-
2
-
-
34347395733
-
Trastuzumab - Mechanism of action and use in clinical practice
-
Hudis CA,. Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med 2007; 357: 39-51.
-
(2007)
N Engl J Med
, vol.357
, pp. 39-51
-
-
Hudis, C.A.1
-
3
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
et al.
-
Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-82.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
4
-
-
0036534121
-
Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
-
et al.
-
Esteva FJ, Valero V, Booser D, et al. Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 2002; 20: 1800-8.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1800-1808
-
-
Esteva, F.J.1
Valero, V.2
Booser, D.3
-
5
-
-
84865401715
-
Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
-
et al.
-
Korkaya H, Kim GI, Davis A, et al. Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. Mol Cell 2012; 47: 570-84.
-
(2012)
Mol Cell
, vol.47
, pp. 570-584
-
-
Korkaya, H.1
Kim, G.I.2
Davis, A.3
-
6
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA,. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
7
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
-
Polyak K, Weinberg RA,. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9: 265-73.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 265-273
-
-
Polyak, K.1
Weinberg, R.A.2
-
8
-
-
79957809539
-
Cancer early dissemination: Cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor beta signalling
-
Sabe H,. Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor beta signalling. J Biochem 2011; 149: 633-9.
-
(2011)
J Biochem
, vol.149
, pp. 633-639
-
-
Sabe, H.1
-
9
-
-
84870020040
-
MED12 controls the response to multiple cancer drugs through regulation of TGF-beta receptor signaling
-
et al.
-
Huang S, Holzel M, Knijnenburg T, et al. MED12 controls the response to multiple cancer drugs through regulation of TGF-beta receptor signaling. Cell 2012; 151: 937-50.
-
(2012)
Cell
, vol.151
, pp. 937-950
-
-
Huang, S.1
Holzel, M.2
Knijnenburg, T.3
-
10
-
-
84857140780
-
The functional crosstalk between HER2 tyrosine kinase and TGF-beta signaling in breast cancer malignancy
-
Wang SE,. The functional crosstalk between HER2 tyrosine kinase and TGF-beta signaling in breast cancer malignancy. J Signal Transduct 2011; 2011: 804236.
-
(2011)
J Signal Transduct
, vol.2011
, pp. 804236
-
-
Wang, S.E.1
-
11
-
-
47549090432
-
TGFbeta in Cancer
-
Massague J,. TGFbeta in Cancer. Cell 2008; 134: 215-30.
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massague, J.1
-
12
-
-
84863928222
-
ZNF217 is a marker of poor prognosis in breast cancer that drives epithelial-mesenchymal transition and invasion
-
et al.
-
Vendrell JA, Thollet A, Nguyen NT, et al. ZNF217 is a marker of poor prognosis in breast cancer that drives epithelial-mesenchymal transition and invasion. Cancer Res 2012; 72: 3593-606.
-
(2012)
Cancer Res
, vol.72
, pp. 3593-3606
-
-
Vendrell, J.A.1
Thollet, A.2
Nguyen, N.T.3
-
13
-
-
65649153358
-
Epithelial-mesenchymal transition: A cancer researcher's conceptual friend and foe
-
Klymkowsky MW, Savagner P,. Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol 2009; 174: 1588-93.
-
(2009)
Am J Pathol
, vol.174
, pp. 1588-1593
-
-
Klymkowsky, M.W.1
Savagner, P.2
-
15
-
-
43049103824
-
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
-
et al.
-
Gregory PA, Bert AG, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10: 593-601.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 593-601
-
-
Gregory, P.A.1
Bert, A.G.2
Paterson, E.L.3
-
16
-
-
79953325707
-
Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition
-
et al.
-
Dave N, Guaita-Esteruelas S, Gutarra S, et al. Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J Biol Chem 2011; 286: 12024-32.
-
(2011)
J Biol Chem
, vol.286
, pp. 12024-12032
-
-
Dave, N.1
Guaita-Esteruelas, S.2
Gutarra, S.3
-
17
-
-
79956313718
-
Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer
-
et al.
-
Gong C, Yao Y, Wang Y, et al. Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J Biol Chem 2011; 286: 19127-37.
-
(2011)
J Biol Chem
, vol.286
, pp. 19127-19137
-
-
Gong, C.1
Yao, Y.2
Wang, Y.3
-
18
-
-
77953973648
-
Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
-
et al.
-
Ulanet DB, Ludwig DL, Kahn CR, et al. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci USA 2010; 107: 10791-8.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 10791-10798
-
-
Ulanet, D.B.1
Ludwig, D.L.2
Kahn, C.R.3
-
19
-
-
0015090564
-
Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro
-
et al.
-
Stephenson JR, Axelrad AA, McLeod DL, et al. Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro. Proc Natl Acad Sci USA 1971; 68: 1542-6.
-
(1971)
Proc Natl Acad Sci USA
, vol.68
, pp. 1542-1546
-
-
Stephenson, J.R.1
Axelrad, A.A.2
McLeod, D.L.3
-
20
-
-
50049105443
-
Pretreatment tumor diameter/volume and pelvic lymph node status assessed by magnetic resonance imaging for uterine cervical carcinoma treated with concurrent chemotherapy and radiotherapy
-
Kim HJ, Kim WC,. Pretreatment tumor diameter/volume and pelvic lymph node status assessed by magnetic resonance imaging for uterine cervical carcinoma treated with concurrent chemotherapy and radiotherapy. J Obstet Gynaecol Res 2008; 34: 529-37.
-
(2008)
J Obstet Gynaecol Res
, vol.34
, pp. 529-537
-
-
Kim, H.J.1
Kim, W.C.2
-
21
-
-
79751473114
-
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
-
et al.
-
Liu C, Kelnar K, Liu B, et al. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 2011; 17: 211-5.
-
(2011)
Nat Med
, vol.17
, pp. 211-215
-
-
Liu, C.1
Kelnar, K.2
Liu, B.3
-
22
-
-
77956178360
-
EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
-
Singh A, Settleman J,. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010; 29: 4741-51.
-
(2010)
Oncogene
, vol.29
, pp. 4741-4751
-
-
Singh, A.1
Settleman, J.2
-
23
-
-
44649163918
-
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
-
et al.
-
Burk U, Schubert J, Wellner U, et al. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 2008; 9: 582-9.
-
(2008)
EMBO Rep
, vol.9
, pp. 582-589
-
-
Burk, U.1
Schubert, J.2
Wellner, U.3
-
24
-
-
84861197166
-
New insights into the mechanisms of organ-specific breast cancer metastasis
-
Lorusso G, Rüegg C,. New insights into the mechanisms of organ-specific breast cancer metastasis. Semin Cancer Biol 2012; 22: 226-33.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 226-233
-
-
Lorusso, G.1
Rüegg, C.2
-
25
-
-
84878016500
-
Reduced in vivo lung metastasis of a breast cancer cell line after treatment with Herceptin mAb conjugated to chemotherapeutic drugs
-
et al.
-
Garcia AG, Nedev H, Bijian K, et al. Reduced in vivo lung metastasis of a breast cancer cell line after treatment with Herceptin mAb conjugated to chemotherapeutic drugs. Oncogene 2013; 32: 2527-33.
-
(2013)
Oncogene
, vol.32
, pp. 2527-2533
-
-
Garcia, A.G.1
Nedev, H.2
Bijian, K.3
-
26
-
-
84863116159
-
Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors
-
et al.
-
Niikura N, Liu J, Hayashi N, et al. Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors. J Clin Oncol 2012; 30: 593-9.
-
(2012)
J Clin Oncol
, vol.30
, pp. 593-599
-
-
Niikura, N.1
Liu, J.2
Hayashi, N.3
-
27
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
et al.
-
Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-90.
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
-
28
-
-
42049116522
-
Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
-
et al.
-
Fuchs BC, Fujii T, Dorfman JD, et al. Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res 2008; 68: 2391-9.
-
(2008)
Cancer Res
, vol.68
, pp. 2391-2399
-
-
Fuchs, B.C.1
Fujii, T.2
Dorfman, J.D.3
-
29
-
-
77957273623
-
TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
-
et al.
-
Yao Z, Fenoglio S, Gao DC, et al. TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proc Natl Acad Sci USA 2010; 107: 15535-40.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 15535-15540
-
-
Yao, Z.1
Fenoglio, S.2
Gao, D.C.3
-
30
-
-
84871392766
-
Expression of Wnt3 activates Wnt/beta-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells
-
et al.
-
Wu Y, Ginther C, Kim J, et al. Expression of Wnt3 activates Wnt/beta-catenin pathway and promotes EMT-like phenotype in trastuzumab- resistant HER2-overexpressing breast cancer cells. Mol Cancer Res 2012; 10: 1597-606.
-
(2012)
Mol Cancer Res
, vol.10
, pp. 1597-1606
-
-
Wu, Y.1
Ginther, C.2
Kim, J.3
-
31
-
-
84883148616
-
Spontaneous epithelial-mesenchymal transition and resistance to HER-2-targeted therapies in HER-2-positive luminal breast cancer
-
et al.
-
Lesniak D, Sabri S, Xu Y, et al. Spontaneous epithelial-mesenchymal transition and resistance to HER-2-targeted therapies in HER-2-positive luminal breast cancer. PLoS One 2013; 8: e71987.
-
(2013)
PLoS One
, vol.8
-
-
Lesniak, D.1
Sabri, S.2
Xu, Y.3
-
32
-
-
56449092072
-
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1
-
et al.
-
Miller TE, Ghoshal K, Ramaswamy B, et al. MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1. J Biol Chem 2008; 283: 29897-903.
-
(2008)
J Biol Chem
, vol.283
, pp. 29897-29903
-
-
Miller, T.E.1
Ghoshal, K.2
Ramaswamy, B.3
-
33
-
-
84878595514
-
Control of metastatic progression by microRNA regulatory networks
-
Pencheva N, Tavazoie SF,. Control of metastatic progression by microRNA regulatory networks. Nat Cell Biol 2013; 15: 546-54.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 546-554
-
-
Pencheva, N.1
Tavazoie, S.F.2
-
34
-
-
84881028557
-
MiR-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer
-
Xia H, Ooi LL, Hui KM,. MiR-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. Hepatology 2013; 58: 629-41.
-
(2013)
Hepatology
, vol.58
, pp. 629-641
-
-
Xia, H.1
Ooi, L.L.2
Hui, K.M.3
-
35
-
-
41649091906
-
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
-
et al.
-
Park SM, Gaur AB, Lengyel E, et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008; 22: 894-907.
-
(2008)
Genes Dev
, vol.22
, pp. 894-907
-
-
Park, S.M.1
Gaur, A.B.2
Lengyel, E.3
-
36
-
-
84876541026
-
Development of therapeutic combinations targeting major cancer signaling pathways
-
Yap TA, Omlin A, de Bono JS,. Development of therapeutic combinations targeting major cancer signaling pathways. J Clin Oncol 2013; 31: 1592-605.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1592-1605
-
-
Yap, T.A.1
Omlin, A.2
De Bono, J.S.3
-
37
-
-
84867984708
-
Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer
-
et al.
-
Gunasinghe NP, Wells A, Thompson EW, et al. Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer. Cancer Metastasis Rev 2012; 31: 469-78.
-
(2012)
Cancer Metastasis Rev
, vol.31
, pp. 469-478
-
-
Gunasinghe, N.P.1
Wells, A.2
Thompson, E.W.3
|