-
1
-
-
84923536376
-
Clearing the way for tau immunotherapy in Alzheimer's disease
-
Herrmann, A. & Spires-Jones, T. Clearing the way for tau immunotherapy in Alzheimer's disease. J. Neurochem. 132, 1-4 (2015).
-
(2015)
J. Neurochem.
, vol.132
, pp. 1-4
-
-
Herrmann, A.1
Spires-Jones, T.2
-
2
-
-
84896691913
-
Pathways to Alzheimer's disease
-
Hardy, J. et al. Pathways to Alzheimer's disease. J. Intern. Med. 275, 296-303 (2014).
-
(2014)
J. Intern. Med.
, vol.275
, pp. 296-303
-
-
Hardy, J.1
-
3
-
-
84863693043
-
An effector-reduced anti-b-amyloid (Ab) antibody with unique Ab binding properties promotes neuroprotection and glial engulfment of Ab
-
Adolfsson, O. et al. An effector-reduced anti-b-amyloid (Ab) antibody with unique Ab binding properties promotes neuroprotection and glial engulfment of Ab. J. Neurosci. 32, 9677-9689 (2012).
-
(2012)
J. Neurosci.
, vol.32
, pp. 9677-9689
-
-
Adolfsson, O.1
-
4
-
-
0345862278
-
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy
-
Legleiter, J. et al. Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy. J. Mol. Biol. 335, 997-1006 (2004).
-
(2004)
J. Mol. Biol.
, vol.335
, pp. 997-1006
-
-
Legleiter, J.1
-
5
-
-
84912064761
-
A three-dimensional human neural cell culture model of Alzheimer's disease
-
Choi, S. H. et al. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature 515, 274-278 (2014).
-
(2014)
Nature
, vol.515
, pp. 274-278
-
-
Choi, S.H.1
-
6
-
-
84892695519
-
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease
-
Salloway, S. et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N. Engl. J. Med. 370, 322-333 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 322-333
-
-
Salloway, S.1
-
7
-
-
84892748542
-
Phase 3 trials of solanezumab formild-to-moderate Alzheimer's disease
-
Doody, R. S. et al. Phase 3 trials of solanezumab formild-to-moderate Alzheimer's disease. N. Engl. J. Med. 370, 311-321 (2014).
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 311-321
-
-
Doody, R.S.1
-
8
-
-
84875250937
-
Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study
-
Villemagne, V. L. et al. Amyloid beta deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study. Lancet Neurol. 12, 357-367 (2013).
-
(2013)
Lancet Neurol.
, vol.12
, pp. 357-367
-
-
Villemagne, V.L.1
-
9
-
-
84866122213
-
Sting of Alzheimer's failures offset by upcoming prevention trials
-
Mullard, A. Sting of Alzheimer's failures offset by upcoming prevention trials. Nat. Rev. Drug Discov. 11, 657-660 (2012).
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 657-660
-
-
Mullard, A.1
-
10
-
-
84886731238
-
The DIAN study
-
Shimada, H. The DIAN study. Brain Nerve 65, 1178-1184 (2013).
-
(2013)
Brain Nerve
, vol.65
, pp. 1178-1184
-
-
Shimada, H.1
-
11
-
-
80055034288
-
Alzheimer's Prevention Initiative: A plan to accelerate the evaluation of presymptomatic treatments
-
Reiman, E. M. et al. Alzheimer's Prevention Initiative: A plan to accelerate the evaluation of presymptomatic treatments. J. Alzheimers Dis. 26, 321-329 (2011).
-
(2011)
J. Alzheimers Dis.
, vol.26
, pp. 321-329
-
-
Reiman, E.M.1
-
12
-
-
84928025258
-
Humanized antibodies that sequester amyloid beta peptide
-
inventors; Bales K. R. et al.assignees 2001 August 30
-
Bales, K. R. et al.,inventors; Bales, K. R. et al.,assignees. Humanized antibodies that sequester amyloid beta peptide. World Intellectual Property Organization patent WO 2001062801 A2. 2001 August 30.
-
World Intellectual Property Organization Patent WO 2001062801 A2.
-
-
Bales, K.R.1
-
13
-
-
84901635792
-
Do current therapeutic anti-Abeta antibodies for Alzheimer's disease engage the target?
-
Watt, A. D. et al. Do current therapeutic anti-Abeta antibodies for Alzheimer's disease engage the target? Acta Neuropath. 127, 803-810 (2014).
-
(2014)
Acta Neuropath.
, vol.127
, pp. 803-810
-
-
Watt, A.D.1
-
14
-
-
80054911951
-
LigPlot1:multiple ligand-protein interaction diagrams for drug discovery
-
Laskowski, R. A. & Swindells, M. B. LigPlot1:multiple ligand-protein interaction diagrams for drug discovery. J. Chem. Inf. Model 51, 2778-2786 (2011).
-
(2011)
J. Chem. Inf. Model
, vol.51
, pp. 2778-2786
-
-
Laskowski, R.A.1
Swindells, M.B.2
-
15
-
-
39649115608
-
Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope
-
Miles, L. A. et al. Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J. Mol. Biol. 377, 181-192 (2008).
-
(2008)
J. Mol. Biol.
, vol.377
, pp. 181-192
-
-
Miles, L.A.1
-
16
-
-
35648994903
-
Molecular basis for passive immunotherapy of Alzheimer's disease
-
Gardberg, A. S. et al. Molecular basis for passive immunotherapy of Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 104, 15659-15664 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA.
, vol.104
, pp. 15659-15664
-
-
Gardberg, A.S.1
-
17
-
-
84855780598
-
Gantenerumab: A novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta
-
Bohrmann, B. et al. Gantenerumab: A novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta. J. Alzheimers Dis. 28, 49-69 (2012).
-
(2012)
J. Alzheimers Dis.
, vol.28
, pp. 49-69
-
-
Bohrmann, B.1
-
18
-
-
77449115957
-
Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease
-
Basi, G. S. et al. Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J. Biol. Chem. 285, 3417-3427 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 3417-3427
-
-
Basi, G.S.1
-
19
-
-
43049084055
-
Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease
-
Wun, K. S. et al. Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease. Acta Crystallogr. F Struct. Biol. Commun. 64, 438-441 (2008).
-
(2008)
Acta Crystallogr. F Struct. Biol. Commun.
, vol.64
, pp. 438-441
-
-
Wun, K.S.1
-
20
-
-
84874330804
-
Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation
-
Miles, L. A., Crespi, G. A., Doughty, L. & Parker, M. W. Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation. Sci. Rep. 3, 1302 doi:10.1038/srep01302 (2013).
-
(2013)
Sci. Rep.
, vol.3
, pp. 1302
-
-
Miles, L.A.1
Crespi, G.A.2
Doughty, L.3
Parker, M.W.4
-
21
-
-
84903815644
-
Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab
-
Feinberg, H. et al. Crystal structure reveals conservation of amyloid-beta conformation recognized by 3D6 following humanization to bapineuzumab. Alzheimers Res. Ther. 6, 31 (2014).
-
(2014)
Alzheimers Res. Ther.
, vol.6
, pp. 31
-
-
Feinberg, H.1
-
22
-
-
84905490065
-
Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-b
-
Crespi, G. A., Ascher, D. B., Parker, M. W. & Miles, L. A. Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-b. Acta Crysta. Sect. F Struct. Biol. Commun. 70, 374-377 (2014).
-
(2014)
Acta Crysta. Sect. F Struct. Biol. Commun.
, vol.70
, pp. 374-377
-
-
Crespi, G.A.1
Ascher, D.B.2
Parker, M.W.3
Miles, L.A.4
-
23
-
-
84864286560
-
Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease
-
La Porte, S. L. et al. Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease. J. Mol. Biol. 421, 525-536 (2012).
-
(2012)
J. Mol. Biol.
, vol.421
, pp. 525-536
-
-
La Porte, S.L.1
-
24
-
-
32344451179
-
The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: A step by step conformational analysis suggests the location of beta conformation seeding
-
Tomaselli, S., et al. The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: A step by step conformational analysis suggests the location of beta conformation seeding. Chembiochem 7, 257-267 (2006).
-
(2006)
Chembiochem
, vol.7
, pp. 257-267
-
-
Tomaselli, S.1
-
25
-
-
0033863792
-
Solution structures in aqueous SDSmicelles of two amyloid beta peptides ofAbeta 1-28 mutated at the alpha-secretase cleavage site (K16E, K16F)
-
Poulsen, S. A., Watson, A. A., Fairlie, D. P. & Craik, D. J. Solution structures in aqueous SDSmicelles of two amyloid beta peptides ofAbeta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F). J. Struct. Biol. 130, 142-152 (2000).
-
(2000)
J. Struct. Biol.
, vol.130
, pp. 142-152
-
-
Poulsen, S.A.1
Watson, A.A.2
Fairlie, D.P.3
Craik, D.J.4
-
26
-
-
80054752317
-
Molecular basis for amyloid-beta polymorphism
-
Colletier, J. P. et al. Molecular basis for amyloid-beta polymorphism. Proc. Natl. Acad. Sci. USA. 108, 16938-16943 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA.
, vol.108
, pp. 16938-16943
-
-
Colletier, J.P.1
-
27
-
-
84898947037
-
X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from Ab 17-36
-
Spencer, R. K., Li, H. & Nowick, J. S. X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from Ab(17-36). J. Am. Chem. Soc. 136, 5595-5598 (2014).
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 5595-5598
-
-
Spencer, R.K.1
Li, H.2
Nowick, J.S.3
-
28
-
-
84877254025
-
Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets?
-
Moreth, J., Mavoungou, C. & Schindowski, K. Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets? Immun. Ageing. 10, 18-26 (2013).
-
(2013)
Immun Ageing.
, vol.10
, pp. 18-26
-
-
Moreth, J.1
Mavoungou, C.2
Schindowski, K.3
-
29
-
-
34548232365
-
Inference of macromolecular assemblies from crystalline state
-
Krissinel, E. & Henrick, K. Inference of macromolecular assemblies from crystalline state. J. Mol. Biol. 372, 774-797 (2007).
-
(2007)
J. Mol. Biol.
, vol.372
, pp. 774-797
-
-
Krissinel, E.1
Henrick, K.2
-
30
-
-
84863246128
-
Antigen-binding site anatomy and somatic mutations in antibodies that recognize different types of antigens
-
Raghunathan, G., Smart, J., Williams, J. & Almagro, J. C. Antigen-binding site anatomy and somatic mutations in antibodies that recognize different types of antigens. J. Mol. Recognit. 25, 103-113 (2012).
-
(2012)
J. Mol. Recognit.
, vol.25
, pp. 103-113
-
-
Raghunathan, G.1
Smart, J.2
Williams, J.3
Almagro, J.C.4
-
31
-
-
84867378143
-
International nonproprietary names for pharmaceutical substances (inn) Recommended INN: List 100
-
World Health Organization. International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended INN: List 100. WHO Drug Information 22, 311-367 (2008).
-
(2008)
WHO Drug Information
, vol.22
, pp. 311-367
-
-
-
32
-
-
0028846780
-
Crystallization of intact monoclonal antibodies
-
Harris, L. J., Skaletsky, E. & McPherson, A. Crystallization of intact monoclonal antibodies. Proteins 23, 285-289 (1995).
-
(1995)
Proteins
, vol.23
, pp. 285-289
-
-
Harris, L.J.1
Skaletsky, E.2
McPherson, A.3
-
33
-
-
0036849859
-
Blu-Ice and the Distributed Control System: Software for data acquisition and instrument control at macromolecular crystallography beamlines
-
McPhillips, T. M. et al. Blu-Ice and the Distributed Control System: Software for data acquisition and instrument control at macromolecular crystallography beamlines. J. Synchrotron Radiat. 9, 401-406 (2002).
-
(2002)
J. Synchrotron Radiat.
, vol.9
, pp. 401-406
-
-
McPhillips, T.M.1
-
35
-
-
0028103275
-
Number 4 the CCP4 suite: Programs for protein crystallography
-
Collaborative Computational Project, Number 4 The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50, 760-763 (1994).
-
(1994)
Acta Crystallogr. D Biol. Crystallogr.
, vol.50
, pp. 760-763
-
-
-
37
-
-
3242886389
-
MOLPROBITY: Structure validation and all-atom contact analysis for nucleic acids and their complexes
-
(Web Server issue)W615-619
-
Davis, I. W.,Murray, L. W., Richardson, J. S. & Richardson, D. C. MOLPROBITY: Structure validation and all-atom contact analysis for nucleic acids and their complexes. Nucleic Acids Res. 32 (Web Server issue)W615-619 doi:10.1093/nar/gkh398 (2004).
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Davis, W.1
Murray, L.W.2
Richardson, J.S.3
Richardson, D.C.4
|