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Volumn 5, Issue 9-10, 2014, Pages 337-347

Mirk Kinase inhibition blocks the in vivo growth of pancreatic cancer cells

Author keywords

dyrk1B; Kras; Mirk; mTOR; Pancreatic cancer

Indexed keywords

MIRK KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

EID: 84927919630     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (24)

References (39)
  • 2
    • 84893468215 scopus 로고    scopus 로고
    • Kras as a key oncogene and therapeutic target in pancreatic cancer
    • PMCID: 3896882
    • Collins MA, Pasca di Magliano M. Kras as a key oncogene and therapeutic target in pancreatic cancer. Front Physiol. 2013;4:407. PMCID: 3896882.
    • (2013) Front Physiol , vol.4 , pp. 407
    • Collins, M.A.1    Pasca Di Magliano, M.2
  • 3
    • 84860321700 scopus 로고    scopus 로고
    • Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
    • Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, et al. Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism. Cell. 2012;149(3):656-70.
    • (2012) Cell , vol.149 , Issue.3 , pp. 656-670
    • Ying, H.1    Kimmelman, A.C.2    Lyssiotis, C.A.3    Hua, S.4    Chu, G.C.5    Fletcher-Sananikone, E.6
  • 4
    • 34547630697 scopus 로고    scopus 로고
    • The survival kinase Mirk/dyrk1B is a downstream effector of oncogenic K-ras
    • Jin K, Park S-J, Ewton D, Friedman E. The survival kinase Mirk/dyrk1B is a downstream effector of oncogenic K-ras. Cancer Res. 2007;67:7247-55.
    • (2007) Cancer Res , vol.67 , pp. 7247-7255
    • Jin, K.1    Park, S.-J.2    Ewton, D.3    Friedman, E.4
  • 5
    • 33748146888 scopus 로고    scopus 로고
    • Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
    • Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate. Cancer Cell. 2006;10:241-52.
    • (2006) Cancer Cell , vol.10 , pp. 241-252
    • Trachootham, D.1    Zhou, Y.2    Zhang, H.3    Demizu, Y.4    Chen, Z.5    Pelicano, H.6
  • 6
    • 65949118505 scopus 로고    scopus 로고
    • Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by decreasing ROS levels
    • Deng X, Ewton DZ, Friedman E. Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by decreasing ROS levels. Cancer Res. 2009;69(8):3317-24.
    • (2009) Cancer Res , vol.69 , Issue.8 , pp. 3317-3324
    • Deng, X.1    Ewton, D.Z.2    Friedman, E.3
  • 7
  • 8
  • 9
    • 33646247855 scopus 로고    scopus 로고
    • The Kinase Mirk/Dyrk1B Mediates Cell Survival in Pancreatic Ductal Adenocarcinoma
    • Deng X, Ewton DZ, Li S, Naqvi A, Mercer SE, Landas S, et al. The Kinase Mirk/Dyrk1B Mediates Cell Survival in Pancreatic Ductal Adenocarcinoma. Cancer Res 2006;66(8):4149-58.
    • (2006) Cancer Res , vol.66 , Issue.8 , pp. 4149-4158
    • Deng, X.1    Ewton, D.Z.2    Li, S.3    Naqvi, A.4    Mercer, S.E.5    Landas, S.6
  • 10
    • 81055127017 scopus 로고    scopus 로고
    • Inactivation of Mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol
    • Ewton D, Hu J, Vilenchik M, Deng X, Luk K-C, Polonskaia A, et al. Inactivation of Mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol. Cancer Ther. 2011;10(11):2104-14.
    • (2011) Cancer Ther , vol.10 , Issue.11 , pp. 2104-2114
    • Ewton, D.1    Hu, J.2    Vilenchik, M.3    Deng, X.4    Luk, K.-C.5    Polonskaia, A.6
  • 11
    • 84874936048 scopus 로고    scopus 로고
    • Ovarian Cancer Cells, not Normal cells, are Damaged by Mirk/Dyrk1B kinase inhibition
    • Hu J, Deng H, Friedman E. Ovarian Cancer Cells, not Normal cells, are Damaged by Mirk/Dyrk1B kinase inhibition Int J Cancer. 2013;132(10):2258-69.
    • (2013) Int J Cancer , vol.132 , Issue.10 , pp. 2258-2269
    • Hu, J.1    Deng, H.2    Friedman, E.3
  • 12
    • 0034235542 scopus 로고    scopus 로고
    • Mirk Protein Kinase Is a Mitogen-activated Protein Kinase Substrate That Mediates Survival of Colon Cancer Cells
    • Lee K, Deng X, Friedman E. Mirk Protein Kinase Is a Mitogen-activated Protein Kinase Substrate That Mediates Survival of Colon Cancer Cells. Cancer Res. 2000;60(13):3631-7.
    • (2000) Cancer Res , vol.60 , Issue.13 , pp. 3631-3637
    • Lee, K.1    Deng, X.2    Friedman, E.3
  • 13
    • 69249110053 scopus 로고    scopus 로고
    • Mirk regulates the exit of colon cancer cells from quiescence
    • Jin K, Ewton D, Park S, Hu J, Friedman E. Mirk regulates the exit of colon cancer cells from quiescence. J Biol. Chemistry. 2009;284(34):22916-25.
    • (2009) J Biol. Chemistry , vol.284 , Issue.34 , pp. 22916-22925
    • Jin, K.1    Ewton, D.2    Park, S.3    Hu, J.4    Friedman, E.5
  • 14
    • 3042684281 scopus 로고    scopus 로고
    • Mirk/dyrk1B Kinase Destabilizes Cyclin D1 by Phosphorylation at Threonine 288
    • Zou Y, Ewton D, Deng D, Mercer S, Friedman E. Mirk/dyrk1B Kinase Destabilizes Cyclin D1 by Phosphorylation at Threonine 288. J Biol Chem. 2004;279:27790-8.
    • (2004) J Biol Chem , vol.279 , pp. 27790-27798
    • Zou, Y.1    Ewton, D.2    Deng, D.3    Mercer, S.4    Friedman, E.5
  • 15
    • 57749107725 scopus 로고    scopus 로고
    • G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation
    • Janumyan Y, Cui Q, Yan L, Sansam CG, Vanlentin M, Yang E. G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation. J Biol Chem 2008;283:34108-20.
    • (2008) J Biol Chem , vol.283 , pp. 34108-34120
    • Janumyan, Y.1    Cui, Q.2    Yan, L.3    Sansam, C.G.4    Vanlentin, M.5    Yang, E.6
  • 18
    • 0037067736 scopus 로고    scopus 로고
    • Mirk Protein Kinase Is Activated by MKK3 and Functions as a Transcriptional Activator of HNF1alpha
    • Lim S, Jin K, Friedman E. Mirk Protein Kinase Is Activated by MKK3 and Functions as a Transcriptional Activator of HNF1alpha. J Biol Chem 2002;277(28):25040-6.
    • (2002) J Biol Chem , vol.277 , Issue.28 , pp. 25040-25046
    • Lim, S.1    Jin, K.2    Friedman, E.3
  • 19
    • 14244258401 scopus 로고    scopus 로고
    • Mirk/dyrk1B Decreases the Nuclear Accumulation of Class II Histone Deacetylases during Skeletal Muscle Differentiation
    • Deng X, Ewton DZ, Mercer SE, Friedman E. Mirk/dyrk1B Decreases the Nuclear Accumulation of Class II Histone Deacetylases during Skeletal Muscle Differentiation. J Biol Chem 2005;280(6):4894-905.
    • (2005) J Biol Chem , vol.280 , Issue.6 , pp. 4894-4905
    • Deng, X.1    Ewton, D.Z.2    Mercer, S.E.3    Friedman, E.4
  • 21
    • 84901271607 scopus 로고    scopus 로고
    • Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression
    • Kinsey C, Balakrishnan V, Äôdell MR, Huang JL, Newman L, Whitney-Miller CL, et al. Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression. Cell Reports. 2014;7(4):1143-55.
    • (2014) Cell Reports , vol.7 , Issue.4 , pp. 1143-1155
    • Kinsey, C.1    Balakrishnan, V.2    Äôdell, M.R.3    Huang, J.L.4    Newman, L.5    Whitney-Miller, C.L.6
  • 22
    • 34748840281 scopus 로고    scopus 로고
    • The phosphatidylinositol 3- kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
    • Howes AL, Chiang GG, Lang ES, Ho CB, Powis G, Vuori K, et al. The phosphatidylinositol 3- kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol Cancer Ther. 2007;6(9):2505-14.
    • (2007) Mol Cancer Ther , vol.6 , Issue.9 , pp. 2505-2514
    • Howes, A.L.1    Chiang, G.G.2    Lang, E.S.3    Ho, C.B.4    Powis, G.5    Vuori, K.6
  • 23
    • 77953540958 scopus 로고    scopus 로고
    • HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment
    • PMCID: 2935800
    • Weigelt B, Lo AT, Park CC, Gray JW, Bissell MJ. HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat. 2010;122(1):35-43. PMCID: 2935800.
    • (2010) Breast Cancer Res Treat , vol.122 , Issue.1 , pp. 35-43
    • Weigelt, B.1    Lo, A.T.2    Park, C.C.3    Gray, J.W.4    Bissell, M.J.5
  • 24
    • 84856989746 scopus 로고    scopus 로고
    • Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells
    • PMCID: 3297962
    • Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, et al. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012;21(2):227-39. PMCID: 3297962.
    • (2012) Cancer Cell , vol.21 , Issue.2 , pp. 227-239
    • Muranen, T.1    Selfors, L.M.2    Worster, D.T.3    Iwanicki, M.P.4    Song, L.5    Morales, F.C.6
  • 25
    • 84907518318 scopus 로고    scopus 로고
    • Mirk/Dyrk1B Kinase Inhibition Targets Ovarian Cancer Ascites
    • Deng X, Hu J, Cunningham M, Friedman E. Mirk/Dyrk1B Kinase Inhibition Targets Ovarian Cancer Ascites. Genes & Cancer. 2014;5(5-6):201-11.
    • (2014) Genes & Cancer , vol.5 , Issue.5-6 , pp. 201-211
    • Deng, X.1    Hu, J.2    Cunningham, M.3    Friedman, E.4
  • 26
    • 84880815785 scopus 로고    scopus 로고
    • A kinome-wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- renal carcinoma cells, despite activation of the NF- kappaB pathway
    • Pan J, Zhang J, Hill A, Lapan P, Berasi S, Bates B, et al. A kinome-wide siRNA screen identifies multiple roles for protein kinases in hypoxic stress adaptation, including roles for IRAK4 and GAK in protection against apoptosis in VHL-/- renal carcinoma cells, despite activation of the NF- kappaB pathway. J Biomol Screen. 2013;18(7):782-96.
    • (2013) J Biomol Screen , vol.18 , Issue.7 , pp. 782-796
    • Pan, J.1    Zhang, J.2    Hill, A.3    Lapan, P.4    Berasi, S.5    Bates, B.6
  • 27
    • 84906835371 scopus 로고    scopus 로고
    • Mirk Kinase is Upregulated Following Inhibition of mTOR
    • in press
    • Deng X, Ewton D, Hu J, Friedman E. Mirk Kinase is Upregulated Following Inhibition of mTOR. Carcinogenesis. 2014;in press.
    • (2014) Carcinogenesis
    • Deng, X.1    Ewton, D.2    Hu, J.3    Friedman, E.4
  • 28
    • 84855405986 scopus 로고    scopus 로고
    • Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids
    • Correa RJM, Peart T, Valdes YR, DiMattia GE, Shepherd TG. Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids. Carcinogenesis. 2012;33(1):49-58.
    • (2012) Carcinogenesis , vol.33 , Issue.1 , pp. 49-58
    • Correa, R.1    Peart, T.2    Valdes, Y.R.3    Dimattia, G.E.4    Shepherd, T.G.5
  • 29
    • 79961121875 scopus 로고    scopus 로고
    • Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by Mirk/dyrk1B and p130/Rb2
    • Hu J, Nakhla H, Friedman E. Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by Mirk/dyrk1B and p130/Rb2 Int J Cancer. 2011;129:307-18.
    • (2011) Int J Cancer , vol.129 , pp. 307-318
    • Hu, J.1    Nakhla, H.2    Friedman, E.3
  • 30
    • 84882580168 scopus 로고    scopus 로고
    • The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis
    • Boichuk S, Parry JA, Makielski KR, Litovchick L, Baron JL, Zewe JP, et al. The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis. Cancer Res. 2013;73(16):5120-9.
    • (2013) Cancer Res , vol.73 , Issue.16 , pp. 5120-5129
    • Boichuk, S.1    Parry, J.A.2    Makielski, K.R.3    Litovchick, L.4    Baron, J.L.5    Zewe, J.P.6
  • 31
    • 84881131933 scopus 로고    scopus 로고
    • The DREAM complex: Master coordinator of cell cycle-dependent gene expression
    • Sadasivam S, DeCaprio JA. The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nat Rev Cancer. 2013;13(8):585-95.
    • (2013) Nat Rev Cancer , vol.13 , Issue.8 , pp. 585-595
    • Sadasivam, S.1    Decaprio, J.A.2
  • 32
    • 0242329867 scopus 로고    scopus 로고
    • Analysis of Ki-67 antigen expression, DNA proliferative fraction, and survival in resected cancer of the pancreas. American
    • Stanton KJ, Sidner RA, Miller GA, Cummings OW, Schmidt CM, Howard TJ, et al. Analysis of Ki-67 antigen expression, DNA proliferative fraction, and survival in resected cancer of the pancreas. American J. Surgery. 2003;186(5):486-92.
    • (2003) J. Surgery , vol.186 , Issue.5 , pp. 486-492
    • Stanton, K.J.1    Sidner, R.A.2    Miller, G.A.3    Cummings, O.W.4    Schmidt, C.M.5    Howard, T.J.6
  • 33
    • 84945931390 scopus 로고    scopus 로고
    • The normal function of the cancer kinase Mirk/dyrk1B is to reduce reactive oxygen species
    • PMCID: 4063251
    • Deng X, Mercer SE, Sun CY, Friedman E. The normal function of the cancer kinase Mirk/dyrk1B is to reduce reactive oxygen species. Genes & Cancer. 2014;5(1-2):22-30. PMCID: 4063251.
    • (2014) Genes & Cancer , vol.5 , Issue.1-2 , pp. 22-30
    • Deng, X.1    Mercer, S.E.2    Sun, C.Y.3    Friedman, E.4
  • 34
    • 0346455774 scopus 로고    scopus 로고
    • Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, et al. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 2003;17(24):3112-26.
    • (2003) Genes Dev , vol.17 , Issue.24 , pp. 3112-3126
    • Aguirre, A.J.1    Bardeesy, N.2    Sinha, M.3    Lopez, L.4    Tuveson, D.A.5    Horner, J.6
  • 35
    • 80054795610 scopus 로고    scopus 로고
    • Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas
    • PMCID: 3201569
    • Fendrich V, Oh E, Bang S, Karikari C, Ottenhof N, Bisht S, et al. Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas. Neoplasia. 2011;13(10):923-30. PMCID: 3201569.
    • (2011) Neoplasia , vol.13 , Issue.10 , pp. 923-930
    • Fendrich, V.1    Oh, E.2    Bang, S.3    Karikari, C.4    Ottenhof, N.5    Bisht, S.6
  • 36
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • Ozdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014;25(6):719-34.
    • (2014) Cancer Cell , vol.25 , Issue.6 , pp. 719-734
    • Ozdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3    Zheng, X.4    Wu, C.C.5    Simpson, T.R.6
  • 37
    • 84902435628 scopus 로고    scopus 로고
    • Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    • Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 2014;25(6):735-47.
    • (2014) Cancer Cell , vol.25 , Issue.6 , pp. 735-747
    • Rhim, A.D.1    Oberstein, P.E.2    Thomas, D.H.3    Mirek, E.T.4    Palermo, C.F.5    Sastra, S.A.6
  • 38
    • 84887532497 scopus 로고    scopus 로고
    • Requirement for interaction of PI3-kinase p110alpha with RAS in lung tumor maintenance
    • PMCID: 3826036
    • Castellano E, Sheridan C, Thin MZ, Nye E, Spencer-Dene B, Diefenbacher ME, et al. Requirement for interaction of PI3-kinase p110alpha with RAS in lung tumor maintenance. Cancer Cell. 2013;24(5):617-30. PMCID: 3826036.
    • (2013) Cancer Cell , vol.24 , Issue.5 , pp. 617-630
    • Castellano, E.1    Sheridan, C.2    Thin, M.Z.3    Nye, E.4    Spencer-Dene, B.5    Diefenbacher, M.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.