Antitumor and antimetastatic activity of interleukin-12

Current Topics in Microbiology and Immunology

Volumn 213 III, Issue , 1996, Pages 65-83

  Hendrzak, J A ^a   Brunda, M J ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12;

ANTINEOPLASTIC ACTIVITY; DRUG EFFICACY; DRUG TOXICITY; HUMAN; METASTASIS; MOLECULAR BIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 0029929132     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-80071-9_5     Document Type: Review

References (123)

1. Allavena P, Paganin C, Zhou D, Bianchi G, Sozzani S, Mantovani A (1994) Interleukin-12 is chemotactic for natural killer cells and stimulates their interaction with vascular endothelium. Blood 84: 2261-2268
2. + T cells. J Immunol 154: 9-16
3. Andrew JVR, Schoof DD, Bertagnolli MM, Peoples GE, Goedegebuure PS, Eberlein TJ (1993) Immunomodulatory effects of interleukin-12 on human tumor-infiltrating lymphocytes J Immunother 14: 1-10
4. Aragone Y, Riemann H, Bhardwaj RS, Schwarz A, Sawada Y, Yamada H, Luger TA, Kubin M, Trinchieri G, Schwarz T (1994) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol 153 5366-5372
5. Aste-Amezaga M, D'Andrea A, Kubin M, Trinchieri G (1994) Cooperation of natural killer cell stimulatory factor/interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells Cell Immunol 156 480-492
6. Bacon CM, McVicar DW, Ortaldo JR, Rees RC, O'Shea JJ, Johnston JA (1995) Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2. differential use of Janus family tyrosine kinases by IL-2 and IL-12 J Exp Med 181: 399-404
7. Bigda J, Mysliwska J, Dziadziuszko R, Bigda J, Mysliwski A, Hellmann A (1993) Interleukin 12 augments natural killer-cell mediated cytotoxicity in hairy cell leukemia. Leuk Lymphoma 10: 121-125
8. Bloom ET, Horvath JA (1994) Cellular and molecular mechanisms of the IL-12- induced increase in allospecific murine cytolytic T cell activity. Implications for the age-related decline in CTL J Immunol 152: 4242-4254
9. Bonnema JD, Rivlin KA, Ting AT, Schoon RA, Abraham RT, Leibson RJ (1994) Cytokine-enhanced NK cell-mediated cytotoxicity Positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis. J Immunol 152: 1883-1887
10. Brunda MJ (1994) Interleukin-12. J Leukoc Biol 55. 280-288
11. Brunda MJ, Gately MK (1994) Anti-tumor activity of interleukin-12. Clin Immunol Immunopathol 71: 253-255
12. Brunda MJ, Gately MK (1995) Interleukin-12: potential role in cancer therapy. In: De Vita VT, Hellman S, Rosenberg SA (eds) Important advances in oncology. Lippincott, Philadelphia, pp 3-18
13. Brunda MJ, Luistro L, Warner RR, Wright RB, Hubbard BR, Murphy M, Wolf SF, Gately MK (1993) Antitumor and antimetastatic activity or interleukin 12 against murine tumors J Exp Med 178: 1223-1230
14. Brunda MJ, Luistro L, Hendrzak JA, Fountoulakis M, Garotta G, Gately MK (1995a) Role of interferon-γ in mediating the antitumor efficacy of interleukin-12. J Immunother 17: 71-77
15. Brunda MJ, Luistro L, Warner RR, Gately MK (1995b) Antitumor activity of interleukin-12 compared to and combined with other cytokines Ninth International Congress of Immunology, July 23-29, 1995, San Francisco, CA, USA
16. Carson WE, Giri JG, Lindermann MJ, Linett ML, Ahdieh M, Paxton R, Anderson D, Eisenmann J, Grabstein K, Caligiuri MA (1994) Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180 1395-1403
17. Cassatella MA, Meda L, Gasperini S, D'Andrea A, Ma X, Trinchieri G (1995) Interleukin-12 production by human polymorphonuclear leukocytes. Eur J Immunol 25: 1-5
18. Cesano A, Visonneau S, Clark SC, Santoli D (1993) Cellular and molecular mechanisms of activation of MHC nonrestricted cytotoxic cells by IL-12. J Immunol 151: 2943-2957
19. Cesano A, Visonneau S, Cioe L, Clark SC, Rovera G, Santoli D (1994) Reversal of acute myelogenous leukemia in humanized SCID mice using a novel adoptive transfer approach. J Clin Invest 94: 1076-1084
20. Chan SH, Perussia B, Gupta JW, Kobayashi M, Young D, Pospisil M, Young HA, Wolf SF, Yound D, Clark SC, Trinchieri G (1991) Induction of interferon γ production by natural killer cell stimulatory factor: characterization of the responding cells and synergy with other inducers. J Exp Med 173: 869-879
21. Chan SH, Kobayashi M, Santoli D, Perussia B, Trinchieri G (1992) Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistsc interaction between NKSF and IL-2. J Immunol 148: 92-98
22. +IL-12 a future immunotherapy approach post cord BMT. Proc Am Assoc Cancer Res 36: 466
23. Chehimi J, Starr SE, Frank I, Rengaraju M, Jackson SJ, Llanes C, Kobayashi M, Perussia B, Young D, Nickbarg E, Wolf SF, Trinchieri G (1992) Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients. J Exp Med 175: 789-796
24. Chehimi J, Valiante NM, D'Andrea A, Rengaraju M, Rosado Z, Kobayashi M, Perussia B, Wolf SF, Starr SE, Trinchieri G (1993) Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur J Immunol 23: 1826-1830
25. Chen PW, Geer DC, Podack ER, Ksander BK (1995) Tumor cells transfected with B7-1 + IL-12 cDNa induce protective immunity Proc Am Assoc Cancer Res 36: 247
26. Chizzonite R, Truitt T, Desai BB, Nunes P, Podlaski FJ, Stern AS, Gately MK (1992) IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts J Immunol 148: 3117-3124
27. Chua AO, Chizzonite R, Desai BB, Truitt TP, Nunes P, Minetti LJ, Warner RR, Presky DH, Levine JF, Gately MK, Gubler U (1994) Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol 153. 128-136
28. Clerici M, Sarin A, Coffman RL, Wynn TA, Blatt SP, Hendrix CW, Wolf SF, Shearer GM, Henkart PA (1994) Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc Natl Acad Sci USA 91: 11811-11815
29. Cox GW, Melillo G, Chattopadhyay U, Mullet D, Fertel RHL Varesio L (1992) Tumor necrosis factor-α-dependent production of reactive nitrogen intermediates mediates IFN-γ plus IL-2-induced murine macrophage tumoricidal activity. J Immunol 149: 3290-3296
30. Croft M, Carter L, Swain SL, Dutton RW (1994) Generation of polarized antigen-specific populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles J Exp Med 180: 1715-1728
31. Del Prete G, Maggi E, Romagnani S (1994) Human Th1 and Th2 cells: functional properties, mechanisms of regulation, and role in disease Lab Invest 70: 299-306
32. Desai BB, Quinn PM, Wolitzky AG, Mongini PKA, Chizzonite R, Gately MK (1992) IL-12 receptor. II. Distribution and regulation of receptor expression. J Immunol 148: 3125-3132
33. D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste M, Chan SH, Kobayashi M, Young D, Nickbarg E, Chizzonite R, Wolf SF, Trinchieri G (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells J Exp Med 176: 1387-1398
34. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G (1993) Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factory/IL-12 synthesis in accessory cells. J Exp Med 178: 1041-1048
35. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, Trinchieri G (1995) Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis α production J Exp Med 181: 537-546
36. Emi Y, Ara G, Holden SA, Clinton S, Teicher BA (1995) Interleukin-12 (IL-12) enhances antitumor activity of chemotherapy and radiotherapy in murine models Proc Am Assoc Cancer Res 36: 480
37. Gately MK, Brunda MJ (1995) Interleukin-12- a pivotal regulator of cell-mediated immunity. In: Kurzrock R, Talpaz M (eds) Cytokines: interleukins and their receptors. Kluwer, Norwell (in press)
38. Gately MK, Desai BB, Wolitzky AG, Quinn PM, Dwyer CM, Podlaski FJ, Famillettt PC, Sinigaglia F, Chizzonite R, Gubler U, Stern AS (1991) Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol 147. 874-882
39. Gately MK, Wolitzky AG, Quinn PM, Chizzonite R (1992) Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol 143: 127-142
40. Gately MK, Gubler U, Brunda MJ, Nadeau RR, Anderson TD, Lipman JM, Sarmiento U (1994a) Interleukin-12, a cytokine with therapeutic potential in oncology and infectious diseases Ther Immunol 1: 187-196
41. Gately MK, Warrier RR, Honasoge S, Carvajal DM, Faherty DA, Connaughton SE, Anderson TD, Sarmiento U, Hubbard BR, Murphy M (1994b) Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN- γ in vivo Int Immunol 6: 157-167
42. Gazzinelli RT, Hieny S, Wynn TA, Wolf S, Sher A (1993) Interleukin 12 is required for the T-lymphocyte-independent induction of interferonγ by an intracellular parasite and induces resistance in T-cell-deficient hosts Proc Natl Acad Sci USA 90: 6115-6119
43. Gearing DP, Cosman D (1991) Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell 66. 9-10
44. Germann T, Gately MK, Schoenhaut DS, Lohoff M, Mattner F, Fischer S, Jin S-C, Schmitt E, Rude E (1993) Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type (TH1) but not Th2 cells. Eur J Immunol 23: 1762-1770
45. Gerosa F, Tommasi M, Benati C, Gandini G, Libonati M, Tridente G, Carra G, Trinchieri G (1993) Differential effects of tyrosine kinase inhibition in CD69 antigen expression and lytic activity induced by rlL-2, rlL-12 and rllFN-α in human NK cells. Cell Immunol 150 382-390
46. Giovarelli M, Santoni A, Jemma C, Musso T, Giuffrida AM, Cavallo G, Landolfo S, Forni G (1988) Obligatory role of IFN- γ in induction of lymphokine-activated and T lymphocyte killer activity, but not in boosting of natural cytotoxicity. J Immunol 141 2831-2836
47. Godfrey DI, Kennedy J, Gately MK, Hakimi J, Hubbard BR, Zlotnik A (1994) IL-12 influences intrathymic T cell development J Immunol 152: 2729-2735
48. Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC, Gately MK (1991) Coexpression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci USA 88: 4143-4417
49. + T-cell subset responses during murine leishmaniasis. Parasitol Today 10: 190-192
50. Heinzel FP, Berko RM, Ling P, Hakimi J, Schoenhaut DS (1994) Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect Immun 62: 4244-4249
51. Hendrzak JA, Brunda MJ (1995) Interleukin-12 biological activity, therapeutic utility and role in disease Lab Invest 72: 619-637
52. Hill LL, Perussia B, McCue PA, Korngold R (1994) Effect of human natural killer cells on the metastatic growth of human melanoma Xenografts in mice with severe combined immunodeficiency. Cancer Res 54: 763-770
53. Hsieh C-S, Macatonia SE, Tripp CS, Wolf SF, O'Garra A, Murphy KM (1993) Development of Th1 CD4 T cells through IL-12 produced by Listeria-induced macrophages Science 260: 547-549
54. Hunter-Mayer SE, O'Donnell M, Szilvasi A, Leonard J, Clinton SK (1995) Combination interleukin-12 and bacille Calmette-Guerin immune therapy of bladder carcinoma in mice. Proc Am Assoc Cancer Res 36: 480
55. Jewett A, Bonavida B (1994) Activation of the human immature natural killer cell subset by IL-12 and its regulation by endogenous TNF-α and IFN-α secretion. Cell Immunol 154: 273-286
56. Kanangat S, Nair S, Babu JS, Rouse BT (1995) Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T-cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens. J Leukoc Biol 57. 310-316
57. Kennedy MK, Picha KS, Shanebeck KD, Anderson DM, Grabstein KH (1994) Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. Eur J Immunol 24: 2271-2278
58. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J Exp Med 170: 827-845
59. Kobayashi M, Nakajima N, Pollard RB, Suzuki F (1995) Tumor immunotherapeutic lipid-arabinomannan extracted from Mycobacterium tuberculosis (Z-100) induces the production of IL-12. Proc Am Assoc Cancer Res 36 467
60. Kubin M, Chow JM, Trinchieri G (1994a) Differential regulation of interleukin-12 (IL-12), tumor necrosis factor α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells Blood 83: 1847-1855
61. Kubin M, Kamoun M, Trinchieri G (1994b) Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells J Exp Med 180: 211-222
62. Ma Y, Seiler KP, Tai KF, Yang L, Woods M, Weis JJ (1994) Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathway Infect Immun 62: 3663-3671
63. Manetti R, Parronchi P, Giudizi MG, Piccinni M-P, Maggi E, Trinchieri G, Romagnani S (1993) Natural killer cell stimulatory (interleukin 12[IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 177: 1199-1204
64. Manetti R, Gerosa F, Giudizi MG, Biagiotti R, Parronchi P, Piccinni M-P, Sampognaro S, Maggi E, Romagnani S, Trinchteri G (1994) Interleukin 12 induces stable priming for interferon γ (IFN- γ) production during differentiation of human T helper (Th) cells and transient IFN- γ production in established Th2 cell clones J Exp Med 179: 1273-1283
65. Martinotti A, Stoppacciaro A, Vagliani M, Melani C, Spreafico F, Wysocka M, Parmiani G, Trinchieri G, Colombo MP (1995) CD4 T cells inhibit in vivo the CD8-mediated immune response against murine colon carcinoma cells transduced with interleukin-12 genes. Eur J Immunol 25: 137-146
66. + T lymphocytes. J Immunol 151 2444-2452
67. Mengel J, Dare L, Dare GM, Delgado M, Nomizo A, Silva JS, Campos-Neto A (1992) An activated murine B cell lymphoma line (A-20) produces a factor-like activity which is functionally related to human natural killer cell stimulatory factor. Eur J Immunol 22: 3173-3178
68. Merberg DM, Wolf SF, Clark SC (1992) Sequence similarity between NKSF and the IL-6/G-CSF family Immunol Today 13: 77-78
69. Morris SC, Madden KB, Adamovicz JJ, Gause WC, Hubbard BR, Gately MK, Finkelman FD (1994) Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol 152. 1047-1056
70. Mosmann TR, Coffman RL (1989) Heterogeneity of cytokine secretion patterns and functions of helper T cells Adv Immunol 46 111-147
71. Muller G, Saloga J, Germann T, Bellinghausen I, Mohamadzadeh M, Knop J, Enk AH (1994) Identification and induction of human keratinocyte-derived IL-12. J Clin Invest 94: 1799-1805
72. Murphy EE, Terres G, Macatonia SE, Hsieh C-S, Mattson J, Lanier L, Wysocka M, Trinchieri G, Murphy K, O'Garra A (1994) B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J Exp Med 180: 223-231
73. - T cell proliferation and cytotoxicity by natural killer cell stimulatory factor (interleukin-12). Jpn J Cancer Res 85: 853-861
74. Nagy E, Buhlmann JE, Henies T, Waugh M, Rigby WFC (1994) Selective modulation of IFN-ã mRNa stability by IL-12/NKSF. Cell Immunol 159. 140-151
75. Nakarai T, Robertson MJ, Streuli M, Wu Z, Ciardelli TL, Smith KA, Ritz J (1994) Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells. J Exp Med 180. 241-251
76. Nastala CL, Edington HD, McKinney TG, Tahara H, Nalesnik MA, Brunda MJ, Gately MK, Wolf SF, Schreiber RD, Storkus WJ, Lotze MT (1994) Recombinant IL-12 administration induces tumor regression in association with IFN- γ production J Immunol 153: 1697-1706
77. + NK cells. J Immunol 148: 2429-2436
78. Naume B, Gately MK, Desai BB, Sundan A, Espevik T (1993a) Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation. Cytokine 5: 38-46
79. + natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12 Eur J Immunol 23: 1831-1838
80. Orange JS, Wolf SF, Biron CA (1994) Effects of IL-12 on the response and susceptibility to experimental viral infections. J Immunol 152: 1253-1264
81. Orange JS, Salazar-Mather TP, Opal SM, Spencer RL, Miller AH, McEwen BS, Biron CA (1995) Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids J Exp Med 181: 901-914
82. Ortaldo JR, Mason AT, O'Shea JJ (1995) Receptor-induced death in human natural killer cells: involvement of CD16. J Exp Med 181: 339-344
83. Oswald IP, Caspar P, Jankovic D, Wynn TA, Pearce EJ, Sher A (1994) IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni. J Immunol 153: 1707-1713
84. O'Toole M, Wolf SF, O'Brien C, Hubbard B, Herrmann S (1993) Effect of in vivo IL-12 administration on murine tumor cell growth J Immunol 150: 294A
85. + T lymphocytes, and NK cells. J Immunol 149: 3495-3502
86. Pignata C, Prasad KVS, Robertson MJ, Levine H, Rudd CE, Ritz J (1993) Fcγ IIIA-mediated signaling involves src-family lck in human natural killer cells. J Immunol 151: 6794-6800
87. Pignata C, Sanghera J, Cossette L, Pelech SL, Ritz J (1994) Interleukin-12 induces tyrosine phosphorylation and activation of 44-kD mitogen-activated protein kinase in human T cells. Blood 83: 184-190
88. Podlaski FJ, Nanduri V, Hulmes JD, Pan Y-CE, Levin W, Danho W, Chizzonite R, Gately MK, Stern AS (1992) Molecular characterization of interleukin 12. Arch Biochem Biophys 294: 230-237
89. Rabinowich H, Herberman RB, WhitesideTL (1993) Differential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cells. Cell Immunol 152. 481-498
90. Radrizzani M, Accornero P, Amidei A, Aiello A, Delia D, Kurrle R, Colombo MP (1995) IL-12 inhibits apoptosis induced in human Th1 clone by gp 120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation Cell Immunol 161: 14-21
91. Reiner SL, Zheng S, Wang Z-E, Stowring L, Locksley RM (1994) Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4 T cells during initiation of infection. J Exp Med 179: 447-456
92. Robertson MJ, Soiffer RJ, Wolf SF, Manley TJ, Donahue C, Young D, Herrmann SH, Ritz J (1992) Responses of human natural killer (NK) cell stimulatory factor (NKSF):cytolytic activity and proliferation of NK cells are differentially regulated by NKSF J Exp Med 175. 779-788
93. Romani L, Mencacci A, Tonnetti L, Spaccapelo R, Cenci E, Puccetti P, Wolf SF, Bistoni F (1994) IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis. J Immunol 153. 5167-5175
94. Rook AH, Kubin M, Cassin M, Vonderheid EC, Vowels BR, Wolfe JT, Wolf SF, Singh A, Trinchieri G, Lessin SR (1995) IL-12 reverses cytokine and immune abnormalities in Sezary syndrome. J Immunol 154 1491-1498
95. Rossi AR, Pericle F, Rashleigh S, Janiec J, Djeu JY (1994) Lysis of neuroblastoma cell lines by human natural killer cells activated by interleukin-2 and interleukin-12. Blood 83: 1323-1328
96. Salcedo TW, Azzoni L, Wolf SF, Perussia B (1993) Modulation of perform and granzyme messenger RNA expression in human natural killer cells J Immunol 151 2511-2520
97. + T cells. Eur J Immunol 24: 343-347
98. + T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β. Eur J Immunol 24: 793-798
99. Schoenhaut DS, Chua AO, Wolitzky AG, Quinn PM, Dwyer CM, McComas W, Familletti PC, Gately MK, Gubler U (1992) Cloning and expression of murine IL-12. J Immunol 148: 3433-3440
100. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming Proc Natl Acad Sci USA 90: 10188-10192
101. Sieburth D, Jabs EW, Warrington JA, Li X, Lasota J, LaForgia S, Kelleher K, Huebner K, Wasmuth JJ, Wolf SF (1992) Assignment of NKSF/IL 12, a unique cytokine composed of two unrelated subunits, to chromosomes 3 and 5. Genomics 14: 59-62
102. Smith TJ, Ducharme LA, Weis JH (1994) Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3. Eur J Immunol 24 822-826
103. Goiffer RJ, Robertson MJ, Murray C, Cochran K, Ritz J (1993) Interleukin-12 augments cytolytic activity of peripheral blood lymphocytes from patients with hematologic and solid malignancies. Blood 82: 2790-2796
104. Stern AS, Podlaski FJ, Hulmes JD, Pan Y-CE, Quinn PM, Wolitzky AG, Familletti PC, Stremlo DL, Truitt T, Chizzonite R, Gately MK (1990) Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci USA 87 6808-6812
105. Stern LL, Tarby CM, Tamborini B, Truitt GA (1993) Preclinical development of IL-12 as an anticancer drug. comparison to IL-2 Proc Am Assoc Cancer Res 34: 520
106. Stuehr DJ, Nathan CF (1989) Nitric oxide: a macrophage product responsible for cytostasis and respiration inhibition in tumor target cells. J Exp Med 169: 1543-1555
107. Tahara H, Zeh HJ, Storkus WJ, Pappo I, Watkins SC, Gubler U, Wolf SF, Robbins PD, Lotze MT (1994) Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res 54: 182-189
108. Tannenbaum CS, Wicker N, Tubbs R, Olenki T, Finke J, Bukowski R, Hamilton TA (1995) Patterns of chemokine expression and leukocyte infiltration in murine models of cytokine immunotherapy. Proc Am Assoc Cancer Res 36. 495
109. Trinchieri G (1994) Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84. 4008-4027
110. Tripp CS, Wolf SF, Unanue ER (1993) Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci USA 90: 3725-3729
111. Valiante NM, Trinchieri G (1993) Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes. J Exp Med 178: 1397-1406
112. Valiante NM, Rengaraju M, Trinchieri G (1992) Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of B cell lines to stimulate T and NK cell proliferation Cell Immunol 145 187-198
113. van der Pouw Kraan TCTM, Boeije LCM, Smeenk RJT, Wijdenes J, Aarden LA (1995) Prostagtandin-E2 is a potent inhibitor of human interleukin 12 production. J Exp Med 181: 775-779
114. Varesio L, Blasi E, Thurman GB, Talmadge JE, Wiltrout RH, Herberman RB (1984) Potent activation of mouse macrophages by recombinant interferon-gamma. Cancer Res 44. 4465-4470
115. Verbik DJ, Stinson WW, Brunda MJ, Kessinger A, Joshi SS (1995) Therapeutic effects of in vivo administration of interleukin-12 against residual lymphoma. Proc Am Assoc Cancer Res 36: 480
116. Vieira LQ, Hondowicz BD, Adonso LC, Wysocka M, Trinchieri G, Scott P (1994) Infection with Leishmania major induces interleukin-12 production in vivo. Immunol Lett 40: 157-161
117. Voest EE, Kenyon BM, Truitt GA, O'Reilly MS, D'Amato RJ, Folkman J (1995) Interleukin 12 inhibits angiogenesis is vivo. J Natl Cancer Inst 87: 581-586
118. Wolf SF, Temple PA, Kobayashi M, Young D, Dicig M, Lowe L, Dzialo R, Fitz L, Ferenz C, Hewick RM, Kelleher K, Herrmann SH, Clark SC, Azzoni L, Chan SH, Trinchieri G, Perussia B (1991) Cloning of cDNA for natural killer cell stimulatory factory, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells J Immunol 146: 3074-3081
119. Wong GHW, Clark-Lewis I, McKimm-Breschkin JL, Harris AW, Schrader JW (1983) Interferon gamma induces enhanced expression of Ia and H-2 antigens on B-lymphoid, macrophage and myeloid cell lines J Immunol 131: 788-793
120. Wong HL, Wilson DE, Jenson JC, Familletti PC, Stremlo DL, Gately MK (1988) Characterization of a factor(s) which synergizes with recombinant interleukin 2 in promoting allogeneic human cytolytic T-lymphocyte responses in vitro. Cell Immunol 111: 39-54
121. Yanagida T, Kato T, Igarashi O, Inoue T, Nariuchi H (1994) Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone J Immunol 152: 4919-1928
122. Yoshida A, Koide Y, Uchijima M, Yoshida TO (1994) IFN-γ induces IL-12 mRNA by a murine macrophage cell line, J774. Biochem Biophys Res Commun 198: 857-861
123. + allergen-specific Th2 T cell clones. Int Immunol 6: 1091-1096