Rational design of triazololipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins

Journal of Medicinal Chemistry

Volumn 58, Issue 8, 2015, Pages 3459-3470

  Beltramo, Massimiliano ^a   Robert, Vincent ^a   Galibert, Mathieu ^b   Madinier, Jean Baptiste ^b   Marceau, Philippe ^b   Dardente, Hugues ^a   Decourt, Caroline ^a   De Roux, Nicolas ^c   Lomet, Didier ^a   Delmas, Agnès F ^b   Caraty, Alain ^a   Aucagne, Vincent ^b  

^a UMR85 PHYSIOLOGIE DE LA REPRODUCTION ET DES COMPORTEMENTS   (France)

^b CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; AMIDE; FOLLITROPIN; GONADOTROPIN; KISSPEPTIN; KISSPEPTIN 10; LIPOPEPTIDE; LUTEINIZING HORMONE; KISS1 PROTEIN, HUMAN; PEPTIDE HYDROLASE; PROTEIN BINDING; SERUM ALBUMIN; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; DELAYED PUBERTY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; EWE; FEMALE; FOLLITROPIN BLOOD LEVEL; FOLLITROPIN RELEASE; HUMAN; HUMAN CELL; HYPOGONADOTROPIC HYPOGONADISM; HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMIC AMENORRHEA; LUTEINIZING HORMONE RELEASE; NONHUMAN; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION; ACETYLATION; AMINO ACID SEQUENCE; ANIMAL; BLOOD; CELL LINE; CHEMISTRY; CHO CELL LINE; CRICETULUS; HEK293 CELL LINE; METABOLISM; SHEEP;

ACETYLATION; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHO CELLS; CRICETULUS; FEMALE; FOLLICLE STIMULATING HORMONE; HEK293 CELLS; HUMANS; KISSPEPTINS; LUTEINIZING HORMONE; PEPTIDE HYDROLASES; PROTEIN BINDING; SERUM ALBUMIN; SHEEP; TRIAZOLES;

EID: 84928473997     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5019675     Document Type: Article

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