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Volumn 17, Issue 1, 2015, Pages 6-9

N-Heterocyclic Carbene Catalyzed Highly Chemoselective Intermolecular Crossed Acyloin Condensation of Aromatic Aldehydes with Trifluoroacetaldehyde Ethyl Hemiacetal

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Indexed keywords


EID: 84928034963     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol502581b     Document Type: Article
Times cited : (33)

References (87)
  • 13
    • 84903500392 scopus 로고    scopus 로고
    • Acyloin Coupling Reactions
    • Knochel, P., Molander, G. S., Eds.; Elsevier: Amsterdam, The Netherlands
    • O'Bryan, E. A.; Scheidt, K. A. Acyloin Coupling Reactions. In Comprehensive Organic Synthesis II; Knochel, P.; Molander, G. S., Eds.; Elsevier: Amsterdam, The Netherlands, 2014; Vol. 3, p 621.
    • (2014) Comprehensive Organic Synthesis II , vol.3 , pp. 621
    • O'Bryan, E.A.1    Scheidt, K.A.2
  • 41
    • 84903491366 scopus 로고    scopus 로고
    • The Stetter Reaction
    • Molander, G. A., Knochel, P., Eds.; Elsevier
    • Holmes, J. M.; Gravel, M. The Stetter Reaction. In Comprehensive Organic Synthesis II; Molander, G. A.; Knochel, P., Eds.; Elsevier: 2014; Vol. 4, p 1384.
    • (2014) Comprehensive Organic Synthesis II , vol.4 , pp. 1384
    • Holmes, J.M.1    Gravel, M.2
  • 83
    • 84937624696 scopus 로고    scopus 로고
    • note
    • Another conceivable explanation for the outcome of the reaction is that even if trifluoroacetaldehyde is present in the solution, the Breslow intermediate derived from it is expected to have a poor nucleophilicity; therefore, it may not react with another molecule of trifluoroacetaldehyde to give 5.
  • 84
    • 84937624697 scopus 로고    scopus 로고
    • note
    • The cross acyloin reaction of p-chlorobenzaldehyde (1) with the following hemiacetals/acetals (A?C) was tried under standard conditions.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.