Physicochemically and pharmacokinetically stable nonapeptide kiss1 receptor agonists with highly potent testosterone-suppressive activity

Journal of Medicinal Chemistry

Volumn 57, Issue 14, 2014, Pages 6105-6115

  Asami, Taiji ^a   Nishizawa, Naoki ^a   Matsui, Hisanori ^a   Takatsu, Yoshihiro ^a   Suzuki, Atsuko ^a   Kiba, Atsushi ^a   Terada, Michiko ^a   Nishibori, Kimiko ^a   Nakayama, Masaharu ^a   Ban, Junko ^a   Matsumoto, Shin Ichi ^a   Tarui, Naoki ^a   Ikeda, Yukihiro ^a   Yamaguchi, Masashi ^a   Kusaka, Masami ^a   Ohtaki, Tetsuya ^a   Kitada, Chieko ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARAGINE; G PROTEIN COUPLED RECEPTOR 54; GLYCINE; METASTIN; NONAPEPTIDE; SERINE; TESTOSTERONE; TRYPTOPHAN; TYROSINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHO CELL LINE; CONTROLLED STUDY; DRUG ACETYLATION; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PH; PHYSICAL CHEMISTRY; RAT; RAT MODEL; REDUCTION; SINGLE DRUG DOSE; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SUPPRESSANT ACTIVITY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CHEMISTRY, PHYSICAL; CHO CELLS; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KISSPEPTINS; MALE; MOLECULAR CONFORMATION; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE;

EID: 84905055099     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5005489     Document Type: Article

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