Bradykinin stimulates prostaglandin E2 production and cyclooxygenase activity in equine nonglandular and glandular gastric mucosa in vitro

Equine Veterinary Journal

Volumn 40, Issue 4, 2008, Pages 332-336

  Morrissey, N K ^a   Bellenger, C R ^b   Baird, A W ^c  

^a UNIVERSITY OF LIMERICK   (Ireland)

^b MACQUARIE UNIVERSITY   (Australia)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Bradykinin; Cyclooxygenase; Gastric ulceration; Horse; Prostaglandin

Indexed keywords

BRADYKININ; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ISOENZYME; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; VASODILATOR AGENT;

ANIMAL; ANIMAL DISEASE; BIOSYNTHESIS; CONFERENCE PAPER; DRUG EFFECT; ENZYMOLOGY; FEMALE; HORSE; MALE; METABOLISM; STOMACH MUCOSA; TISSUE CULTURE TECHNIQUE;

ANIMALS; BRADYKININ; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; FEMALE; GASTRIC MUCOSA; HORSES; ISOENZYMES; MALE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; TISSUE CULTURE TECHNIQUES; VASODILATOR AGENTS;

EQUIDAE;

EID: 45849135959     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516408X293556     Document Type: Conference Paper

References (45)

1. Alzamora, A.C., Ferreira, P.M., de Oliveira, C.N., Alzamora, F. and Ribeiro-Vieira, M.A. (1998) Kinin receptors mediating the effect of bradykinin on gastric acid secretion. Regulat. Pept. 73, 113-117.
2. Argenzio, R.A. (1999) Comparative pathophysiology of nonglandular ulcer disease: a review of experimental studies. Equine vet. J., Suppl. 29, 19-23.
3. Baker, S.J. and Gerring, E.L. (1993) Technique for prolonged minimally invasive monitoring of intragastric pH in ponies. Am. J. vet. Res. 54, 1725-1734.
4. 2, and carbenoxolone. Gastroenterol. 80, 770-775.
5. Brideau, C., van Staden, C. and Chan, C.C. (2001) In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats. Am. J. vet. Res. 62, 1755-1760.
6. 2 content before and during pentagastrin infusion. J. vet. intern. Med. 18, 545-549.
7. Chaudhury, T.K. and Jacobson, E.D. (1978) Prostaglandin cytoprotection of gastric mucosa. Gastroenterol. 74, 58-63.
8. 2 production by dispersed canine fundic mucosal cells. Contribution of macrophages and endothelial cells as major sources. J. clin. Invest. 84, 1536-1549.
9. Chen, M.C., Sanders, M., Thomas, L., Amirian, D., Kauffman, G. and Soll, A.H. (1986) Prostaglandin (PG) production in canine fundic mucosa: Identification of major cellular sources. (Abstract) Gastroenterol. 90, 1371.
10. 2. Am. J. vet. Res. 46, 1605-1615.
11. Cuthbert, A.W., Halushka, P.V., Margolius, H.S. and Spayne, J.A. (1984) Role of calcium ions in kinin-induced chloride secretion. Br. J. Pharmacol. 82, 587-595.
12. Dawson, D.C. and Cooke, A.R. (1978) Parallel pathways for ion transport across rat gastric mucosa: effect of ethanol. Am. J. Physiol. 235, E7-E15.
13. Diller, A., Vagin, O., Sachs, G. and Apell, H.-J. (2005) Electrogenic partial reactions of the gastric H,K-ATPase. Biophys. J. 88, 3348-3359.
14. Ferraz, J.G., Sharkey, K.A., Reuter, B.K., Asfaha, S. Tigley, A.W., Brown, M.L., McKnight, W. and Wallace, J.L. (1997) Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxaemia: role in resistance to damage. Gastroenterol. 113, 195-204.
15. Hammond, C.J., Mason, D.K. and Watkins, K.L. (1986) Gastric ulceration in mature Thoroughbred horses. Equine vet. J. 18, 284-287.
16. Jackson, L.M., Wu, K.C., Mahida, Y.R., Jenkins, D. and Hawkey, C.J. (2000) Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa. Gut 47, 762-770.
17. Kargman, S., Charleson, S., Cartwright, M., Frank, J., Riendeau, D., Mancini, J., Evans, J. and O'Neill, G. (1996) Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterol. 111, 445-454.
18. Konturek, S.J., Konturek, P.C., Pawlik, T., Sliwowski, Z., Ochmanski, W. and Hahn, E.G. (2004) Duodenal mucosal protection by bicarbonate secretion and its mechanisms. J. Physiol. Pharmacol. 55, Suppl. 2, 5-17.
19. Lawson, L.D. and Powell, D.W. (1987) Bradykinin-stimulated eicosanoid synthesis and secretion by rabbit ileal components. Am. J. Physiol. 252, G783-G790.
20. 2 release by canine tracheal epithelium. Am. J. Physiol. 248, F48-F55.
21. 2 in response to interleukin-1β, tumour necrosis factor-α and bradykinin. Eur. J. Pharmacol. 416, 255-263.
22. Little, D., Jones, S.L. and Blikslager, A.T. (2007) Cyclooxygenase (COX) inhibitors and the intestine. J. vet. intern. Med. 21, 367-377.
23. Ma, L., Del Soldato, P. and Wallace, J.L. (2002) Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: shifting the angiogenic balance. Proc. Nat. Acad. Sci. USA 99, 13243-13247.
24. MacAllister, C.G., Morgan, S.J., Borne, A.T. and Pollet, R.A. (1993) Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses. J. Am. vet. med. Ass. 202, 71-77.
25. MacKay, R.J., French, T.W., Nguyen, H.T. and Mayhew, I.G. (1983) Effects of large doses of phenylbutazone administration to horses. Am. J. vet. Res. 44, 774-780.
26. Manning, D., Snyder, S.M., Kachur, J.F., Miller, R.J. and Field, M. (1982) Bradykinin receptor mediated Cl- secretion in the intestine. Nature 299, 256-259.
27. May, S.A., Hooke, R.E. and Lees, P. (1989) Identity of the E-series prostaglandin produced by equine chondrocytes and synovial cells in response to a variety of stimuli. Res. vet. Sci. 46, 54-57.
28. McGreevy, J.M. (1984) Gastric surface cell function: potential difference and mucosal barrier. Am. J. Physiol. 247, G79-G87.
29. Meschter, C.L., Gilbert, M., Krook, L., Maylin, G. and Corradino, R. (1990) The effects of phenylbutazone on the morphology and prostaglandin concentrations of the pyloric mucosa of the equine stomach. Vet. Pathol. 27, 244-253.
30. Morrissey, N.K. (2002) Gastric Ulceration in Thoroughbred Racehorses in Training in Ireland. MVM Thesis, University College Dublin.
31. Murray, M.J. (1994) Equine model of inducing ulceration in alimentary squamous epithelial mucosa. Digest. Dis. Sci. 39, 2530-2535.
32. Murray, M.J., Schusser, G.F., Pipers, F.S. and Gross, S.J. (1996) Factors associated with gastric lesions in Thoroughbred racehorses. Equine vet. J. 28, 368-374.
33. Nadeau, J.A., Andrews, F.M., Patton, C.S., Argenzio, R.A., Mathew, A.G. and Saxon, A.M. (2003) Effects of hydrochloric, butyric, and proprionic acids on pathogenesis of ulcers in the nonglandular portion of the stomach of horses. Am. J. vet. Res. 64, 404-412.
34. Panara, M.R., Greco, A., Santini, G., Sciulli, M.G., Rotondo, M.T., Padovano, R., di Giamberardino, M., Cipollone, F., Cuccurullo, F., Patrono, C. and Patrigani, P. (1995) Effects of the novel anti-inflammatory compounds, N-[2(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothio-phenyl)-1-indanone (L-745,337), on the cyclo-oxygenase activity of human blood prostaglandin endoperoxide synthases. Br. J. Pharmacol. 116, 2429-2434.
35. Phillips, J.A. and Hoult, J.R.S. (1988) Secretory effects of kinins on colonic epithelium in relation to prostaglandins released from cells of the lamina propria. Br. J. Pharmacol. 95, 701-712.
36. Regoli, D. and Barabé, J. (1980) Pharmacology of bradykinin and related kinins. Pharmacol. Rev. 32, 1-45.
37. 2 synthesis by the stomach and retards gastric emptying. Life Sciences 48, 123-134.
38. Rydning, A., Bakkelund, K., Chen, D., Falkmer, S. and Grønbech, J.E. (2004) Role of bradykinin in gastric vasodilation caused by hypertonic saline and acid back diffusion. Regulatory Peptides 119, 139-148.
39. Sachs, G., Chang, H.H., Rabon, E., Schackman, R., Lewin, M. and Saccomani, G. (1976) A non electrogenic H+ ion pump in plasma membrane of hog stomach. J. biol. Chem. 251, 7690-7698.
40. Sarosiek, J., Murty, V.L.N., Nadziejko, C., Slomiany, A. and Slomiany, B.L. (1986) Prostaglandin effect on the physical properties of gastric mucus glycoprotein and its susceptibility to pepsin. Prostaglandins 32, 635-646.
41. Sawant, S., Snyman, C. and Bhoola, K. (2001) Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms. Int. Immunopharmacol. 1, 2063-2080.
42. Smith, G.S., Warhurst, G. and Turnberg, L.A. (1982) Synthesis and degradation of prostaglandin E2 in the epithelial and sub-epithelial layers of the rat intestine. Biochem. Biophys. Acta 713, 684-687.
43. Vane, J.R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol. 23, 231, 232-235.
44. Warner, T.D., Giuliano, F., Vojnovic, I., Bukasa, A., Mitchell, J.A. and Vane, J.R. (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclooxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc. Nat. Acad. Sci. USA 96, 7563-7568.
45. Widenhouse, T.V., Lester, G.D. and Merritt, A.M. (2002) Effect of hydrochloric acid, pepsin, or taurocholate on bioelectric properties of gastric squamous mucosa in horses. Am. J. vet. Res. 63, 744-749.