Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Tang, Jun ^a,b   Zhu, Chao ^c   Li, Zhi hong ^d   Liu, Xiao yu ^a   Sun, Shu kai ^b   Zhang, Ting ^b   Luo, Zhuo jing ^c   Zhang, Hui ^b   Li, Wei yan ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Analgesic; Astrocytes; MCP 1; Neuropathic pain; Tanshinone IIA sulfonate

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TANSHINONE IIA; TANSHINONE IIA SULFONATE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ABIETANE DERIVATIVE; ANALGESIC AGENT; CCL2 PROTEIN, RAT; TANSHINONE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HYPERSENSITIVITY; IN VIVO STUDY; INHIBITION KINETICS; MALE; MECHANICAL PAW WITHDRAWAL THRESHOLD; MOTOR PERFORMANCE; NEUROPATHIC PAIN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; RAT; ROTAROD TEST; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; UPREGULATION; ANALYSIS OF VARIANCE; ANIMAL; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; HYPERALGESIA; INJURIES; METABOLISM; MOVEMENT DISORDERS; NEURALGIA; PAIN THRESHOLD; PATHOLOGY; SPINAL CORD; SPINAL NERVE; SPRAGUE DAWLEY RAT;

ANALGESICS; ANALYSIS OF VARIANCE; ANIMALS; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERALGESIA; MALE; MAP KINASE SIGNALING SYSTEM; MOVEMENT DISORDERS; NEURALGIA; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL NERVES;

EID: 84928235514     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0279-7     Document Type: Article

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