Orally administered phenylbutazone causes oxidative stress in the equine gastric mucosa

Journal of Veterinary Pharmacology and Therapeutics

Volumn 38, Issue 3, 2015, Pages 257-264

  Martinez Aranzales J R ^a   Candido de Andrade B S ^b   Silveira Alves, G E ^c  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b Faculdade de Vértice Univértix   (Brazil)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; GLUTATHIONE; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE; PHENYLBUTAZONE; PROSTAGLANDIN E2; SUPEROXIDE DISMUTASE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXIDASE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; ENZYME ACTIVITY; EQUIDAE; FEMALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SINGLE DRUG DOSE; STOMACH CONTENT; STOMACH MUCOSA; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; GASTRIC MUCOSA; GASTROSCOPY; HORSE; HORSE DISEASE; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; STOMACH ULCER; VETERINARY;

EQUIDAE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATALASE; DINOPROSTONE; FEMALE; GASTRIC MUCOSA; GASTROSCOPY; GLUTATHIONE; HORSE DISEASES; HORSES; MALE; MALONDIALDEHYDE; NITRIC OXIDE; OXIDATIVE STRESS; PEROXIDASE; PHENYLBUTAZONE; STOMACH ULCER; SUPEROXIDE DISMUTASE;

EID: 84928205217     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/jvp.12168     Document Type: Article

References (40)

1. Abdallah, D.M. (2010) Nicotinamide alleviates indomethacin - induced gastric ulcers: a novel antiulcer agent. European Journal Pharmacology, 627, 276-280.
2. Abukhalaf, I.K., Silvestrov, N.A., Menter, J.N., Deutsh, D.A., Bayorh, M.A., Socci, R.R. & Ganafa, A.A. (2002) High performance liquid chromatographic assay for the quantitation of total glutathione in plasma. Journal of Pharmaceutical Biomedical Analysis, 28, 637-643.
3. Aebi, H. (1984) Catalas-Medhod. Enzymology, 105, 121-126.
4. Basiviredy, J., Jacob, M., Ramamoorthy, P., Pulimood, A. & Balasubramanian, K. (2003) Indomethacin-induced free radical mediate changes in the intestinal brush border membranes. Biochemical Pharmacology, 65, 683-695.
5. Bell, R.J., Mogg, T. & Kingston, J. (2007) Equine gastric ulcer syndrome in adult horses: a review. New Zealand Veterinary Journal, 55, 1-12.
6. Belo, A.V., Barcelos, L.S., Ferreira, M., Texeira, M.M. & Andrade, S.P. (2004) Inhibition of inflammatory angiogenesis by distant subcutaneous tumor in mice. Life Science, 74, 2827-2837.
7. Chattopadhyay, I., Bandyopadhyay, U., Biswas, K., Mcity, P. & Banarjee, R. (2006) Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. Free Radical Biology & Medicine, 40, 1397-1408.
8. Dieterich, S., Bieligk, U., Beulich, K., Hasenfuss, G. & Prestle, J. (2000) Gene expression of antioxidative enzymes in the human heart: increased expression of catalase in the end-stage failing heart. Circulation, 101, 33-39.
9. El-Ashker, M., El-Khodery, S., Metwally, N., Hussein, H. & El-Boshy, M. (2012) Prognostic significance of oxidative stress markers in colitis associated with phenylbutazone administration in draft horses. Journal Equine Veterinary Science, 32, 146-152.
10. Graaf-Roelfsema, E.D., Keizer, H.D., Wijnberg, I.D. & Van Der Kolk, J.H. (2010) The incidence and severity of gastric ulceration does not increase in overtrained Standardbred horses. Equine Veterinary Journal, 42, 8-61.
11. Halliwell, B. (1994) Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet, 344, 721-724.
12. Karatas, F., Karatepe, M. & Baysar, A. (2002) Determination of free malondialdehyde in human serum by high-performance liquid chromatography. Analytical Biochemistry, 311, 76-79.
13. Lanas, A., Panes, J. & Pique, J.M. (2003) Clinical implications of COX-1 and/or COX2 inhibition for the distal gastrointestinal tract. Current Pharmaceutical Design, 9, 2253-2266.
14. Lorenzo-Figueras, M., Jones, G. & Merritt, A. (2002) Effects of various diets on gastric tone in the proximal portion of the stomach of horses. American Journal Veterinary Research, 63, 1275-1278.
15. MacAllister, C.G., Morgan, S.J., Borne, A.T. & Pollet, R.A. (1993) Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses. Journal of American of Veterinary Medical Association, 202, 71-77.
16. MacAllister, C.G., Andrews, F.M., Deegan, E., Ruoff, W. & Olovson, S.G. (1997) A scoring system for gastric ulcers in the horse. Equine Veterinary Journal, 29, 430-433.
17. Mahadik, S.P. & Scheffer, R.E. (1999) Oxidative injury and potential use of antioxidants in schizophrenia. Prostaglandins, Leukotrienes and Essential Fatty Acids, 55, 45-54.
18. McConnico, R., Morgan, T., Williams, C., Hubert, J. & Moore, R. (2008) Pathophysiologic effects of phenylbutazone on the right dorsal colon in horses. American Journal Veterinary Research, 69, 1496-1505.
19. Meister, A. & Anderson, M.E. (1983) Glutathione. Annual Review of Biochemistry, 52, 711-760.
20. Merritt, A.M. (2003) The Equine Stomach: A Personal Perspective (1963-2003). Proc. 49TH Annual Convention of the American Association of Equine Practitioners. Louisiana.
21. Miranda, K.M., Espey, M.G. & Wink, D.A. (2001) A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide, 5, 62-71.
22. 2 production and cyclooxygenase activity in equine nonglandular and glandular gastric mucosa in vitro. Equine Veterinary Journal, 40, 332-336.
23. Murakami, K., Okajima, K., Harada, N., Isobe, H., Liu, W. & Johno, M. (1999) Pleunutol prevents indomethacin-induced gastric mucosal injury in rats by inhibiting neutrophil activation. Alimentary Pharmacology & Therapeutics, 13, 521-530.
24. Murray, M.J. & Grodinsky, C. (1989) Regional gastric pH measurement in horses and foals. Equine Veterinary Journal, 21, 73-76.
25. Naito, Y., Yoshikawa, T., Yoshida, N. & Kondo, M. (1998) Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury. Digestive Diseases and Sciences, 43, 30-34.
26. Nieto, J., Aleman, M., Anderson, J., Fiack, C. & Snyder, J. (2012) Effects of phenylbutazone on gene expression of cyclooxygenase-1 and -2 in the oral, glandular gastric, and bladder mucosae of healthy horses. American Journal Veterinary Research, 73, 98-104.
27. Odabasoglu, F., Halici, Z., Cakir, A., Halici, M., Aygun, H., Suleyman, H., Cadirci, E. & Atalay, F. (2008) Beneficial effects of vegetable oils (corn, olive and sunflower oils) and α tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats. European Journal Pharmacology, 591, 300-306.
28. Polat, B., Suleyman, H. & Hakan, A. (2010) Adaptation of rat gastric tissue against indomethacin toxicity. Chemico-Biological Interactions, 186, 82-89.
29. Radi, Z.A. & Khan, N.K. (2006) Effects of cyclooxygenase inhibition on the gastrointestinal tract. Experiment. Toxicologic Pathology, 58, 163-173.
30. Rocha, G.A., Queiroz, D.M., Mendes, E.N., Lage, A.P. & Barbosa, A.J. (1989) Simple carbolfuchsin staining for showing C. pylori and other spiral bacteria in gastric mucosa. Journal of Clinical Pathology, 42, 1004-1005.
31. Sanchez, S., Martin, M.J., Ortiz, P., Motiva, V. & Lastra, C.A. (2002) Effects of dypirone on inflammatory infiltration and oxidative metabolism in gastric mucosa: comparison with acetaminophen and diclofenac. Digestive Diseases and Sciences, 47, 1389-1398.
32. Sedlak, J. & Lindsay, R.H. (1968) Estimation of total, protein-bound, and non-protein sulfhydryls groups in tissue with Ellman′s reagent. Analytical Biochemistry, 25, 192-205.
33. Slomiany, B.L., Piotrowski, J. & Slomiany, A. (1999) Role of caspase-3 and nitric oxide synthase in gastric mucosal injury induced by indomethacin: effect to sucralfate. Journal of Physiology and Pharmacology, 50, 3-16.
34. Spiers, V.C. (1997) The alimentary tract. In Clinical Examination of Horses. Ed. Robinson, N.E., pp. 261-298. W.B. Saunders, Philadelphia, PA.
35. Sundaresan, R.D., Narayan, S., Vani, G. & Shyamala, C.H. (2007) Gastroprotective effect of Terminalia arjuna bark on diclofenaco sodium induced gastric ulcer. Chemico-Biological Interactions, 167, 71-83.
36. Takeuchi, K., Yasuhiro, T., Asada, Y. & Sugawa, Y. (1998) Role of nitric oxide in pathogenesis of aspirin-induced gastric mucosal damage in rats. Digest, 59, 298-307.
37. Tanaka, K., Nishimoto, K., Tomisato, W., Tsutsumi, S., Hoshino, T., Tomofusa, T. & Mizushima, T. (2004) Adaptive cytoprotection induced by pretreatment with ethanol protects against gastric cell damage by NSAIDs. Digestive Diseases and Sciences, 49, 210-217.
38. Tomisato, W., Tsutsumi, S., Hoshino, T., Hwang, H., Mio, M., Tsuchiya, T. & Mizushima, T. (2004) Role of direct cytotoxic effects of NSAID in the induction of gastric lesions. Biochemical Pharmacology, 67, 575-585.
39. Wallace, J.L., McKnight, W., Reuter, B.K. & Vergnolle, N. (2000) NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology, 119, 706-714.
40. Wink, D.A., Miranda, K.M., Espey, M.G., Pluta, R.M., Hewett, S.J., Colton, C., Vitek, M., Feelisch, M. & Grisham, M.B. (2001) Mechanisms of the antioxidant effects of nitric oxide. Antioxidants & Redox Signaling, 3, 203-213.