-
Bakkus, M.H.1
Heirman, C.2
Van Riet, I.3
Van Camp, B.4
Thielemans, K.5
-
4
-
-
0030464093
-
Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma
-
P.L. Bergsagel, M. Chesi, E. Nardini, L.A. Brents, S.L. Kirby, and W.M. Kuehl Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma Proc Natl Acad Sci U S A 93 1996 13931 13936
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13931-13936
-
-
Bergsagel, P.L.1
Chesi, M.2
Nardini, E.3
Brents, L.A.4
Kirby, S.L.5
Kuehl, W.M.6
-
5
-
-
0031985198
-
Multiple myeloma: Increasing evidence for a multistep transformation process
-
M. Hallek, P.L. Bergsagel, and K.C. Anderson Multiple myeloma: increasing evidence for a multistep transformation process Blood 91 1998 3 21
-
(1998)
Blood
, vol.91
, pp. 3-21
-
-
Hallek, M.1
Bergsagel, P.L.2
Anderson, K.C.3
-
6
-
-
84879399749
-
Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells
-
B.A. Walker, C.P. Wardell, D.C. Johnson, and et al. Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells Blood 121 2013 3413 3419
-
(2013)
Blood
, vol.121
, pp. 3413-3419
-
-
Walker, B.A.1
Wardell, C.P.2
Johnson, D.C.3
-
7
-
-
84655166569
-
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
-
P. Broderick, D. Chubb, D. Johnson, and et al. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk Nat Genet 44 2012 58 61
-
(2012)
Nat Genet
, vol.44
, pp. 58-61
-
-
Broderick, P.1
Chubb, D.2
Johnson, D.3
-
8
-
-
77957761400
-
Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma
-
T. Rasmussen, J. Haaber, I. Dahl, and et al. Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma Haematologica 95 2010 1730 1737
-
(2010)
Haematologica
, vol.95
, pp. 1730-1737
-
-
Rasmussen, T.1
Haaber, J.2
Dahl, I.3
-
9
-
-
1442285889
-
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma
-
E. Hurt, A. Wiestner, A. Rosenwald, and et al. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma Cancer Cell 5 2004 191 199
-
(2004)
Cancer Cell
, vol.5
, pp. 191-199
-
-
Hurt, E.1
Wiestner, A.2
Rosenwald, A.3
-
10
-
-
0037103287
-
Genomic abnormalities in monoclonal gammopathy of undetermined significance
-
R. Fonseca, R.J. Bailey, G.J. Ahmann, and et al. Genomic abnormalities in monoclonal gammopathy of undetermined significance Blood 100 2002 1417 1424
-
(2002)
Blood
, vol.100
, pp. 1417-1424
-
-
Fonseca, R.1
Bailey, R.J.2
Ahmann, G.J.3
-
12
-
-
79951494668
-
Initial genome sequencing and analysis of multiple myeloma
-
M.A. Chapman, M.S. Lawrence, J.J. Keats, and et al. Initial genome sequencing and analysis of multiple myeloma Nature 471 2011 467 472
-
(2011)
Nature
, vol.471
, pp. 467-472
-
-
Chapman, M.A.1
Lawrence, M.S.2
Keats, J.J.3
-
13
-
-
57849129292
-
Clinical and biological significance of RAS mutations in multiple myeloma
-
W.J. Chng, N. Gonzalez-Paz, T. Price-Troska, and et al. Clinical and biological significance of RAS mutations in multiple myeloma Leukemia 22 2008 2280 2284
-
(2008)
Leukemia
, vol.22
, pp. 2280-2284
-
-
Chng, W.J.1
Gonzalez-Paz, N.2
Price-Troska, T.3
-
14
-
-
74049162897
-
International Myeloma Working Group molecular classification of multiple myeloma: Spotlight review
-
R. Fonseca, P.L. Bergsagel, J. Drach, and et al. International Myeloma Working Group molecular classification of multiple myeloma: spotlight review Leukemia 23 2009 2210 2221
-
(2009)
Leukemia
, vol.23
, pp. 2210-2221
-
-
Fonseca, R.1
Bergsagel, P.L.2
Drach, J.3
-
15
-
-
77954603996
-
Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms
-
A. Zingone, C.M. Cultraro, D.M. Shin, and et al. Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms Leukemia 24 2010 1171 1178
-
(2010)
Leukemia
, vol.24
, pp. 1171-1178
-
-
Zingone, A.1
Cultraro, C.M.2
Shin, D.M.3
-
16
-
-
84887579782
-
Molecular pathogenesis of multiple myeloma: Basic and clinical updates
-
M. Chesi, and P.L. Bergsagel Molecular pathogenesis of multiple myeloma: basic and clinical updates Int J Hematol 97 2013 313 323
-
(2013)
Int J Hematol
, vol.97
, pp. 313-323
-
-
Chesi, M.1
Bergsagel, P.L.2
-
17
-
-
79951507143
-
Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival
-
T. Steinbrunn, T. Stuhmer, S. Gattenlohner, and et al. Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival Blood 117 2011 1998 2004
-
(2011)
Blood
, vol.117
, pp. 1998-2004
-
-
Steinbrunn, T.1
Stuhmer, T.2
Gattenlohner, S.3
-
18
-
-
78650981573
-
Pathogenesis of monoclonal gammopathy of undetermined significance and progression to multiple myeloma
-
A. Zingone, and W.M. Kuehl Pathogenesis of monoclonal gammopathy of undetermined significance and progression to multiple myeloma Semin Hematol 48 2011 4 12
-
(2011)
Semin Hematol
, vol.48
, pp. 4-12
-
-
Zingone, A.1
Kuehl, W.M.2
-
19
-
-
84905690692
-
Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma [published online January 13, 2014]
-
Melchor L, Brioli A, Wardell CP, et al. Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma [published online January 13, 2014]. Leukemia.
-
Leukemia
-
-
Melchor, L.1
Brioli, A.2
Wardell, C.P.3
-
20
-
-
84866552319
-
Addiction to c-MYC in multiple myeloma
-
T. Holien, T.K. Vatsveen, H. Hella, A. Waage, and A. Sundan Addiction to c-MYC in multiple myeloma Blood 120 2012 2450 2453
-
(2012)
Blood
, vol.120
, pp. 2450-2453
-
-
Holien, T.1
Vatsveen, T.K.2
Hella, H.3
Waage, A.4
Sundan, A.5
-
21
-
-
44349090331
-
Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors
-
A. Gabrea, M.L. Martelli, Y. Qi, and et al. Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors Genes Chromosomes Cancer 47 2008 573 590
-
(2008)
Genes Chromosomes Cancer
, vol.47
, pp. 573-590
-
-
Gabrea, A.1
Martelli, M.L.2
Qi, Y.3
-
22
-
-
77957949804
-
A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value
-
B.A. Walker, P.E. Leone, L. Chiecchio, and et al. A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value Blood 116 2010 e56 e65
-
(2010)
Blood
, vol.116
, pp. e56-e65
-
-
Walker, B.A.1
Leone, P.E.2
Chiecchio, L.3
-
23
-
-
0035892119
-
Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors
-
H. Avet-Loiseau, F. Gerson, F. Magrangeas, and et al. Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors Blood 98 2001 3082 3086
-
(2001)
Blood
, vol.98
, pp. 3082-3086
-
-
Avet-Loiseau, H.1
Gerson, F.2
Magrangeas, F.3
-
24
-
-
79958095463
-
Clinical and biological implications of MYC activation: A common difference between MGUS and newly diagnosed multiple myeloma
-
W.J. Chng, G.F. Huang, T.H. Chung, and et al. Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma Leukemia 25 2011 1026 1035
-
(2011)
Leukemia
, vol.25
, pp. 1026-1035
-
-
Chng, W.J.1
Huang, G.F.2
Chung, T.H.3
-
25
-
-
84901846972
-
Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients
-
B. Walker, C. Wardell, A. Brioli, and et al. Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients Blood Cancer J 2014 4
-
(2014)
Blood Cancer J
, pp. 4
-
-
Walker, B.1
Wardell, C.2
Brioli, A.3
-
26
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
-
C.M. Annunziata, R.E. Davis, Y. Demchenko, and et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma Cancer Cell 12 2007 115 130
-
(2007)
Cancer Cell
, vol.12
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
-
27
-
-
34547660308
-
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
-
J.J. Keats, R. Fonseca, M. Chesi, and et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma Cancer Cell 12 2007 131 144
-
(2007)
Cancer Cell
, vol.12
, pp. 131-144
-
-
Keats, J.J.1
Fonseca, R.2
Chesi, M.3
-
29
-
-
52149094341
-
Characterization of MYC translocations in multiple myeloma cell lines
-
A. Dib, A. Gabrea, O.K. Glebov, P.L. Bergsagel, and W.M. Kuehl Characterization of MYC translocations in multiple myeloma cell lines J Natl Cancer Inst Monogr 2008 25 31
-
(2008)
J Natl Cancer Inst Monogr
, pp. 25-31
-
-
Dib, A.1
Gabrea, A.2
Glebov, O.K.3
Bergsagel, P.L.4
Kuehl, W.M.5
-
30
-
-
78149246124
-
Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma
-
L. Lode, M. Eveillard, V. Trichet, and et al. Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma Haematologica 95 2010 1973 1976
-
(2010)
Haematologica
, vol.95
, pp. 1973-1976
-
-
Lode, L.1
Eveillard, M.2
Trichet, V.3
-
31
-
-
74549190701
-
Prognostic significance of copy-number alterations in multiple myeloma
-
H. Avet-Loiseau, C. Li, F. Magrangeas, and et al. Prognostic significance of copy-number alterations in multiple myeloma J Clin Oncol 27 2009 4585 4590
-
(2009)
J Clin Oncol
, vol.27
, pp. 4585-4590
-
-
Avet-Loiseau, H.1
Li, C.2
Magrangeas, F.3
-
32
-
-
33947217497
-
A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
-
J.D. Shaughnessy Jr., F. Zhan, B.E. Burington, and et al. A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1 Blood 109 2007 2276 2284
-
(2007)
Blood
, vol.109
, pp. 2276-2284
-
-
Shaughnessy, J.D.1
Zhan, F.2
Burington, B.E.3
-
33
-
-
33847378314
-
Genetic abnormalities and survival in multiple myeloma: The experience of the Intergroupe Francophone du Myelome
-
H. Avet-Loiseau, M. Attal, P. Moreau, and et al. Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myelome Blood 109 2007 3489 3495
-
(2007)
Blood
, vol.109
, pp. 3489-3495
-
-
Avet-Loiseau, H.1
Attal, M.2
Moreau, P.3
-
34
-
-
84856706335
-
A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: Analysis of patients treated in the MRC Myeloma IX trial
-
K.D. Boyd, F.M. Ross, L. Chiecchio, and et al. A novel prognostic model in myeloma based on co-segregating adverse FISH lesions and the ISS: analysis of patients treated in the MRC Myeloma IX trial Leukemia 26 2012 349 355
-
(2012)
Leukemia
, vol.26
, pp. 349-355
-
-
Boyd, K.D.1
Ross, F.M.2
Chiecchio, L.3
-
35
-
-
84863290659
-
Trisomies in multiple myeloma: Impact on survival in patients with high-risk cytogenetics
-
S. Kumar, R. Fonseca, R.P. Ketterling, and et al. Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogenetics Blood 119 2012 2100 2105
-
(2012)
Blood
, vol.119
, pp. 2100-2105
-
-
Kumar, S.1
Fonseca, R.2
Ketterling, R.P.3
-
36
-
-
84899023638
-
The impact of thalidomide maintenance therapy varies dependent upon biological risk grouping
-
A. Brioli, F.M. Ross, M.F. Kaiser, and et al. The impact of thalidomide maintenance therapy varies dependent upon biological risk grouping ASH Annual Meeting Abstracts 120 2012 199
-
(2012)
ASH Annual Meeting Abstracts
, vol.120
, pp. 199
-
-
Brioli, A.1
Ross, F.M.2
Kaiser, M.F.3
-
37
-
-
84897616698
-
Co-existent hyperdiploidy does not abrogate the poor prognosis associated with adverse cytogenetics in myeloma
-
(abstract 529)
-
C. Pawlyn, L. Melchor, E.M. Boyle, and et al. Co-existent hyperdiploidy does not abrogate the poor prognosis associated with adverse cytogenetics in myeloma ASH Annual Meeting Abstracts 2013 (abstract 529)
-
(2013)
ASH Annual Meeting Abstracts
-
-
Pawlyn, C.1
Melchor, L.2
Boyle, E.M.3
-
38
-
-
84875209671
-
Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: An International Myeloma Working Group collaborative project
-
H. Avet-Loiseau, B. Durie, M. Cavo, and et al. Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: an International Myeloma Working Group collaborative project Leukemia 27 2013 711 717
-
(2013)
Leukemia
, vol.27
, pp. 711-717
-
-
Avet-Loiseau, H.1
Durie, B.2
Cavo, M.3
-
39
-
-
33745779502
-
The molecular classification of multiple myeloma
-
F. Zhan, Y. Huang, S. Colla, and et al. The molecular classification of multiple myeloma Blood 108 2006 2020 2028
-
(2006)
Blood
, vol.108
, pp. 2020-2028
-
-
Zhan, F.1
Huang, Y.2
Colla, S.3
-
40
-
-
77957733923
-
Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients
-
A. Broyl, D. Hose, H. Lokhorst, and et al. Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients Blood 116 2010 2543 2553
-
(2010)
Blood
, vol.116
, pp. 2543-2553
-
-
Broyl, A.1
Hose, D.2
Lokhorst, H.3
-
41
-
-
77953632707
-
Superior results of Total Therapy 3 (2003-33) in gene expression profiling-defined low-risk multiple myeloma confirmed in subsequent trial 2006-66 with VRD maintenance
-
B. Nair, F. van Rhee, J. Shaughnessy, and et al. Superior results of Total Therapy 3 (2003-33) in gene expression profiling-defined low-risk multiple myeloma confirmed in subsequent trial 2006-66 with VRD maintenance Blood 115 2010 4168 4173
-
(2010)
Blood
, vol.115
, pp. 4168-4173
-
-
Nair, B.1
Van Rhee, F.2
Shaughnessy, J.3
-
42
-
-
54249092519
-
Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: A study of the Intergroupe Francophone du MyéLome
-
O. Decaux, L. Lodé, F. Magrangeas, and et al. Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du Myélome J Clin Oncol 26 2008 4798 4805
-
(2008)
J Clin Oncol
, vol.26
, pp. 4798-4805
-
-
Decaux, O.1
Lodé, L.2
Magrangeas, F.3
-
43
-
-
77949686098
-
Homozygous deletion mapping in myeloma samples identifies genes and an expression signature relevant to pathogenesis and outcome
-
N.J. Dickens, B.A. Walker, P.E. Leone, and et al. Homozygous deletion mapping in myeloma samples identifies genes and an expression signature relevant to pathogenesis and outcome Clin Cancer Res 16 2010 1856 1864
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1856-1864
-
-
Dickens, N.J.1
Walker, B.A.2
Leone, P.E.3
-
44
-
-
84857767379
-
Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results
-
G.J. Morgan, F.E. Davies, W.M. Gregory, and et al. Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results Haematologica 97 2012 442 450
-
(2012)
Haematologica
, vol.97
, pp. 442-450
-
-
Morgan, G.J.1
Davies, F.E.2
Gregory, W.M.3
-
45
-
-
84875805126
-
Response and biological subtype of myeloma are independent prognostic factors and combine to define outcome after high-dose therapy
-
A. Brioli, K.D. Boyd, M.F. Kaiser, and et al. Response and biological subtype of myeloma are independent prognostic factors and combine to define outcome after high-dose therapy Br J Haematol 161 2013 291 294
-
(2013)
Br J Haematol
, vol.161
, pp. 291-294
-
-
Brioli, A.1
Boyd, K.D.2
Kaiser, M.F.3
-
46
-
-
84893810104
-
Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms
-
[published online July 2, 2013]
-
B.A. Walker, C.P. Wardell, L. Melchor, and et al. Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms [published online July 2, 2013] Leukemia 28 2014 384 390
-
(2014)
Leukemia
, vol.28
, pp. 384-390
-
-
Walker, B.A.1
Wardell, C.P.2
Melchor, L.3
-
47
-
-
84864544413
-
Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma
-
B.A. Walker, C.P. Wardell, L. Melchor, and et al. Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma Blood 120 2012 1077 1086
-
(2012)
Blood
, vol.120
, pp. 1077-1086
-
-
Walker, B.A.1
Wardell, C.P.2
Melchor, L.3
-
48
-
-
84861532638
-
Clonal competition with alternating dominance in multiple myeloma
-
J.J. Keats, M. Chesi, J.B. Egan, and et al. Clonal competition with alternating dominance in multiple myeloma Blood 120 2012 1067 1076
-
(2012)
Blood
, vol.120
, pp. 1067-1076
-
-
Keats, J.J.1
Chesi, M.2
Egan, J.B.3
-
49
-
-
0038509089
-
Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group
-
Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group Br J Haematol 121 2003 749 757
-
(2003)
Br J Haematol
, vol.121
, pp. 749-757
-
-
-
50
-
-
84873565928
-
Minor clone provides a reservoir for relapse in multiple myeloma
-
F. Magrangeas, H. Avet-Loiseau, W. Gouraud, and et al. Minor clone provides a reservoir for relapse in multiple myeloma Leukemia 27 2013 473 481
-
(2013)
Leukemia
, vol.27
, pp. 473-481
-
-
Magrangeas, F.1
Avet-Loiseau, H.2
Gouraud, W.3
-
51
-
-
55549101623
-
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
-
T.J. Ley, E.R. Mardis, L. Ding, and et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome Nature 456 2008 66 72
-
(2008)
Nature
, vol.456
, pp. 66-72
-
-
Ley, T.J.1
Mardis, E.R.2
Ding, L.3
-
52
-
-
77953006634
-
The mutation spectrum revealed by paired genome sequences from a lung cancer patient
-
W. Lee, Z. Jiang, J. Liu, and et al. The mutation spectrum revealed by paired genome sequences from a lung cancer patient Nature 465 2010 473 477
-
(2010)
Nature
, vol.465
, pp. 473-477
-
-
Lee, W.1
Jiang, Z.2
Liu, J.3
-
53
-
-
33645396945
-
Genetic clonal diversity predicts progression to esophageal adenocarcinoma
-
C.C. Maley, P.C. Galipeau, J.C. Finley, and et al. Genetic clonal diversity predicts progression to esophageal adenocarcinoma Nat Genet 38 2006 468 473
-
(2006)
Nat Genet
, vol.38
, pp. 468-473
-
-
Maley, C.C.1
Galipeau, P.C.2
Finley, J.C.3
-
54
-
-
84863115580
-
Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation
-
F. Su, W.D. Bradley, Q. Wang, and et al. Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation Cancer Res 72 2012 969 978
-
(2012)
Cancer Res
, vol.72
, pp. 969-978
-
-
Su, F.1
Bradley, W.D.2
Wang, Q.3
-
55
-
-
78049380554
-
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
-
P.J. Campbell, S. Yachida, L.J. Mudie, and et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer Nature 467 2010 1109 1113
-
(2010)
Nature
, vol.467
, pp. 1109-1113
-
-
Campbell, P.J.1
Yachida, S.2
Mudie, L.J.3
-
56
-
-
70349969478
-
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
-
S.P. Shah, R.D. Morin, J. Khattra, and et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution Nature 461 2009 809 813
-
(2009)
Nature
, vol.461
, pp. 809-813
-
-
Shah, S.P.1
Morin, R.D.2
Khattra, J.3
-
57
-
-
78650303860
-
Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: A randomised phase 3 study
-
M. Cavo, P. Tacchetti, F. Patriarca, and et al. Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study Lancet 376 2010 2075 2085
-
(2010)
Lancet
, vol.376
, pp. 2075-2085
-
-
Cavo, M.1
Tacchetti, P.2
Patriarca, F.3
-
58
-
-
73249146496
-
Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: An open-label randomised controlled trial
-
S.V. Rajkumar, S. Jacobus, N.S. Callander, and et al. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial Lancet Oncol 11 2010 29 37
-
(2010)
Lancet Oncol
, vol.11
, pp. 29-37
-
-
Rajkumar, S.V.1
Jacobus, S.2
Callander, N.S.3
-
59
-
-
78049488759
-
Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: Results of the IFM 2005-01 phase III trial
-
J.L. Harousseau, M. Attal, H. Avet-Loiseau, and et al. Bortezomib plus dexamethasone is superior to vincristine plus doxorubicin plus dexamethasone as induction treatment prior to autologous stem-cell transplantation in newly diagnosed multiple myeloma: results of the IFM 2005-01 phase III trial J Clin Oncol 28 2010 4621 4629
-
(2010)
J Clin Oncol
, vol.28
, pp. 4621-4629
-
-
Harousseau, J.L.1
Attal, M.2
Avet-Loiseau, H.3
-
60
-
-
50449086728
-
Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
-
J.F. San Miguel, R. Schlag, N.K. Khuageva, and et al. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma N Engl J Med 359 2008 906 917
-
(2008)
N Engl J Med
, vol.359
, pp. 906-917
-
-
San Miguel, J.F.1
Schlag, R.2
Khuageva, N.K.3
-
61
-
-
84860744403
-
Continuous lenalidomide treatment for newly diagnosed multiple myeloma
-
A. Palumbo, R. Hajek, M. Delforge, and et al. Continuous lenalidomide treatment for newly diagnosed multiple myeloma N Engl J Med 366 2012 1759 1769
-
(2012)
N Engl J Med
, vol.366
, pp. 1759-1769
-
-
Palumbo, A.1
Hajek, R.2
Delforge, M.3
-
62
-
-
79954448518
-
Melphalan and prednisone versus melphalan, prednisone and thalidomide for elderly and/or transplant ineligible patients with multiple myeloma: A meta-analysis
-
P. Kapoor, S.V. Rajkumar, A. Dispenzieri, and et al. Melphalan and prednisone versus melphalan, prednisone and thalidomide for elderly and/or transplant ineligible patients with multiple myeloma: a meta-analysis Leukemia 25 2011 689 696
-
(2011)
Leukemia
, vol.25
, pp. 689-696
-
-
Kapoor, P.1
Rajkumar, S.V.2
Dispenzieri, A.3
-
63
-
-
78649707335
-
Lenalidomide mode of action: Linking bench and clinical findings
-
F. Davies, and R. Baz Lenalidomide mode of action: linking bench and clinical findings Blood Rev 24 suppl 1 2010 S13 S19
-
(2010)
Blood Rev
, vol.24
, pp. S13-S19
-
-
Davies, F.1
Baz, R.2
-
64
-
-
84859408579
-
New insights into therapeutic targets in myeloma
-
K.C. Anderson New insights into therapeutic targets in myeloma Hematology Am Soc Hematol Educ Program 2011 2011 184 190
-
(2011)
Hematology Am Soc Hematol Educ Program
, vol.2011
, pp. 184-190
-
-
Anderson, K.C.1
-
65
-
-
43249127114
-
Targeting proteasomes as therapy in multiple myeloma
-
D. Chauhan, T. Hideshima, and K.C. Anderson Targeting proteasomes as therapy in multiple myeloma Adv Exp Med Biol 615 2008 251 260
-
(2008)
Adv Exp Med Biol
, vol.615
, pp. 251-260
-
-
Chauhan, D.1
Hideshima, T.2
Anderson, K.C.3
-
66
-
-
38849130851
-
Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
-
S. Mukherjee, N. Raje, J.A. Schoonmaker, and et al. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice J Clin Invest 118 2008 491 504
-
(2008)
J Clin Invest
, vol.118
, pp. 491-504
-
-
Mukherjee, S.1
Raje, N.2
Schoonmaker, J.A.3
-
67
-
-
84862937267
-
The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis
-
G.J. Morgan, W.M. Gregory, F.E. Davies, and et al. The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis Blood 119 2012 7 15
-
(2012)
Blood
, vol.119
, pp. 7-15
-
-
Morgan, G.J.1
Gregory, W.M.2
Davies, F.E.3
-
68
-
-
84860741191
-
Lenalidomide after stem-cell transplantation for multiple myeloma
-
P.L. McCarthy, K. Owzar, C.C. Hofmeister, and et al. Lenalidomide after stem-cell transplantation for multiple myeloma N Engl J Med 366 2012 1770 1781
-
(2012)
N Engl J Med
, vol.366
, pp. 1770-1781
-
-
McCarthy, P.L.1
Owzar, K.2
Hofmeister, C.C.3
-
69
-
-
84898026370
-
Initial phase 3 results of the first (frontline investigation of lenalidomide + dexamethasone versus standard thalidomide) trial (MM-020/IFM 07 01) in newly diagnosed multiple myeloma (NDMM) patients (Pts) ineligible for stem cell transplantation (SCT)
-
T. Facon, M.A. Dimopoulos, A. Dispenzieri, and et al. Initial phase 3 results of the first (frontline investigation of lenalidomide + dexamethasone versus standard thalidomide) trial (MM-020/IFM 07 01) in newly diagnosed multiple myeloma (NDMM) patients (Pts) ineligible for stem cell transplantation (SCT) Blood 122 2013 2
-
(2013)
Blood
, vol.122
, pp. 2
-
-
Facon, T.1
Dimopoulos, M.A.2
Dispenzieri, A.3
-
70
-
-
84865171981
-
Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: Results of the randomized phase III HOVON-65/GMMG-HD4 trial
-
P. Sonneveld, I.G. Schmidt-Wolf, B. van der Holt, and et al. Bortezomib induction and maintenance treatment in patients with newly diagnosed multiple myeloma: results of the randomized phase III HOVON-65/GMMG-HD4 trial J Clin Oncol 30 2012 2946 2955
-
(2012)
J Clin Oncol
, vol.30
, pp. 2946-2955
-
-
Sonneveld, P.1
Schmidt-Wolf, I.G.2
Van Der Holt, B.3
-
71
-
-
84860709392
-
Lenalidomide maintenance after stem-cell transplantation for multiple myeloma
-
M. Attal, V. Lauwers-Cances, G. Marit, and et al. Lenalidomide maintenance after stem-cell transplantation for multiple myeloma N Engl J Med 366 2012 1782 1791
-
(2012)
N Engl J Med
, vol.366
, pp. 1782-1791
-
-
Attal, M.1
Lauwers-Cances, V.2
Marit, G.3
-
73
-
-
77951719556
-
Classical and/or alternative NF-kappaB pathway activation in multiple myeloma
-
Y.N. Demchenko, O.K. Glebov, A. Zingone, J.J. Keats, P.L. Bergsagel, and W.M. Kuehl Classical and/or alternative NF-kappaB pathway activation in multiple myeloma Blood 115 2010 3541 3552
-
(2010)
Blood
, vol.115
, pp. 3541-3552
-
-
Demchenko, Y.N.1
Glebov, O.K.2
Zingone, A.3
Keats, J.J.4
Bergsagel, P.L.5
Kuehl, W.M.6
-
74
-
-
70349675652
-
Atacicept in relapsed/refractory multiple myeloma or active Waldenström's macroglobulinemia: A phase i study
-
J.F. Rossi, J. Moreaux, D. Hose, and et al. Atacicept in relapsed/refractory multiple myeloma or active Waldenström's macroglobulinemia: a phase I study Br J Cancer 101 2009 1051 1058
-
(2009)
Br J Cancer
, vol.101
, pp. 1051-1058
-
-
Rossi, J.F.1
Moreaux, J.2
Hose, D.3
-
75
-
-
84881490568
-
Targeting the BRAF V600E mutation in multiple myeloma
-
[published online April 23, 2013]
-
M. Andrulis, N. Lehners, D. Capper, and et al. Targeting the BRAF V600E mutation in multiple myeloma [published online April 23, 2013] Cancer Discov 3 2013 862 869
-
(2013)
Cancer Discov
, vol.3
, pp. 862-869
-
-
Andrulis, M.1
Lehners, N.2
Capper, D.3
-
76
-
-
84898953453
-
Low rate of second primary malignancies (SPMs) in newly diagnosed multiple myeloma (MM) patients treated with lenalidomide: First results from the MRC MM XI trial (18th Congress of the European Hematology Association, Stockholm, Sweden, June 13-16, 2013)
-
(P242)
-
A. Brioli, F.E. Davies, W.M. Gregory, and et al. Low rate of second primary malignancies (SPMs) in newly diagnosed multiple myeloma (MM) patients treated with lenalidomide: first results from the MRC MM XI trial (18th Congress of the European Hematology Association, Stockholm, Sweden, June 13-16, 2013) Haematologica 98 suppl 1 2013 104 (P242)
-
(2013)
Haematologica
, vol.98
, pp. 104
-
-
Brioli, A.1
Davies, F.E.2
Gregory, W.M.3
|