Mutations in pneumococcal cpsE generated via In Vitro serial passaging reveal a potential mechanism of reduced encapsulation utilized by a conjunctival isolate

Journal of Bacteriology

Volumn 197, Issue 10, 2015, Pages 1781-1791

  Shainheit, Mara G ^a,b   Valentino, Michael D ^c   Gilmore, Michael S ^c   Camilli, Andrew ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOWSON UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; COMPLEMENT COMPONENT C3; PHOSPHORYLCHOLINE; POLYSACCHARIDE; GLYCOSYLTRANSFERASE; MUTANT PROTEIN;

ALLELE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL CONJUNCTIVITIS; BACTERIAL GROWTH; BACTERIAL MUTATION; CELL ENCAPSULATION; CONTROLLED STUDY; ENZYME MECHANISM; EPITHELIUM CELL; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENE DUPLICATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MISSENSE MUTATION; NONHUMAN; PHENOTYPIC VARIATION; PNEUMOCOCCAL CONJUNCTIVITIS; PRIORITY JOURNAL; SEPSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STREPTOCOCCUS PNEUMONIAE; WILD TYPE; BACTERIAL CAPSULE; CONJUNCTIVA; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MUTATION; PNEUMOCOCCAL INFECTION; VIRULENCE; VIRUS CULTURE;

STREPTOCOCCUS PNEUMONIAE;

BACTERIAL CAPSULES; CONJUNCTIVA; GLYCOSYLTRANSFERASES; MUTAGENESIS, INSERTIONAL; MUTANT PROTEINS; MUTATION; MUTATION, MISSENSE; PNEUMOCOCCAL INFECTIONS; SERIAL PASSAGE; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

EID: 84928569456     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.02602-14     Document Type: Article

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