Focused ultrasound-induced blood-brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: A preclinical feasibility study

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Chen, Pin Yuan ^a,c   Hsieh, Han Yi ^b   Huang, Chiung Yin ^a   Lin, Chun Yen ^a,c   Wei, Kuo Chen ^a,c   Liu, Hao Li ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Blood brain barrier; Focused ultrasound; IL 12; Immune therapy

Indexed keywords

INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CANCER GROWTH; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CD3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG RESPONSE; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLIOBLASTOMA; HELPER CELL; HIGH INTENSITY FOCUSED ULTRASOUND; HISTOPATHOLOGY; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IN VIVO STUDY; LYMPHOCYTE COUNT; MACROPHAGE ACTIVATION; MALE; MICROBUBBLE; MULTIPLE CYCLE TREATMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; REGULATORY T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR LOCALIZATION; UPREGULATION; ANIMAL; BRAIN NEOPLASMS; ECHOGRAPHY; FEASIBILITY STUDY; GLIOMA; IMMUNOLOGY; IMMUNOTHERAPY; SPRAGUE DAWLEY RAT; T LYMPHOCYTE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; FEASIBILITY STUDIES; GLIOMA; IMMUNOTHERAPY; INTERLEUKIN-12; MALE; RATS; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES;

EID: 84928232393     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0451-y     Document Type: Article

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