Spillover of cytokines and reactive oxygen species in ventilator-induced lung injury associated with inflammation and apoptosis in distal organs

Respiratory Care

Volumn 59, Issue 9, 2014, Pages 1422-1432

  Liu, Yung Yang ^a   Chiang, Chi Huei ^a,b,c,d   Chuang, Chiao Hui ^a   Liu, Shiou Ling ^a,b   Jheng, Yi Han ^f   Ryu, Jay H ^e  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b Institute of Clinical Medicine   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^e MAYO CLINIC   (United States)

^f NONE

Author keywords

Apoptosis; Inflammation; Reactive oxygen species; Ventilator induced lung injury

Indexed keywords

CASPASE 3; CYTOKINE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; CXCL2 CHEMOKINE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38;

AIRWAY PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CAPNOMETRY; CELL LABELING; CONTROLLED STUDY; DISEASE ASSOCIATION; HEART; INFLAMMATION; LEUKOCYTE COUNT; LIVER; LUNG WEIGHT; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; NONHUMAN; PROTEIN ANALYSIS; RAT; SCORING SYSTEM; UPREGULATION; VENTILATOR INDUCED LUNG INJURY; WESTERN BLOTTING; ANIMAL; BLOOD; CHEMISTRY; COMPLICATION; ENZYMOLOGY; HEART MUSCLE; KIDNEY; LUNG; LUNG LAVAGE; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PULMONARY EDEMA; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; CASPASE 3; CHEMOKINE CXCL2; INTERLEUKIN-1BETA; JANUS KINASES; KIDNEY; LIVER; LUNG; MALE; MYOCARDIUM; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; VENTILATOR-INDUCED LUNG INJURY;

EID: 84928175633     PISSN: 00201324     EISSN: 19433654     Source Type: Journal    
DOI: 10.4187/respcare.02992     Document Type: Article

References (38)

1. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342(18): 1301-1308.
2. Ferguson ND, Frutos-Vivar F, Esteban A, Anzueto A, Alia I, Brower RG, et al. Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome. Crit Care Med 2005; 33(1): 21-30.
3. Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with adult respiratory distress syndrome. Am Rev Respir Dis 1985; 132(3): 485-489.
4. Stapleton RD, Wang BM, Hudson LD, Rubenfeld GD, Caldwell ES, Steinberg KP. Causes and timing of death in patients with ARDS. Chest 2005; 128(2): 525-532.
5. Suchyta MR. The changing face of organ failure in ARDS. Chest 2003; 124(5): 1871-1879.
6. Slutsky AS, Tremblay LN. Multiple system organ failure: Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 1998; 157(6): 1721-1725.
7. Dreyfuss D, Soler P, Basset G, Saumon G. High inflation pressure pulmonary edema: respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 1988; 137(5): 1159-1164.
8. dos Santos CC, Slutsky AS. The contribution of biophysical lung injury to the development of biotrauma. Annu Rev Physiol 2006; 68: 585-618.
9. Uhlig U, Haitsma JJ, Goldmann T, Poelma DL, Lachmann B, Uhlig S. Ventilation-induced activation of the mitogen-activated protein kinase pathway. Eur Respir J 2002; 20(4): 946-956.
10. Wilson MR, Choudhury S, Goddard ME, O'Dea KP, Nicholson AG, Takata M. High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury. J Appl Physiol 2003; 95(4): 1385-1393.
11. Chiang CH, Chuang CH, Liu SL, Lee TS, Kou YR, Zhang H. Apo-cynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Intensive Care Med 2011; 37(8): 1360-1367.
12. Bilali A, Kurata S, Ikeda S, Georgieva GS, Zhu C, Tomita M, et al. Lung-lung interaction in isolated perfused unilateral hyperventilated rat lungs. Transl Res 2010; 155(5): 228-237.
13. Plötz FB, Slutsky AS, van Vught AJ, Heijnen CJ. Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med 2004; 30(10): 1865-1872.
14. Del Sorbo L, Slutsky AS. Acute respiratory distress syndrome and multiple organ failure. Curr Opin Crit Care 2011; 17(1): 1-6.
15. Jaecklin T, Otulakowski G, Kavanagh B. Do soluble mediators cause ventilator-induced lung injury and multi-organ failure? Intensive Care Med 2010; 36(5): 750-757.
16. Kuebler WM. From a distance: ventilation-dependent extra-pulmo-nary injury. Transl Res 2010; 155(5): 217-219.
17. Ciesla DJ, Moore EE, Johnson JL, Burch JM, Cothren CC, Sauaia A. The role of the lung in post-injury multiple organ failure. Surgery 2005; 138(4): 749-757; discussion 757-758.
18. Liu YY, Lee CH, Dedaj R, Zhao H, Mrabat H, Sheidlin A, et al. High-molecular-weight hyaluronan-a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats. Crit Care 2008; 12(4): R 102.
19. Chiang CH, Pai HI, Liu SL. Ventilator-induced lung injury (VILI) promotes ischemia/reperfusion lung injury (I/R) and NF-KB antibody attenuates both injuries. Resuscitation 2008; 79(1): 147-154.
20. Slutsky AS. Ventilator-induced lung injury: from barotrauma to biotrauma. Respir Care 2005; 50(5): 646-659.
21. Haitsma JJ, Uhlig S, Göggel R, Verbrugge SJ, Lachmann U, Lachmann B. Ventilator-induced lung injury leads to loss of alveolar and systemic compartmentalization of tumor necrosis factor-alpha. Intensive Care Med 2000; 26(10): 1515-1522.
22. Kotani M, Kotani T, Li Z, Silbajoris R, Piantadosi CA, Huang YC. Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch. Eur Respir J 2004; 24(2): 238-246.
23. Tremblay L, Valenza F, Ribeiro SP, Li J, and Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 1997; 99(5): 944-952.
24. Tremblay LN, Miatto D, Hamid Q, Govindarajan A, Slutsky AS. Injurious ventilation induces widespread pulmonary epithelial expression of tumor necrosis factor-alpha and interleukin-6 messenger RNA. Crit Care Med 2002; 30(8): 1693-1700.
25. Welk B, Malloy JL, Joseph M, Yao LJ, Veldhuizen AW. Surfactant treatment for ventilation-induced lung injury in rats: effects on lung compliance and cytokines. Exp Lung Res 2001; 27(6): 505-520.
26. Hoegl S, Boost KA, Flondor M, Scheiermann P, Muhl H, Pfeilschifter J, et al. Short-term exposure to high-pressure ventilation leads to pulmonary biotrauma and systemic inflammation in the rat. Int J Mol Med 2008; 21 (4): 513-519.
27. Syrkina O, Jafari B, Hales CA, Quinn DA. Oxidant stress mediates inflammation and apoptosis in ventilator-induced lung injury. Re-spirology 2008; 13(3): 333-340.
28. Hegeman MA, Hennus MP, Heijnen CJ, Specht PA. Lachmann B, Jansen NJ, et al. Ventilator-induced endothelial activation and inflammation in the lung and distal organs. Crit Care 2009; 13(6): R 182.
29. Choi WI, Quinn DA, Park KM, Moufarrej RK, Jafari B, Syrkina O. et al. Systemic microvascular leak in an in vivo rat model of venti-lator-induced lung injury. Am J Respir Crit Care Med 2003: 167(12): 1627-1632.
30. Guery BP, Welsh DA, Viget NB, Robriquet L, Fialdes P, Mason CM, et al. Ventilation-induced lung injury is associated with an increase in gut permeability. Shock 2003; 19(6): 559-563.
31. Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, et al. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 2003; 289(16): 2104-2112.
32. Patterson EK, Yao LJ, Ramie N, Lewis JF, Cepinskas G, McCaig L, et al. Lung-derived mediators induce cytokine production in downstream organs via an NF-KB-dependent mechanism. Mediators Inflamm 2013; 2013: 586895.
33. Koyner JL, Murray PT. Mechanical ventilation and the kidney. Blood Purif 2010; 29(1): 52-68.
34. Kuiper JW, Groeneveld AB, Slutsky AS, Plötz FB. Mechanical ventilation and acute renal failure. Crit Care Med 2005; 33(6): 1408-1415.
35. Ranieri VM, Giunta F, Suter PM, Slutsky AS. Mechanical ventilation as a mediator of multisystem organ failure in acute respiratory distress syndrome. JAMA 2000; 284(1): 43-44.
36. Walker MG, Yao LJ, Patterson EK, Joseph MG, Cepinskas G, Veld-huizen RA, et al. The effect of tidal volume on systemic inflammation in acid-induced lung injury. Respiration 2011; 81(4): 333-342.
37. Soutiere SE, Mitzner W. On defining total lung capacity in the mouse. J Appl Phyiol 2004; 96(5): 1658-1664.
38. Wilson MR, Patel BV, Takata M. Ventilation with "clinically relevant" high tidal volumes does not promote stretch-induced injury in the lungs of healthy mice. Crit Care Med 2012; 40(10): 2850-2857.