Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes

Biochemical Pharmacology

Volumn 65, Issue 4, 2003, Pages 683-695

  Basivireddy, Jayasree ^a   Jacob, Molly ^a   Ramamoorthy, Prabhu ^a   Pulimood, Anna B ^a   Balasubramanian, Kunissery A ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Allopurinol; Indomethacin; Intestinal brush border membrane; Nitric oxide; Nonsteroidal anti inflammatory drugs; Oxidative stress; Zinc

Indexed keywords

ALKALINE PHOSPHATASE; ALLOPURINOL; ALPHA GLUCOSIDASE; ALPHA TOCOPHEROL; ARGININE; FREE RADICAL; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; PHOSPHOLIPASE A2; SUCRASE; XANTHINE OXIDASE; ZINC SULFATE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; GLUCOSE TRANSPORT; HISTOPATHOLOGY; INTESTINE BRUSH BORDER MEMBRANE; INTESTINE CELL; LIPID COMPOSITION; MALE; NONHUMAN; OXIDATIVE STRESS; PEROXIDATION; PRIORITY JOURNAL; RAT; SMALL INTESTINE MUCOSA;

EID: 0037441333     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01616-7     Document Type: Article

References (52)

1. Gabriel S.E., Jaakkimainen L., Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: a meta-analysis. Ann. Int. Med. 115:1999;787-796.
2. Langenbach R., Morham S.G., Tiano H.F.et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 83:1995;483-492.
3. Somasundaram S., Rafi S., Hayllar J., Sigthorsson G., Jacob M., Price A.B., Macpherson A., Mahmod T., Scott D., Wrigglesworth J.M., Bjarnason I. Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID-induced injury to the rat intestine. Gut. 41:1997;344-353.
4. Somasundaram S., Sigthorsson G., Simpson R.J., Watts J., Jacob M., Tavares I.A., Rafi S., Roseth R., Foster R., Price A.B., Wrigglesworth J.M., Bjarnason I. Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat. Aliment Pharmacol. Ther. 14:2000;639-650.
5. Basivireddy J., Vasudevan A., Jacob M., Balasubramanian K.A. Indomethacin-induced mitochondrial dysfunction and oxidative stress in villus enterocytes. Biochem. Pharmacol. 64:2002;339-349.
6. Jacob M., Bjarnason I., Simpson R.J. In vitro evidence for mitochondrial effects of indomethacin. Biochem. Soc. Trans. 26:1998;S315.
7. Jacob M., Bjarnason I., Simpson R.J. Effects of indomethacin on energy metabolism in rat and human jejunal tissue in vitro. Clin. Sci. 101:2001;493-498.
8. Miura S., Suematsu M., Tanaka S., Nagata H., Houzawa S., Sduzuki M., Kurose I., Serizawa H., Tsuchiya M. Microcirculatory disturbance in indomethacin-induced intestinal ulcer. Am. J. Physiol. 261:1991;G213-G219.
9. Nalini S., Mathan M.M., Balasubramanian K.A. Free radical-induced damage during intestinal ischaemia reperfusion in normal and xanthine oxidase deficient rats. Mol. Cell Biochem. 124:1993;59-66.
10. Lopez-Belmonte J., Whittle B.J.R., Moncad S. The actions of nitric oxide donors in the prevention of induction of injury to the rat gastric mucosa. Br. J. Pharmacol. 108:1993;73-78.
11. Bulbena O., Escolar G., Navarro C., Braro L., Pfeiffer C.J. Gastroprotective effect of zinc acexamate against damage induced by nonsteroidal anti-inflammatory drugs - a morphological study. Dig. Dis. Sci. 38:1993;730-739.
12. Deitch E.A. Multiple organ failure: pathophysiology and potential future therapy. Ann. Surg. 216:1993;117.
13. Bjarnason I., Fehilly B., Smethurst P., Menzies I.S., Levi A.J. Effects of non-steroidal anti-inflammatory drugs on permeability of the small intestine in humans. J. Rheumatol. 19(Suppl. 36):1992;83-84.
14. Choi V.M.F., Coates J.E., Chooi J., Thomson A.B.R., Russel A.S. Small bowel permeability - a variable effect of NSAIDs. Clin. Invest. Med. 18:1995;357-361.
15. Angele M.K., Smail N., Wang P., Cloffi W.G., Bland K.I., Chandry I.H. L-Arginine restores the depressed output and regional perfusion after trauma haemorrhage. Surgery. 124:1998;94-402.
16. Joseph R.M., Varela V., Kanji V.K., Subramong C., Mihas A.A. Protective effects of zinc in indomethacin-induced gastric mucosal injury: evidence for a dual mechanism involving lipid peroxidation and nitric oxide. Aliment Pharmacol. Ther. 13:1999;203-208.
17. Hogaboam C.M., Jacobson K., Collins S.M., Blennerhassett M.G. The selective beneficial effects of NO inhibition in experimental colitis. Am. J. Physiol. 268:1995;G673-G684.
18. Prabhu R., Balasubramanian K.A. A novel method of preparation of small intestinal brush border membrane vesicles by poly ethylene glycol precipitation. Anal. Biochem. 289:2001;157-161.
19. Kraswisz J.E., Sharon P., Stenson W.F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology. 87:1984;1344-1350.
20. Parks D.A., William T.K., Beckman J.S. Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a re-evaluation. Am. J. Physiol. 254:1988;G768-G774.
21. Aebi H. Catalase in vitro. Methods Enzymol. 105:1984;121-126.
22. Nakamura W., Hosada S., Hayashi K. Purification and properties of rat liver glutathione peroxidase. Biochem. Biophys. Acta. 358:1974;251-261.
23. Racker E. Glutathione reductase (liver and yeast). Methods Enzymol. 2:1955;722-725.
24. Ohkuma N., Matsuo S., Tsutsui M., Ohkawara A. Superoxide dismutase in the epidermis (authors translation). Nippon Hifuka Gakkai. Zasshi. 92:1982;583-590.
25. Wolfenden R., Sharpless T.K., Allan R. Substrate binding by adenosine deaminase. J. Biol. Chem. 242:1967;977-983.
26. Thambidurai D., Bachawat B.K. Purification and properties of brain alkaline phosphatase. J. Neurochem. 29:1977;503-512.
27. Dalqvist A. Assay of small intestinal disaccharidase. Anal. Biochem. 22:1968;99-107.
28. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1970;265-275.
29. Ohkawn J.P., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:1979;351-358.
30. Chan H.W., Levett G. Auto oxidation of methyl linoleate. Separation and analysis of isomeric mixtures of methyl linoleate hydroperoxides and methyl hydroxy linoleates. Lipids. 12:1972;99-104.
31. Sohal R.S., Agarwal S., Dubey A., Orr W.C. Protein oxidative damage is associated with life expectancy of houseflies. PNAS. 90:1993;7255-7259.
32. Cheeseman K.H., Davies M.J., Emery S., Maddix S.P., Slater T.F. Effects of alpha-tocopherol on carbon tetrachloride metabolism in rat liver microsomes. Free Radic. Res. Commun. 3:1987;325-331.
33. Tiruppathi C., Miyamoto Y., Ganapathi V., Leibach F.H. Fatty acid induced alterations in transport systems of the small brush border membrane. Biol. Pharmacol. 37:1988;1399-1405.
34. Bliigh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:1959;911-917.
35. Zlatkis A., Zak B., Boyle A.J. A new method for the direct determination of serum cholesterol. J. Lab. Clin. Med. 41:1953;486-492.
36. Synder F., Stephens N. A simplified spectrophotometric determination of ester groups in lipids. Biochim. Biophys. Acta. 34:1959;244-245.
37. Cohen P., Derksen A. Comparison of phospholipid and fatty acid composition of human erythrocytes and platelets. Br. J. Haematol. 17:1969;359-371.
38. Bartlett G.R. Phosphorous assay in column chromatography. J. Biol. Chem. 234:1959;466-468.
39. 2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. J. Biol. Chem. 270:1995;15359-15367.
40. Anup R., Aparna V., Pulimood A., Balasubramanian K.A. Surgical stress and the small intestine: role of oxygen free radicals. Surgery. 125:1999;560-569.
41. Yoshino M., Murakami K. Stabilization of the adenylate energy charge by the depletion of adenylates without glycolytic stimulation. Biochem. Biophys. Res. Commun. 129:1985;287-292.
42. Matsumoto S.S., Raivio K.O., Seegmiller J.E. Adenine nucleotide degradation during energy depletion in human lymphoblasts. J. Biol. Chem. 54:1979;8956-8962.
43. Brasitus T.A., Schachter D. Lipid composition and fluidity of rat enterocyte basolateral membranes regional differences. Biochim. Biophys. Acta. 774:1984;138-146.
44. Brasitus T.A., Yeh K.Y., Holt P.R., Schachter D. Lipid fluidity and composition of intestinal microvillus membranes isolated from rats of different ages. Biochim. Biophys. Acta. 778:1984;341-348.
45. 51Cr -EDTA in rats with experimentally induced enteropathy Gut. 26:1985;579-585.
46. Bjarnason I., Fehilly B., Smethurst P., Menzies I.S., Levi A.J. The importance of local versus systemic effects of non-steroidal anti-inflammatory drugs to increase intestinal permeability in man. Gut. 32:1991;275-277.
47. 2 by superoxide. Arch. Biochem. Biophys. 364:1997;187-192.
48. Levine L. Stimulated release of arachidonic acid from rat liver cells by celecoxib and indomethacin. Prostaglandins Leukot. Essent. Fatty Acids. 65(1):2001;31-35.
49. Faure M., Lissi E.A., Videla L.A. Antioxidant capacity of allopurinol in biological systems. Biochem. Int. 21:1990;357.
50. Tanaka A., Mizoguchi H., Kunikata T., Miyazawa T., Takeuchi K. Protection by constitutively formed nitric oxide of intestinal damage induced by indomethacin in rats. J. Physiol. (Paris). 95:2000;35-41.
51. Rubayani G.M., Ho E.H., Cantor E.H., Lumma W.C., Botelho L.H.P. Cytoprotective function nitric oxide: inactivation of superoxide radicals produced by human leukocytes. Biochem. Biophys. Res. Commun. 181:1991;1392-1397.
52. Sturniolo G.C., Barollo M., Fries W., Mazzon E., Ferronato A., D'Inca R., Di Leo V. The many functions of zinc in inflammatory conditions of the gastrointestinal tract. J. Trace Elements Exp. Med. 13:2000;33-39.