Molecular subtypes in stage II-III colon cancer defined by genomic instability: Early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Berg, Marianne ^a,b   Nordgaard, Oddmund ^b   Kørner, Hartwig ^b,c   Oltedal, Satu ^b   Smaaland, Rune ^b   Søreide, Jon Arne ^b,c   Søreide, Kjetil ^b,c  

^a UNIVERSITY OF STAVANGER   (Norway)

^b STAVANGER UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; NEUROGENIN 1; PROTEIN MLH1; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR RUNX3; RUNX3 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BRAF GENE; CACNA1G GENE; CANCER MORTALITY; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CANCER SURVIVOR; CDKN2A GENE; COLON CANCER; CONTROLLED STUDY; COPY NUMBER VARIATION; CPG ISLAND; CPG ISLAND METHYLATOR PHENOTYPE; CRABP1 GENE; DISEASE ASSOCIATION; DNA METHYLATION; FEMALE; GENE; GENE LOSS; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; IGF2 GENE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MLH1 GENE; MOLECULAR GENETICS; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; NEUROG1 GENE; ONCOGENE K RAS; OUTCOME ASSESSMENT; PHENOTYPE; PREVALENCE; RECURRENCE RISK; RUNX3 GENE; SOCS1 GENE; TUMOR SUPPRESSOR GENE; COHORT ANALYSIS; COLON TUMOR; GENETICS; MIDDLE AGED; RECURRENT DISEASE; SURVIVAL ANALYSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; COLONIC NEOPLASMS; CORE BINDING FACTOR ALPHA 3 SUBUNIT; DNA COPY NUMBER VARIATIONS; FEMALE; GENES, P16; GENOMIC INSTABILITY; HUMANS; MALE; MIDDLE AGED; RECURRENCE; SURVIVAL ANALYSIS;

EID: 84928243516     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122391     Document Type: Article

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