Potential antifibrotic and angiostatic impact of idebenone, carnosine and vitamin e in nano-sized titanium dioxide-induced liver injury

Cellular Physiology and Biochemistry

Volumn 35, Issue 6, 2015, Pages 2402-2411

  Abdelazim, Samy A ^a   Darwish, Hebatallah A ^a   Ali, Sanaa A ^b   Rizk, Maha Z ^b   Kadry, Mai O ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

In vitro; Nano titanium dioxide; VEGF and western blot

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; ASPARTATE AMINOTRANSFERASE; CARNOSINE; GLUTATHIONE TRANSFERASE; IDEBENONE; MESSENGER RNA; NITRATE; NITRITE; SMAD2 PROTEIN; TITANIUM DIOXIDE NANOPARTICLE; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; ANTIOXIDANT; NITRIC ACID DERIVATIVE; TITANIUM; TITANIUM DIOXIDE; TRANSFORMING GROWTH FACTOR BETA; UBIQUINONE; VASCULOTROPIN A;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIFIBROTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL VIABILITY; COLLAGEN FIBER; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG ACTIVITY; ENDOTHELIUM; HEPG2 CELL LINE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; LIVER INJURY; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; WESTERN BLOTTING; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; DRUG-INDUCED LIVER INJURY; LIVER CIRRHOSIS; METABOLISM; TUMOR CELL LINE;

MUS;

ALANINE TRANSAMINASE; ANGIOGENESIS INHIBITORS; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; CARNOSINE; CELL LINE, TUMOR; DRUG-INDUCED LIVER INJURY; GLUTATHIONE TRANSFERASE; HEP G2 CELLS; HUMANS; LIVER CIRRHOSIS; MALE; MICE; NITRATES; NITRITES; SMAD2 PROTEIN; TITANIUM; TRANSFORMING GROWTH FACTOR BETA; UBIQUINONE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VITAMIN E;

EID: 84928137739     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000374041     Document Type: Article

References (46)

1. Cunningham BW, Orbegoso CM, Dmitriev AE, Hallab NJ, Sefter JC, McAfee PC: The effect of titanium particulate on development and maintenance of a posterolateral spinal arthrodesis. an in vivo rabbit model. Spine 2002;27:1971-1981.
2. Lynch I, Dawson KA, Linse S: Detecting cryptic epitopes created by nanoparticles. Sci STKE 2006;14.
3. Borm PJ, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins R, Stone V, Kreyling W, Lademann J, Krutmann J, Warheit D, Brown JS, Zeman KL, Bennett WD: Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am J Respir Crit Care Med 2002;166:1240.
4. Wang JX, Zhou GQ, Chen CY, Yu HW, Wang TC, Ma YM, Jia G, Gao YX, Li B, Sun J, Li YF, Jia F, Zhao YL, Chai ZF: Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 2007;168:176-185.
5. Armand L, Dagouassat M, Belade E, Simon-Deckers A, Le Gouvello S, Tharabat C, Duprez C, Andujar P, Pairon J, Boczkowski J, Lanone S:Titanium Dioxide Nanoparticles Induce Matrix Metalloprotease 1 in Human Pulmonary Fibroblasts Partly via an Interleukin-1β-Dependent Mechanism. Am J Res Cell Mol Biol 2013;48:354-363.
6. Valencia S, Gretzer C, Cooper LF: Surface nanofeature effects on titanium-adherent human mesenchymal stem cells. Int J Oral Maxillofac Implants 2009;24:38-46.
7. Ghulam RL, and Dileep KR:Targeting apoptosis with compounds from commonly used medicinal plants: A possible aid in the fight against cancer. Med Hypothesis Res 2006;3:10.
8. Ali SA, Aly HF, Faddah LM, Zaidi ZF: Dietary supplementation of some antioxidants against hypoxia. World J Gastroenterol 2012;28:6379-6386.
9. Parnetti L: Clinical pharmacokinetics of drugs for Alzheimers disease. Clinpharmcokinet 1995;29:110-129.
10. Torii H, Yoshida K, Kobayashi T: Disposition of idebenone (CV-2619) a new cerebral metabolism improving agent, in mice and dogs. J Pharmacobiodyn 1985;8:457-467: 42-51.
11. Ali SA: Evaluation of immunological effect of beta alanyl-l-histidine against Schistosoma mansoni antigens of Rabbits. J Infect Dev Ctries 2012;6:166-175.
12. Schaffer S, Muller WE, Eckert GP: Tocotrienols constitutional effects in aging and disease. J Nutr 2005;135:151-154.
13. Zingg JM: Modulation of signal transduction by vitamin E. Mol Aspects Med 2007;28:481-500.
14. Qureshi AA, Reis JC, Qurush N, Papasian CJ, Morrison DC, Schaefer DM: δ-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens. Lipids in Health and Disease 2011;10:39-58.
15. Li N, Ma L, Wang J, Zheng L, Liu J, Duan Y, Liu H, Zhao X, Wang S, Wang H, Hong F: Interaction between nano-anatase TiO2 and liver DNA from mice in vitro.Nanoscale Res Lett 2010;5:108-115.
16. Gunnar M, Buyse GM, Michael E, Jan D, Erik V, Alejandro J, An Van DB, Luc M, Isabelle CF, Patrizia B, Thomas:Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance. Eur Heart J 2009;30:116-124.
17. Zhang X, Song L, Cheng X, Yang Y, Luan B, Jia L, Xu F, Zhang Z: Carnosine pretreatment protects against hypoxia-ischemia brain damage in the neonatal rat model. Eur J Pharmacol 2011;667:202-207.
18. Ishrat T, Parveen K, Hoda MN, Khan MB, Yousuf S, Ansari MA, Saleem S, Islam F: Effects of Pycnogenol and Vit E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in mice. Behav Pharmacol 2009;20:567-575.
19. Bassem S, Walid F, Khaled M, Salwa M, May E, Maria HO, Stig L: Screening of natural products for Therapeutic activity against solid tumors. Indian J of Exp Biol 2010;48:258-264.
20. Reitman S, Frankle S: A colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Path 1957;28.
21. Ou BX, Huang DJ, Hampsch-Woodill M, Flanagan JA, Deemer EK: Analysis of antioxidant activities of common vegetables employing oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays: a comparative study. J Agric Food Chem 2002;50:3122-3128.
22. Jocelyn PC: Biochemistry of the SH Group. Academic Press, London 1972; 10.
23. Miranda KM, Espey MG, Wink DA: A rapid simple spectrophotometric method for simultaneous detection of nitrate and nitrite.Nitric Oxide 2001;5:62-71.
24. Liu B, Zhang X, Zhang FC, Zong JB, Zhang W, Zhao Y:Aberrant TGF-β1 signaling contributes to the development of primary biliary cirrhosis in murine model.World J Gastroenterol 2013;19:5828-5836.
25. Grünblatt E, Mandel S, Maor G, Youdim MB: Effects of R-apomorphine and S-apomorphine on MPTPinduced nigro-striatal dopamine neuronal loss. J Neurochem 2001;77:146-156.
26. Bancroft JD, Stevens A: Theory and Practice of Histological Techniques.4 ed., Churchill Livingstone. London 1996.
27. Xiong D, Fang T, Yu L, Sima X, Zhu W: Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebra fish acute toxicity oxidative stress and oxidative damage. Sci Total Environ 2011;409:1444-1452.
28. Sayes CM, Fortner JD, Guo W, Lyon D, Boyd A, Ausman K, Tao Y, Sitharaman B, Wilson L, Hughes J, West J, Colvin V: The differential cytotoxicity of water soluble fullerenes. Nano Lett 2004;4:1881-1887
29. Baykara B, Tekmen I, Pekcetin C, Ulukus C, Tuncel P, Sagol O, Ormen M, Ozogul C: The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liver.ActaHistochem 2008;111:42-51.
30. Velanganni AA, Balasundaram C: Effect of antioxidant vitamins A, C, E and their analogues on azo-dye binding protein in liver of rats treated with p-dimethylaminoazobenzene. Indian J Exp Biol 2010;48:373-377.
31. Ma LL, Liu J, Li N, Wang J, Duan YM, Yan JY, Liu HT, Wang H, Hong FS: Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity. Biomaterials 2010;31:99-105.
32. Liu HT, Ma LL, Zhao JF, Liu J, Yan JY, Ruan J, Hong FS: Toxicity of nanoanatase TiO2 to mice liver injury oxidative stress. Toxicol Env Chem 2010;92:175-186.
33. Yan SL, Wu ST, Yin MC, Chen HT, Chen HC: Protective effects from carnosine and histidine on acetaminophen-induced liver injury. J Food Sci 2009;74: 259-265.
34. Derynck R, Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-584.
35. Kikuchi K, Tanaka A, Matsushita M, Kitazawa E, Hosoya N, Kawashima Y, Selmi C, Gershwin ME, Miyakawa H: Genetic polymorphisms of transforming growth factor beta-1 promoter and primary biliary cirrhosis in Japanese patients. Ann N Y Acad Sci 2007;1110:15-22.
36. Armand L, Dagouassat M, Belade E, Simon-Deckers A, Le Gouvello S, Tharabat C, Duprez C, Andujar P, Pairon J, Boczkowski J, Lanone S: Titanium Dioxide Nanoparticles Induce Matrix Metalloprotease 1 in Human Pulmonary Fibroblasts Partly via an Interleukin-1β-Dependent Mechanism. Amer J Resp Cell Mol Biol 2013;48:354-363.
37. Köppel H, Riedl E, Braunagel M, Sauerhoefer S, Ehnert S, Godoy P, Sternik P, Dooley S, Yard BA: L-carnosine inhibits high-glucose-mediated matrix accumulation in human mesangial cells by interfering with TGF-β production and signalling. Nephrol Dial Transplant 2001;26:3852-3858.
38. Ito-Kato E, Suzuki N, Maeno M, Takada T, Tanabe N, Takayama T, Ito K, Otsuka K: Effect of carnosine on runt-related transcription factor-2/core binding factor alpha-1 and Sox9 expressions of human periodontal ligament cells. J Periodontal Res 2004;39:199-204.
39. Tasanarong A: Vitamin E ameliorates renal fibrosis by inhibition of TGF-beta/Smad2/3 signaling pathway in UUO mice. J Med Assoc Thai 2011;94:S1-9.
40. Calvisi DF, Ladu S, Hironaka K, Factor VM, Thorgeirsson SS: Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer. J Hepatol 2004;41:815-822.
41. Ding YH, Luan XD, Li J: Exercise-induced over expression of angiogenic factors and reduction of ischemia/ reperfusion injury in stroke. Curr Neurovasc Res2004;1:411-420.
42. Prior BM, Yang HT, Terjung RL: What makes vessels grow with exercise training?. J Appl Physiol 2004;97:1119-1128.
43. Jackson JR, Seed MP, Kircher CH, Willoughby DA, Winkler JD: The codependence of angiogenesis and chronic inflammation. FASEB J 1997;11:457-465.
44. Al-Rasheed NM, Faddah LM, Mohamed AM, Abdel Baky NA, Mohammad RA: Potential Impact of Quercetin and Idebenone against Immuno- inflammatory and Oxidative Renal Damage Induced in Rats by Titanium Dioxide Nanoparticles Toxicity. J Oleo Sci 2013;62:961-971.
45. Pfister F, Riedl E, Wang Q, Vom Hagen F, Deinzer M, Harmsen MC, Molema G, Yard B, Feng Y: Hammes HP. Oral carnosine supplementation prevents vascular damage in experimental diabeticretinopathy. Cell Physiol Biochem 2011;28:125-136.
46. Nespereira B, Pérez-Ilzarbe M, Fernández P, Fuentes AM, Páramo JA, Rodríguez JA:Vitamins C and E down regulate vascular VEGF and VEGFR-2 expression in apo-lipoprotein-E-deficient mice. Atherosclerosis 2003;171:67-73.