In vitro and in vivo evaluation of Δ9-tetrahidrocannabinol/PLGA nanoparticles for cancer chemotherapy

International Journal of Pharmaceutics

Volumn 487, Issue 1-2, 2015, Pages 205-212

  Martin Banderas L ^a   Munoz Rubio I ^a   Prados, J ^b   Alvarez Fuentes J ^a   Calderon Montano J M ^a   Lopez Lazaro M ^a   Arias, J L ^b,c   Leiva, M C ^b   Holgado, M A ^a   Fernandez Arevalo M ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

Blood compatibility; Chitosan; Lung cancer; Nanoparticles; PEGylation; PLGA; 9 Tetrahidrocannabinol

Indexed keywords

ALPHA TOCOPHEROL; CHITOSAN; GLYCOLIC ACID DERIVATIVE; MACROGOL; NANOCOATING; NANOPARTICLE; TETRAHYDROCANNABINOL; ANTINEOPLASTIC AGENT; DRONABINOL; LACTIC ACID; MACROGOL DERIVATIVE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

A549 CELL LINE; ADSORPTION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD COMPATIBILITY; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER SIZE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; CYTOTOXICITY ASSAY; DRUG DEGRADATION; DRUG DIFFUSION; DRUG RELEASE; DRUG SAFETY; DRUG STABILITY; ELECTRICITY; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; IC50; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OPSONIZATION; PARTICLE SIZE; PLASMA CLEARANCE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN SECRETION; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; SYNTHESIS; THROMBOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CELL SURVIVAL; DRUG EFFECTS; DRUG FORMULATION; DRUG SCREENING; MATERIALS TESTING; MEDICINAL CHEMISTRY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRONABINOL; DRUG COMPOUNDING; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTIC ACID; MATERIALS TESTING; MICE; MICE, INBRED C57BL; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84928119347     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.04.054     Document Type: Article

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