-
2
-
-
84867773087
-
Mitophagy: Mechanisms, pathophysiological roles, and analysis
-
Ding, W.X. & Yin, X.M. Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol. Chem. 393, 547-564 (2012).
-
(2012)
Biol. Chem.
, vol.393
, pp. 547-564
-
-
Ding, W.X.1
Yin, X.M.2
-
3
-
-
84876685141
-
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
-
Lupfer, C. et al. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat. Immunol. 14, 480-488 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 480-488
-
-
Lupfer, C.1
-
4
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou, R., Yazdi, A.S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225 (2011).
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
5
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira, K. et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222-230 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
-
6
-
-
84905573756
-
Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy
-
Hollville, E., Carroll, R.G., Cullen, S.P. & Martin, S.J. Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy. Mol. Cell 55, 451-466 (2014).
-
(2014)
Mol. Cell
, vol.55
, pp. 451-466
-
-
Hollville, E.1
Carroll, R.G.2
Cullen, S.P.3
Martin, S.J.4
-
7
-
-
84890429468
-
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
-
Hasson, S.A. et al. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature 504, 291-295 (2013).
-
(2013)
Nature
, vol.504
, pp. 291-295
-
-
Hasson, S.A.1
-
8
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler, S. et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 12, 119-131 (2010).
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 119-131
-
-
Geisler, S.1
-
9
-
-
84901751574
-
Ubiquitin is phosphorylated by PINK1 to activate parkin
-
Koyano, F. et al. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature 510, 162-166 (2014).
-
(2014)
Nature
, vol.510
, pp. 162-166
-
-
Koyano, F.1
-
10
-
-
66449114033
-
P62 at the crossroads of autophagy, apoptosis, and cancer
-
Moscat, J. & Diaz-Meco, M.T. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137, 1001-1004 (2009).
-
(2009)
Cell
, vol.137
, pp. 1001-1004
-
-
Moscat, J.1
Diaz-Meco, M.T.2
-
11
-
-
77952326081
-
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
-
Lee, J.Y., Nagano, Y., Taylor, J.P., Lim, K.L. & Yao, T.P. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 189, 671-679 (2010).
-
(2010)
J. Cell Biol.
, vol.189
, pp. 671-679
-
-
Lee, J.Y.1
Nagano, Y.2
Taylor, J.P.3
Lim, K.L.4
Yao, T.P.5
-
12
-
-
77954695260
-
P62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
-
Okatsu, K. et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells 15, 887-900 (2010).
-
(2010)
Genes Cells
, vol.15
, pp. 887-900
-
-
Okatsu, K.1
-
13
-
-
77956252454
-
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming
-
Ding, W.X. et al. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J. Biol. Chem. 285, 27879-27890 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 27879-27890
-
-
Ding, W.X.1
-
14
-
-
84900315972
-
Paternal mitochondrial destruction after fertilization is mediated by a common endocytic and autophagic pathway in Drosophila
-
Politi, Y. et al. Paternal mitochondrial destruction after fertilization is mediated by a common endocytic and autophagic pathway in Drosophila. Dev. Cell 29, 305-320 (2014).
-
(2014)
Dev. Cell
, vol.29
, pp. 305-320
-
-
Politi, Y.1
-
15
-
-
84905482172
-
The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy
-
Geisler, S., Vollmer, S., Golombek, S. & Kahle, P.J. The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy. J. Cell Sci. 127, 3280-3293 (2014).
-
(2014)
J. Cell Sci.
, vol.127
, pp. 3280-3293
-
-
Geisler, S.1
Vollmer, S.2
Golombek, S.3
Kahle, P.J.4
-
16
-
-
84919777530
-
Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy
-
Park, S., Choi, S.G., Yoo, S.M., Son, J.H. & Jung, Y.K. Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy. Autophagy 10, 1906-1920 (2014).
-
(2014)
Autophagy
, vol.10
, pp. 1906-1920
-
-
Park, S.1
Choi, S.G.2
Yoo, S.M.3
Son, J.H.4
Jung, Y.K.5
-
17
-
-
65549142204
-
A role for ubiquitin in selective autophagy
-
Kirkin, V., McEwan, D.G., Novak, I. & Dikic, I. A role for ubiquitin in selective autophagy. Mol. Cell 34, 259-269 (2009).
-
(2009)
Mol. Cell
, vol.34
, pp. 259-269
-
-
Kirkin, V.1
McEwan, D.G.2
Novak, I.3
Dikic, I.4
-
18
-
-
84896970273
-
Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids
-
Sahani, M.H., Itakura, E. & Mizushima, N. Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids. Autophagy 10, 431-441 (2014).
-
(2014)
Autophagy
, vol.10
, pp. 431-441
-
-
Sahani, M.H.1
Itakura, E.2
Mizushima, N.3
-
19
-
-
33646523798
-
A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death
-
Reef, S. et al. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol. Cell 22, 463-475 (2006).
-
(2006)
Mol. Cell
, vol.22
, pp. 463-475
-
-
Reef, S.1
-
20
-
-
53549087505
-
Nucleolar p19ARF, unlike mitochondrial smARF, is incapable of inducing p53-independent autophagy
-
Reef, S. & Kimchi, A. Nucleolar p19ARF, unlike mitochondrial smARF, is incapable of inducing p53-independent autophagy. Autophagy 4, 866-869 (2008).
-
(2008)
Autophagy
, vol.4
, pp. 866-869
-
-
Reef, S.1
Kimchi, A.2
-
21
-
-
84885611579
-
A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction
-
Budina-Kolomets, A., Hontz, R.D., Pimkina, J. & Murphy, M.E. A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction. Autophagy 9, 1553-1565 (2013).
-
(2013)
Autophagy
, vol.9
, pp. 1553-1565
-
-
Budina-Kolomets, A.1
Hontz, R.D.2
Pimkina, J.3
Murphy, M.E.4
-
22
-
-
39049144417
-
P53-Dependent and p53-independent activation of autophagy by ARF
-
Abida, W.M. & Gu, W. p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res. 68, 352-357 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 352-357
-
-
Abida, W.M.1
Gu, W.2
-
23
-
-
0027423418
-
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
-
Hibi, M., Lin, A., Smeal, T., Minden, A. & Karin, M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135-2148 (1993).
-
(1993)
Genes Dev.
, vol.7
, pp. 2135-2148
-
-
Hibi, M.1
Lin, A.2
Smeal, T.3
Minden, A.4
Karin, M.5
-
24
-
-
0035282334
-
Mammalian MAP kinase signalling cascades
-
Chang, L. & Karin, M. Mammalian MAP kinase signalling cascades. Nature 410, 37-40 (2001).
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.1
Karin, M.2
-
25
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis, R.J. Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252 (2000).
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
26
-
-
10044247350
-
C-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor α-induced c-Jun kinase activation and apoptosis
-
Liu, J., Minemoto, Y. & Lin, A. c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor α-induced c-Jun kinase activation and apoptosis. Mol. Cell. Biol. 24, 10844-10856 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 10844-10856
-
-
Liu, J.1
Minemoto, Y.2
Lin, A.3
-
27
-
-
4444341881
-
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
-
Sabapathy, K. et al. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol. Cell 15, 713-725 (2004).
-
(2004)
Mol. Cell
, vol.15
, pp. 713-725
-
-
Sabapathy, K.1
-
28
-
-
0029829562
-
Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase
-
Fuchs, S.Y., Dolan, L., Davis, R.J. & Ronai, Z. Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase. Oncogene 13, 1531-1535 (1996).
-
(1996)
Oncogene
, vol.13
, pp. 1531-1535
-
-
Fuchs, S.Y.1
Dolan, L.2
Davis, R.J.3
Ronai, Z.4
-
29
-
-
0031283180
-
C-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors
-
Fuchs, S.Y. et al. c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors. J. Biol. Chem. 272, 32163-32168 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 32163-32168
-
-
Fuchs, S.Y.1
-
30
-
-
0032541565
-
Stress-activated kinases regulate protein stability
-
Fuchs, S.Y., Fried, V.A. & Ronai, Z. Stress-activated kinases regulate protein stability. Oncogene 17, 1483-1490 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 1483-1490
-
-
Fuchs, S.Y.1
Fried, V.A.2
Ronai, Z.3
-
31
-
-
0032169459
-
JNK targets p53 ubiquitination and degradation in nonstressed cells
-
Fuchs, S.Y. et al. JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev. 12, 2658-2663 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 2658-2663
-
-
Fuchs, S.Y.1
-
32
-
-
44949237240
-
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
-
Wei, Y., Pattingre, S., Sinha, S., Bassik, M. & Levine, B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 30, 678-688 (2008).
-
(2008)
Mol. Cell
, vol.30
, pp. 678-688
-
-
Wei, Y.1
Pattingre, S.2
Sinha, S.3
Bassik, M.4
Levine, B.5
-
33
-
-
84899789746
-
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy
-
Wu, W. et al. ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy. EMBO Rep. 15, 566-575 (2014).
-
(2014)
EMBO Rep.
, vol.15
, pp. 566-575
-
-
Wu, W.1
-
34
-
-
84862789618
-
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
-
Liu, L. et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 14, 177-185 (2012).
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 177-185
-
-
Liu, L.1
-
35
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
Guo, J.Y. et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 25, 460-470 (2011).
-
(2011)
Genes Dev.
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
-
36
-
-
84890048128
-
Killing cancer cells, twice with one shot
-
Bianchi, M.E. Killing cancer cells, twice with one shot. Cell Death Differ. 21, 1-2 (2014).
-
(2014)
Cell Death Differ.
, vol.21
, pp. 1-2
-
-
Bianchi, M.E.1
-
37
-
-
84876789628
-
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice
-
Li, N. et al. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J. Clin. Invest. 123, 2231-2243 (2013).
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 2231-2243
-
-
Li, N.1
-
38
-
-
3543148255
-
N-terminal polyubiquitination and degradation of the Arf tumor suppressor
-
Kuo, M.L., den Besten, W., Bertwistle, D., Roussel, M.F. & Sherr, C.J. N-terminal polyubiquitination and degradation of the Arf tumor suppressor. Genes Dev. 18, 1862-1874 (2004).
-
(2004)
Genes Dev.
, vol.18
, pp. 1862-1874
-
-
Kuo, M.L.1
Den Besten, W.2
Bertwistle, D.3
Roussel, M.F.4
Sherr, C.J.5
-
39
-
-
77950092933
-
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
-
Chen, D., Shan, J., Zhu, W.G., Qin, J. & Gu, W. Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Nature 464, 624-627 (2010).
-
(2010)
Nature
, vol.464
, pp. 624-627
-
-
Chen, D.1
Shan, J.2
Zhu, W.G.3
Qin, J.4
Gu, W.5
-
40
-
-
65249097276
-
ARF, autophagy and tumor suppression
-
Pimkina, J. & Murphy, M.E. ARF, autophagy and tumor suppression. Autophagy 5, 397-399 (2009).
-
(2009)
Autophagy
, vol.5
, pp. 397-399
-
-
Pimkina, J.1
Murphy, M.E.2
-
41
-
-
77953621745
-
P53 and ARF: Unexpected players in autophagy
-
Balaburski, G.M., Hontz, R.D. & Murphy, M.E. p53 and ARF: unexpected players in autophagy. Trends Cell Biol. 20, 363-369 (2010).
-
(2010)
Trends Cell Biol.
, vol.20
, pp. 363-369
-
-
Balaburski, G.M.1
Hontz, R.D.2
Murphy, M.E.3
-
42
-
-
78649300971
-
P62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
-
Narendra, D., Kane, L.A., Hauser, D.N., Fearnley, I.M. & Youle, R.J. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6, 1090-1106 (2010).
-
(2010)
Autophagy
, vol.6
, pp. 1090-1106
-
-
Narendra, D.1
Kane, L.A.2
Hauser, D.N.3
Fearnley, I.M.4
Youle, R.J.5
-
43
-
-
47049100413
-
Essential role for Nix in autophagic maturation of erythroid cells
-
Sandoval, H. et al. Essential role for Nix in autophagic maturation of erythroid cells. Nature 454, 232-235 (2008).
-
(2008)
Nature
, vol.454
, pp. 232-235
-
-
Sandoval, H.1
-
44
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss, R.S. & Karl, I.E. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348, 138-150 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
46
-
-
84882977493
-
An integrated clinico-metabolomic model improves prediction of death in sepsis
-
Langley, R.J. et al. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci. Transl. Med. 5, 195ra195 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 195ra195
-
-
Langley, R.J.1
-
47
-
-
84887559345
-
Anthracyclines induce DNA damage response-mediated protection against severe sepsis
-
Figueiredo, N. et al. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity 39, 874-884 (2013).
-
(2013)
Immunity
, vol.39
, pp. 874-884
-
-
Figueiredo, N.1
-
48
-
-
84887529311
-
Septic shock: On the importance of being tolerant
-
Medzhitov, R. Septic shock: on the importance of being tolerant. Immunity 39, 799-800 (2013).
-
(2013)
Immunity
, vol.39
, pp. 799-800
-
-
Medzhitov, R.1
-
49
-
-
84876672758
-
Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ
-
Do-Umehara, H.C. et al. Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ. Nat. Immunol. 14, 461-469 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 461-469
-
-
Do-Umehara, H.C.1
-
50
-
-
84862928017
-
Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation
-
Liu, J. et al. Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation. Proc. Natl. Acad. Sci. USA 109, 191-196 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 191-196
-
-
Liu, J.1
|