Characterization of MYC translocations in multiple myeloma cell lines

Journal of the National Cancer Institute - Monographs

Volumn , Issue 39, 2008, Pages 25-31

  Dib, Amel ^a   Gabrea, Ana ^a   Glebov, Oleg K ^a   Bergsagel, P Leif ^b   Kuehl, W Michael ^a,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MAYO CLINIC   (United States)

^c NAVAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; MYC PROTEIN;

CANCER CELL CULTURE; CHROMOSOME ABERRATION; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONFERENCE PAPER; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DUPLICATION; GENE IDENTIFICATION; GENE INSERTION; GENE LOCUS; GENE REARRANGEMENT; GENE SWITCHING; HUMAN; HUMAN CELL; MOLECULAR CLONING; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN STRUCTURE;

CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 8; GENE EXPRESSION PROFILING; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN HEAVY CHAIN; GENES, MYC; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MULTIPLE MYELOMA; NUCLEIC ACID HYBRIDIZATION; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 52149094341     PISSN: 10526773     EISSN: 17456614     Source Type: Book Series    
DOI: 10.1093/jncimonographs/lgn011     Document Type: Conference Paper

References (18)

1. Bergsagel PL, Kuehl WM. Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol. 2005;26(26):6333-6338.
2. Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy J Jr. Cyclin D dysregulation: An early and unifying pathogenic event in multiple myeloma. Blood. 2005;106(1):296-303.
3. Fonseca R, Bailey RJ, Ahmann GJ, et al. Genomic abnormalities in monoclonal gammopathy of undetermined significance. Blood. 2002;100(4): 1417-1424.
4. Fonseca R, Barlogie B, Bataille R, et al. Genetics and cytogenetics of multiple myeloma: A workshop report. Cancer Res. 2004;64(4):1546-1558.
5. Bergsagel PL, Kuehl WM. Chromosomal translocations in multiple myeloma. Oncogene. 2001;20(40):5611-5622.
6. Gabrea A, Leif Bergsagel P, Michael Kuehl W. Distinguishing primary and secondary translocations in multiple myeloma. DNA Repair(Amst). 2006;5(9-10):1225-1233.
7. Avet-Loiseau H, Gerson F, Margrangeas F, Minvielle S, Harousseau J-L, Bataille R. Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors. Blood. 2001;98(10):3082-3086.
8. Dalla-Favera R, Gaidano G. Molecular biology of lymphoma. In: DeVita VT, Hellman S, Rosenberg SA, ed. Cancer: Principles and Practice of Oncology. 6th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2001:2215-2235.
9. Potter M. Neoplastic development in plasma cells. Immunol Rev. 2003; 194(1):177-195.
10. Klein U, Tu Y, Stolovitzky GA, et al. Transcriptional analysis of the B cell germinal center reaction. Proc Natl Acad Sci USA. 2003;100(5):2639-2644.
11. Zhan F, Barlogie B, Arzoumanian V, et al. Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis. Blood. 2007;109(4):1692-1700.
12. Shou Y, Martelli ML, Gabrea A, et al. Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. Proc Natl Acad Sci USA. 2000;97(1):228-233.
13. Drexler HG, Matsuo Y. Malignant hematopoietic cell lines: In vitro models for the study of multiple myeloma and plasma cell leukemia. Leuk Res. 2000;24(8):681-703.
14. Zhan F, Huang Y, Colla S, et al. The molecular classification of multiple myeloma. Blood. 2006;108(6):2020-2028.
15. Hollis GF, Gazdar AF, Bertness V, Kirsch IR. Complex translocation disrupts c-myc regulation in a human plasma cell myeloma. Mol Cell Biol. 1988;8(1):124-129.
16. Fabris S, Storlazzi CT, Baldini L, et al. Heterogeneous pattern of chromosomal breakpoints involving the MYC locus in multiple myeloma. Genes Chromosomes Cancer. 2003;37(3):261-269.
17. Chesi M, Bergsagel PL, Shonukan OO, et al. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma. Blood. 1998;91(12):4457-4463.
18. Gabrea A, Martelli ML, Qi Y, et al. Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors. Genes Chrom Cancer 2008;47(7):573-590.