-
1
-
-
0037433652
-
Down's syndrome
-
Roizen NJ, Patterson D (2003) Down's syndrome. Lancet 361: 1281-1288.
-
(2003)
Lancet
, vol.361
, pp. 1281-1288
-
-
Roizen, N.J.1
Patterson, D.2
-
2
-
-
0028856422
-
A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart
-
Fuentes JJ, Pritchard MA, Planas AM, Bosch A, Ferrer I, et al. (1995) A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum Mol Genet 4: 1935-1944.
-
(1995)
Hum Mol Genet
, vol.4
, pp. 1935-1944
-
-
Fuentes, J.J.1
Pritchard, M.A.2
Planas, A.M.3
Bosch, A.4
Ferrer, I.5
-
3
-
-
0029436021
-
Epilogue: Toward the twenty-first century with Down syndrome - A personal view of how far we have come and of how far we can reasonably expect to go
-
Epstein CJ (1995) Epilogue: toward the twenty-first century with Down syndrome - a personal view of how far we have come and of how far we can reasonably expect to go. Prog Clin Biol Res 393: 241-246.
-
(1995)
Prog Clin Biol Res
, vol.393
, pp. 241-246
-
-
Epstein, C.J.1
-
4
-
-
0031572313
-
Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down Syndrome Candidate Region 1) gene
-
DOI 10.1006/geno.1997.4866
-
Fuentes JJ, Pritchard MA, Estivill X (1997) Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Genomics 44: 358-361. (Pubitemid 27419014)
-
(1997)
Genomics
, vol.44
, Issue.3
, pp. 358-361
-
-
Fuentes, J.J.1
Pritchard, M.A.2
Estivill, X.3
-
5
-
-
0034234543
-
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways
-
Fuentes JJ, Genesca L, Kingsbury TJ, Cunningham KW, Perez-Riba M, et al. (2000) DSCR1, over-expressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet 9: 1681-1690. (Pubitemid 30427005)
-
(2000)
Human Molecular Genetics
, vol.9
, Issue.11
, pp. 1681-1690
-
-
Fuentes, J.J.1
Genesca, L.2
Kingsbury, T.J.3
Cunningham, K.W.4
Perez-Riba, M.5
Estivill, X.6
De La, L.S.7
-
6
-
-
0034708825
-
A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling
-
DOI 10.1074/jbc.275.12.8719
-
Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, et al. (2000) A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem 275: 8719-8725. (Pubitemid 30180224)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.12
, pp. 8719-8725
-
-
Rothermel, B.1
Vega, R.B.2
Yang, J.3
Wu, H.4
Bassel-Duby, R.5
Williams, R.S.6
-
7
-
-
0033779701
-
Calcineurin: Form and function
-
Rusnak F, Mertz P (2000) Calcineurin: form and function. Physiol Rev 80: 1483-1521.
-
(2000)
Physiol Rev
, vol.80
, pp. 1483-1521
-
-
Rusnak, F.1
Mertz, P.2
-
8
-
-
0041761256
-
Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life
-
DOI 10.1042/BJ20030267
-
Genescà L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, et al. (2003) Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. Biochem J 374: 567-575. (Pubitemid 37094118)
-
(2003)
Biochemical Journal
, vol.374
, Issue.2
, pp. 567-575
-
-
Genesca, L.1
Aubareda, A.2
Fuentes, J.J.3
Estivill, X.4
De La, L.S.5
Perez-Riba, M.6
-
9
-
-
0030834976
-
Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family
-
DOI 10.1074/jbc.272.44.28001
-
Yang WM, Yao YL, Sun JM, Davie JR, Seto E (1997) Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem 272: 28001-28007. (Pubitemid 27473607)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.44
, pp. 28001-28007
-
-
Yang, W.-M.1
Yao, Y.-L.2
Sun, J.-M.3
Davie, J.R.4
Seto, E.5
-
11
-
-
2942724589
-
Histone deacetylase inhibitors: Development as cancer therapy
-
Marks PA, Richon VM, Kelly WK, Chiao JH, Miller T (2004) Histone deacetylase inhibitors: Development as cancer therapy. Novartis Found Symp 259: 269-281.
-
(2004)
Novartis Found Symp
, vol.259
, pp. 269-281
-
-
Marks, P.A.1
Richon, V.M.2
Kelly, W.K.3
Chiao, J.H.4
Miller, T.5
-
12
-
-
0034717022
-
N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase-3 are essential for the viability of the DT40 chicken B cell line
-
DOI 10.1074/jbc.M908066199
-
Takami Y, Nakayama T (2000) N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase-3 are essential for the viability of the DT40 chicken B cell line. J Biol Chem 275: 16191-16201. (Pubitemid 30366931)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.21
, pp. 16191-16201
-
-
Takami, Y.1
Nakayama, T.2
-
13
-
-
33746578975
-
Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src
-
DOI 10.1038/sj.onc.1209473, PII 1209473
-
Longworth MS, Laimins LA (2006) Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src. Oncogene 25: 4495-4500. (Pubitemid 44141638)
-
(2006)
Oncogene
, vol.25
, Issue.32
, pp. 4495-4500
-
-
Longworth, M.S.1
Laimins, L.A.2
-
14
-
-
33846940901
-
Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2
-
DOI 10.1128/MCB.00882-06
-
Grégoire S, Xiao L, Nie J, Zhang X, Xu M, et al. (2007) Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol 27: 1280-1295. (Pubitemid 46239812)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.4
, pp. 1280-1295
-
-
Gregoire, S.1
Xiao, L.2
Nie, J.3
Zhang, X.4
Xu, M.5
Li, J.6
Wong, J.7
Seto, E.8
Yang, X.-J.9
-
15
-
-
0035979737
-
Duration of nuclear NF-kappaB action regulated by reversible acetylation
-
DOI 10.1126/science.1062374
-
Chen LF, Fischle W, Verdin E, Greene WC (2001) Duration of nuclear NF-kappa B action regulated by reversible acetylation. Science 293: 1653-1657. (Pubitemid 32807844)
-
(2001)
Science
, vol.293
, Issue.5535
, pp. 1653-1657
-
-
Chen, L.-F.1
Fischle, W.2
Verdin, E.3
Greene, W.C.4
-
16
-
-
0035420715
-
The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein
-
Nicolas E, AitSiAli S, Trouche D (2001) The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein. Nucleic Acids Res 29: 3131- 3136.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 3131-3136
-
-
Nicolas, E.1
AitSiAli, S.2
Trouche, D.3
-
17
-
-
17044370869
-
Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4
-
Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, et al. (2005) Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev 19: 827-839.
-
(2005)
Genes Dev
, vol.19
, pp. 827-839
-
-
Zhang, X.1
Ozawa, Y.2
Lee, H.3
Wen, Y.D.4
Tan, T.H.5
-
18
-
-
34248179064
-
Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity
-
DOI 10.1074/jbc.M609009200
-
Jeyakumar M, Liu XF, ErdjumentBromage H, Tempst P, Bagchi MK (2007) Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity. J Biol Chem 282: 9312-9322. (Pubitemid 47104611)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.13
, pp. 9312-9322
-
-
Jeyakumar, M.1
Liu, X.-F.2
Erdjument-Bromage, H.3
Tempst, P.4
Bagchi, M.K.5
-
19
-
-
30744458869
-
IkB kinase α-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300
-
DOI 10.1128/MCB.26.2.457-471.2006
-
Hoberg JE, Popko AE, Ramsey CS, Mayo MW (2006) IkB kinase α-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol 26: 457-471. (Pubitemid 43090920)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.2
, pp. 457-471
-
-
Hoberg, J.E.1
Popko, A.E.2
Ramsey, C.S.3
Mayo, M.W.4
-
20
-
-
84862823681
-
The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7
-
Lee JW, Kang HS, Lee JY, Lee EJ, Rhim H, et al. (2012) The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7. Biochem Biophy Res Commun 420: 404-410.
-
(2012)
Biochem Biophy Res Commun
, vol.420
, pp. 404-410
-
-
Lee, J.W.1
Kang, H.S.2
Lee, J.Y.3
Lee, E.J.4
Rhim, H.5
-
21
-
-
41249098372
-
NF-κB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1
-
Lee EJ, Seo SR, Um JW, Park J, Oh Y, et al. (2008) NF-κB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1. J Biol Chem 283: 3392-3400.
-
(2008)
J Biol Chem
, vol.283
, pp. 3392-3400
-
-
Lee, E.J.1
Seo, S.R.2
Um, J.W.3
Park, J.4
Oh, Y.5
-
22
-
-
71549158526
-
Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling
-
Lee JY, Lee HJ, Lee EJ, Jang SH, Kim H, et al. (2009) Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling. Biochim Biophys Acta 1790: 1673- 1680.
-
(2009)
Biochim Biophys Acta
, vol.1790
, pp. 1673-1680
-
-
Lee, J.Y.1
Lee, H.J.2
Lee, E.J.3
Jang, S.H.4
Kim, H.5
-
23
-
-
0347758480
-
GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs
-
DOI 10.1101/gad.1159204
-
Hilioti Z, Gallagher DA, LowNam ST, Ramaswamy P, Gajer P, et al. (2004) GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes Dev 18: 35-47. (Pubitemid 38090686)
-
(2004)
Genes and Development
, vol.18
, Issue.1
, pp. 35-47
-
-
Hilioti, Z.1
Gallagher, D.A.2
Low-Nam, S.T.3
Ramaswamy, P.4
Gajer, P.5
Kingsbury, T.J.6
Birchwood, C.J.7
Levchenko, A.8
Cunningham, K.W.9
-
24
-
-
84897561558
-
Transcription and beyond: The role of mammalian class I lysine deacetylases
-
Moser MA, Hagelkruys A, Seiser C (2014) Transcription and beyond: the role of mammalian class I lysine deacetylases. Chromosoma 123: 67-78.
-
(2014)
Chromosoma
, vol.123
, pp. 67-78
-
-
Moser, M.A.1
Hagelkruys, A.2
Seiser, C.3
-
25
-
-
84862820897
-
Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1)
-
Kim SS, Oh Y, Chung KC, Seo SR (2012) Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1). Biochem Biophys Res Commun 418: 657-661.
-
(2012)
Biochem Biophys Res Commun
, vol.418
, pp. 657-661
-
-
Kim, S.S.1
Oh, Y.2
Chung, K.C.3
Seo, S.R.4
-
26
-
-
81155126062
-
Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation
-
Jung MS, Park JH, Ryu YS, Choi SH, Yoon SH, et al. (2011) Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation. J Biol Chem 286: 40401-40412.
-
(2011)
J Biol Chem
, vol.286
, pp. 40401-40412
-
-
Jung, M.S.1
Park, J.H.2
Ryu, Y.S.3
Choi, S.H.4
Yoon, S.H.5
-
27
-
-
27744595555
-
The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation
-
DOI 10.1074/jbc.M506493200
-
Abbasi S, Su B, Kellems RE, Yang J, Xia Y (2005) The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated Tcells activation. J Biol Chem 280: 36737-36746. (Pubitemid 41587753)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.44
, pp. 36737-36746
-
-
Abbasi, S.1
Su, B.2
Kellems, R.E.3
Yang, J.4
Xia, Y.5
-
28
-
-
33646357770
-
Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1
-
DOI 10.1074/jbc.M510775200
-
Abbasi S, Lee JD, Su B, Chen X, Alcon JL, et al. (2006) Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin- interacting protein 1. J Biol Chem 281: 7717-7726. (Pubitemid 43847385)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.12
, pp. 7717-7726
-
-
Abbasi, S.1
Lee, J.-D.2
Su, B.3
Chen, X.4
Alcon, J.L.5
Yang, J.6
Kellems, R.E.7
Xia, Y.8
-
29
-
-
59649116320
-
Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signaling nodal control point
-
Liu Q, Busby JC, Molkentin JD (2009) Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signaling nodal control point. Nat Cell Biol 11: 154-161.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 154-161
-
-
Liu, Q.1
Busby, J.C.2
Molkentin, J.D.3
-
30
-
-
84868267663
-
Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin
-
Noh EH, Hwang HS, Hwang HS, Min B, Im E, et al. (2012) Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin. PLoS One 7: e48315.
-
(2012)
PLoS One
, vol.7
-
-
Noh, E.H.1
Hwang, H.S.2
Hwang, H.S.3
Min, B.4
Im, E.5
-
31
-
-
52049085775
-
Oxidative stress-induced ubiquitination of RCAN1 mediated by SCF b-TrCP ubiquitin ligase
-
Asada S, Ikeda A, Nagao R, Hama H, Sudo T, et al. (2008) Oxidative stress-induced ubiquitination of RCAN1 mediated by SCF b-TrCP ubiquitin ligase. Int J Mol Med 22: 95-104.
-
(2008)
Int J Mol Med
, vol.22
, pp. 95-104
-
-
Asada, S.1
Ikeda, A.2
Nagao, R.3
Hama, H.4
Sudo, T.5
-
32
-
-
44449127083
-
CREB activates proteasomal degradation of DSCR1/RCAN1
-
Seo SR, Chung KC (2008) CREB activates proteasomal degradation of DSCR1/RCAN1. FEBS Lett 582: 1889-1893.
-
(2008)
FEBS Lett
, vol.582
, pp. 1889-1893
-
-
Seo, S.R.1
Chung, K.C.2
-
33
-
-
84880546234
-
Histone deacetylase 3 regulates cyclin A stability
-
Vidal-Laliena M, Gallastegui E, Mateo F, Martínez-Balbás M, Pujol MJ, et al. (2013) Histone deacetylase 3 regulates cyclin A stability. J Biol Chem 288: 21096-21104.
-
(2013)
J Biol Chem
, vol.288
, pp. 21096-21104
-
-
Vidal-Laliena, M.1
Gallastegui, E.2
Mateo, F.3
Martínez-Balbás, M.4
Pujol, M.J.5
-
34
-
-
84867424393
-
HIF1 α protein stability is increased by acetylation at lysine 709
-
Geng H, Liu Q, Xue C, David LL, Beer TM, et al. (2012) HIF1 α protein stability is increased by acetylation at lysine 709. J Biol Chem 287: 35496- 35505.
-
(2012)
J Biol Chem
, vol.287
, pp. 35496-35505
-
-
Geng, H.1
Liu, Q.2
Xue, C.3
David, L.L.4
Beer, T.M.5
-
35
-
-
62449135654
-
Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1
-
Park J, Oh Y, Chung KC (2009) Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. BMB Rep 42: 6-15.
-
(2009)
BMB Rep
, vol.42
, pp. 6-15
-
-
Park, J.1
Oh, Y.2
Chung, K.C.3
-
36
-
-
70349666552
-
Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways
-
Liu H, Wang P, Song W, Sun X (2009) Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways. FASEB J 23: 3383-3392
-
(2009)
FASEB J
, vol.23
, pp. 3383-3392
-
-
Liu, H.1
Wang, P.2
Song, W.3
Sun, X.4
-
37
-
-
36849020875
-
The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin
-
Kishi T, Ikeda A, Nagao R, Koyama N (2007) The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin. Proc Natl Acad Sci U S A 104: 17418-17423.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 17418-17423
-
-
Kishi, T.1
Ikeda, A.2
Nagao, R.3
Koyama, N.4
-
38
-
-
84862785207
-
Nedd4-2 ubiquitin ligase interacts with RCAN1 (DSCR1) for the proteasomal degradation
-
Kim SS, Seo SR (2010) Nedd4-2 ubiquitin ligase interacts with RCAN1 (DSCR1) for the proteasomal degradation. Genes & Genomics 32: 578-582.
-
(2010)
Genes & Genomics
, vol.32
, pp. 578-582
-
-
Kim, S.S.1
Seo, S.R.2
-
40
-
-
2942752412
-
Regulation of NF-κB action by reversible acetylation
-
Greene WC, Chen LF (2004) Regulation of NF-κB action by reversible acetylation. Novartis Found Symp 259: 208-217.
-
(2004)
Novartis Found Symp
, vol.259
, pp. 208-217
-
-
Greene, W.C.1
Chen, L.F.2
-
41
-
-
84866620575
-
Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A)
-
Ishfaq M, Maeta K, Maeda S, Natsume T, Ito A, et al. (2012) Acetylation regulates subcellular localization of eukaryotic translation initiation factor 5A (eIF5A). FEBS Lett 586: 3236-3241.
-
(2012)
FEBS Lett
, vol.586
, pp. 3236-3241
-
-
Ishfaq, M.1
Maeta, K.2
Maeda, S.3
Natsume, T.4
Ito, A.5
-
42
-
-
0037444225
-
Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
-
DOI 10.1101/gad.1042403
-
Gay F, Calvo D, Lo MC, Ceron J, Maduro M, et al. (2003) Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1. Genes Dev 17: 717-722. (Pubitemid 36359189)
-
(2003)
Genes and Development
, vol.17
, Issue.6
, pp. 717-722
-
-
Gay, F.1
Calvo, D.2
Lo, M.-C.3
Ceron, J.4
Maduro, M.5
Lin, R.6
Shi, Y.7
-
43
-
-
78149304022
-
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation
-
Pickard A, Wong PP, McCance DJ (2010) Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. J Cell Sci 123: 3718-3726.
-
(2010)
J Cell Sci
, vol.123
, pp. 3718-3726
-
-
Pickard, A.1
Wong, P.P.2
McCance, D.J.3
-
44
-
-
84887206685
-
Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization
-
Lv L, Xu YP, Zhao D, Li FL, Wang W, et al. (2013) Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell 52: 340-352. MSIP^NRF^National Research Foundation of Korea
-
(2013)
Mol Cell
, vol.52
, pp. 340-352
-
-
Lv, L.1
Xu, Y.P.2
Zhao, D.3
Li, F.L.4
Wang, W.5
|