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Volumn 16, Issue 7, 2015, Pages 2591-2600

Recent progress in HER2 associated breast cancer

Author keywords

Breast cancer; HER2; Mechanism; Treatment

Indexed keywords

ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; ESTROGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROGESTERONE RECEPTOR; PROTEIN KINASE B;

EID: 84928600474     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2015.16.7.2591     Document Type: Review
Times cited : (25)

References (97)
  • 1
    • 84856253626 scopus 로고    scopus 로고
    • Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance
    • Aksamitiene E, Kiyatkin A, Kholodenko BN (2012). Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance. Biochem Soc T, 40, 139-46.
    • (2012) Biochem Soc T , vol.40 , pp. 139-146
    • Aksamitiene, E.1    Kiyatkin, A.2    Kholodenko, B.N.3
  • 2
    • 84892746649 scopus 로고    scopus 로고
    • Antitumor response of an ERBB2 amplified inflammatory breast carcinoma with EGFR mutation to the EGFR-TKI erlotinib
    • Ali SM, Alpaugh RK, Buell JK, et al (2014). Antitumor response of an ERBB2 amplified inflammatory breast carcinoma with EGFR mutation to the EGFR-TKI erlotinib. Clin Breast Cancer, 14, 14-6.
    • (2014) Clin Breast Cancer , vol.14 , pp. 14-16
    • Ali, S.M.1    Alpaugh, R.K.2    Buell, J.K.3
  • 3
    • 84911961587 scopus 로고    scopus 로고
    • Impact of estrogen receptor (ER) and human epidermal growth factor receptor-2 (HER2) co-expression on breast cancer disease characteristics: implications for tumor biology and research
    • Alqaisi A, Chen L, Romond E, et al (2014). Impact of estrogen receptor (ER) and human epidermal growth factor receptor-2 (HER2) co-expression on breast cancer disease characteristics: implications for tumor biology and research. Breast Cancer Res Treat, 148, 437-44.
    • (2014) Breast Cancer Res Treat , vol.148 , pp. 437-444
    • Alqaisi, A.1    Chen, L.2    Romond, E.3
  • 4
    • 84866360342 scopus 로고    scopus 로고
    • Prevalence, clinicopathologic associations and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
    • Arcila ME, Chaft JE, Nafa K, et al (2012). Prevalence, clinicopathologic associations and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res, 18.
    • (2012) Clin Cancer Res , pp. 18
    • Arcila, M.E.1    Chaft, J.E.2    Nafa, K.3
  • 5
    • 84902484568 scopus 로고    scopus 로고
    • Flotillin depletion affects ErbB protein levels in different human breast cancer cells
    • Asp N, Pust S, Sandvig K (2014). Flotillin depletion affects ErbB protein levels in different human breast cancer cells. Biochim Biophys Acta, 1843, 1987-96.
    • (2014) Biochim Biophys Acta , vol.1843 , pp. 1987-1996
    • Asp, N.1    Pust, S.2    Sandvig, K.3
  • 6
    • 84893666005 scopus 로고    scopus 로고
    • Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival
    • Auvinen P, Rilla K, Tumelius R, et al (2014). Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival. Breast Cancer Res Treat, 143, 277-86.
    • (2014) Breast Cancer Res Treat , vol.143 , pp. 277-286
    • Auvinen, P.1    Rilla, K.2    Tumelius, R.3
  • 7
    • 84904065393 scopus 로고    scopus 로고
    • MiR-200c suppresses TGF-beta signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer
    • Bai WD, Ye XM, Zhang MY, et al (2014). MiR-200c suppresses TGF-beta signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer. Int J Cancer, 135, 1356-68.
    • (2014) Int J Cancer , vol.135 , pp. 1356-1368
    • Bai, W.D.1    Ye, X.M.2    Zhang, M.Y.3
  • 8
    • 84929263565 scopus 로고    scopus 로고
    • Current HER2 testing recommendations and clinical relevance as a predictor of response to targeted therapy
    • Ballinger TJ, Sanders ME, Abramson VG (2014). Current HER2 testing recommendations and clinical relevance as a predictor of response to targeted therapy. Clin Breast Cancer.
    • (2014) Clin Breast Cancer
    • Ballinger, T.J.1    Sanders, M.E.2    Abramson, V.G.3
  • 9
    • 84887178013 scopus 로고    scopus 로고
    • Biological therapies in breast cancer: common toxicities and management strategies
    • Barroso-Sousa R, Santana IA, Testa L, et al (2013). Biological therapies in breast cancer: common toxicities and management strategies. Breast, 22, 1009-18.
    • (2013) Breast , vol.22 , pp. 1009-1018
    • Barroso-Sousa, R.1    Santana, I.A.2    Testa, L.3
  • 10
    • 62549147841 scopus 로고    scopus 로고
    • Persistent elimination of ErbB-2/HER2-overexpressing tumors using combinations of monoclonal antibodies: Relevance of receptor endocytosis
    • Ben-Kasus T, Schechter B, Lavi S, et al (2009). Persistent elimination of ErbB-2/HER2-overexpressing tumors using combinations of monoclonal antibodies: Relevance of receptor endocytosis. Proc Natl Acad Sci USA, 106, 3294-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3294-3299
    • Ben-Kasus, T.1    Schechter, B.2    Lavi, S.3
  • 11
    • 84907186638 scopus 로고    scopus 로고
    • Effects of anti-proliferative lichen metabolite, protolichesterinic acid on fatty acid synthase, cell signalling and drug response in breast cancer cells
    • Bessadottir M, Skuladottir EA, Gowan S, et al (2014). Effects of anti-proliferative lichen metabolite, protolichesterinic acid on fatty acid synthase, cell signalling and drug response in breast cancer cells. Phytomedicine, 21, 1717-24.
    • (2014) Phytomedicine , vol.21 , pp. 1717-1724
    • Bessadottir, M.1    Skuladottir, E.A.2    Gowan, S.3
  • 12
    • 84868200630 scopus 로고    scopus 로고
    • Assessing HER2 amplification in breast cancer: findings from the Australian In situ hybridization program
    • Bilous M, Morey AL, Armes JE, et al (2012). Assessing HER2 amplification in breast cancer: findings from the Australian In situ hybridization program. Breast Cancer Res Treat, 134, 617-24.
    • (2012) Breast Cancer Res Treat , vol.134 , pp. 617-624
    • Bilous, M.1    Morey, A.L.2    Armes, J.E.3
  • 13
    • 84874430114 scopus 로고    scopus 로고
    • Cytoplasmic overexpression of HER2: a key factor in colorectal cancer
    • Blok EJ, Kuppen PJ, van Leeuwen JE, et al (2013). Cytoplasmic overexpression of HER2: a key factor in colorectal cancer. Clin Med Insights Oncol, 7, 41-51.
    • (2013) Clin Med Insights Oncol , vol.7 , pp. 41-51
    • Blok, E.J.1    Kuppen, P.J.2    van Leeuwen, J.E.3
  • 14
    • 84891628913 scopus 로고    scopus 로고
    • HER2-positive gastric cancer
    • Boku N (2014). HER2-positive gastric cancer. Gastric Cancer, 17, 1-12.
    • (2014) Gastric Cancer , vol.17 , pp. 1-12
    • Boku, N.1
  • 15
    • 84923373832 scopus 로고    scopus 로고
    • HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer
    • Boulbes DR, Arold ST, Chauhan GB, et al (2014). HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer. Mol Oncol, 9, 586-600.
    • (2014) Mol Oncol , vol.9 , pp. 586-600
    • Boulbes, D.R.1    Arold, S.T.2    Chauhan, G.B.3
  • 16
    • 84892566293 scopus 로고    scopus 로고
    • Enhanced PI3K p110alpha signaling confers acquired lapatinib resistance that can be effectively reversed by a p110alpha-selective PI3K inhibitor
    • Brady SW, Zhang J, Seok D, et al (2014). Enhanced PI3K p110alpha signaling confers acquired lapatinib resistance that can be effectively reversed by a p110alpha-selective PI3K inhibitor. Mol Cancer Ther, 13, 60-70.
    • (2014) Mol Cancer Ther , vol.13 , pp. 60-70
    • Brady, S.W.1    Zhang, J.2    Seok, D.3
  • 17
    • 84882708425 scopus 로고    scopus 로고
    • DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice
    • Cao J, Jin Y, Li W, et al (2013). DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice. BMC Immunol, 14, 39.
    • (2013) BMC Immunol , vol.14 , pp. 39
    • Cao, J.1    Jin, Y.2    Li, W.3
  • 18
    • 84897516001 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells
    • Chen L, Bourguignon LY (2014). Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells. Mol Cancer, 13, 52.
    • (2014) Mol Cancer , vol.13 , pp. 52
    • Chen, L.1    Bourguignon, L.Y.2
  • 19
    • 84928640089 scopus 로고    scopus 로고
    • Oncogenic alterations in ERBB2/HER2 represent potential therapeutic targets across tumors from diverse anatomic sites of origin
    • Chmielecki J, Ross JS, Wang K, et al (2014). Oncogenic alterations in ERBB2/HER2 represent potential therapeutic targets across tumors from diverse anatomic sites of origin. Oncologist.
    • (2014) Oncologist
    • Chmielecki, J.1    Ross, J.S.2    Wang, K.3
  • 20
    • 84871735036 scopus 로고    scopus 로고
    • Hypothesized role of pregnancy hormones on HER2+ breast tumor development
    • Cruz GI, Martinez ME, Natarajan L, et al (2013). Hypothesized role of pregnancy hormones on HER2+ breast tumor development. Breast Cancer Res Treat, 137, 237-46.
    • (2013) Breast Cancer Res Treat , vol.137 , pp. 237-246
    • Cruz, G.I.1    Martinez, M.E.2    Natarajan, L.3
  • 21
    • 84858984798 scopus 로고    scopus 로고
    • The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches
    • De Luca A, Maiello MR, D'Alessio A, et al (2012). The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets, 16, 17-27.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 17-27
    • De Luca, A.1    Maiello, M.R.2    D'Alessio, A.3
  • 22
    • 84892420958 scopus 로고    scopus 로고
    • Cost-effectiveness of lapatinib plus letrozole in post-menopausal women with hormone receptor-and HER2-positive metastatic breast cancer
    • Delea TE, Hawkes C, Amonkar MM, et al (2013). Cost-effectiveness of lapatinib plus letrozole in post-menopausal women with hormone receptor-and HER2-positive metastatic breast cancer. Breast Care (Basel), 8, 429-37.
    • (2013) Breast Care (Basel) , vol.8 , pp. 429-437
    • Delea, T.E.1    Hawkes, C.2    Amonkar, M.M.3
  • 23
    • 84928609969 scopus 로고    scopus 로고
    • The HER2 signaling network in breast cancer-like a spider in its web
    • [Epub ahead of print]
    • Dittrich A, Gautrey H, Browell D, et al (2014). The HER2 signaling network in breast cancer-like a spider in its web. J Mammary Gland Biol Neoplasia, [Epub ahead of print].
    • (2014) J Mammary Gland Biol Neoplasia
    • Dittrich, A.1    Gautrey, H.2    Browell, D.3
  • 24
    • 84967239659 scopus 로고    scopus 로고
    • Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis
    • Dong Y, Van Tine BA, Oyama T, et al (2014). Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis. Cell Res, 24, 1354-66.
    • (2014) Cell Res , vol.24 , pp. 1354-1366
    • Dong, Y.1    Van Tine, B.A.2    Oyama, T.3
  • 25
    • 84925485871 scopus 로고    scopus 로고
    • Predicting early brain metastases based on clinicopathological factors and gene expression analysis in advanced HER2-positive breast cancer patients
    • Duchnowska R, Jassem J, Goswami CP, et al (2015). Predicting early brain metastases based on clinicopathological factors and gene expression analysis in advanced HER2-positive breast cancer patients. J Neurooncol, 122, 205-16.
    • (2015) J Neurooncol , vol.122 , pp. 205-216
    • Duchnowska, R.1    Jassem, J.2    Goswami, C.P.3
  • 26
    • 84891354826 scopus 로고    scopus 로고
    • PI3K regulates MEK/ERK signaling in breast cancer via the rac-GEF, P-Rex1
    • Ebi H, Costa C, Faber AC, et al (2013). PI3K regulates MEK/ERK signaling in breast cancer via the rac-GEF, P-Rex1. Proc Natl Acad Sci U S A, 110, 21124-9.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 21124-21129
    • Ebi, H.1    Costa, C.2    Faber, A.C.3
  • 27
    • 84855568731 scopus 로고    scopus 로고
    • HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy
    • Fountzilas G, Valavanis C, Kotoula V, et al (2012). HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy. J Transl Med, 10, 10.
    • (2012) J Transl Med , vol.10 , pp. 10
    • Fountzilas, G.1    Valavanis, C.2    Kotoula, V.3
  • 28
    • 67649452382 scopus 로고    scopus 로고
    • The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies
    • Freudenberg JA, Wang Q, Katsumata M, et al (2009). The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies. Exp Mol Pathol, 87, 1-11.
    • (2009) Exp Mol Pathol , vol.87 , pp. 1-11
    • Freudenberg, J.A.1    Wang, Q.2    Katsumata, M.3
  • 29
    • 84873370707 scopus 로고    scopus 로고
    • Dual blockade of HER2 in HER2-overexpressing tumor cells does not completely eliminate HER3 function
    • Garrett J, Sutton C, Kuba M, et al (2013). Dual blockade of HER2 in HER2-overexpressing tumor cells does not completely eliminate HER3 function. Clin Cancer Res, 19, 610-9.
    • (2013) Clin Cancer Res , vol.19 , pp. 610-619
    • Garrett, J.1    Sutton, C.2    Kuba, M.3
  • 30
    • 4444372733 scopus 로고    scopus 로고
    • Pilot study of the mechanism of action ofpreoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2
    • Gennari R, Menard S, Fagnoni F, et al (2004). Pilot study of the mechanism of action ofpreoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2. Clin Cancer Res, 10, 5650-5.
    • (2004) Clin Cancer Res , vol.10 , pp. 5650-5655
    • Gennari, R.1    Menard, S.2    Fagnoni, F.3
  • 31
    • 84894541188 scopus 로고    scopus 로고
    • ErbB2 upregulates the Na+, HCO3 (-)-cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Kruppel-like factor 4
    • Gorbatenko A, Olesen CW, Morup N, et al (2014). ErbB2 upregulates the Na+, HCO3 (-)-cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Kruppel-like factor 4. Faseb J, 28, 350-63.
    • (2014) Faseb J , vol.28 , pp. 350-363
    • Gorbatenko, A.1    Olesen, C.W.2    Morup, N.3
  • 32
    • 84900513002 scopus 로고    scopus 로고
    • HER2/HER3 heterodimers and p21 expression are capable of predicting adjuvant trastuzumab response in HER2+ breast cancer
    • Green AR, Barros FF, Abdel-Fatah TM, et al (2014). HER2/HER3 heterodimers and p21 expression are capable of predicting adjuvant trastuzumab response in HER2+ breast cancer. Breast Cancer Res Treat, 145, 33-44.
    • (2014) Breast Cancer Res Treat , vol.145 , pp. 33-44
    • Green, A.R.1    Barros, F.F.2    Abdel-Fatah, T.M.3
  • 33
    • 84904308303 scopus 로고    scopus 로고
    • Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells
    • Hosonaga M, Arima Y, Sugihara E, et al (2014). Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells. Cancer Sci, 105, 779-87.
    • (2014) Cancer Sci , vol.105 , pp. 779-787
    • Hosonaga, M.1    Arima, Y.2    Sugihara, E.3
  • 34
    • 84890118466 scopus 로고    scopus 로고
    • Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy
    • Huang L, Chen T, Chen C, et al (2013). Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy. World J Surg Oncol, 11, 307.
    • (2013) World J Surg Oncol , vol.11 , pp. 307
    • Huang, L.1    Chen, T.2    Chen, C.3
  • 35
    • 84919480571 scopus 로고    scopus 로고
    • Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib
    • Huang W, Wu QD, Zhang M, et al (2015). Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib. Cancer Lett, 356, 862-71.
    • (2015) Cancer Lett , vol.356 , pp. 862-871
    • Huang, W.1    Wu, Q.D.2    Zhang, M.3
  • 36
    • 84902044721 scopus 로고    scopus 로고
    • FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation
    • Huang W, Ye M, Zhang LR, et al (2014). FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol Cancer, 13, 150.
    • (2014) Mol Cancer , vol.13 , pp. 150
    • Huang, W.1    Ye, M.2    Zhang, L.R.3
  • 37
    • 84887667026 scopus 로고    scopus 로고
    • A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors
    • Hudis C, Swanton C, Janjigian YY, et al (2013). A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors. Breast Cancer Res, 15, 110.
    • (2013) Breast Cancer Res , vol.15 , pp. 110
    • Hudis, C.1    Swanton, C.2    Janjigian, Y.Y.3
  • 38
    • 84919630737 scopus 로고    scopus 로고
    • MicroRNA-7 Inhibits multiple oncogenic pathways to suppress HER2Delta16 mediated breast tumorigenesis and reverse trastuzumab resistance
    • Huynh FC, Jones FE (2014). MicroRNA-7 Inhibits multiple oncogenic pathways to suppress HER2Delta16 mediated breast tumorigenesis and reverse trastuzumab resistance. PLoS One, 9, 114419.
    • (2014) PLoS One , vol.9 , pp. 114419
    • Huynh, F.C.1    Jones, F.E.2
  • 39
    • 84870672644 scopus 로고    scopus 로고
    • Temporal profiling of lapatinib-suppressed phosphorylation signals in EGFR/HER2 pathways
    • Imami K, Sugiyama N, Imamura H, et al (2012). Temporal profiling of lapatinib-suppressed phosphorylation signals in EGFR/HER2 pathways. Mol Cell Proteomics, 11, 1741-57.
    • (2012) Mol Cell Proteomics , vol.11 , pp. 1741-1757
    • Imami, K.1    Sugiyama, N.2    Imamura, H.3
  • 40
    • 84925831666 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 (HER2) in Cancers: overexpression and therapeutic implications
    • Iqbal N, Iqbal N (2014). Human epidermal growth factor receptor 2 (HER2) in Cancers: overexpression and therapeutic implications. Mol Biol Int, 2014, 852748.
    • (2014) Mol Biol Int , vol.2014 , pp. 852748
    • Iqbal, N.1    Iqbal, N.2
  • 41
    • 84897052943 scopus 로고    scopus 로고
    • Structure-activity relationships of peptidomimetics that inhibit PPI of HER2-HER3
    • Kanthala S, Gauthier T, Satyanarayanajois S (2014). Structure-activity relationships of peptidomimetics that inhibit PPI of HER2-HER3. Biopolymers, 101, 693-702.
    • (2014) Biopolymers , vol.101 , pp. 693-702
    • Kanthala, S.1    Gauthier, T.2    Satyanarayanajois, S.3
  • 42
    • 84919832238 scopus 로고    scopus 로고
    • Pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer
    • Kawajiri H, Takashima T, Kashiwagi S, et al (2015). Pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer. Expert Rev Anticancer Ther, 15, 17-26.
    • (2015) Expert Rev Anticancer Ther , vol.15 , pp. 17-26
    • Kawajiri, H.1    Takashima, T.2    Kashiwagi, S.3
  • 43
    • 84910639102 scopus 로고    scopus 로고
    • Centchroman suppresses breast cancer metastasis by reversing epithelial-mesenchymal transition via downregulation of HER2/ERK1/2/MMP-9 signaling
    • Khan S, Shukla S, Sinha S, et al (2015). Centchroman suppresses breast cancer metastasis by reversing epithelial-mesenchymal transition via downregulation of HER2/ERK1/2/MMP-9 signaling. Int J Biochem Cell Biol, 58, 1-16.
    • (2015) Int J Biochem Cell Biol , vol.58 , pp. 1-16
    • Khan, S.1    Shukla, S.2    Sinha, S.3
  • 44
    • 84888307687 scopus 로고    scopus 로고
    • A systematic review of dual targeting in HER2-positive breast cancer
    • Kumler I, Tuxen MK, Nielsen DL (2014). A systematic review of dual targeting in HER2-positive breast cancer. Cancer Treat Rev, 40, 259-70.
    • (2014) Cancer Treat Rev , vol.40 , pp. 259-270
    • Kumler, I.1    Tuxen, M.K.2    Nielsen, D.L.3
  • 45
    • 84930697083 scopus 로고    scopus 로고
    • Inhibition of EGFR, HER2 and HER3 signaling with AZD8931 alone and in combination with paclitaxel: phase i study in Japanese patients with advanced solid malignancies and advanced breast cancer
    • Kurata T, Tsurutani J, Fujisaka Y, et al (2014). Inhibition of EGFR, HER2 and HER3 signaling with AZD8931 alone and in combination with paclitaxel: phase i study in Japanese patients with advanced solid malignancies and advanced breast cancer. Invest New Drugs, 32, 946-54.
    • (2014) Invest New Drugs , vol.32 , pp. 946-954
    • Kurata, T.1    Tsurutani, J.2    Fujisaka, Y.3
  • 46
    • 77956070565 scopus 로고    scopus 로고
    • Anti-HER2 vaccines: new prospects for breast cancer therapy
    • Ladjemi MZ, Jacot W, Chardes T, et al (2010). Anti-HER2 vaccines: new prospects for breast cancer therapy. Cancer Immunol Immunother, 59, 1295-312.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1295-1312
    • Ladjemi, M.Z.1    Jacot, W.2    Chardes, T.3
  • 47
    • 84938288374 scopus 로고    scopus 로고
    • The effect of adjuvant trastuzumab on locoregional recurrence of human epidermal growth factor receptor 2-positive breast cancer treated with mastectomy
    • Lanning RM, Morrow M, Riaz N, et al (2015). The effect of adjuvant trastuzumab on locoregional recurrence of human epidermal growth factor receptor 2-positive breast cancer treated with mastectomy. Ann Surg Oncol.
    • (2015) Ann Surg Oncol.
    • Lanning, R.M.1    Morrow, M.2    Riaz, N.3
  • 48
    • 84927741187 scopus 로고    scopus 로고
    • Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy
    • Lapin V, Shirdel EA, Wei X, et al (2014). Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy. Oncogenesis, 3, 133.
    • (2014) Oncogenesis , vol.3 , pp. 133
    • Lapin, V.1    Shirdel, E.A.2    Wei, X.3
  • 49
    • 84920686176 scopus 로고    scopus 로고
    • Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer
    • Lee HJ, Seo AN, Kim EJ, et al (2015). Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer. Br J Cancer, 112, 103-11.
    • (2015) Br J Cancer , vol.112 , pp. 103-111
    • Lee, H.J.1    Seo, A.N.2    Kim, E.J.3
  • 50
    • 84908105853 scopus 로고    scopus 로고
    • Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells
    • Lee MY, Marina M, King JL, et al (2014). Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells. Cell Div, 9, 3.
    • (2014) Cell Div , vol.9 , pp. 3
    • Lee, M.Y.1    Marina, M.2    King, J.L.3
  • 51
    • 84892953786 scopus 로고    scopus 로고
    • High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth
    • Leivonen SK, Sahlberg KK, Makela R, et al (2014). High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth. Mol Oncol, 8, 93-104.
    • (2014) Mol Oncol , vol.8 , pp. 93-104
    • Leivonen, S.K.1    Sahlberg, K.K.2    Makela, R.3
  • 52
    • 84916910754 scopus 로고    scopus 로고
    • ER-Poor and HER2-positive: a potential subtype of breast cancer to avoid axillary dissection in node positive patients after neoadjuvant chemo-trastuzumab therapy
    • Li JW, Mo M, Yu KD, et al (2014). ER-Poor and HER2-positive: a potential subtype of breast cancer to avoid axillary dissection in node positive patients after neoadjuvant chemo-trastuzumab therapy. PLoS One, 9, 114646.
    • (2014) PLoS One , vol.9 , pp. 114646
    • Li, J.W.1    Mo, M.2    Yu, K.D.3
  • 53
    • 84889050826 scopus 로고    scopus 로고
    • Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker
    • Liu Y, Liu Q, Wang T, et al (2013). Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker. BMC Cancer, 13, 202.
    • (2013) BMC Cancer , vol.13 , pp. 202
    • Liu, Y.1    Liu, Q.2    Wang, T.3
  • 54
    • 84928617782 scopus 로고    scopus 로고
    • (188) Re-HYNIC-trastuzumab enhances the effect of apoptosis induced by trastuzumab in HER2-overexpressing breast cancer cells
    • Luo TY, Cheng PC, Chiang PF, et al (2015). (188) Re-HYNIC-trastuzumab enhances the effect of apoptosis induced by trastuzumab in HER2-overexpressing breast cancer cells. Ann Nucl Med, 29, 52-62.
    • (2015) Ann Nucl Med , vol.29 , pp. 52-62
    • Luo, T.Y.1    Cheng, P.C.2    Chiang, P.F.3
  • 55
    • 79959584093 scopus 로고    scopus 로고
    • Combining emerging agents in advanced breast cancer
    • Luu T, Chung C, Somlo G (2011). Combining emerging agents in advanced breast cancer. Oncologist, 16, 760-71.
    • (2011) Oncologist , vol.16 , pp. 760-771
    • Luu, T.1    Chung, C.2    Somlo, G.3
  • 56
    • 84890869129 scopus 로고    scopus 로고
    • Co-targeting estrogen receptor and HER2 pathways in breast cancer
    • Mehta A, Tripathy D (2014). Co-targeting estrogen receptor and HER2 pathways in breast cancer. Breast, 23, 2-9.
    • (2014) Breast , vol.23 , pp. 2-9
    • Mehta, A.1    Tripathy, D.2
  • 57
    • 60549105908 scopus 로고    scopus 로고
    • tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO)
    • Menendez JA, Vazquez-Martin A, Garcia-Villalba R, et al (2008). tabAnti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial Extra-Virgin Olive Oil (EVOO). BMC Cancer, 8, 377.
    • (2008) BMC Cancer , vol.8 , pp. 377
    • Menendez, J.A.1    Vazquez-Martin, A.2    Garcia-Villalba, R.3
  • 58
    • 84928596873 scopus 로고    scopus 로고
    • Prevalence of HER-2 and hormone receptors and P53 mutations in the pathologic specimens of breast cancer patients
    • Mirmalek SA, Hajilou M, Salimi Tabatabaee SA, et al (2014). Prevalence of HER-2 and hormone receptors and P53 mutations in the pathologic specimens of breast cancer patients. Int J Breast Cancer, 2014, 564308.
    • (2014) Int J Breast Cancer , vol.2014 , pp. 564308
    • Mirmalek, S.A.1    Hajilou, M.2    Salimi Tabatabaee, S.A.3
  • 59
    • 77954540202 scopus 로고    scopus 로고
    • A novel interaction between HER2/neu and cyclin E in breast cancer
    • Mittendorf EA, Liu Y, Tucker SL, et al (2010). A novel interaction between HER2/neu and cyclin E in breast cancer. Oncogene, 29, 3896-907.
    • (2010) Oncogene , vol.29 , pp. 3896-3907
    • Mittendorf, E.A.1    Liu, Y.2    Tucker, S.L.3
  • 60
    • 84869781977 scopus 로고    scopus 로고
    • Overcoming resistance and restoring sensitivity to HER2-targeted therapies in breast cancer
    • Mohd Sharial MSN, Crown J, Hennessy BT (2012). Overcoming resistance and restoring sensitivity to HER2-targeted therapies in breast cancer. Ann Oncol, 23, 3007-16.
    • (2012) Ann Oncol , vol.23 , pp. 3007-3016
    • Mohd Sharial, M.S.N.1    Crown, J.2    Hennessy, B.T.3
  • 61
    • 84939885519 scopus 로고    scopus 로고
    • PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling
    • [Epub ahead of print]
    • Moody SE, Schinzel AC, Singh S, et al (2014). PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling. Oncogene, [Epub ahead of print].
    • (2014) Oncogene
    • Moody, S.E.1    Schinzel, A.C.2    Singh, S.3
  • 62
    • 84896546116 scopus 로고    scopus 로고
    • Therapeutic potential of the dual EGFR/HER2 inhibitor AZD8931 in circumventing endocrine resistance
    • Morrison G, Fu X, Shea M, et al (2014). Therapeutic potential of the dual EGFR/HER2 inhibitor AZD8931 in circumventing endocrine resistance. Breast Cancer Res Treat, 144, 263-72.
    • (2014) Breast Cancer Res Treat , vol.144 , pp. 263-272
    • Morrison, G.1    Fu, X.2    Shea, M.3
  • 63
    • 84894733061 scopus 로고    scopus 로고
    • Functional imaging of human epidermal growth factor receptor 2-positive metastatic breast cancer using (64)Cu-DOTA-trastuzumab PET
    • Mortimer JE, Bading JR, Colcher DM, et al (2014). Functional imaging of human epidermal growth factor receptor 2-positive metastatic breast cancer using (64)Cu-DOTA-trastuzumab PET. J Nucl Med, 55, 23-9.
    • (2014) J Nucl Med , vol.55 , pp. 23-29
    • Mortimer, J.E.1    Bading, J.R.2    Colcher, D.M.3
  • 64
    • 84903991659 scopus 로고    scopus 로고
    • Significant survival impact of MACC1 polymorphisms in HER2 positive breast cancer patients
    • Muendlein A, Hubalek M, Geller-Rhomberg S, et al (2014). Significant survival impact of MACC1 polymorphisms in HER2 positive breast cancer patients. Eur J Cancer, 50, 2134-41.
    • (2014) Eur J Cancer , vol.50 , pp. 2134-2141
    • Muendlein, A.1    Hubalek, M.2    Geller-Rhomberg, S.3
  • 65
    • 84876266920 scopus 로고    scopus 로고
    • Molecular mechanisms of trastuzumab-based treatment in HER2-overexpressing breast cancer
    • Nahta R (2012). Molecular mechanisms of trastuzumab-based treatment in HER2-overexpressing breast cancer. ISRN Oncol, 2012.
    • (2012) ISRN Oncol, 2012
    • Nahta, R.1
  • 66
    • 84904984976 scopus 로고    scopus 로고
    • c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer
    • Nair R, Roden DL, Teo WS, et al (2014). c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer. Oncogene, 33, 3992-4002.
    • (2014) Oncogene , vol.33 , pp. 3992-4002
    • Nair, R.1    Roden, D.L.2    Teo, W.S.3
  • 67
    • 84919485646 scopus 로고    scopus 로고
    • A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer
    • Nam S, Chang HR, Jung HR, et al (2015). A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer. Cancer Lett, 356, 880-90.
    • (2015) Cancer Lett , vol.356 , pp. 880-890
    • Nam, S.1    Chang, H.R.2    Jung, H.R.3
  • 68
    • 84904610164 scopus 로고    scopus 로고
    • miR-21 expression in cancer cells may not predict resistance to adjuvant trastuzumab in primary breast cancer
    • Nielsen BS, Balslev E, Poulsen TS, et al (2014). miR-21 expression in cancer cells may not predict resistance to adjuvant trastuzumab in primary breast cancer. Front Oncol, 4, 207.
    • (2014) Front Oncol , vol.4 , pp. 207
    • Nielsen, B.S.1    Balslev, E.2    Poulsen, T.S.3
  • 69
    • 84904434702 scopus 로고    scopus 로고
    • A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines
    • Omenn GS, Guan Y, Menon R (2014). A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines. J Proteomics, 107, 103-12.
    • (2014) J Proteomics , vol.107 , pp. 103-112
    • Omenn, G.S.1    Guan, Y.2    Menon, R.3
  • 70
    • 84891824350 scopus 로고    scopus 로고
    • IGKC and FcgammaR genotypes and humoral immunity to HER2 in breast cancer
    • Pandey JP, Kistner-Griffin E, Black L, et al (2014). IGKC and FcgammaR genotypes and humoral immunity to HER2 in breast cancer. Immunobiol, 219, 113-7.
    • (2014) Immunobiol , vol.219 , pp. 113-117
    • Pandey, J.P.1    Kistner-Griffin, E.2    Black, L.3
  • 71
    • 84901889553 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in PIK3CA gene is inversely associated with P53 protein expression in breast cancer
    • Pang B, Sun SP, Gao L, et al (2014). A single nucleotide polymorphism in PIK3CA gene is inversely associated with P53 protein expression in breast cancer. Med Oncol, 31, 30.
    • (2014) Med Oncol , vol.31 , pp. 30
    • Pang, B.1    Sun, S.P.2    Gao, L.3
  • 72
    • 84893353153 scopus 로고    scopus 로고
    • Detection of HER2 status in breast cancer: comparison of current methods with MLPA and real-time RT-PCR
    • Pazhoomand R, Keyhani E, Banan M, et al (2013). Detection of HER2 status in breast cancer: comparison of current methods with MLPA and real-time RT-PCR. Asian Pac J Cancer Prev, 14, 7621-8.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 7621-7628
    • Pazhoomand, R.1    Keyhani, E.2    Banan, M.3
  • 73
    • 84930718892 scopus 로고    scopus 로고
    • Molecular features and survival outcomes of the intrinsic subtypes within HER2-positive breast cancer
    • Prat A, Carey LA, Adamo B, et al (2014). Molecular features and survival outcomes of the intrinsic subtypes within HER2-positive breast cancer. J Natl Cancer Inst, 106.
    • (2014) J Natl Cancer Inst , pp. 106
    • Prat, A.1    Carey, L.A.2    Adamo, B.3
  • 74
    • 84961290694 scopus 로고    scopus 로고
    • Updated UK recommendations for HER2 assessment in breast cancer
    • Rakha EA, Pinder SE, Bartlett JM, et al (2015). Updated UK recommendations for HER2 assessment in breast cancer. J Clin Pathol, 68, 93-9
    • (2015) J Clin Pathol , vol.68 , pp. 93-99
    • Rakha, E.A.1    Pinder, S.E.2    Bartlett, J.M.3
  • 75
    • 84928641230 scopus 로고    scopus 로고
    • A neoadjuvant, randomized, open-label phase II trial of afatinib versus trastuzumab versus lapatinib in patients with locally advanced HER2-positive breast cancer
    • Rimawi MF, Aleixo SB, Rozas AA, et al (2014). A neoadjuvant, randomized, open-label phase II trial of afatinib versus trastuzumab versus lapatinib in patients with locally advanced HER2-positive breast cancer. Clin Breast Cancer.
    • (2014) Clin Breast Cancer
    • Rimawi, M.F.1    Aleixo, S.B.2    Rozas, A.A.3
  • 76
    • 84908137256 scopus 로고    scopus 로고
    • HER2 overexpression a major risk factor for recurrence in pT1a-bN0M0 breast cancer: results from a French regional cohort
    • Rouanet P, Roger P, Rousseau E, et al (2014). HER2 overexpression a major risk factor for recurrence in pT1a-bN0M0 breast cancer: results from a French regional cohort. Cancer Med, 3, 134-42.
    • (2014) Cancer Med , vol.3 , pp. 134-142
    • Rouanet, P.1    Roger, P.2    Rousseau, E.3
  • 77
    • 84887059018 scopus 로고    scopus 로고
    • Racial disparities in treatment patterns and clinical outcomes in patients with HER2-positive metastatic breast cancer
    • Rugo HS, Brufsky AM, Ulcickas Yood M, et al (2013). Racial disparities in treatment patterns and clinical outcomes in patients with HER2-positive metastatic breast cancer. Breast Cancer Res Treat, 141, 461-70.
    • (2013) Breast Cancer Res Treat , vol.141 , pp. 461-470
    • Rugo, H.S.1    Brufsky, A.M.2    Ulcickas Yood, M.3
  • 78
    • 84964307819 scopus 로고    scopus 로고
    • High HER2 expression correlates with response to the combination of lapatinib and trastuzumab
    • Scaltriti M, Nuciforo P, Bradbury I, et al (2014). High HER2 expression correlates with response to the combination of lapatinib and trastuzumab. Clin Cancer Res, 21, 569-76.
    • (2014) Clin Cancer Res , vol.21 , pp. 569-576
    • Scaltriti, M.1    Nuciforo, P.2    Bradbury, I.3
  • 79
    • 84907439121 scopus 로고    scopus 로고
    • Small molecule tyrosine kinase inhibitors of ErbB2/HER2/Neu in the treatment of aggressive breast cancer
    • Schroeder RL, Stevens CL, Sridhar J (2014). Small molecule tyrosine kinase inhibitors of ErbB2/HER2/Neu in the treatment of aggressive breast cancer. Molecules, 19, 15196-212.
    • (2014) Molecules , vol.19 , pp. 15196-15212
    • Schroeder, R.L.1    Stevens, C.L.2    Sridhar, J.3
  • 80
    • 84888776574 scopus 로고    scopus 로고
    • HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab
    • Sclafani F, Roy A, Cunningham D, et al (2013). HER2 in high-risk rectal cancer patients treated in EXPERT-C, a randomized phase II trial of neoadjuvant capecitabine and oxaliplatin (CAPOX) and chemoradiotherapy (CRT) with or without cetuximab. Ann Oncol, 24, 3123-8.
    • (2013) Ann Oncol , vol.24 , pp. 3123-3128
    • Sclafani, F.1    Roy, A.2    Cunningham, D.3
  • 81
    • 84925535810 scopus 로고    scopus 로고
    • Calcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cells
    • Segovia-Mendoza M, Diaz L, Gonzalez-Gonzalez ME, et al (2015). Calcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cells. J Steroid Biochem Mol Biol, 148, 122-31
    • (2015) J Steroid Biochem Mol Biol , vol.148 , pp. 122-131
    • Segovia-Mendoza, M.1    Diaz, L.2    Gonzalez-Gonzalez, M.E.3
  • 82
    • 84920491466 scopus 로고    scopus 로고
    • Pathologic complete response rates in triple-negative, HER2-positive, and hormone receptor-positive breast cancers after anthracycline-free neoadjuvant chemotherapy with carboplatin and paclitaxel with or without trastuzumab
    • Shinde AM, Zhai J, Yu KW, et al (2015). Pathologic complete response rates in triple-negative, HER2-positive, and hormone receptor-positive breast cancers after anthracycline-free neoadjuvant chemotherapy with carboplatin and paclitaxel with or without trastuzumab. Breast, 24, 18-23.
    • (2015) Breast , vol.24 , pp. 18-23
    • Shinde, A.M.1    Zhai, J.2    Yu, K.W.3
  • 83
    • 84925393960 scopus 로고    scopus 로고
    • Phase 1 dose-escalation study of S-222611, an oral reversible dual tyrosine kinase inhibitor of EGFR and HER2, in patients with solid tumours
    • Spicer J, Baird R, Suder A, et al (2015). Phase 1 dose-escalation study of S-222611, an oral reversible dual tyrosine kinase inhibitor of EGFR and HER2, in patients with solid tumours. Eur J Cancer, 51, 137-45.
    • (2015) Eur J Cancer , vol.51 , pp. 137-145
    • Spicer, J.1    Baird, R.2    Suder, A.3
  • 84
    • 84919909647 scopus 로고    scopus 로고
    • An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer
    • Sueta A, Yamamoto Y, Yamamoto-Ibusuki M, et al (2014). An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer. PLoS One, 9, 116054.
    • (2014) PLoS One , vol.9 , pp. 116054
    • Sueta, A.1    Yamamoto, Y.2    Yamamoto-Ibusuki, M.3
  • 85
    • 84987932389 scopus 로고    scopus 로고
    • "Omics" and Immunologic approaches to optimizing cure rates in HER2-positive breast carcinomas
    • Tagliabue E, Campiglio M (2014). "Omics" and Immunologic approaches to optimizing cure rates in HER2-positive breast carcinomas. Front Oncol, 4, 334.
    • (2014) Front Oncol , vol.4 , pp. 334
    • Tagliabue, E.1    Campiglio, M.2
  • 86
    • 84886753482 scopus 로고    scopus 로고
    • Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy
    • Takada M, Higuchi T, Tozuka K, et al (2013). Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy. BMC Cancer, 13, 241.
    • (2013) BMC Cancer , vol.13 , pp. 241
    • Takada, M.1    Higuchi, T.2    Tozuka, K.3
  • 87
    • 84920561845 scopus 로고    scopus 로고
    • Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer
    • Tolaney SM, Barry WT, Dang CT, et al (2015). Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer. N Engl J Med, 372, 134-41.
    • (2015) N Engl J Med , vol.372 , pp. 134-141
    • Tolaney, S.M.1    Barry, W.T.2    Dang, C.T.3
  • 88
    • 84898789008 scopus 로고    scopus 로고
    • Overexpression of HER-2/neu protein attenuates the oxidative systemic profile in women diagnosed with breast cancer
    • Victorino VJ, Campos FC, Herrera AC, et al (2014). Overexpression of HER-2/neu protein attenuates the oxidative systemic profile in women diagnosed with breast cancer. Tumour Biol, 35, 3025-34.
    • (2014) Tumour Biol , vol.35 , pp. 3025-3034
    • Victorino, V.J.1    Campos, F.C.2    Herrera, A.C.3
  • 89
    • 44849124183 scopus 로고    scopus 로고
    • Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer
    • Wu Y, Mohamed H, Chillar R, et al (2008). Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. Breast Cancer Res, 10, 3.
    • (2008) Breast Cancer Res , vol.10 , pp. 3
    • Wu, Y.1    Mohamed, H.2    Chillar, R.3
  • 90
    • 84884170935 scopus 로고    scopus 로고
    • An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models
    • Xia W, Petricoin EF, Zhao S, et al (2013). An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models. Breast Cancer Res, 15, 85.
    • (2013) Breast Cancer Res , vol.15 , pp. 85
    • Xia, W.1    Petricoin, E.F.2    Zhao, S.3
  • 91
    • 84891936355 scopus 로고    scopus 로고
    • S100A14, a member of the EF-hand calcium-binding proteins, is overexpressed in breast cancer and acts as a modulator of HER2 signaling
    • Xu C, Chen H, Wang X, et al (2014). S100A14, a member of the EF-hand calcium-binding proteins, is overexpressed in breast cancer and acts as a modulator of HER2 signaling. J Biol Chem, 289, 827-37.
    • (2014) J Biol Chem , vol.289 , pp. 827-837
    • Xu, C.1    Chen, H.2    Wang, X.3
  • 92
    • 84939873145 scopus 로고    scopus 로고
    • A novel function of HER2/Neu in the activation of G2/M checkpoint in response to gamma-irradiation
    • [Epub ahead of print]
    • Yan Y, Hein AL, Greer PM, et al (2014). A novel function of HER2/Neu in the activation of G2/M checkpoint in response to gamma-irradiation. Oncogene, 0. [Epub ahead of print]
    • (2014) Oncogene , pp. 0
    • Yan, Y.1    Hein, A.L.2    Greer, P.M.3
  • 93
    • 84921418304 scopus 로고    scopus 로고
    • Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors
    • Yeh ES, Abt MA, Hill EG (2014). Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors. Breast Cancer Res Treat, 149, 91-8
    • (2014) Breast Cancer Res Treat , vol.149 , pp. 91-98
    • Yeh, E.S.1    Abt, M.A.2    Hill, E.G.3
  • 94
    • 84925482750 scopus 로고    scopus 로고
    • Trastuzumab interruption and treatment-induced cardiotoxicity in early HER2-positive breast cancer
    • Yu AF, Yadav NU, Lung BY, et al (2015). Trastuzumab interruption and treatment-induced cardiotoxicity in early HER2-positive breast cancer. Breast Cancer Res Treat, 149, 489-95.
    • (2015) Breast Cancer Res Treat , vol.149 , pp. 489-495
    • Yu, A.F.1    Yadav, N.U.2    Lung, B.Y.3
  • 95
    • 84904736127 scopus 로고    scopus 로고
    • C-FLIP (L) contributes to TRAIL resistance in HER2-positive breast cancer
    • Zang F, Wei X, Leng X, et al (2014). C-FLIP (L) contributes to TRAIL resistance in HER2-positive breast cancer. Biochem Biophys Res Commun, 450, 267-73.
    • (2014) Biochem Biophys Res Commun , vol.450 , pp. 267-273
    • Zang, F.1    Wei, X.2    Leng, X.3
  • 96
    • 79953745096 scopus 로고    scopus 로고
    • Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
    • Zhang S, Huang WC, Li P, et al (2011). Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med, 17, 461-9.
    • (2011) Nat Med , vol.17 , pp. 461-469
    • Zhang, S.1    Huang, W.C.2    Li, P.3
  • 97
    • 84893386775 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab added to standard treatments for HER2-positive metastatic breast cancer patients
    • Zhu ZL, Zhang J, Chen ML, et al (2013). Efficacy and safety of trastuzumab added to standard treatments for HER2-positive metastatic breast cancer patients. Asian Pac J Cancer Prev, 14, 7111-6.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 7111-7116
    • Zhu, Z.L.1    Zhang, J.2    Chen, M.L.3


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