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Volumn 2, Issue 3, 2014, Pages 133-142

MicroRNAs in Cholangiopathies

Author keywords

Biliary atresia; Cholangiocarcinoma; Cholangiocytes; MicroRNAs, cholangiopathies; Polycystic liver disease; Primary biliary cirrhosis; Primary sclerosing cholangitis

Indexed keywords


EID: 84928539225     PISSN: None     EISSN: 2167485X     Source Type: Journal    
DOI: 10.1007/s40139-014-0048-9     Document Type: Review
Times cited : (26)

References (87)
  • 1
    • 7644234675 scopus 로고    scopus 로고
    • The cholangiopathies: disorders of biliary epithelia
    • COI: 1:CAS:528:DC%2BD2cXhtVKisrrM, PID: 15521023
    • Lazaridis KN, Strazzabosco M, Larusso NF (2004) The cholangiopathies: disorders of biliary epithelia. Gastroenterology 127:1565–1577
    • (2004) Gastroenterology , vol.127 , pp. 1565-1577
    • Lazaridis, K.N.1    Strazzabosco, M.2    Larusso, N.F.3
  • 2
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • COI: 1:CAS:528:DC%2BD1MXhs1Kiuro%3D, PID: 19167326
    • Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136:215–233
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 3
    • 77957361864 scopus 로고    scopus 로고
    • Targeting microRNAs in cancer: rationale, strategies and challenges
    • COI: 1:CAS:528:DC%2BC3cXht1akur7L, PID: 20885409
    • Garzon R, Marcucci G, Croce CM (2010) Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 9:775–789
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 775-789
    • Garzon, R.1    Marcucci, G.2    Croce, C.M.3
  • 4
    • 84902786936 scopus 로고    scopus 로고
    • Cholangiocarcinoma
    • Razumilava N, Gores GJ (2014) Cholangiocarcinoma. Lancet. doi:10.1016/S0140-6736(13)61903-0
    • (2014) Lancet
    • Razumilava, N.1    Gores, G.J.2
  • 7
    • 84890772872 scopus 로고    scopus 로고
    • miR-204 inhibits epithelial to mesenchymal transition by targeting slug in intrahepatic cholangiocarcinoma cells
    • PID: 24280681
    • Qiu YH, Wei YP, Shen NJ, Wang ZC, Kan T, Yu WL, Yi B, Zhang YJ (2013) miR-204 inhibits epithelial to mesenchymal transition by targeting slug in intrahepatic cholangiocarcinoma cells. Cell Physiol Biochem 32:1331–1341
    • (2013) Cell Physiol Biochem , vol.32 , pp. 1331-1341
    • Qiu, Y.H.1    Wei, Y.P.2    Shen, N.J.3    Wang, Z.C.4    Kan, T.5    Yu, W.L.6    Yi, B.7    Zhang, Y.J.8
  • 8
    • 84862513160 scopus 로고    scopus 로고
    • Down-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist
    • COI: 1:CAS:528:DC%2BC38XpvFOns7c%3D, PID: 22540680
    • Li B, Han Q, Zhu Y, Yu Y, Wang J, Jiang X (2012) Down-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist. FEBS J 279:2393–2398
    • (2012) FEBS J , vol.279 , pp. 2393-2398
    • Li, B.1    Han, Q.2    Zhu, Y.3    Yu, Y.4    Wang, J.5    Jiang, X.6
  • 9
    • 84890425122 scopus 로고    scopus 로고
    • Direct targeting of SUZ12/ROCK2 by miR-200b/c inhibits cholangiocarcinoma tumourigenesis and metastasis
    • COI: 1:CAS:528:DC%2BC3sXhslWqtLzK, PID: 24169343
    • Peng F, Jiang J, Yu Y, Tian R, Guo X, Li X, Shen M, Xu M, Zhu F, Shi C, Hu J, Wang M, Qin R (2013) Direct targeting of SUZ12/ROCK2 by miR-200b/c inhibits cholangiocarcinoma tumourigenesis and metastasis. Br J Cancer 109:3092–3104
    • (2013) Br J Cancer , vol.109 , pp. 3092-3104
    • Peng, F.1    Jiang, J.2    Yu, Y.3    Tian, R.4    Guo, X.5    Li, X.6    Shen, M.7    Xu, M.8    Zhu, F.9    Shi, C.10    Hu, J.11    Wang, M.12    Qin, R.13
  • 10
    • 77956547097 scopus 로고    scopus 로고
    • Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
    • COI: 1:CAS:528:DC%2BC3cXhtFGjt7zM, PID: 20832727
    • Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl K (2010) Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell 39:761–772
    • (2010) Mol Cell , vol.39 , pp. 761-772
    • Iliopoulos, D.1    Lindahl-Allen, M.2    Polytarchou, C.3    Hirsch, H.A.4    Tsichlis, P.N.5    Struhl, K.6
  • 11
    • 84885803796 scopus 로고    scopus 로고
    • MiR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells
    • MicroRNA expression profiling of a gemcitabine resistant cell line (HuH28) vs. a sensitive cell line (HuCCT1) revealed three downregulated microRNAs and one upregulated microRNA associated with chemotherapeutic resistance
    • •• Okamoto K, Miyoshi K, Murawaki Y (2013) miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells. PLoS One 8:e77623. MicroRNA expression profiling of a gemcitabine resistant cell line (HuH28) vs. a sensitive cell line (HuCCT1) revealed three downregulated microRNAs and one upregulated microRNA associated with chemotherapeutic resistance.
    • (2013) Plos One , vol.8
    • Okamoto, K.1    Miyoshi, K.2    Murawaki, Y.3
  • 12
    • 33744521896 scopus 로고    scopus 로고
    • Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines
    • COI: 1:CAS:528:DC%2BD28XntVWit7g%3D, PID: 16762633
    • Meng F, Henson R, Lang M, Wehbe H, Maheshwari S, Mendell JT, Jiang J, Schmittgen TD, Patel T (2006) Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology 130:2113–2129
    • (2006) Gastroenterology , vol.130 , pp. 2113-2129
    • Meng, F.1    Henson, R.2    Lang, M.3    Wehbe, H.4    Maheshwari, S.5    Mendell, J.T.6    Jiang, J.7    Schmittgen, T.D.8    Patel, T.9
  • 13
    • 84880786960 scopus 로고    scopus 로고
    • MiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line
    • COI: 1:CAS:528:DC%2BC3sXht1GisLbN, PID: 23922722
    • Iwaki J, Kikuchi K, Mizuguchi Y, Kawahigashi Y, Yoshida H, Uchida E, Takizawa T (2013) MiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line. PLoS One 8:e69496
    • (2013) PLoS One , vol.8
    • Iwaki, J.1    Kikuchi, K.2    Mizuguchi, Y.3    Kawahigashi, Y.4    Yoshida, H.5    Uchida, E.6    Takizawa, T.7
  • 14
    • 84876276223 scopus 로고    scopus 로고
    • Downregulation of microRNA-138 enhances the proliferation, migration and invasion of cholangiocarcinoma cells through the upregulation of RhoC/p-ERK/MMP-2/MMP-9
    • COI: 1:CAS:528:DC%2BC3sXntlGlsro%3D, PID: 23446431
    • Wang Q, Tang H, Yin S, Dong C (2013) Downregulation of microRNA-138 enhances the proliferation, migration and invasion of cholangiocarcinoma cells through the upregulation of RhoC/p-ERK/MMP-2/MMP-9. Oncol Rep 29:2046–2052
    • (2013) Oncol Rep , vol.29 , pp. 2046-2052
    • Wang, Q.1    Tang, H.2    Yin, S.3    Dong, C.4
  • 15
    • 84884745343 scopus 로고    scopus 로고
    • miR-31 promotes oncogenesis in intrahepatic cholangiocarcinoma cells via the direct suppression of RASA1
    • COI: 1:CAS:528:DC%2BC3sXhvVGht7vK, PID: 24223656
    • Hu C, Huang F, Deng G, Nie W, Huang W, Zeng X (2013) miR-31 promotes oncogenesis in intrahepatic cholangiocarcinoma cells via the direct suppression of RASA1. Exp Ther Med 6:1265–1270
    • (2013) Exp Ther Med , vol.6 , pp. 1265-1270
    • Hu, C.1    Huang, F.2    Deng, G.3    Nie, W.4    Huang, W.5    Zeng, X.6
  • 16
    • 84866602061 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-124 by hepatitis C virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3
    • COI: 1:CAS:528:DC%2BC38XhtFeiur3J, PID: 22819820
    • Zeng B, Li Z, Chen R, Guo N, Zhou J, Zhou Q, Lin Q, Cheng D, Liao Q, Zheng L, Gong Y (2012) Epigenetic regulation of miR-124 by hepatitis C virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3. FEBS Lett 586:3271–3278
    • (2012) FEBS Lett , vol.586 , pp. 3271-3278
    • Zeng, B.1    Li, Z.2    Chen, R.3    Guo, N.4    Zhou, J.5    Zhou, Q.6    Lin, Q.7    Cheng, D.8    Liao, Q.9    Zheng, L.10    Gong, Y.11
  • 17
    • 84902657217 scopus 로고    scopus 로고
    • MiR-21 targets 15-PGDH and promotes cholangiocarcinoma growth
    • Lu L, Byrnes K, Han C, Wang Y, Wu T (2014) MiR-21 targets 15-PGDH and promotes cholangiocarcinoma growth. Mol Cancer Res. doi:10.1158/1541-7786
    • (2014) Mol Cancer Res
    • Lu, L.1    Byrnes, K.2    Han, C.3    Wang, Y.4    Wu, T.5
  • 19
    • 84869471263 scopus 로고    scopus 로고
    • Polycystic liver disease: a clinical review
    • PID: 23109444
    • Chandok N (2012) Polycystic liver disease: a clinical review. Ann Hepatol 11:819–826
    • (2012) Ann Hepatol , vol.11 , pp. 819-826
    • Chandok, N.1
  • 20
    • 84873471538 scopus 로고    scopus 로고
    • Diagnosis and management of polycystic liver disease
    • COI: 1:CAS:528:DC%2BC3sXit1WitLY%3D, PID: 23296249
    • Gevers TJ, Drenth JP (2013) Diagnosis and management of polycystic liver disease. Nat Rev Gastroenterol Hepatol 10(2):101–108
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , Issue.2 , pp. 101-108
    • Gevers, T.J.1    Drenth, J.P.2
  • 21
    • 67651101020 scopus 로고    scopus 로고
    • Cholangiociliopathies: genetics, molecular mechanisms and potential therapies
    • COI: 1:CAS:528:DC%2BD1MXkvVGlsrY%3D, PID: 19349863
    • Masyuk T, Masyuk A, Larusso N (2009) Cholangiociliopathies: genetics, molecular mechanisms and potential therapies. Curr Opin Gastroenterol 25:265–271
    • (2009) Curr Opin Gastroenterol , vol.25 , pp. 265-271
    • Masyuk, T.1    Masyuk, A.2    Larusso, N.3
  • 22
    • 79954468469 scopus 로고    scopus 로고
    • microRNAs in kidneys: biogenesis, regulation, and pathophysiological roles
    • COI: 1:CAS:528:DC%2BC3MXjs1Gqt7k%3D, PID: 21228106
    • Bhatt K, Mi QS, Dong Z (2011) microRNAs in kidneys: biogenesis, regulation, and pathophysiological roles. Am J Physiol Renal Physiol 300:F602–F610
    • (2011) Am J Physiol Renal Physiol , vol.300 , pp. F602-F610
    • Bhatt, K.1    Mi, Q.S.2    Dong, Z.3
  • 23
    • 55849085074 scopus 로고    scopus 로고
    • MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease
    • COI: 1:CAS:528:DC%2BD1cXhtlGltLjP, PID: 18949056
    • Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N (2008) MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest 118:3714–3724
    • (2008) J Clin Invest , vol.118 , pp. 3714-3724
    • Lee, S.O.1    Masyuk, T.2    Splinter, P.3    Banales, J.M.4    Masyuk, A.5    Stroope, A.6    Larusso, N.7
  • 24
    • 65949096824 scopus 로고    scopus 로고
    • MicroRNAs in cholangiociliopathies
    • COI: 1:CAS:528:DC%2BD1MXmvFCitbo%3D, PID: 19342876
    • Masyuk T, Masyuk A, Larusso N (2009) MicroRNAs in cholangiociliopathies. Cell Cycle 8:1324–1328
    • (2009) Cell Cycle , vol.8 , pp. 1324-1328
    • Masyuk, T.1    Masyuk, A.2    Larusso, N.3
  • 25
    • 60749100351 scopus 로고    scopus 로고
    • Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease
    • PID: 19102782
    • Pandey P, Brors B, Srivastava PK, Bott A, Boehn SN, Groene HJ, Gretz N (2008) Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease. BMC Genomics 9:624
    • (2008) BMC Genomics , vol.9 , pp. 624
    • Pandey, P.1    Brors, B.2    Srivastava, P.K.3    Bott, A.4    Boehn, S.N.5    Groene, H.J.6    Gretz, N.7
  • 26
    • 79960105492 scopus 로고    scopus 로고
    • Polycystic kidney disease and therapeutic approaches
    • COI: 1:CAS:528:DC%2BC3MXps1Shtr8%3D, PID: 21699747
    • Park EY, Woo YM, Park JH (2011) Polycystic kidney disease and therapeutic approaches. BMB Rep 44:359–368
    • (2011) BMB Rep , vol.44 , pp. 359-368
    • Park, E.Y.1    Woo, Y.M.2    Park, J.H.3
  • 27
    • 84899929999 scopus 로고    scopus 로고
    • Polycystic liver disease: ductal plate malformation and the primary cilium
    • COI: 1:CAS:528:DC%2BC2cXhvFGkt70%3D, PID: 24506938
    • Wills ES, Roepman R, Drenth JP (2014) Polycystic liver disease: ductal plate malformation and the primary cilium. Trends Mol Med 20:261–270
    • (2014) Trends Mol Med , vol.20 , pp. 261-270
    • Wills, E.S.1    Roepman, R.2    Drenth, J.P.3
  • 28
    • 79958081521 scopus 로고    scopus 로고
    • Polycystic liver diseases: Congenital disorders of cholangiocyte signaling
    • Strazzabosco M, Somlo S (2011) Polycystic liver diseases: congenital disorders of cholangiocyte signaling. Gastroenterology 140:1855–1859, 1859 e1851.
    • (2011) Gastroenterology , vol.140 , Issue.1855-1859 , pp. 1859
    • Strazzabosco, M.1    Somlo, S.2
  • 30
    • 77950502479 scopus 로고    scopus 로고
    • The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity
    • COI: 1:CAS:528:DC%2BC3cXmtleisr4%3D, PID: 20215348
    • Tran U, Zakin L, Schweickert A, Agrawal R, Doger R, Blum M, De Robertis EM, Wessely O (2010) The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. Development 137:1107–1116
    • (2010) Development , vol.137 , pp. 1107-1116
    • Tran, U.1    Zakin, L.2    Schweickert, A.3    Agrawal, R.4    Doger, R.5    Blum, M.6    De Robertis, E.M.7    Wessely, O.8
  • 31
    • 77958016655 scopus 로고    scopus 로고
    • Progressive renal distortion by multiple cysts in transgenic mice expressing artificial microRNAs against Pkd1
    • COI: 1:CAS:528:DC%2BC3cXhsVKis7nL, PID: 20814903
    • Wang E, Hsieh-Li HM, Chiou YY, Chien YL, Ho HH, Chin HJ, Wang CK, Liang SC, Jiang ST (2010) Progressive renal distortion by multiple cysts in transgenic mice expressing artificial microRNAs against Pkd1. J Pathol 222:238–248
    • (2010) J Pathol , vol.222 , pp. 238-248
    • Wang, E.1    Hsieh-Li, H.M.2    Chiou, Y.Y.3    Chien, Y.L.4    Ho, H.H.5    Chin, H.J.6    Wang, C.K.7    Liang, S.C.8    Jiang, S.T.9
  • 32
    • 84897398761 scopus 로고    scopus 로고
    • MicroRNAs in kidney diseases: new promising biomarkers for diagnosis and monitoring
    • COI: 1:CAS:528:DC%2BC2cXlsFOns78%3D, PID: 23787546
    • Schena FP, Serino G, Sallustio F (2014) MicroRNAs in kidney diseases: new promising biomarkers for diagnosis and monitoring. Nephrol Dial Transplant 29:755–763
    • (2014) Nephrol Dial Transplant , vol.29 , pp. 755-763
    • Schena, F.P.1    Serino, G.2    Sallustio, F.3
  • 33
    • 78651233303 scopus 로고    scopus 로고
    • Biliary differentiation and bile duct morphogenesis in development and disease
    • COI: 1:CAS:528:DC%2BC3MXmsVKktQ%3D%3D, PID: 19735739
    • Raynaud P, Carpentier R, Antoniou A, Lemaigre FP (2011) Biliary differentiation and bile duct morphogenesis in development and disease. Int J Biochem Cell Biol 43:245–256
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 245-256
    • Raynaud, P.1    Carpentier, R.2    Antoniou, A.3    Lemaigre, F.P.4
  • 35
    • 70449672812 scopus 로고    scopus 로고
    • Liver and kidney disease in ciliopathies
    • COI: 1:CAS:528:DC%2BD1MXhsFWjsbzI, PID: 19876928
    • Gunay-Aygun M (2009) Liver and kidney disease in ciliopathies. Am J Med Genet C Semin Med Genet 151C:296–306
    • (2009) Am J Med Genet C Semin Med Genet , vol.151C , pp. 296-306
    • Gunay-Aygun, M.1
  • 36
    • 0031609085 scopus 로고    scopus 로고
    • Ludwig symposium on biliary disorders: part I. Pathogenesis of ductal plate abnormalities
    • COI: 1:STN:280:DyaK1c7gtl2hsw%3D%3D, PID: 9443684
    • Desmet VJ (1998) Ludwig symposium on biliary disorders: part I. Pathogenesis of ductal plate abnormalities. Mayo Clin Proc 73:80–89
    • (1998) Mayo Clin Proc , vol.73 , pp. 80-89
    • Desmet, V.J.1
  • 37
  • 39
    • 84868657171 scopus 로고    scopus 로고
    • Cilia, Wnt signaling, and the cytoskeleton
    • COI: 1:CAS:528:DC%2BC38XhsVOjsbfN, PID: 23351924
    • May-Simera HL, Kelley MW (2012) Cilia, Wnt signaling, and the cytoskeleton. Cilia 1:7
    • (2012) Cilia , vol.1 , pp. 7
    • May-Simera, H.L.1    Kelley, M.W.2
  • 40
    • 34248187071 scopus 로고    scopus 로고
    • Wnt signaling in polycystic kidney disease
    • COI: 1:CAS:528:DC%2BD2sXls1Glurw%3D, PID: 17429050
    • Benzing T, Simons M, Walz G (2007) Wnt signaling in polycystic kidney disease. J Am Soc Nephrol 18:1389–1398
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1389-1398
    • Benzing, T.1    Simons, M.2    Walz, G.3
  • 41
    • 63949088362 scopus 로고    scopus 로고
    • FGF signalling during embryo development regulates cilia length in diverse epithelia
    • COI: 1:CAS:528:DC%2BD1MXisVOrtbo%3D, PID: 19242413
    • Neugebauer JM, Amack JD, Peterson AG, Bisgrove BW, Yost HJ (2009) FGF signalling during embryo development regulates cilia length in diverse epithelia. Nature 458:651–654
    • (2009) Nature , vol.458 , pp. 651-654
    • Neugebauer, J.M.1    Amack, J.D.2    Peterson, A.G.3    Bisgrove, B.W.4    Yost, H.J.5
  • 43
    • 34548319067 scopus 로고    scopus 로고
    • Screening and outcomes in biliary atresia: summary of a National Institutes of Health workshop
    • COI: 1:CAS:528:DC%2BD2sXhtVSisbzL, PID: 17661405
    • Sokol RJ, Shepherd RW, Superina R, Bezerra JA, Robuck P, Hoofnagle JH (2007) Screening and outcomes in biliary atresia: summary of a National Institutes of Health workshop. Hepatology 46:566–581
    • (2007) Hepatology , vol.46 , pp. 566-581
    • Sokol, R.J.1    Shepherd, R.W.2    Superina, R.3    Bezerra, J.A.4    Robuck, P.5    Hoofnagle, J.H.6
  • 44
    • 67349240835 scopus 로고    scopus 로고
    • Primary biliary cirrhosis is associated with altered hepatic microRNA expression
    • This is the first report of microRNA expression analyses used to identify dysregulated microRNAs and PBC
    • • Padgett KA, Lan RY, Leung PC, Lleo A, Dawson K, Pfeiff J, Mao TK, Coppel RL, Ansari AA, Gershwin ME (2009) Primary biliary cirrhosis is associated with altered hepatic microRNA expression. J Autoimmun 32:246–253. This is the first report of microRNA expression analyses used to identify dysregulated microRNAs and PBC.
    • (2009) J Autoimmun , vol.32 , pp. 246-253
    • Padgett, K.A.1    Lan, R.Y.2    Leung, P.C.3    Lleo, A.4    Dawson, K.5    Pfeiff, J.6    Mao, T.K.7    Coppel, R.L.8    Ansari, A.A.9    Gershwin, M.E.10
  • 45
    • 0031021891 scopus 로고    scopus 로고
    • Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis
    • COI: 1:STN:280:DyaK2s7jvVagsA%3D%3D, PID: 8985258
    • Medina JF, Martinez A, Vazquez JJ, Prieto J (1997) Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis. Hepatology 25:12–17
    • (1997) Hepatology , vol.25 , pp. 12-17
    • Medina, J.F.1    Martinez, A.2    Vazquez, J.J.3    Prieto, J.4
  • 47
    • 33644524109 scopus 로고    scopus 로고
    • Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger
    • COI: 1:CAS:528:DC%2BD28XhvVSnsrc%3D, PID: 16440368
    • Banales JM, Arenas F, Rodriguez-Ortigosa CM, Saez E, Uriarte I, Doctor RB, Prieto J, Medina JF (2006) Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger. Hepatology 43:266–275
    • (2006) Hepatology , vol.43 , pp. 266-275
    • Banales, J.M.1    Arenas, F.2    Rodriguez-Ortigosa, C.M.3    Saez, E.4    Uriarte, I.5    Doctor, R.B.6    Prieto, J.7    Medina, J.F.8
  • 48
    • 33745698666 scopus 로고    scopus 로고
    • Cholangiocyte anion exchange and biliary bicarbonate excretion
    • COI: 1:CAS:528:DC%2BD28XntVSrs7s%3D, PID: 16773707
    • Banales JM, Prieto J, Medina JF (2006) Cholangiocyte anion exchange and biliary bicarbonate excretion. World J Gastroenterol 12:3496–3511
    • (2006) World J Gastroenterol , vol.12 , pp. 3496-3511
    • Banales, J.M.1    Prieto, J.2    Medina, J.F.3
  • 49
    • 84864376260 scopus 로고    scopus 로고
    • Up-regulation of microRNA 506 leads to decreased Cl-/HCO 3 - anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis
    • Determined that the upregulated microRNA, miR-506, targeted the chloride/bicarbonate exchanger, AE2, in PBC cholangiocytes; and suppression of miR-506 in isolated PBC cholangiocytes improves AE2 activity
    • 3 - anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis. Hepatology 56:687–697. Determined that the upregulated microRNA, miR-506, targeted the chloride/bicarbonate exchanger, AE2, in PBC cholangiocytes; and suppression of miR-506 in isolated PBC cholangiocytes improves AE2 activity.
    • (2012) Hepatology , vol.56 , pp. 687-697
    • Banales, J.M.1    Saez, E.2    Uriz, M.3    Sarvide, S.4    Urribarri, A.D.5    Splinter, P.6    Tietz Bogert, P.S.7    Bujanda, L.8    Prieto, J.9    Medina, J.F.10    Larusso, N.F.11
  • 50
    • 84874372441 scopus 로고    scopus 로고
    • Analysis of altered microRNA expression profiles in peripheral blood mononuclear cells from patients with primary biliary cirrhosis
    • COI: 1:CAS:528:DC%2BC3sXjsFGhtbo%3D, PID: 23173724
    • Qin B, Huang F, Liang Y, Yang Z, Zhong R (2013) Analysis of altered microRNA expression profiles in peripheral blood mononuclear cells from patients with primary biliary cirrhosis. J Gastroenterol Hepatol 28:543–550
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 543-550
    • Qin, B.1    Huang, F.2    Liang, Y.3    Yang, Z.4    Zhong, R.5
  • 51
    • 84878919588 scopus 로고    scopus 로고
    • Distinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers
    • COI: 1:CAS:528:DC%2BC3sXhtVanu7%2FP, PID: 23776611
    • Ninomiya M, Kondo Y, Funayama R, Nagashima T, Kogure T, Kakazu E, Kimura O, Ueno Y, Nakayama K, Shimosegawa T (2013) Distinct microRNAs expression profile in primary biliary cirrhosis and evaluation of miR 505-3p and miR197-3p as novel biomarkers. PLoS One 8:e66086
    • (2013) PLoS One , vol.8
    • Ninomiya, M.1    Kondo, Y.2    Funayama, R.3    Nagashima, T.4    Kogure, T.5    Kakazu, E.6    Kimura, O.7    Ueno, Y.8    Nakayama, K.9    Shimosegawa, T.10
  • 52
    • 70349569615 scopus 로고    scopus 로고
    • The immunobiology of primary sclerosing cholangitis
    • COI: 1:CAS:528:DC%2BD1MXhtFOrsLnE, PID: 19468733
    • Aron JH, Bowlus CL (2009) The immunobiology of primary sclerosing cholangitis. Semin Immunopathol 31:383–397
    • (2009) Semin Immunopathol , vol.31 , pp. 383-397
    • Aron, J.H.1    Bowlus, C.L.2
  • 59
    • 26244442249 scopus 로고    scopus 로고
    • Potential etiologies of biliary atresia
    • PID: 16176425
    • Bezerra JA (2005) Potential etiologies of biliary atresia. Pediatr Transplant 9:646–651
    • (2005) Pediatr Transplant , vol.9 , pp. 646-651
    • Bezerra, J.A.1
  • 60
    • 84856258714 scopus 로고    scopus 로고
    • • Hand NJ, Horner AM, Master ZR, Boateng LA, LeGuen C, Uvaydova M, Friedman JR (2012) MicroRNA profiling identifies miR-29 as a regulator of disease-associated pathways in experimental biliary atresia. J Pediatr Gastroenterol Nutr 54:186–192. A family of microRNAs dysregulated in the RRV model of BA was identified. Moreover, in vivo suppression of miR-29, using intraperitoneal injection of antisense oligonucleotides, resulted in a concomitant increase in predicted targets of this microRNA.
  • 62
    • 84885527917 scopus 로고    scopus 로고
    • Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia
    • An integrative genomics approach was used to reveal potential functional relevance of microRNAs and predicted targets in biliary atresia; provides information for further diagnostic and pathogenesis research
    • •• Bessho K, Shanmukhappa K, Sheridan R, Shivakumar P, Mourya R, Walters S, Kaimal V, Dilbone E, Jegga AG, Bezerra JA (2013) Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia. BMC Syst Biol 7:104. An integrative genomics approach was used to reveal potential functional relevance of microRNAs and predicted targets in biliary atresia; provides information for further diagnostic and pathogenesis research.
    • (2013) BMC Syst Biol , vol.7 , pp. 104
    • Bessho, K.1    Shanmukhappa, K.2    Sheridan, R.3    Shivakumar, P.4    Mourya, R.5    Walters, S.6    Kaimal, V.7    Dilbone, E.8    Jegga, A.G.9    Bezerra, J.A.10
  • 64
    • 3042663173 scopus 로고    scopus 로고
    • A review and update on cholangiocarcinoma
    • PID: 15218306
    • Olnes MJ, Erlich R (2004) A review and update on cholangiocarcinoma. Oncology 66:167–179
    • (2004) Oncology , vol.66 , pp. 167-179
    • Olnes, M.J.1    Erlich, R.2
  • 65
    • 84887422384 scopus 로고    scopus 로고
    • Challenges of cholangiocarcinoma detection in patients with primary sclerosing cholangitis
    • Tabibian JH, Lindor KD (2012) Challenges of cholangiocarcinoma detection in patients with primary sclerosing cholangitis. J Anal Oncol 1:50–55
    • (2012) J Anal Oncol , vol.1 , pp. 50-55
    • Tabibian, J.H.1    Lindor, K.D.2
  • 66
    • 33644633063 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis and cholangiocarcinoma
    • COI: 1:CAS:528:DC%2BD28XivVWhs7Y%3D, PID: 16496232
    • Lazaridis KN, Gores GJ (2006) Primary sclerosing cholangitis and cholangiocarcinoma. Semin Liver Dis 26:42–51
    • (2006) Semin Liver Dis , vol.26 , pp. 42-51
    • Lazaridis, K.N.1    Gores, G.J.2
  • 67
    • 70349563344 scopus 로고    scopus 로고
    • Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990–2009
    • COI: 1:CAS:528:DC%2BD1MXhtFKrs7zI, PID: 19750567
    • Aljiffry M, Walsh MJ, Molinari M (2009) Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990–2009. World J Gastroenterol 15:4240–4262
    • (2009) World J Gastroenterol , vol.15 , pp. 4240-4262
    • Aljiffry, M.1    Walsh, M.J.2    Molinari, M.3
  • 69
    • 84874686039 scopus 로고    scopus 로고
    • Concomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma
    • Oxford, The authors demonstrated the prognostic value of two microRNAs form CCA tissues
    • • McNally ME, Collins A, Wojcik SE, Liu J, Henry JC, Jiang J, Schmittgen T, Bloomston M (2013) Concomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma. HPB (Oxford) 15:260–264. The authors demonstrated the prognostic value of two microRNAs form CCA tissues.
    • (2013) HPB , vol.15 , pp. 260-264
    • McNally, M.E.1    Collins, A.2    Wojcik, S.E.3    Liu, J.4    Henry, J.C.5    Jiang, J.6    Schmittgen, T.7    Bloomston, M.8
  • 70
    • 84877671251 scopus 로고    scopus 로고
    • MicroRNA-21 regulates the invasion and metastasis in cholangiocarcinoma and may be a potential biomarker for cancer prognosis
    • PID: 23621247
    • Huang Q, Liu L, Liu CH, You H, Shao F, Xie F, Lin XS, Hu SY, Zhang CH (2013) MicroRNA-21 regulates the invasion and metastasis in cholangiocarcinoma and may be a potential biomarker for cancer prognosis. Asian Pac J Cancer Prev 14:829–834
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 829-834
    • Huang, Q.1    Liu, L.2    Liu, C.H.3    You, H.4    Shao, F.5    Xie, F.6    Lin, X.S.7    Hu, S.Y.8    Zhang, C.H.9
  • 74
    • 84887150782 scopus 로고    scopus 로고
    • Progress in microRNA delivery
    • COI: 1:CAS:528:DC%2BC3sXhvFOjt7jL, PID: 24075926
    • Zhang Y, Wang Z, Gemeinhart RA (2013) Progress in microRNA delivery. J Control Release 172:962–974
    • (2013) J Control Release , vol.172 , pp. 962-974
    • Zhang, Y.1    Wang, Z.2    Gemeinhart, R.A.3
  • 75
    • 34247244657 scopus 로고    scopus 로고
    • The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes
    • COI: 1:CAS:528:DC%2BD2sXis1Kgtbg%3D, PID: 17220301
    • Meng F, Henson R, Wehbe-Janek H, Smith H, Ueno Y, Patel T (2007) The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes. J Biol Chem 282:8256–8264
    • (2007) J Biol Chem , vol.282 , pp. 8256-8264
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Smith, H.4    Ueno, Y.5    Patel, T.6
  • 76
    • 84877264003 scopus 로고    scopus 로고
    • Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing MicroRNA-21
    • COI: 1:CAS:528:DC%2BC3MXhs1OqsbrL, PID: 22213145
    • He Q, Cai L, Shuai L, Li D, Wang C, Liu Y, Li X, Li Z, Wang S (2013) Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing MicroRNA-21. Mol Carcinog 52:286–296
    • (2013) Mol Carcinog , vol.52 , pp. 286-296
    • He, Q.1    Cai, L.2    Shuai, L.3    Li, D.4    Wang, C.5    Liu, Y.6    Li, X.7    Li, Z.8    Wang, S.9
  • 78
    • 84856366992 scopus 로고    scopus 로고
    • miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma
    • COI: 1:CAS:528:DC%2BC38Xht1yqur4%3D, PID: 21953056
    • Razumilava N, Bronk SF, Smoot RL, Fingas CD, Werneburg NW, Roberts LR, Mott JL (2012) miR-25 targets TNF-related apoptosis inducing ligand (TRAIL) death receptor-4 and promotes apoptosis resistance in cholangiocarcinoma. Hepatology 55:465–475
    • (2012) Hepatology , vol.55 , pp. 465-475
    • Razumilava, N.1    Bronk, S.F.2    Smoot, R.L.3    Fingas, C.D.4    Werneburg, N.W.5    Roberts, L.R.6    Mott, J.L.7
  • 79
    • 84862762321 scopus 로고    scopus 로고
    • MicroRNA-26a promotes cholangiocarcinoma growth by activating beta-catenin
    • Zhang J, Han C, Wu T (2012) MicroRNA-26a promotes cholangiocarcinoma growth by activating beta-catenin. Gastroenterology 143(246–256):e248
    • (2012) Gastroenterology , vol.143 , Issue.246-256
    • Zhang, J.1    Han, C.2    Wu, T.3
  • 80
    • 79959968604 scopus 로고    scopus 로고
    • A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression
    • 388
    • Yang H, Li TW, Peng J, Tang X, Ko KS, Xia M, Aller MA (2011) A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression. Gastroenterology 141:378–388, 388 e371–374.
    • (2011) Gastroenterology , vol.141 , Issue.378-388 , pp. e371-e374
    • Yang, H.1    Li, T.W.2    Peng, J.3    Tang, X.4    Ko, K.S.5    Xia, M.6    Aller, M.A.7
  • 81
    • 84655169703 scopus 로고    scopus 로고
    • MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression
    • COI: 1:CAS:528:DC%2BC38XmtFOh, PID: 22146319
    • Zhong XY, Yu JH, Zhang WG, Wang ZD, Dong Q, Tai S, Cui YF, Li H (2012) MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression. Gene 493:44–51
    • (2012) Gene , vol.493 , pp. 44-51
    • Zhong, X.Y.1    Yu, J.H.2    Zhang, W.G.3    Wang, Z.D.4    Dong, Q.5    Tai, S.6    Cui, Y.F.7    Li, H.8
  • 82
    • 77950600443 scopus 로고    scopus 로고
    • MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes
    • COI: 1:CAS:528:DC%2BC3cXks1Sqs7w%3D, PID: 20146264
    • Braconi C, Huang N, Patel T (2010) MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. Hepatology 51:881–890
    • (2010) Hepatology , vol.51 , pp. 881-890
    • Braconi, C.1    Huang, N.2    Patel, T.3
  • 84
    • 38049152791 scopus 로고    scopus 로고
    • Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes
    • COI: 1:CAS:528:DC%2BD1cXksVKnsQ%3D%3D, PID: 17621267
    • Meng F, Wehbe-Janek H, Henson R, Smith H, Patel T (2008) Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes. Oncogene 27:378–386
    • (2008) Oncogene , vol.27 , pp. 378-386
    • Meng, F.1    Wehbe-Janek, H.2    Henson, R.3    Smith, H.4    Patel, T.5
  • 85
    • 79959721605 scopus 로고    scopus 로고
    • miR-373 negatively regulates methyl-CpG-binding domain protein 2 (MBD2) in hilar cholangiocarcinoma
    • COI: 1:CAS:528:DC%2BC3MXmtlyqurc%3D, PID: 21086164
    • Chen Y, Luo J, Tian R, Sun H, Zou S (2011) miR-373 negatively regulates methyl-CpG-binding domain protein 2 (MBD2) in hilar cholangiocarcinoma. Dig Dis Sci 56:1693–1701
    • (2011) Dig Dis Sci , vol.56 , pp. 1693-1701
    • Chen, Y.1    Luo, J.2    Tian, R.3    Sun, H.4    Zou, S.5
  • 87
    • 34548687035 scopus 로고    scopus 로고
    • mir-29 regulates Mcl-1 protein expression and apoptosis
    • COI: 1:CAS:528:DC%2BD2sXhtVeisLvJ, PID: 17404574
    • Mott JL, Kobayashi S, Bronk SF, Gores GJ (2007) mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 26:6133–6140
    • (2007) Oncogene , vol.26 , pp. 6133-6140
    • Mott, J.L.1    Kobayashi, S.2    Bronk, S.F.3    Gores, G.J.4


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