Controlled drug release from antibiotic-loaded layered double hydroxide coatings on porous titanium implants in a mouse model

Journal of Biomedical Materials Research - Part A

Volumn 103, Issue 6, 2015, Pages 2141-2149

  Badar, Muhammad ^a,b   Rahim, Muhammad Imran ^a   Kieke, Marc ^c   Ebel, Thomas ^d   Rohde, Manfred ^a   Hauser, Hansjörg ^a   Behrens, Peter ^c   Mueller, Peter P ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b GOMAL UNIVERSITY   (Pakistan)

^c LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^d INSTITUTE OF MATERIALS RESEARCH   (Germany)

Author keywords

bacterial biofilm; degradable implant coating; implant infection; layered double hydroxides; local drug delivery

Indexed keywords

ANTIBIOTICS; CONTROLLED DRUG DELIVERY; MAMMALS; TITANIUM;

BACTERIAL BIOFILM; CONTROLLED DRUG RELEASE; IMPLANT INFECTIONS; LAYERED DOUBLE HYDROXIDES; LOCAL DRUG DELIVERY; NONINVASIVE IN VIVO IMAGING; POROUS TITANIUM IMPLANTS; PSEUDOMONAS AERUGINOSA;

ORGANIC COATINGS;

CIPROFLOXACIN; HYDROXIDE; LACTATE DEHYDROGENASE; TITANIUM; ANTIINFECTIVE AGENT; BIOCOMPATIBLE COATED MATERIAL; DELAYED RELEASE FORMULATION; HYDROXIDE ION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BIODEGRADABLE IMPLANT; CELL ADHESION; CELL PROLIFERATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DEVICE INFECTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ELECTRON MICROSCOPY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MATERIAL COATING; MECHANICAL STRESS; MOUSE; MOUSE MODEL; NON INVASIVE PROCEDURE; NONHUMAN; POROSITY; PROTECTION; PSEUDOMONAS AERUGINOSA; REFLECTOMETRY; X RAY DIFFRACTION; 3T3 CELL LINE; ANIMAL; BAGG ALBINO MOUSE; DELAYED RELEASE FORMULATION; PHARMACOLOGY; VOLATILIZATION;

ANIMALS; ANTI-BACTERIAL AGENTS; CIPROFLOXACIN; COATED MATERIALS, BIOCOMPATIBLE; DELAYED-ACTION PREPARATIONS; FEMALE; HYDROXIDES; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; NIH 3T3 CELLS; POROSITY; TITANIUM; VOLATILIZATION;

EID: 84928523091     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35358     Document Type: Article

References (42)

1. Ochsner PE,. Osteointegration of orthopaedic devices. Semin Immunopathol 2011; 33: 245-256.
2. Palmquist A, Omar OM, Esposito M, Lausmaa J, Thomsen P,. Titanium oral implants: Surface characteristics, interface biology and clinical outcome. J R Soc Interface 2010; 7 Suppl 5: S515-S527.
3. Wongwiwat P, Boonma A, Lee YS, Narayan RJ,. Bioceramics in ossicular replacement prostheses: A review. J Long Term Eff Med Implants 2011; 21: 169-183.
4. Briceno DF, Quinn JP, Villegas MV,. Treatment options for multidrug-resistant nonfermenters. Expert Rev Anti Infect Ther 2010; 8: 303-315.
5. Haussler S,. Multicellular signalling and growth of Pseudomonas aeruginosa. Int J Med Microbiol 2010; 300: 544-548.
6. Costerton JW, Montanaro L, Arciola CR,. Biofilm in implant infections: Its production and regulation. Int J Artif Organs 2005; 28: 1062-1068.
7. Trampuz A, Widmer AF,. Infections associated with orthopedic implants. Curr Opin Infect Dis 2006; 19: 349-356.
8. Busscher HJ, van der Mei HC, Subbiahdoss G, Jutte PC, van den Dungen JJ, Zaat SA, Schultz MJ, Grainger DW,. Biomaterial-associated infection: Locating the finish line in the race for the surface. Sci Transl Med 2012; 4: 153rv10.
9. Salwiczek M, Qu Y, Gardiner J, Strugnell RA, Lithgow T, McLean KM, Thissen H,. Emerging rules for effective antimicrobial coatings. Trends Biotechnol 2014; 32: 82-90.
10. Romanò CL, Toscano M, Romanò D, Drago L,. Antibiofilm agents and implant-related infections in orthopaedics: Where are we? J Chemother 2013; 25: 65-80.
11. Zalavras CG, Patzakis MJ, Holtom P,. Local antibiotic therapy in the treatment of open fractures and osteomyelitis. Clin Orthop Relat Res 2004: 86-93.
12. Schmidmaier G, Lucke M, Wildemann B, Haas NP, Raschke M,. Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: A review. Injury 2006; 37 Suppl 2: S105-S112.
13. Hetrick EM, Schoenfisch MH,. Reducing implant-related infections: Active release strategies. Chem Soc Rev 2006; 35: 780-789.
14. Simchi A, Tamjid E, Pishbin F, Boccaccini AR,. Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications. Nanomedicine 2011; 7: 22-39.
15. Hart E, Azzopardi K, Taing H, Graichen F, Jeffery J, Mayadunne R, Wickramaratna M, O'Shea M, Nijagal B, Watkinson R, O'Leary S, Finnin B, Tait R, Robins-Browne R., Efficacy of antimicrobial polymer coatings in an animal model of bacterial infection associated with foreign body implants. J Antimicrob Chemother 2010; 65: 974-980.
16. Kluin OS, van der Mei HC, Busscher HJ, Neut D,. Biodegradable vs non-biodegradable antibiotic delivery devices in the treatment of osteomyelitis. Expert Opin Drug Deliv 2013; 10: 341-351.
17. Wohl-Bruhn S, Badar M, Bertz A, Tiersch B, Koetz J, Menzel H, Mueller PP, Bunjes H,. Comparison of in vitro and in vivo protein release from hydrogel systems. J Control Release 2012; 162: 127-133.
18. Kastrati A,. Drug for a while, polymer for life: Is it a good solution? Catheter Cardiovasc Interv 2008; 71: 340-341.
19. Byrne RA, Kastrati A, Tiroch K, Schulz S, Pache J, Pinieck S, Massberg S, Seyfarth M, Laugwitz KL, Birkmeier KA, Schömig A, Mehilli J,; ISAR-TEST-2 Investigators. 2-Year clinical and angiographic outcomes from a randomized trial of polymer-free dual drug-eluting stents versus polymer-based cypher and endeavor, drug-eluting stents. J Am Coll Cardiol 2010; 55: 2536-2543.
20. Cavani F, Trifirò F, Vaccari A,. Hydrotalcite-type anionic clays: Preparation, properties and applications. Catal Today 1991; 11: 173-1301.
21. Playle AC, Gunning SR, Llewellyn AF,. The in vitro antacid and anti pepsin activity of hydrotalcite. Pharm Acta Helv 1974; 49: 298-302.
22. Chokr A, Leterme D, Watier D, Jabbouri S,. Neither the presence of ica locus, nor in vitro-biofilm formation ability is a crucial parameter for some Staphylococcus epidermidis strains to maintain an infection in a guinea pig tissue cage model. Microb Pathog 2007; 42: 94-97.
23. Bjarnsholt T, Alhede M, Alhede M, Eickhardt-Sørensen SR, Moser C, Kühl M, Jensen PØ, Høiby N,. The in vivo biofilm. Trends Microbiol 2013; 21: 466-474.
24. Kadurugamuwa JL, Sin L, Albert E, Yu J, Francis K, DeBoer M, Rubin M, Bellinger-Kawahara C, Parr Jr TR, Jr., Contag PR., Direct continuous method for monitoring biofilm infection in a mouse model. Infect Immun 2003; 71: 882-890.
25. Badar M, Hemmen K, Nimtz M, Stieve M, Stiesch M, Lenarz T, Hauser H, Möllmann U, Vogt S, Schnabelrauch M, Mueller PP,. Evaluation of madurahydroxylactone as a slow release antibacterial implant coating. Open Biomed Eng J 2010; 4: 263-270.
26. Ehlert N, Badar M, Christel A, Lohmeier SJ, Luessenhop T, Stieve M, Lenarz T, Mueller PP, Behrens P,. Mesoporous silica coatings for controlled release of the antibiotic ciprofloxacin from implants. J Mater Chem 2011; 21: 752.
27. Koort JK, Makinen TJ, Suokas E, Veiranto M, Jalava J, Knuuti J, Tormala P, Aro HT,. Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus. Antimicrob Agents Chemother 2005; 49: 1502-1508.
28. Sjollema J, Sharma PK, Dijkstra RJ, van Dam GM, van der Mei HC, Engelsman AF, Busscher HJ,. The potential for bio-optical imaging of biomaterial-associated infection in vivo. Biomaterials 2010; 31: 1984-1995.
29. Hesse D, Badar M, Bleich A, Smoczek A, Glage S, Kieke M, Behrens P, Müller PP, Esser KH, Stieve M, Prenzler NK,. Layered double hydroxides as efficient drug delivery system of ciprofloxacin in the middle ear: An animal study in rabbits. J Mater Sci Mater Med 2013; 24: 129-136.
30. Cazedey ECL, Salgado HRN,. Spectrophotometric determination of ciprofloxacin hydrochloride in ophthalmic solution. Adv Anal Chem 2012; 2: 74-79.
31. Nijhu RS, Jhanker YM, Sutradhar KB,. Development of an assay method for simultaneous determination of ciprofloxacin and naproxen by uv spectrophotometric method. Stamford J Pharm Sci 2011; 4: 84-90.
32. Becher A, Schweizer HP,. Integration-proficient Pseudomonas aeruginosa vectors for isolation of single-copy chromosomal lacZ and lux gene fusions. Biotechniques 2000; 29: 948-952.
33. Fletcher MP, Diggle SP, Camara M, Williams P,. Biosensor-based assays for PQS, HHQ and related 2-alkyl-4-quinolone quorum sensing signal molecules. Nat Protoc 2007; 2: 1254-1262.
34. Uan J-Y, Lin J-K, Tung Y-S,. Direct growth of oriented Mg-Al layered double hydroxide film on Mg alloy in aqueous HCO 3-/ CO 3 2-solution. J Mater Chem 2010; 20: 761-766.
35. Lawrence JW, Claire DC, Weissig V, Rowe TC,. Delayed cytotoxicity and cleavage of mitochondrial DNA in ciprofloxacin-treated mammalian cells. Mol Pharmacol 1996; 50: 1178-1188.
36. Gurbay A, Garrel C, Osman M, Richard MJ, Favier A, Hincal F,. Cytotoxicity in ciprofloxacin-treated human fibroblast cells and protection by vitamin E. Hum Exp Toxicol 2002; 21: 635-641.
37. Miclau T, Edin ML, Lester GE, Lindsey RW, Dahners LE,. Effect of ciprofloxacin on the proliferation of osteoblast-like MG-63 human osteosarcoma cells in vitro. J Orthopaedic Res 1998; 16: 509-512.
38. Gurbay A, Gonthier B, Barret L, Favier A, Hincal F,. Cytotoxic effect of ciprofloxacin in primary culture of rat astrocytes and protection by vitamin E. Toxicology 2007; 229: 54-61.
39. Tyner KM, Roberson MS, Berghorn KA, Li L, Gilmour RF, Jr., Batt CA, Giannelis EP., Intercalation, delivery, and expression of the gene encoding green fluorescence protein utilizing nanobiohybrids. J Control Release 2004; 100: 399-409.
40. Tyner KM, Schiffman SR, Giannelis EP,. Nanobiohybrids as delivery vehicles for camptothecin. J Controlled Release 2004; 95: 501-514.
41. Barman TK, Rao M, Bhati A, Kishore K, Shukla G, Kumar M, Mathur T, Pandya M, Upadhyay DJ,. Non invasive real-time monitoring of bacterial infection & therapeutic effect of anti-microbials in five mouse models. Indian J Med Res 2011; 134: 688-695.
42. Engelsman AF, van der Mei HC, Francis KP, Busscher HJ, Ploeg RJ, van Dam GM,. Real time noninvasive monitoring of contaminating bacteria in a soft tissue implant infection model. J Biomed Mater Res B Appl Biomater 2009; 88: 123-129.