A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity

Obesity

Volumn 23, Issue 5, 2015, Pages 1022-1029

  Zheng, Chao ^a,b   Dalla Man, Chiara ^c   Cobelli, Claudio ^c   Groop, Leif ^d   Zhao, Hongyu ^e   Bale, Allen E ^a   Shaw, Melissa ^a   Duran, Elvira ^a   Pierpont, Bridget ^a   Caprio, Sonia ^a   Santoro, Nicola ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF PADOVA   (Italy)

^d LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^e YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; AFRICAN AMERICAN; ALLELE; ARTICLE; CAUCASIAN; CHILD; DISEASE PREDISPOSITION; ETHNIC DIFFERENCE; FEMALE; FOLLOW UP; G6PC2 GENE; GENE; GENE FUNCTION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HISPANIC; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MALE; MTNR1B GENE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PATHOGENESIS; RISK ASSESSMENT; RISK FACTOR; CHILDHOOD OBESITY; DIET RESTRICTION; GENETICS; GLUCOSE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; SECRETION (PROCESS); SINGLE NUCLEOTIDE POLYMORPHISM;

GLUCOSE BLOOD LEVEL; INSULIN; MELATONIN 2 RECEPTOR; MTNR1B PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOLESCENT; AFRICAN AMERICANS; BLOOD GLUCOSE; CHILD; DIABETES MELLITUS, TYPE 1; EUROPEAN CONTINENTAL ANCESTRY GROUP; FASTING; FEMALE; HISPANIC AMERICANS; HUMANS; INSULIN; MALE; PEDIATRIC OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDIABETIC STATE; RECEPTOR, MELATONIN, MT2;

EID: 84928544326     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.21030     Document Type: Article

References (40)

1. Caprio S,. Development of type 2 diabetes mellitus in the obese adolescent: a growing challenge. Endocr Pract 2012; 18: 791-795.
2. Narayan KM, Boyle JP, Thompson TJ, et al. Lifetime risk for diabetes mellitus in the United States. JAMA 2003; 290: 1884-1890.
3. Writing Group for the SfDiYSG, Dabelea D, Bell RA, D'Agostino RB, Jr,. et al. Incidence of diabetes in youth in the United States. JAMA 2007; 297: 2716-2724.
4. Fazeli Farsani S, van der Aa MP, van der Vorst MM, et al. Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches. Diabetologia 2013; 56: 1471-1488.
5. Pettitt DJ, Talton J, Dabelea D, et al. Prevalence of diabetes mellitus in U.S. youth in 2009: the SEARCH for diabetes in youth study. Diabetes care 2013.
6. Cali AM, Bonadonna RC, Trombetta M, et al. Metabolic abnormalities underlying the different prediabetic phenotypes in obese adolescents. J Clin Endocrinol Metab 2008; 93: 1767-1773.
7. Goran MI, Ball GD, Cruz ML,. Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. J Clin Endocrinol Metab 2003; 88: 1417-1427.
8. Copeland KC, Zeitler P, Geffner M, et al. Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab 2011; 96: 159-167.
9. Group TS,. Rapid rise in hypertension and nephropathy in youth with type 2 diabetes: the TODAY clinical trial. Diabetes care 2013; 36: 1735-1741.
10. Giannini C, Weiss R, Cali A, et al. Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: a longitudinal study. Diabetes 2012; 61: 606-614.
11. Takeuchi F, Katsuya T, Chakrewarthy S, et al. Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia 2010; 53: 299-308.
12. Weiss R, Caprio S, Trombetta M, et al. Beta-cell function across the spectrum of glucose tolerance in obese youth. Diabetes 2005; 54: 1735-1743.
13. Weiss R, Taksali SE, Tamborlane WV, et al. Predictors of changes in glucose tolerance status in obese youth. Diabetes care 2005; 28: 902-909.
14. O'Malley G, Santoro N, Northrup V, et al. High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation. Diabetologia 2010; 53: 1199-1209.
15. Been LF, Hatfield JL, Shankar A, et al. A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity. Nutr Metab Cardiovasc Dis 2012; 22: 944-951.
16. O'Brien RM,. Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose. Curr Diab Rep 2013; 13: 768-777.
17. Ramos E, Chen G, Shriner D, et al. Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans. Diabetologia 2011; 54: 783-788.
18. Rasmussen-Torvik LJ, Guo X, Bowden DW, et al. Fasting glucose GWAS candidate region analysis across ethnic groups in the multiethnic study of atherosclerosis (MESA). Genet Epidemiol 2012; 36: 384-391.
19. Prokopenko I, Langenberg C, Florez JC, et al. Variants in MTNR1B influence fasting glucose levels. Nature Genet 2009; 41: 77-81.
20. Kelliny C, Ekelund U, Andersen LB, et al. Common genetic determinants of glucose homeostasis in healthy children: the European youth heart study. Diabetes 2009; 58: 2939-2945.
21. Barker A, Sharp SJ, Timpson NJ, et al. Association of genetic loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes 2011; 60: 1805-1812.
22. Lyssenko V, Nagorny CL, Erdos MR, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nature Genet 2009; 41: 82-88.
23. Baerenwald DA, Bonnefond A, Bouatia-Naji N, et al. Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels. Diabetologia 2013; 56: 1306-1316.
24. Amiel SA, Sherwin RS, Simonson DC, et al. Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes. New Engl J Med 1986; 315: 215-219.
25. Tanner JM, Whitehouse RH, Marshall WA, et al. Prediction of adult height from height, bone age, and occurrence of menarche, at ages 4 to 16 with allowance for midparent height. Arch Dis Child 1975; 50: 14-26.
26. Giannini C, Dalla Man C, Groop L, et al. Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes. Diabetes care 2014; 37: 475-482.
27. Bailey CJ, Atkins TW, Matty AJ,. Melatonin inhibition of insulin secretion in the rat and mouse. Horm Res 1974; 5: 21-28.
28. Langenberg C, Pascoe L, Mari A, et al. Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia 2009; 52: 1537-1542.
29. Stancakova A, Kuulasmaa T, Paananen J, et al. Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes 2009; 58: 2129-2136.
30. Ingelsson E, Langenberg C, Hivert MF, et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. Diabetes 2010; 59: 1266-1275.
31. Holzapfel C, Siegrist M, Rank M, et al. Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS. Eur J Endocrinol 2011; 164: 205-212.
32. Ren J, Xiang AH, Trigo E, et al. Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans. Diabetologia 2014; 57: 1391-1399.
33. Dabelea D, Mayer-Davis EJ, Saydah S, et al. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA 2014; 311: 1778-1786.
34. Florez JC, Jablonski KA, McAteer JB, et al. Effects of genetic variants previously associated with fasting glucose and insulin in the diabetes prevention program. PloS one 2012; 7: e44424.
35. Rose CS, Grarup N, Krarup NT, et al. A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads. Diabetologia 2009; 52: 2122-2129.
36. Mithieux G,. New knowledge regarding glucose-6 phosphatase gene and protein and their roles in the regulation of glucose metabolism. Eur J Endocrinol 1997; 136: 137-145.
37. van de Werve G, Lange A, Newgard C, et al. New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. Euro J Biochem 2000; 267: 1533-1549.
38. Reiling E, van 't Riet E, Groenewoud MJ, et al. Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia 2009; 52: 1866-1870.
39. Dupuis J, Langenberg C, Prokopenko I, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genet. 2010; 42: 105-116.
40. Bouatia-Naji N, Bonnefond A, Baerenwald DA et al.Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels. Diabetes 2010; 59: 2662-2671.