MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease

Journal of Clinical Investigation

Volumn 118, Issue 11, 2008, Pages 3714-3724

  Lee, Seung Ok ^a,b   Masyuk, Tatyana ^a   Splinter, Patrick ^a   Banales, Jesús M ^a,c   Masyuk, Anatoliy ^a   Stroope, Angela ^a   LaRusso, Nicholas ^a  

^a MAYO CLINIC   (United States)

^b Chonbuk National University Medical School   (South Korea)

^c UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ISOENZYME; MICRORNA; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL PROLIFERATION; HUMAN; HUMAN TISSUE; KIDNEY POLYCYSTIC DISEASE; LIVER POLYCYSTIC DISEASE; MICROARRAY ANALYSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSCRIPTION REGULATION;

ANIMALS; BILE DUCTS; CDC25 PHOSPHATASES; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; LIVER DISEASES; MICRORNAS; POLYCYSTIC KIDNEY, AUTOSOMAL RECESSIVE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 55849085074     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI34922     Document Type: Article

References (40)

1. Masyuk, T., and LaRusso, N. 2006. Polycystic liver disease: new insights into disease pathogenesis. Hepatology. 43:906-908.
2. Everson, G.T., Taylor, M.R., and Doctor, R.B. 2004. Polycystic disease of the liver. Hepatology. 40:774-782.
3. Drenth, J.P., Martina, J.A., Te Morsche, R.H., Jansen, J.B., and Bonifacino, J.S. 2004. Molecular characterization of hepatocystin, the protein that is defective in autosomal dominant polycystic liver disease. Gastroenterology. 126:1819-1827.
4. Chang, M.Y., and Ong, A.C. 2008. Autosomal dominant polycystic kidney disease: recent advances in pathogenesis and treatment. Nephron Physiol. 108:p1-p7.
5. Onuchic, L.F., et al. 2002. PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. Am. J. Hum. Genet. 70:1305-1317.
6. Ward, C.J., et al. 2002. The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. Nat. Genet. 30:259-269.
7. Shneider, B.L., and Magid, M.S. 2005. Liver disease in autosomal recessive polycystic kidney disease. Pediatr. Transplant. 9:634-639.
8. Katsuyama, M., Masuyama, T., Komura, I., Hibino, T., and Takahashi, H. 2000. Characterization of a novel polycystic kidney rat model with accompanying polycystic liver. Exp. Anim. 49:51-55.
9. Masyuk, T.V., et al. 2004. Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease. Am. J. Pathol. 165:1719-1730.
10. Masyuk, T.V., Masyuk, A.I., Torres, V.E., Harris, P.C., and Larusso, N.F. 2007. Octreotide inhibits hepatic cystogenesis in a rodent model of polycystic liver disease by reducing cholangiocyte adenosine 3′,5′-cyclic monophosphate. Gastroenterology. 132:1104-1116.
11. Lager, D.J., Qian, Q., Bengal, R.J., Ishibashi, M., and Torres, V.E. 2001. The pck rat: a new model that resembles human autosomal dominant polycystic kidney and liver disease. Kidney Int. 59:126-136.
12. Muff, M.A., et al. 2006. Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of autosomal recessive polycystic kidney disease. Lab. Invest. 86:940-950.
13. Karlsson-Rosenthal, C., and Millar, J.B. 2006. Cdc25: mechanisms of checkpoint inhibition and recovery. Trends Cell Biol. 16:285-292.
14. Sadhu, K., Reed, S.I., Richardson, H., and Russell, P. 1990. Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc. Natl. Acad. Sci. U. S. A. 87:5139-5143.
15. Galaktionov, K., and Beach, D. 1991. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell. 67:1181-1194.
16. Boutros, R., Dozier, C., and Ducommun, B. 2006. The when and wheres of CDC25 phosphatases. Curr. Opin. Cell Biol. 18:185-191.
17. Kristjansdottir, K., and Rudolph, J. 2004. Cdc25 phosphatases and cancer. Chem. Biol. 11:1043-1051
18. Prevost, G.P., et al. 2003. Inhibitors of the CDC25 phosphatases. Prog. Cell Cycle Res. 5:225-234.
19. Miska, E.A. 2005. How microRNAs control cell division, differentiation and death. Curr. Opin. Genet. Dev. 15:563-568.
20. Carthew, R.W. 2006. Gene regulation by microRNAs. Curr. Opin. Genet. Dev. 16:203-208.
21. Chan, J.A., Krichevsky, A.M., and Kosik, K.S. 2005. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 65:6029-6033.
22. Cimmino, A., et al. 2005. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. U. S. A. 102:13944-13949.
23. Hwang, H.W., and Mendell, J.T. 2006. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br. J. Cancer. 94:776-780.
24. Calin, G.A., and Croce, C.M. 2006. MicroRNA-cancer connection: the beginning of a new tale. Cancer Res. 66:7390-7394.
25. Lu, J., et al. 2005. MicroRNA expression profiles classify human cancers. Nature. 435:834-838.
26. Wienholds, E., et al. 2005. MicroRNA expression in zebrafish embryonic development. Science. 309:310-311.
27. Nelson, P.T., et al. 2006. RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA. 12:187-191.
28. Johnson, C.D., et al. 2007. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 67:7713-7722.
29. Tian, Z., Greene, A.S., Pietrusz, J.L., Matus, I.R., and Liang, M. 2008. MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis. Genome Res. 18:404-411.
30. Bak, M., et al. 2008. MicroRNA expression in the adult mouse central nervous system. RNA. 14:432-444.
31. Porkka, K.P., et al. 2007. MicroRNA expression profiling in prostate cancer. Cancer Res. 67:6130-6135.
32. Yanaihara, N., et al. 2006. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 9:189-198.
33. Chauveau, D., Fakhouri, F., and Grunfeld, J.P. 2000. Liver involvement in autosomal-dominant polycystic kidney disease: therapeutic dilemma. J. Am. Soc. Nephrol. 11:1767-1775.
34. O'Donnell, K.A., Wentzel, E.A., Zeller, K.I., Dang, C.V., and Mendell, J.T. 2005. c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 435:839-843.
35. Lee, Y., et al. 2004. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23:4051-4060.
36. Lund, E., Guttinger, S., Calado, A., Dahlberg, J.E., and Kutay, U. 2004. Nuclear export of microRNA precursors. Science. 303:95-98.
37. Thomson, J.M., et al. 2006. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 20:2202-2207.
38. Bukanov, N.O., et al. 2006. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine. Nature. 444:949-952.
39. Vroman, B., and LaRusso, N.F. 1996. Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells. Lab. Invest. 74:303-313.
40. Chen, X.M., et al. 2005. Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-kappaB. J. Immunol. 175:7447-7456.