Chabamide induces cell cycle arrest and apoptosis by the Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells

Anti-Cancer Drugs

Volumn 26, Issue 5, 2014, Pages 498-507

  Ren, Jie ^a   Xu, Yuanyuan ^a   Huang, Qianhui ^a   Yang, Jie ^a   Yang, Meng ^a   Hu, Kun ^a   Wei, Kun ^b  

^a CHANGZHOU UNIVERSITY   (China)

^b YUNNAN UNIVERSITY   (China)

Author keywords

apoptosis; chabamide; mitogen activated protein kinases; P glycoprotein; reactive oxygen species

Indexed keywords

ALKALOID DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CHABAMIDE; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYTOCHROME C; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P21; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; PIPERIDINE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; K562 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL CYCLE CHECKPOINT; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; MULTIDRUG RESISTANCE; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE CHECKPOINTS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; G0 PHASE; G1 PHASE; HUMANS; K562 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOGEN-ACTIVATED PROTEIN KINASES; P-GLYCOPROTEIN; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84928104273     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0000000000000209     Document Type: Article

References (28)

1. Su X, Li Y, Wang P, Wang X, Liu Q. Protoporphyrin IX-mediated sonodynamic action induces apoptosis of K562 cells. Ultrasonics 2014; 54:275-284.
2. Rivera E. Management of metastatic breast cancer: Monotherapy options for patients resistant to anthracyclines and taxanes. Am J Clin Oncol 2010; 33:176-185.
3. Teodori E, Dei S, Martelli C, Scapecchi S, Gualtieri F. The functions and structure of ABC transporters: Implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR). Curr Drug Targets 2006; 7:893-909.
4. Xie Q, Zhou Y, Lan G, Yang L, Zheng W, Liang Y, Chen T. Sensitization of cancer cells to radiation by selenadiazole derivatives by regulation of ROSmediated DNA damage and ERK and AKT pathways. Biochem Biophys Res Commun 2014; 449:88-93.
5. Felix RA, Barrand MA. P-glycoprotein expression in rat brain endothelial cells: Evidence for regulation by transient oxidative stress. J Neurochem 2002; 80:64-72.
6. Joshi G, Hardas S, Sultana R, St Clair DK, Vore M, Butterfield DA. Lutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain. J Neurosci Res 2007; 85:497-503.
7. Hsu PC, Hung HC, Liao YF, Liu CC, Tsay GJ, Liu GY. Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells. Leuk Res 2008; 32:1530-1540.
8. Azijli K, Weyhenmeyer B, Peters GJ, De Jong S, Kruyt FA. Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: Discord in the death receptor family. Cell Death Differ 2013; 20:858-868.
9. Al-Azayzih A, Gao F, Goc A, Somanath PR. TGF-?1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspases. Biochem Biophys Res Commun 2012; 427:165-170.
10. Martin-Cordero C, Leon-Gonzalez AJ, Calderon-Montano JM, Burgos-Moron E, Lopez-Lazaro M. Pro-oxidant natural products as anticancer agents. Curr Drug Targets 2012; 13:1006-1028.
11. Petit K, Biard JF. Marine natural products and related compounds as anticancer agents: An overview of their clinical status. Anticancer Agents Med Chem 2013; 13:603-631.
12. Kaur K, Kumar V, Sharma AK, Gupta GK. Isoxazoline containing natural products as anticancer agents: A review. Eur J Med Chem 2014; 77:121-133.
13. Rama SRV, Suresh G, Suresh BK, Satyanarayana RS, Vishnu vardhan MVPS, Sistla R. Novel dimeric amide alkaloids from Piper chaba Hunter: Isolation, cytotoxic activity, and their biomimetic synthesis. Tetrahedron 2011; 67:1885-1892.
14. Wang SF, Chou YC, Mazumder N, Kao FJ, Nagy LD, Guengerich FP, et al. 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Biochem Pharmacol 2013; 86:548-560.
15. Hokita S, Aikou T, Shigami S, Miyazono F, Nakajo A, Uenosono Y, et al. Combination chemotherapy study of biweekly paclitaxel and S-1 administration in patients with advanced gastric cancer. Gan To Kagaku Ryoho 2006; 33:95-98.
16. Lu YJ, Yang SH, Chien CM, Lin YH, Hu XW, Wu ZZ, et al. Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. Toxicol In Vitro 2007; 21:90-98.
17. Vermeulen K, Van Bockstaele DR, Berneman ZN. The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif 2003; 36:131-149.
18. Jung YS, Qian Y, Chen X. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 2010; 22:1003-1012.
19. Gartel AL, Serfas MS, Tyner AL. p21-negative regulator of the cell cycle. Proc Soc Exp Biol Med 1996; 213:138-149.
20. Xu S, Guo P, Gao Y, Shi Q, He D, Gao Y, Zhang H. Acyldepsipeptides inhibit the growth of renal cancer cells through G1 phase cell cycle arrest. Biochem Biophys Res Commun 2013; 438:468-472.
21. Kong X, Ge H, Hou L, Shi L, Liu Z. Induction of apoptosis in K562/ADM cells by gamma-linolenic acid involves lipid peroxidation and activation of caspase-3. Chem Biol Interact 2006; 162:140-148.
22. Douglas RG, Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004; 305:626-629.
23. Zhang Y, Zhang X, Park TS, Gidday JM. Cerebral endothelial cell apoptosis after ischemia-reperfusion: Role of PARP activation and AIF translocation. J Cereb Blood Flow Metab 2005; 25:868-877.
24. Sawyers CL, Callahan W, Witte ON. Dominant negative MYC blocks transformation by ABL oncogenes. Cell 1992; 70:901-910.
25. Samanta AK, Lin H, Sun T, Kantarjian H, Arlinghaus RB. Janus kinase 2: A critical target in chronic myelogenous leukemia. Cancer Res 2006; 66:6468-6472.
26. Samanta AK, Chakraborty SN, Wang Y, Kantarjian H, Sun X, Hood J, et al. Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients. Oncogene 2009; 28:1669-1681.
27. Faust D, Schmitt C, Oesch F, Oesch-Bartlomowicz B, Schreck I, Weiss C, Dietrich C. Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts. Cell Commun Signal 2012; 10:6.
28. Shi L, Yu X, Yang H, Wu X. Advanced glycation end products induce human corneal epithelial cells apoptosis through generation of reactive oxygen species and activation of JNK and p38 MAPK pathways. PLoS One 2013; 8:e66781.