Glucotoxicity inhibits cAMP-protein kinase A-potentiated glucose-stimulated insulin secretion in pancreatic β-cells

Journal of Diabetes

Volumn 7, Issue 3, 2015, Pages 378-385

  Kong, Xiangchen ^a   Yan, Dan ^a   Wu, Xuerui ^a   Guan, Youfei ^a   Ma, Xiaosong ^a  

^a Shenzhen University School of Medicine   (China)

Author keywords

cAMP; Glucagon like peptide 1; Glucotoxicity; Insulin secretion; Protein kinase A

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; CYCLIC AMP; INSULIN; SWEETENING AGENT;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GLUCOTOXICITY; HYPERGLYCEMIA; IMMUNOBLOTTING; INSULIN LIKE ACTIVITY; INSULIN RELEASE; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; METABOLISM; SECRETION (PROCESS);

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; SWEETENING AGENTS;

EID: 84928209642     PISSN: 17530393     EISSN: 17530407     Source Type: Journal    
DOI: 10.1111/1753-0407.12185     Document Type: Article

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