Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Li, Aimei ^a,b   Shuai, Xuanyu ^a   Jia, Zhijun ^b   Li, Hangyu ^c   Liang, Xiubin ^a   Su, Dongming ^a,d   Guo, Wanhua ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^c CHINA MEDICAL UNIVERSITY   (China)

^d THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Effector T cell; Ganoderma lucidum polysaccharides; Hepatocellular carcinoma; miR 125b; Regulatory T cell

Indexed keywords

GANODERMA LUCIDUM EXTRACT; MICRORNA 125B; NOTCH1 RECEPTOR; POLYSACCHARIDE; TRANSCRIPTION FACTOR FOXP3; MICRORNA; MIRN125 MICRORNA, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ISOLATION; CELL VIABILITY; CENTRIFUGATION; CONTROLLED STUDY; EFFECTOR CELL; GENE EXPRESSION REGULATION; LIVER CELL CARCINOMA; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; JURKAT CELL LINE; LIVER TUMOR; METABOLISM; PATHOLOGY;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; HUMANS; JURKAT CELLS; LIVER NEOPLASMS; MALE; MICE, INBRED BALB C; MICRORNAS; POLYSACCHARIDES; T-LYMPHOCYTES, REGULATORY;

EID: 84928104316     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0465-5     Document Type: Article

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