Pathophysiologic effects of phenylbutazone on the right dorsal colon in horses

American Journal of Veterinary Research

Volumn 69, Issue 11, 2008, Pages 1496-1505

  McConnico, Rebecca S ^a   Morgan, Timothy W ^a   Williams, Cathleen C ^a   Hubert, Jeremy D ^a   Moore, Rustin M ^a,b  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALBUMIN; MALONALDEHYDE; MYELOPEROXIDASE; PHENYLBUTAZONE; PHENYLZONE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; VOLATILE FATTY ACID;

ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; COLITIS; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; HORSE DISEASE; HYPOALBUMINEMIA; NEUTROPENIA; NEUTROPHIL COUNT; NONHUMAN; OBSERVATIONAL STUDY; PATHOPHYSIOLOGY; TOXICITY TESTING; TREATMENT DURATION;

ANIMALS; COLITIS; COLON; CROSS-OVER STUDIES; FATTY ACIDS; HORSE DISEASES; HORSES; MALONDIALDEHYDE; PEROXIDASE; PHENYLBUTAZONE; PROSTAGLANDINS E; REGIONAL BLOOD FLOW; TIME FACTORS;

ANIMALIA; EQUIDAE;

EID: 56749161741     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.69.11.1496     Document Type: Article

References (36)

1. Brakke Consulting Inc. Equine market megastudy. Dallas: Brakke Consulting Inc, 2007.
2. Snow DH, Bogan JA, Douglas TA, et al. Phenylbutazone toxicity in ponies. Vet Rec 1979;105:26-30.
3. Lees P, Michell AR. Phenylbutazone toxicity in ponies. Vet Rec 1979;105:150-151.
4. Snow DH, Douglas TA, Thompson H, et al. Phenylbutazone toxicosis in equidae: a biochemical and pathophysiological study Am J Vet Res 1981;42:1754-1759.
5. Collins LG, Tyler DE. Phenylbutazone toxicosis in the horse: a clinical study. J Am Vet Med Assoc 1984;184:699-703.
6. Karcher LF, Dill SG, Anderson WI, et al. Right dorsal colitis. J Vet Intern Med 1990;4:247-253.
7. Meschter CL, Tyler DE, White NA, et al. Histologic findings in the gastrointestinal tract of horses with colic. Am J Vet Res 1986;47:598-606.
8. Papich MG. Phenylbutazone. In: Papich MG, ed. Saunders handbook of veterinary drugs. 2nd ed. St Louis: Saunders Elsevier, 2007;521-522.
9. Meschter CL, Gilbert M, Krook L, et al. The effects of phenylbutazone on the intestinal mucosa of the horse: a morphological, ultrastructural and biochemical study. Equine Vet J 1990;22:255-263.
10. Rolandelli RH, Koruda MJ, Settle RG, et al. Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomosis in the rat. Surgery 1986;100:198-203.
11. Gustafsson A, Lund-Tonnesen S, Berstad A, et al. Faecal short-chain fatty acids in patients with antibiotic-associated diarrhoea, before and after faecal enema treatment. Scand J Gastroenterol 1998;33:721-727.
12. Ruthig DJ, Meckling-Gill KA. Both (n-3) and (n-6) fatty acids stimulate wound healing in the rat intestinal epithelial cell line, IEC-6. J Nutr 1999;129:1791-1798.
13. Wilkins PA, Lowe JE. Technique for long-term right dorsal colon fistulization in ponies. Am J Vet Res 1993;54:183-184.
14. Smeak DD. The Chinese finger trap suture technique for fastening tubes and catheters. J Am Anim Hosp Assoc 1990;26:215-218.
15. Stallings CC. Manure scoring as a management tool. Western-Canadian-Dairy-Seminar 1998;10:287-296.
16. Moore RM, Bertone AL, Muir WW, et al. Histopathologic evidence of reperfusion injury in the large colon of horses after low-flow ischemia. Am J Vet Res 1994;55:1434-1443.
17. Grisham MB, Benoit JN, Granger DN. Assessment of leukocyte involvement during ischemia and reperfusion of intestine. Methods Enzymol 1990;186:729-742.
18. McConnico RS, Weinstock D, Poston ME, et al. Myeloperoxidase activity of the large colon in an equine model of acute colitis. Am J Vet Res 1999;60:807-814.
19. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-358.
20. Argenzio RA, Lecce J, Powell DW. Prostanoids inhibit intestinal NaCl absorption in experimental porcine cryptosporidiosis. Gastroenterology 1993;104:440-447.
21. Bateman HG, Williams CC, Chung Y-H. Effects of supplemental zinc in high quality diets on ruminal fermentation and degradation of urea in vitro and in vivo. Prof Anim Sci 2002;18:363-367.
22. Reed SK, Messer NT, Tessman RK, et al. Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses. Am J Vet Res 2006;67:398-402.
23. Meyer J, Delay J, Bienzle D. Clinical, laboratory, and histopathologic features of equine lymphoma. Vet Pathol 2006;43:914-924.
24. Peregrine AS, McEwen B, Bienzle D, et al. Larval cyathostominosis in horses in Ontario: an emerging disease? Can Vet J 2006;47:80-82.
25. Blikslager AT, Moeser AJ, Gookin JL, et al. Restoration of barrier function in injured intestinal mucosa. Physiol Rev 2007; 87:545-564.
26. Campbell NB, Jones SL, Blikslager AT. The effects of cyclooxygenase inhibitors on bile-injured and normal equine colon. Equine Vet J 2002;34:493-498.
27. Morris DD, Crowe N, Moore JN. Correlation of clinical and laboratory data with serum tumor necrosis factor activity in horses with experimentally induced endotoxemia. Am J Vet Res 1990; 51:1935-1940.
28. Chidlow JH, Langston W, Greer JJ, et al. Differential angiogenic regulation of experimental colitis. Am J Pathol 2006; 169:2014-2030.
29. Chidlow JH Jr, Shukla D, Grisham MB, et al. Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues. Am J Physiol Gastrointest Liver Physiol 2007;293: G5-G18.
30. Rainsford KD, Stetsko PI, Sirko SP, et al. Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indomethacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease. J Pharm Pharmacol 2003;55:661-668.
31. MacAllister CG, Morgan SJ, Borne AT, et al. Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses. J Am Vet Med Assoc 1993;202:71-77.
32. Andrews FM, Robertson JT. Diagnosis and surgical treatment of functional obstruction of the right dorsal colon in a horse. J Am Vet Med Assoc 1988;193:956-958.
33. Simmons TR, Gaughan EM, Ducharme NG, et al. Treatment of right dorsal ulcerative colitis in a horse. J Am Vet Med Assoc 1990; 196:455-458.
34. Hough ME, Steel CM, Bolton JR, et al. Ulceration and stricture of the right dorsal colon after phenylbutazone administration in four horses. Aust Vet J 1999;77:785-788.
35. Matsumoto T, Hayasaki T, Nishimura Y, et al. Butyrate induces necrotic cell death in murine colonic epithelial cell MCE301. Biol Pharm Bull 2006;29:2041-2045.
36. Sakuma K, Fujimori T, Hirabayashi K, et al. Cyclooxygenase (COX)-2 inummoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer. J Gastroenterol 1999;34:189-194.