-
1
-
-
33947489961
-
Isolation, structure and partial synthesis of an active constituent of hashish
-
Gaoni Y, Mechoulam R, (1964) Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 86: 1646-1647.
-
(1964)
J Am Chem Soc
, vol.86
, pp. 1646-1647
-
-
Gaoni, Y.1
Mechoulam, R.2
-
2
-
-
18444376760
-
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
-
Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, et al. (2002) International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54: 161-202.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 161-202
-
-
Howlett, A.C.1
Barth, F.2
Bonner, T.I.3
Cabral, G.4
Casellas, P.5
-
3
-
-
33845959991
-
Cannabinoid CB2 receptor: a new target for controlling neural cell survival?
-
Fernandez-Ruiz J, Romero J, Velasco G, Tolon R, Ramos J, et al. (2007) Cannabinoid CB2 receptor: a new target for controlling neural cell survival? Trends Pharmacol Sci 28: 39-45.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 39-45
-
-
Fernandez-Ruiz, J.1
Romero, J.2
Velasco, G.3
Tolon, R.4
Ramos, J.5
-
4
-
-
67449119913
-
The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation
-
Di Marzo V, (2009) The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacol Res 60: 77-84.
-
(2009)
Pharmacol Res
, vol.60
, pp. 77-84
-
-
Di Marzo, V.1
-
5
-
-
65449146377
-
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
-
Pertwee RG, (2009) Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol 156: 397-411.
-
(2009)
Br J Pharmacol
, vol.156
, pp. 397-411
-
-
Pertwee, R.G.1
-
6
-
-
84861530762
-
Towards the use of cannabinoids as antitumour agents
-
Velasco G, Sanchez C, Guzman M, (2012) Towards the use of cannabinoids as antitumour agents. Nat Rev Cancer 12: 436-444.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 436-444
-
-
Velasco, G.1
Sanchez, C.2
Guzman, M.3
-
7
-
-
39049104489
-
Cannabinoids for cancer treatment: progress and promise
-
Sarfaraz S, Adhami VM, Syed DN, Afaq F, Mukhtar H, (2008) Cannabinoids for cancer treatment: progress and promise. Cancer research 68: 339-342.
-
(2008)
Cancer Research
, vol.68
, pp. 339-342
-
-
Sarfaraz, S.1
Adhami, V.M.2
Syed, D.N.3
Afaq, F.4
Mukhtar, H.5
-
8
-
-
33645763253
-
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
-
Carracedo A, Lorente M, Egia A, Blazquez C, Garcia S, et al. (2006) The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 9: 301-312.
-
(2006)
Cancer Cell
, vol.9
, pp. 301-312
-
-
Carracedo, A.1
Lorente, M.2
Egia, A.3
Blazquez, C.4
Garcia, S.5
-
9
-
-
17344380844
-
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
-
Galve-Roperh I, Sanchez C, Cortes ML, Gómez del Pulgar T, Izquierdo M, et al. (2000) Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 6: 313-319.
-
(2000)
Nat Med
, vol.6
, pp. 313-319
-
-
Galve-Roperh, I.1
Sanchez, C.2
Cortes, M.L.3
Gómez del Pulgar, T.4
Izquierdo, M.5
-
10
-
-
66449115318
-
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
-
Salazar M, Carracedo A, Salanueva IJ, Hernandez-Tiedra S, Lorente M, et al. (2009) Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. The Journal of clinical investigation 119: 1359-1372.
-
(2009)
The Journal of Clinical Investigation
, vol.119
, pp. 1359-1372
-
-
Salazar, M.1
Carracedo, A.2
Salanueva, I.J.3
Hernandez-Tiedra, S.4
Lorente, M.5
-
11
-
-
84855339807
-
Effects on cell viability
-
Guzmán M (2005) Effects on cell viability. Handb Exp Pharmacol 627-642.
-
(2005)
Handb Exp Pharmacol
, pp. 627-642
-
-
Guzmán, M.1
-
12
-
-
70349189518
-
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
-
Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R, (2009) Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 30: 515-527.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 515-527
-
-
Izzo, A.A.1
Borrelli, F.2
Capasso, R.3
Di Marzo, V.4
Mechoulam, R.5
-
13
-
-
33747624175
-
Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
-
Ligresti A, Moriello AS, Starowicz K, Matias I, Pisanti S, et al. (2006) Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma. J Pharmacol Exp Ther 318: 1375-1387.
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 1375-1387
-
-
Ligresti, A.1
Moriello, A.S.2
Starowicz, K.3
Matias, I.4
Pisanti, S.5
-
14
-
-
33748492117
-
The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
-
Massi P, Vaccani A, Bianchessi S, Costa B, Macchi P, et al. (2006) The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cell Mol Life Sci 63: 2057-2066.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 2057-2066
-
-
Massi, P.1
Vaccani, A.2
Bianchessi, S.3
Costa, B.4
Macchi, P.5
-
15
-
-
38449109178
-
5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid
-
Massi P, Valenti M, Vaccani A, Gasperi V, Perletti G, et al. (2008) 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. Journal of neurochemistry 104: 1091-1100.
-
(2008)
Journal of Neurochemistry
, vol.104
, pp. 1091-1100
-
-
Massi, P.1
Valenti, M.2
Vaccani, A.3
Gasperi, V.4
Perletti, G.5
-
16
-
-
36749015683
-
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
-
McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez PY, (2007) Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Molecular cancer therapeutics 6: 2921-2927.
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, pp. 2921-2927
-
-
McAllister, S.D.1
Christian, R.T.2
Horowitz, M.P.3
Garcia, A.4
Desprez, P.Y.5
-
17
-
-
79960835512
-
Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
-
McAllister SD, Murase R, Christian RT, Lau D, Zielinski AJ, et al. (2011) Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast cancer research and treatment 129: 37-47.
-
(2011)
Breast Cancer Research and Treatment
, vol.129
, pp. 37-47
-
-
McAllister, S.D.1
Murase, R.2
Christian, R.T.3
Lau, D.4
Zielinski, A.J.5
-
18
-
-
78751527443
-
A combined preclinical therapy of cannabinoids and temozolomide against glioma
-
Torres S, Lorente M, Rodriguez-Fornes F, Hernandez-Tiedra S, Salazar M, et al. (2011) A combined preclinical therapy of cannabinoids and temozolomide against glioma. Molecular cancer therapeutics 10: 90-103.
-
(2011)
Molecular Cancer Therapeutics
, vol.10
, pp. 90-103
-
-
Torres, S.1
Lorente, M.2
Rodriguez-Fornes, F.3
Hernandez-Tiedra, S.4
Salazar, M.5
-
19
-
-
73949139182
-
Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
-
Marcu JP, Christian RT, Lau D, Zielinski AJ, Horowitz MP, et al. (2010) Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Molecular cancer therapeutics 9: 180-189.
-
(2010)
Molecular Cancer Therapeutics
, vol.9
, pp. 180-189
-
-
Marcu, J.P.1
Christian, R.T.2
Lau, D.3
Zielinski, A.J.4
Horowitz, M.P.5
-
20
-
-
33748703859
-
The endocannabinoid system as an emerging target of pharmacotherapy
-
Pacher P, Batkai S, Kunos G, (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58: 389-462.
-
(2006)
Pharmacol Rev
, vol.58
, pp. 389-462
-
-
Pacher, P.1
Batkai, S.2
Kunos, G.3
-
21
-
-
0016138682
-
Physicochemical properties, solubility, and protein binding of D9-Tetrahydrocannabinol
-
Garrett ER, Hunt A, (1974) Physicochemical properties, solubility, and protein binding of D9-Tetrahydrocannabinol. J Pharm Sci 63: 1056-1064.
-
(1974)
J Pharm Sci
, vol.63
, pp. 1056-1064
-
-
Garrett, E.R.1
Hunt, A.2
-
22
-
-
4444246813
-
Polymer microspheres for controlled drug release
-
Freiberg S, Zhu XX, (2004) Polymer microspheres for controlled drug release. Int J Pharm 282: 1-18.
-
(2004)
Int J Pharm
, vol.282
, pp. 1-18
-
-
Freiberg, S.1
Zhu, X.X.2
-
23
-
-
0344494508
-
Advancing the field of drug delivery: taking aim at cancer
-
Moses MA, Brem H, Langer R, (2003) Advancing the field of drug delivery: taking aim at cancer. Cancer Cell 4: 337-341.
-
(2003)
Cancer Cell
, vol.4
, pp. 337-341
-
-
Moses, M.A.1
Brem, H.2
Langer, R.3
-
24
-
-
82455181871
-
Targeting for drug delivery and imaging: an overview of the state of the art in cancer
-
Dubernet C, (2011) Targeting for drug delivery and imaging: an overview of the state of the art in cancer. Bull Cancer 98: 1363-1371.
-
(2011)
Bull Cancer
, vol.98
, pp. 1363-1371
-
-
Dubernet, C.1
-
25
-
-
0034632936
-
Investigation of the role of macrophages on the cytotoxicity of doxorubicin and doxorubicin-loaded nanoparticles on M5076 cells in vitro
-
Soma CE, Dubernet C, Barratt G, Benita S, Couvreur P, (2000) Investigation of the role of macrophages on the cytotoxicity of doxorubicin and doxorubicin-loaded nanoparticles on M5076 cells in vitro. J Control Release 68: 283-289.
-
(2000)
J Control Release
, vol.68
, pp. 283-289
-
-
Soma, C.E.1
Dubernet, C.2
Barratt, G.3
Benita, S.4
Couvreur, P.5
-
26
-
-
0344560656
-
Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles
-
Soma CE, Dubernet C, Bentolila D, Benita S, Couvreur P, (2000) Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles. Biomaterials 21: 1-7.
-
(2000)
Biomaterials
, vol.21
, pp. 1-7
-
-
Soma, C.E.1
Dubernet, C.2
Bentolila, D.3
Benita, S.4
Couvreur, P.5
-
27
-
-
13444254143
-
In vitro study of anticancer drug doxorubicin in PLGA-based microparticles
-
Lin R, Shi Ng L, Wang CH, (2005) In vitro study of anticancer drug doxorubicin in PLGA-based microparticles. Biomaterials 26: 4476-4485.
-
(2005)
Biomaterials
, vol.26
, pp. 4476-4485
-
-
Lin, R.1
Shi Ng, L.2
Wang, C.H.3
-
28
-
-
56349107029
-
Three weeks release BCNU loaded hydrophilic-PLGA microspheres for interstitial chemotherapy: Development and activity against human glioblastoma cells
-
Gil-Alegre MEG-ÁI, Gutiérrez-Pauls L, Torres-Suárez AI, (2008) Three weeks release BCNU loaded hydrophilic-PLGA microspheres for interstitial chemotherapy: Development and activity against human glioblastoma cells. J Microencap 25: 561-568.
-
(2008)
J Microencap
, vol.25
, pp. 561-568
-
-
Gil-Alegre, M.E.G.-A.I.1
Gutiérrez-Pauls, L.2
Torres-Suárez, A.I.3
-
29
-
-
13244260729
-
Preparation and Characterization of 5-Fluoruracil-Loaded Poly (ε-caprolactone) Microspheres for Drug Administration
-
Sastre RL BM, Teijón C, Olmo R, Teijón JM, (2004) Preparation and Characterization of 5-Fluoruracil-Loaded Poly (ε-caprolactone) Microspheres for Drug Administration. Drug Dev Res 63: 41-53.
-
(2004)
Drug Dev Res
, vol.63
, pp. 41-53
-
-
Sastre, R.L.B.M.1
Teijón, C.2
Olmo, R.3
Teijón, J.M.4
-
30
-
-
84864575352
-
Poly-epsilon-caprolactone microspheres as a drug delivery system for cannabinoid administration: Development, characterization and in vitro evaluation of their antitumoral efficacy
-
Hernan Perez de la Ossa D, Ligresti A, Gil-Alegre ME, Aberturas MR, Molpeceres J, et al. (2012) Poly-epsilon-caprolactone microspheres as a drug delivery system for cannabinoid administration: Development, characterization and in vitro evaluation of their antitumoral efficacy. J Control Release 161: 927-932.
-
(2012)
J Control Release
, vol.161
, pp. 927-932
-
-
Hernan Perez de la Ossa, D.1
Ligresti, A.2
Gil-Alegre, M.E.3
Aberturas, M.R.4
Molpeceres, J.5
-
31
-
-
33746138649
-
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
-
Carracedo A, Gironella M, Lorente M, Garcia S, Guzman M, et al. (2006) Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer research 66: 6748-6755.
-
(2006)
Cancer Research
, vol.66
, pp. 6748-6755
-
-
Carracedo, A.1
Gironella, M.2
Lorente, M.3
Garcia, S.4
Guzman, M.5
-
32
-
-
79958809001
-
Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
-
Vara D, Salazar M, Olea-Herrero N, Guzman M, Velasco G, et al. (2011) Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell death and differentiation 18: 1099-1111.
-
(2011)
Cell Death and Differentiation
, vol.18
, pp. 1099-1111
-
-
Vara, D.1
Salazar, M.2
Olea-Herrero, N.3
Guzman, M.4
Velasco, G.5
-
33
-
-
63149091690
-
Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth
-
Benny O, Menon LG, Ariel G, Goren E, Kim SK, et al. (2009) Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth. Clin Cancer Res 15: 1222-1231.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1222-1231
-
-
Benny, O.1
Menon, L.G.2
Ariel, G.3
Goren, E.4
Kim, S.K.5
-
34
-
-
0033997784
-
Development of microspheres for neurological disorders: from basics to clinical applications
-
Benoit JP, Faisant N, Venier-Julienne MC, Menei P, (2000) Development of microspheres for neurological disorders: from basics to clinical applications. J Control Release 65: 285-296.
-
(2000)
J Control Release
, vol.65
, pp. 285-296
-
-
Benoit, J.P.1
Faisant, N.2
Venier-Julienne, M.C.3
Menei, P.4
-
35
-
-
23644435297
-
Drug delivery into the brain using poly(lactide-co-glycolide) microspheres
-
Menei P, Montero-Menei C, Venier MC, Benoit JP, (2005) Drug delivery into the brain using poly(lactide-co-glycolide) microspheres. Expert opinion on drug delivery 2: 363-376.
-
(2005)
Expert Opinion on Drug Delivery
, vol.2
, pp. 363-376
-
-
Menei, P.1
Montero-Menei, C.2
Venier, M.C.3
Benoit, J.P.4
-
36
-
-
34547697294
-
Core-shell microspheres with surface grafted poly(vinyl alcohol) as drug carriers for the treatment of hepatocellular carcinoma
-
Nguyen TLU, Farrugia B, Davis TP, Barner-Kowollik C, Stenzel MH, (2007) Core-shell microspheres with surface grafted poly(vinyl alcohol) as drug carriers for the treatment of hepatocellular carcinoma. J Polym Sci 45: 3256-3272.
-
(2007)
J Polym Sci
, vol.45
, pp. 3256-3272
-
-
Nguyen, T.L.U.1
Farrugia, B.2
Davis, T.P.3
Barner-Kowollik, C.4
Stenzel, M.H.5
-
37
-
-
80052970987
-
The intracellular uptake of CD95 modified paclitaxel-loaded poly(lactic-co-glycolic acid) microparticles
-
Ateh DD, Leinster VH, Lambert SR, Shah A, Khan A, et al. (2011) The intracellular uptake of CD95 modified paclitaxel-loaded poly(lactic-co-glycolic acid) microparticles. Biomaterials 32: 8538-8547.
-
(2011)
Biomaterials
, vol.32
, pp. 8538-8547
-
-
Ateh, D.D.1
Leinster, V.H.2
Lambert, S.R.3
Shah, A.4
Khan, A.5
-
38
-
-
79955032379
-
Enhanced cellular association of paclitaxel delivered in chitosan-PLGA particles
-
Chakravarthi SS, Robinson DH, (2011) Enhanced cellular association of paclitaxel delivered in chitosan-PLGA particles. Int J Pharm 409: 111-120.
-
(2011)
Int J Pharm
, vol.409
, pp. 111-120
-
-
Chakravarthi, S.S.1
Robinson, D.H.2
-
39
-
-
78649978573
-
Increased efficacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy
-
Hillegass JM, Blumen SR, Cheng K, MacPherson MB, Alexeeva V, et al. (2011) Increased efficacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy. International journal of cancer 129: 233-244.
-
(2011)
International Journal of Cancer
, vol.129
, pp. 233-244
-
-
Hillegass, J.M.1
Blumen, S.R.2
Cheng, K.3
MacPherson, M.B.4
Alexeeva, V.5
-
40
-
-
84861225755
-
Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer
-
Kim I, Byeon HJ, Kim TH, Lee ES, Oh KT, et al. (2012) Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer. Biomaterials 33: 5574-5583.
-
(2012)
Biomaterials
, vol.33
, pp. 5574-5583
-
-
Kim, I.1
Byeon, H.J.2
Kim, T.H.3
Lee, E.S.4
Oh, K.T.5
-
41
-
-
84864287155
-
Sustained release of an antitumoral drug from alginate-chitosan hydrogel beads and its potential use as colonic drug delivery
-
Torelli-Souza RR, Cavalcante Bastos LA, Nunes HGL, Camara CA, Amorim RVS, (2012) Sustained release of an antitumoral drug from alginate-chitosan hydrogel beads and its potential use as colonic drug delivery Journal of Applied Polymer Science. 126: E409-E418.
-
(2012)
Journal of Applied Polymer Science
, vol.126
-
-
Torelli-Souza, R.R.1
Cavalcante Bastos, L.A.2
Nunes, H.G.L.3
Camara, C.A.4
Amorim, R.V.S.5
|