Mitochondrial DNA damage is associated with damage accrual and disease duration in patients with Systemic Lupus Erythematosus

Lupus

Volumn 23, Issue 11, 2014, Pages 1133-1141

  Lopez Lopez L ^a   Nieves Plaza, M ^b,c   Castro, M Del R ^a   Font, Y M ^a   Torres Ramos, C A ^a   Vila L M ^a   Ayala Pena S ^a  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^b UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS   (Puerto Rico)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Disease activity; Disease damage; Mitochondrial dna; Mitochondrial dysfunction; Oxidative stress; Systemic lupus erythematosus

Indexed keywords

ACETYLSALICYLIC ACID; AZATHIOPRINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCOCORTICOID; HYDROXYCHLOROQUINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHOTREXATE; MITOCHONDRIAL DNA; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ADULT; ARTHRITIS; ARTICLE; CELLULAR CAST; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DISEASE ACTIVITY; DISEASE CLASSIFICATION; DISEASE DURATION; DNA DAMAGE; FEMALE; HEMOLYTIC ANEMIA; HUMAN; LEUKOPENIA; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALAR RASH; MALE; MEDICAL SOCIETY; MOUTH ULCER; PERICARDITIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHOTOSENSITIVITY; PLEURISY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEINURIA; PSYCHOSIS; QUANTITATIVE ANALYSIS; SEIZURE; SKIN MANIFESTATION; SOCIOECONOMICS; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; CASE CONTROL STUDY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; TIME;

ADULT; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DNA DAMAGE; DNA, MITOCHONDRIAL; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 84928164761     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203314537697     Document Type: Article

References (51)

1. Perl A. Pathogenic mechanisms in systemic lupus erythematosus. Autoimmunity 2010; 43: 1-6.
2. Ma ZA, Zhao Z, Turk J. Mitochondrial Dysfunction and -Cell Failure in Type 2 Diabetes Mellitus. Exp Diabetes Res. 2012 doi: 10.1155/2012/703538.
3. Lowell BB, Shulman GI. Mitochondrial Dysfunction and Type 2 Diabetes. Science 2005; 307: 384-7.
4. Shukla V, Mishra SK, Pant HC. Oxidative stress in neurodegeneration. Adv Pharmacol Sci 2011 doi: 10.1155/2012/703538.
5. Perl A. Oxidative stress in the pathology and treatment of systemic lupus erythematosus. Nat Rev Rheumatol 2013 Oct 8. doi: 10.1038/nrrheum.2013.147.
6. Gergely Jr P, Grossman C, Niland B, et al. Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus. Arthritis Rheum 2002; 46: 175-90.
7. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973; 134: 707-16.
8. Perl A, Gergely Jr P, Nagy G, Koncz A, Banki K. Mitochondrial hyperpolarization: A checkpoint of T-cell life, death and autoimmunity. Trends Immunol 2004; 25: 360-7.
9. Kesarwani P, Murali AK, Al-Khami AA, Mehrotra S. Redox regulation of T-cell function: From molecular mechanisms to significance in human health and disease. Antioxid Redox Signal 2013; 18: 1497-534.
10. Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000; 29(3-4): 222-30.
11. Perl A, Gergely Jr P, Banki K. Mitochondrial dysfunction in T cells of patients with systemic lupus erythematosus. Int Rev Immunol 2004; 23(3-4): 293-313.
12. Nagy G, Barcza M, Gonchoroff N, Phillips PE, Perl A. Nitric oxide-dependent mitochondrial biogenesis generates Ca2 signaling profile of lupus T cells. J Immunol 2004; 173: 3676-83.
13. Clayton DA. Transcription of the mammalian mitochondrial genome. Annu Rev Biochem 1984; 53: 573-94.
14. Attardi G. The elucidation of the human mitochondrial genome. Bioessays 1986; 5: 34-9.
15. Yakes FM, VanHouten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A 1997; 94: 514-9.
16. Vyshkina T, Sylvester A, Sadiq S, et al. Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus. Clin Immunol 2008; 129: 31-5.
17. Jönsen A, Yu X, Truedsson L, et al. Mitochondrial DNA polymorphisms are associated with susceptibility and phenotype of systemic lupus erythematosus. Lupus 2009; 18: 309-12.
18. Jiang X, Chen F. The effect of lipid peroxides and superoxide dismutase on systemic lupus erythematosus: A preliminary study. Clin Immunol Immunopathol 1992; 63: 39-44.
19. Grune T, Michel P, Sitte N, et al. Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases. Free Radic Biol Med 1997; 23: 357-60.
20. Kurien BT, Scofield RH. Free radical mediated peroxidative damage in systemic lupus erythematosus. Life Sci 2003; 73: 1655-66.
21. Mansour RB, Lassoued S, Gargouri B, El Gaïd A, Attia H, Fakhfakh F. Increased levels of autoantibodies against catalase and superoxide dismutase associated with oxidative stress in patients with rheumatoid arthritis and systemic lupus erythematosus. Scand J Rheumatol 2008; 37: 103-8.
22. Shah D, Kiran R, Wanchu A, Bhatnagar A. Oxidative stress in systemic lupus erythematosus: Relationship to Th1 cytokine and disease activity. Immunol Lett 2010; 129: 7-12.
23. Iuliano L, Praticò D, Ferro D, et al. Enhanced lipid peroxidation in patients positive for antiphospholipid antibodies. Blood 1997; 90: 3931-5.
24. Avalos I, Chung CP, Oeser A, et al. Oxidative stress in systemic lupus erythematosus: relationship to disease activity and symptoms. Lupus 2007; 16: 195-200.
25. Morgan PE, Sturgess AD, Davies MJ. Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus. Arthritis Rheum 2005; 52: 2069-79.
26. Morgan PE, Sturgess AD, Davies MJ. Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients. Free Radic Res 2009; 43: 117-27.
27. Shah D, Sah S, Wanchu A, Wu MX, Bhatnagar A. Altered redox state and apoptosis in the pathogenesis of systemic lupus erythematosus. Immunobiology 2013; 218: 620-7.
28. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-7.
29. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1725.
30. Uribe AG, Vilá LM, McGwin Jr G, Sanchez ML, Reveille JD, Alarcón GS. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. J Rheumatol 2004; 31: 1934-40.
31. Liang MH, Socher SA, Larson MG, Schur PH. Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum 1989; 32: 1107-18.
32. Liang MH, Fortin PR, Isenberg DA, Snaith L. Quantitative clinical assessment of disease activity in systemic lupus erythematosus: progress report and research agenda. Rheumatol Int 1991; 11: 133-6.
33. Gladman DD, Goldsmith CH, Urowitz MB, et al. The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index for Systemic Lupus Erythematosus International Comparison. J Rheumatol 2000; 27: 373-6.
34. Castro M del R, Suarez E, Kraiselburd E, et al. Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys. Exp Gerontol 2012; 47: 29-37.
35. Siddiqui A, Rivera-Sánchez S, Castro M del R, et al. Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease. Free Radic Biol Med 2012; 53: 1478-88.
36. Ayala-Torres S, Chen Y, Svoboda T, Rosenblatt J, Van Houten B. Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction. Methods 2000; 22: 135-47.
37. Wang G, Pierangeli SS, Papalardo E, Ansari GA, Khan MF. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity. Arthritis Rheum 2010; 62: 2064-72.
38. Bashir S, Harris G, Denman MA, Blake DR, Winyard PG. Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases. Annals of the Rheumatic Diseases 1993; 52: 659-66.
39. Lunec J, Herbert K, Blount S, Griffiths HR, Emery P. 8- Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus. FEBS Lett 1994; 348: 131-8.
40. Emlen W, Niebur J, Kadera R. Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus. J Immunol 1994; 152: 3685-92.
41. Wallace SS. Biological consequences of free radical-damaged DNA bases. Free Radic Biol Med 2002; 33: 1-14.
42. Caldecott KW. Single-strand break repair and genetic disease. Nat Rev Genet 2008; 9: 619-31.
43. Tann AW, Boldogh I, Meiss G, et al. Apoptosis induced by persistent single-strand breaks in mitochondrial genome. J Biol Chem 2011; 286: 31975-83.
44. Furda AM, Marrangoni AM, Lokshin A, Van Houten B. Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction. DNA Repair (Amst) 2012; 11: 684-92.
45. Lee H-T, Lin CS, Chen WS, Liao HT, Tsai CY, Wei YH. Leukocyte mitochondrial DNA alteration in systemic lupus erythematosus and its relevance to the susceptibility to lupus nephritis. Int J Mol Sci 2012; 13: 8853-68.
46. Lee HM, Sugino H, Aoki C, Nishimoto N. Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus. Arthritis Res Ther 2011; 13: R63.
47. Cordero MD, DeMiguel M, Moreno Fernández AM, et al. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: Implications in the pathogenesis of the disease. Arthritis Res Ther 2010; 12: R17.
48. Cordero MD, De Miguel M, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM. Oxidative stress and mitochondrial dysfunction in fibromyalgia. Neuro Endocrinol Lett 2010; 31: 169-73.
49. Kurien BT, Scofield RH. Lipid peroxidation in systemic lupus erythematosus. Indian J Exp Biol 2006; 44: 349-56.
50. Hassan SZ, Gheita TA, Kenawy SA, Fahim AT, El-Sorougy IM, Abdou MS. Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity. Int J Rheum Dis 2011; 14: 325-31.
51. Shah D, Wanchu A, Bhatnagar A. Interaction between oxidative stress and chemokines: possible pathogenic role in systemic lupus erythematosus and rheumatoid arthritis. Immunobiology 2011; 216: 1010-7.