Hunk/Mak-v is a negative regulator of intestinal cell proliferation

BMC Cancer

Volumn 15, Issue 1, 2015, Pages

  Reed, Karen R ^a   Korobko, Igor V ^a,b   Ninkina, Natalia ^a,c   Korobko, Elena V ^b   Hopkins, Ben R ^a   Platt, James L ^a   Buchman, Vladimir ^a   Clarke, Alan R ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSTITUTE OF GENE BIOLOGY   (Russian Federation)

^c INSTITUTE OF GENERAL PATHOLOGY AND PATHOPHYSIOLOGY   (Russian Federation)

Author keywords

ApcMin microarray; Cancer; Hunk; Intestine; Mak V; Wnt signalling

Indexed keywords

HORMONALLY UPREGULATED NEU ASSOCIATED KINASE; PROTEIN MAK V; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; HUNK PROTEIN, MOUSE; PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SIZE; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GROWTH REGULATION; HISTOPATHOLOGY; HOMEOSTASIS; HORMONALLY UPREGULATED NEU ASSOCIATED KINASE GENE; INTESTINE CELL; INTESTINE EPITHELIUM CELL; INTESTINE FUNCTION; INTESTINE HOMEOSTASIS; MALE; MICROARRAY ANALYSIS; MOUSE; MOUSE MODEL; NONHUMAN; OVERALL SURVIVAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE CANCER; SURVIVAL RATE; TUMOR VOLUME; WNT SIGNALING PATHWAY; AMINO ACID SEQUENCE; ANIMAL; CELL TRANSFORMATION; DEFICIENCY; DISEASE MODEL; EMBRYONIC STEM CELL; GENE LOCUS; GENE SILENCING; GENE TARGETING; GENETICS; INTESTINE; METABOLISM; MOLECULAR GENETICS; MORTALITY; NEOPLASM; NUCLEOTIDE SEQUENCE; PATHOLOGY; UPREGULATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; FEMALE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENE TARGETING; GENETIC LOCI; INTESTINES; MALE; MICE; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROTEIN KINASES; TUMOR BURDEN; UP-REGULATION; WNT SIGNALING PATHWAY;

EID: 84928239089     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1087-2     Document Type: Article

References (22)

1. Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 2004;18:1385-90.
2. Korobko IV, Kabishev AA, Kiselev SL. Identification of the new protein kinase specifically transcribed in mouse tumors with high metastatic potential. Dokl Akad Nauk. 1997;354(4):554-6.
3. Korobko IV, Kalinichenko SV, Korobko EV, Ninkina NN, Kiselev SL, Buchman VL. Pro-survival activity of the MAK-V protein kinase in PC12 cells. Cell Cycle. 2010;9(20):4248-9.
4. Gardner HP, Wertheim GBW, Ha SI, Copeland NG, Gilbert DJ, Jenkins NA, et al. Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. Genomics. 2000;63:46-59.
5. Kalinichenko SV, Itoh K, Korobko EV, Sokol SY, Buchman VL. Korobko IV identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase. PLoS One. 2012;7(6):e39505.
6. Kalinichenko SV, Vikhreva PN, Korobko IV. Interaction between MAK-V protein kinase and synaptopodin. Biochemistry (Mosc). 2011;76(2):196-201.
7. Korobko IV, Korobko EV, Kiselev SL. The MAK-V protein kinase regulates endocytosis in mouse. Mol Gen Genet. 2000;264(4):411-8.
8. Quintela-Fandino M, Arpaia E, Brenner D, Goh T, Yeung FA, Blaser H. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Proc Natl Acad Sci U S A. 2010;107(6):2622-7.
9. Gardner HP, Belka GK, Wertheim GB, Hartman JL, Ha SI, Gimotty PA, et al. Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland. Development. 2000;127(20):4493-509.
10. Saki M, Tamura K, Tsurumi Y, Tanaka Y, Koide Y, Matsuda M, et al. Renal Expression of MAK-V/Hunk in renal distal tubules and its possible involvement in proliferative suppression. Am J Physiol. 2007;292(5):F1526-36.
11. Korobko IV, Zavalishina LE, Kiselev SL, Raĭkhlin NT, Frank GA. Proteinkinase MAK-V/Hunk as a possible diagnostic and prognostic marker of human breast carcinoma. Arkh Patol. 2004;66(5):6-9.
12. Wertheim GBW, Yang TW, Pan T, Ramne A, Liu Z, Gardner HP, et al. The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc Natl Acad Sci U S A. 2009;106:15855-60.
13. Yeh ES, Yang TW, Jung JJ, Gardner HP, Cardiff RD, Chodosh LA. Hunk is required for HER2/neu-induced mammary tumorigenesis. J Clin Invest. 2011;121(3):866-79.
14. Yeh ES, Belka GK, Vernon AE, Chen CC, Jung JJ. Chodosh LA Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. Proc Natl Acad Sci U S A. 2013;110(15):6103-8.
15. Kibardin A, Ossipova O, Sokol SY. Metastasis associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis. Development. 2006;133(15):2845-54.
16. Tybulewicz VL, Crawford CE, Jackson PK, Bronson RT, Mulligan RC. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell. 1991;65:1153-63.
17. Ninkina N, Papachroni K, Robertson DC, Schmidt O, Delaney L, O'Neil F, et al. Neurons expressing the highest levels of Γ-synuclein are unaffected by targeted inactivation of the gene. Mol Cel Biology. 2003;23:8233-45.
18. Buchman VL, Luke C, Borthwick EB, Ninkina N. Organisation of the mouse Ruk locus and expression of isoforms in mouse tissues. Gene. 2002;295:13-7.
19. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 2001;25:402-8.
20. Reed KR, Athineos D, Meniel VS, Wilkins JA, Ridgway RA, Burke ZD, et al. B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of Apc loss in the liver. Proc Natl Acad Sci U S A. 2008;105(48):18919-23s.
21. Xu B, Chen C, Chen H, Zheng SG, Bringas Jr P, et al. Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development. Development. 2011;138(5):925-35.
22. Dao DY, Yang X, Chen D, Zuscik M, O'Keefe RJ. Axin1 andAxin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways. Ann N Y Acad Sci. 2007;1116:82-99.