Acyldepsipeptides inhibit the growth of renal cancer cells through G1 phase cell cycle arrest

Biochemical and Biophysical Research Communications

Volumn 438, Issue 3, 2013, Pages 468-472

  Xu, Shan ^a,b   Guo, Peng ^a,b   Gao, Yang ^a,b,c   Shi, Qi ^a,b   He, Dalin ^a,b   Zhang, Hailong ^c  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Acyldepsipeptide; Antitumor; Cell cycle; Cyclin D1; Renal cell carcinoma

Indexed keywords

ACYLDEPSIPEPTIDE 1; ACYLDEPSIPEPTIDE 2; ACYLDEPSIPEPTIDE DERIVATIVE; ANTINEOPLASTIC AGENT; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN C FOS; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GROWTH INHIBITION; HUMAN; HUMAN CELL; KIDNEY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; STREPTOMYCES; STREPTOMYCES HAWAIIENSIS; WESTERN BLOTTING;

ACYLDEPSIPEPTIDE; ANTITUMOR; CELL CYCLE; CYCLIN D1; RENAL CELL CARCINOMA;

ANTIBIOTICS, ANTINEOPLASTIC; CARCINOMA, RENAL CELL; CYCLIN D1; DEPSIPEPTIDES; G1 PHASE; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; KIDNEY NEOPLASMS; MAP KINASE SIGNALING SYSTEM; PEPTIDES, CYCLIC;

STREPTOMYCES; STREPTOMYCES HAWAIIENSIS;

EID: 84882846356     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.07.119     Document Type: Article

References (19)

1. Li L., Gao Y., Zhang L., Zeng J., He D., Sun Y. Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma. Cancer Lett. 2008, 272:61-69.
2. Liang L., Li L., Zeng J., Gao Y., Chen Y.L., Wang Z.Q., Wang X.Y., Chang L.S., He D. Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR/MMP-9 signaling pathway. Oncol. Rep. 2012, 28:999-1005.
3. Boysen G., Bausch-Fluck D., Thoma C.R., Nowicka A.M., Stiehl D.P., Cima I., Luu V.D., von Teichman A., Hermanns T., Sulser T., Ingold-Heppner B., Fankhauser N., Wenger R.H., Krek W., Schraml P., Wollscheid B., Moch H. Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Neoplasia 2012, 14:535-546.
4. Waldert M., Haitel A., Marberger M., Katzenbeisser D., Ozsoy M., Stadler E., Remzi M. Comparison of type I and II papillary renal cell carcinoma (RCC) and clear cell RCC. BJU Int. 2008, 102:1381-1384.
5. Kaelin W.G. The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin. Cancer Res. 2007, 13:680s-684s.
6. Demain A.L., Vaishnav P. Natural products for cancer chemotherapy. Microb. Biotechnol. 2011, 4:687-699.
7. K.H.K. Machel, R.E., A54556 antibiotics and process for production thereof, US patent 4492650 (1985).
8. Brotz-Oesterhelt H., Beyer D., Kroll H.P., Endermann R., Ladel C., Schroeder W., Hinzen B., Raddatz S., Paulsen H., Henninger K., Bandow J.E., Sahl H.G., Labischinski H. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat. Med. 2005, 11:1082-1087.
9. Kirstein J., Hoffmann A., Lilie H., Schmidt R., Rubsamen-Waigmann H., Brotz-Oesterhelt H., Mogk A., Turgay K. The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease. EMBO Mol. Med. 2009, 1:37-49.
10. Shukla S., Gupta S. Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells. Cell cycle 2007, 6:1102-1114.
11. Modi P.K., Komaravelli N., Singh N., Sharma P. Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons. Mol. Biol. Cell 2012, 23:3722-3730.
12. Sass P., Josten M., Famulla K., Schiffer G., Sahl H.G., Hamoen L., Brotz-Oesterhelt H. Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:17474-17479.
13. Lee B.G., Park E.Y., Lee K.E., Jeon H., Sung K.H., Paulsen H., Rubsamen-Schaeff H., Brotz-Oesterhelt H., Song H.K. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nat. Struct. Mol. Biol. 2010, 17:471-478.
14. Ho A., Dowdy S.F. Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. Curr. Opin. Genet. Dev. 2002, 12:47-52.
15. Coqueret O. Linking cyclins to transcriptional control. Gene 2002, 299:35-55.
16. Gumz M.L., Zou H., Kreinest P.A., Childs A.C., Belmonte L.S., LeGrand S.N., Wu K.J., Luxon B.A., Sinha M., Parker A.S., Sun L.Z., Ahlquist D.A., Wood C.G., Copland J.A. Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin. Cancer Res. 2007, 13:4740-4749.
17. Kaelin W.G. Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein. Cancer 2009, 115:2262-2272.
18. Musgrove E.A., Caldon C.E., Barraclough J., Stone A., Sutherland R.L. Cyclin D as a therapeutic target in cancer. Nat. Rev. Cancer 2011, 11:558-572.
19. Schodel J., Bardella C., Sciesielski L.K., Brown J.M., Pugh C.W., Buckle V., Tomlinson I.P., Ratcliffe P.J., Mole D.R. Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nat. Genet. 2012, 44:420-425. S421-422.