IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk

Journal of Immunology

Volumn 166, Issue 6, 2001, Pages 3890-3899

  Strasly, M ^a   Cavallo, F ^a   Geuna, M ^a   Mitola, S ^a   Colombo, M P ^a   Forni, G ^a   Bussolino, F ^a  

^a Instituto Ricerca   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CONCANAVALIN A; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; MONOKINE; VASCULAR CELL ADHESION MOLECULE 1; VITRONECTIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; ENDOTHELIUM CELL; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; SPLEEN CELL;

EID: 0035869599     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.6.3890     Document Type: Article

References (73)

1. Angiogenesis in cancer, vascular, rheumatoid and other disease
2. Angiogenesis and tumor metastasis
3. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
4. The origin and function of tumor-associated macrophages
5. Tumor induction of VEGF promoter activity in stromal cells
6. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: A potential role for T cells in angiogenesis
7. T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: A potential pathologic role
8. T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism: Implications for tubule formation
9. Cytokine regulation of endothelial cell function: From molecular level to the bedside
10. Molecular mechanisms of blood vessel formation
11. Chemokines
12. Macrophage formation of angiostatin during inflammation: A byproduct of the activation of plasminogen
13. Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice
14. Ability of systemic interleukin-12 to hamper progressive stages of mammary carcinogenesis in HER2/neu transgenic mice
15. + T cells and granulocyte/macrophage colony-stimulating factor
16. Antitumor efficacy of adenocarcinoma cells engineered to produce IL-12 or other cytokines compared with exogenous IL-12
17. Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12
18. Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis
19. Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin-12 or interleukin-18, which activate type 1 helper T cells
20. The antiangiogenesis effect of interleukin 12 during early growth of human pancreatic cancer in SCID mice
21. The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor
22. Inhibition of angiogenesis in vivo by interleukin 12
23. Tumor cell responses to IFNγ affect tumorigenicity and response to IL-12 therapy and antiangiogenesis
24. Hypoxia-mediated apoptosis from angiogenesis inhibition underlies tumor control by recombinant interleukin 12
25. Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12
26. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis
27. Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10
28. IL-6 is an in vitro and in vivo autocrine growth factor for middle T antigen-transformed endothelial cells
29. Murine endothelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines
30. Anti-tumor activity of cytokines against opportunistic vascular tumors in mice
31. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial eel motility and growth
32. In vitro reeducated T helper cells from sarcoma-bearing mice inhibit sarcoma growth in vivo
33. Rous sarcoma virus induced tumors in mice: Macrophage mediated natural cytotoxicity
34. 3) in human endothelial cells
35. c-fos-induced growth factor/vascular endothelial growth factor-D induces angiogenesis in vivo and in vitro
36. The catabolism of extracellular matrix components
37. Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor
38. Cell proliferation and ploidy of human solid tumours: Methodological experience with in vivo bromodeoxyuridine and DNA flow cytometry
39. Antitumor and antimetastatic activity of interleukin 12 against murine tumors
40. The involvement of apoptosis in etoposide-induced thymic atrophy
41. Role of integrins in angiogenesis
42. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
43. 3 blocks human breast cancer growth and angiogenesis in human skin
44. The structural bases of integrin-ligand interactions
45. In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices
46. Intracellular mechanisms involved in basement membrane induced blood vessels differentiation in vitro
47. Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis
48. Matrix metalloproteinases regulates neovascularization by acting as pericellular fibrinolysis
49. Nude mice in immunology
50. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
51. Interferon-γ and CXC chemokine induction by interleukin 12 in renal cell carcinoma
52. Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase
53. 3 for angiogenesis
54. Suppression of p53 activity and p21WAF/C1P1 expression by vascular cell integrin avb3 during angiogenesis
55. 1 phase of the cell cycle
56. 3 antagonist and inducing apoptosis
57. 3 integrin monoclonal antibody
58. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
59. Hypoxic tumor cell death and modulation of endothelial adhesion molecules in the regression of G-CSF transduced tumors
60. The IP-10 chemokine binds to a specific cell surface heparin sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation
61. Chemokine receptors in human endothelial cells: Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines
62. CXC chemokine receptor expression on human endothelial cells
63. Contribution of natural killer cells to inhibition of angiogenesis by interleukin-12
64. Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cells
65. The CC chemokines 6Ckine binds the CXC chemokine receptor CXCR3
66. Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12
67. Mig and IP-10: CXC chemokines that target lymphocytes
68. Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12
69. Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively
70. Peripheral blood mononuclear cells induced programmed cell death in human endothelial cells and may prevent repair: Role of cytokines
71. Activated lymphocytes promote endothelial cell detachment from matrix: A role for modulation of endothelial cell beta I integrin affinity
72. + T cells and accumulation of IL-12Rβ1 and IL-12Rβ2 by costimulation with B7-2 molecules
73. Regression of an established tumor genetically modified to release granulocyte colony-stimulating factor requires granulocyte-T cell cooperation and T cell-produced interferon γ