A point mutation in cpsE renders Streptococcus pneumoniae nonencapsulated and enhances its growth, adherence and competence

BMC Microbiology

Volumn 14, Issue 1, 2014, Pages

  Schaffner, Thierry O ^a   Hinds, Jason ^b   Gould, Katherine A ^b   Wüthrich, Daniel ^a,c   Bruggmann, Rémy ^a,c   Küffer, Marianne ^a   Mühlemann, Kathrin ^a,d   Hilty, Markus ^a,d   Hathaway, Lucy J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b ST GEORGE S HOSPITAL   (United Kingdom)

^c SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Capsule; cpsE; Nonencapsulated; SNP; Streptococcus pneumoniae

Indexed keywords

AMINO ACID; ARGININE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GLYCINE; MEMBRANE PROTEIN; BACTERIAL PROTEIN; MUTANT PROTEIN;

ARTICLE; BACTERIAL CAPSULE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIUM ADHERENCE; BACTERIUM COMPETENCE; BACTERIUM ISOLATION; COMPARATIVE STUDY; CONTROLLED STUDY; CPSE GENE; CYTOPLASM; ELECTRON MICROSCOPY; ENCAPSULATION; EPITHELIUM CELL; FLUORESCENCE ANALYSIS; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSFORMATION; GENOME ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NASOPHARYNX; NONHUMAN; OPERON; PHENOTYPIC VARIATION; POINT MUTATION; SEROTYPE; SEROTYPING; SINGLE NUCLEOTIDE POLYMORPHISM; STREPTOCOCCUS PNEUMONIAE; BACTERIAL GENOME; CELL LINE; DNA SEQUENCE; GENETICS; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PNEUMOCOCCAL INFECTION;

STREPTOCOCCUS PNEUMONIAE;

BACTERIAL ADHESION; BACTERIAL CAPSULES; BACTERIAL PROTEINS; CELL LINE; DNA MUTATIONAL ANALYSIS; DNA TRANSFORMATION COMPETENCE; EPITHELIAL CELLS; GENOME, BACTERIAL; HUMANS; MUTANT PROTEINS; NASOPHARYNX; PNEUMOCOCCAL INFECTIONS; POINT MUTATION; SEQUENCE ANALYSIS, DNA; STREPTOCOCCUS PNEUMONIAE; TRANSFORMATION, GENETIC;

EID: 84908555028     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/s12866-014-0210-x     Document Type: Article

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